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Updated November 2019
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Protein Info
Short Name:
MED12
Full Name:
Mediator of RNA polymerase II transcription subunit 12
Alias:
Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat 45; CAGH45; HOPA; KIAA0192; Mediator complex subunit 12; Mediator of RNA polymerase II transcription 12; Mediator of RNA polymerase II transcription, subunit 12; OPA1; OPA-containing; Thyroid hormone receptor-associated protein complex 230 kDa component; TNRC11; TRAP230; Trinucleotide repeat-containing gene 11
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Mass (Da):
243081
Number AA:
2177
UniProt ID:
Q93074
International Prot ID:
IPI00004068
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0016592
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0016455
GO:0030374
GO:0019904
PhosphoSite+
KinaseNET
Biological Process:
GO:0030521
GO:0045944
GO:0006367
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
A
F
G
I
L
S
Y
E
H
R
P
L
K
Site 2
Y9
A
A
F
G
I
L
S
Y
E
H
R
P
L
K
R
Site 3
Y25
R
L
G
P
P
D
V
Y
P
Q
D
P
K
Q
K
Site 4
T37
K
Q
K
E
D
E
L
T
A
L
N
V
K
Q
G
Site 5
S63
H
G
S
A
K
N
V
S
F
N
P
A
K
I
S
Site 6
S70
S
F
N
P
A
K
I
S
S
N
F
S
S
I
I
Site 7
S75
K
I
S
S
N
F
S
S
I
I
A
E
K
L
R
Site 8
T85
A
E
K
L
R
C
N
T
L
P
D
T
G
R
R
Site 9
T89
R
C
N
T
L
P
D
T
G
R
R
K
P
Q
V
Site 10
T106
K
D
N
F
W
L
V
T
A
R
S
Q
S
A
I
Site 11
T115
R
S
Q
S
A
I
N
T
W
F
T
D
L
A
G
Site 12
T127
L
A
G
T
K
P
L
T
Q
L
A
K
K
V
P
Site 13
Y145
K
K
E
E
V
F
G
Y
L
A
K
Y
T
V
P
Site 14
Y166
L
I
K
M
T
C
A
Y
Y
A
A
I
S
E
T
Site 15
Y204
Q
L
Q
K
M
A
E
Y
Y
R
P
G
P
A
G
Site 16
S212
Y
R
P
G
P
A
G
S
G
G
C
G
S
T
I
Site 17
S217
A
G
S
G
G
C
G
S
T
I
G
P
L
P
H
Site 18
T218
G
S
G
G
C
G
S
T
I
G
P
L
P
H
D
Site 19
Y235
V
A
I
R
Q
W
D
Y
T
E
K
L
A
M
F
Site 20
S290
Y
S
G
E
F
V
Q
S
A
Y
L
S
R
R
L
Site 21
Y292
G
E
F
V
Q
S
A
Y
L
S
R
R
L
A
Y
Site 22
Y299
Y
L
S
R
R
L
A
Y
F
C
T
R
R
L
A
Site 23
T302
R
R
L
A
Y
F
C
T
R
R
L
A
L
Q
L
Site 24
S314
L
Q
L
D
G
V
S
S
H
S
S
H
V
I
S
Site 25
S316
L
D
G
V
S
S
H
S
S
H
V
I
S
A
Q
Site 26
S317
D
G
V
S
S
H
S
S
H
V
I
S
A
Q
S
Site 27
S321
S
H
S
S
H
V
I
S
A
Q
S
T
S
T
L
Site 28
S324
S
H
V
I
S
A
Q
S
T
S
T
L
P
T
T
Site 29
T330
Q
S
T
S
T
L
P
T
T
P
A
P
Q
P
P
Site 30
T331
S
T
S
T
L
P
T
T
P
A
P
Q
P
P
T
Site 31
T338
T
P
A
P
Q
P
P
T
S
S
T
P
S
T
P
Site 32
S339
P
A
P
Q
P
P
T
S
S
T
P
S
T
P
F
Site 33
S340
A
P
Q
P
P
T
S
S
T
P
S
T
P
F
S
Site 34
T341
P
Q
P
P
T
S
S
T
P
S
T
P
F
S
D
Site 35
S343
P
P
T
S
S
T
P
S
T
P
F
S
D
L
L
Site 36
T344
P
T
S
S
T
P
S
T
P
F
S
D
L
L
M
Site 37
S347
S
T
P
S
T
P
F
S
D
L
L
M
C
P
Q
Site 38
S382
S
A
L
V
W
H
Y
S
L
T
D
S
R
I
K
Site 39
T384
L
V
W
H
Y
S
L
T
D
S
R
I
K
T
G
Site 40
S386
W
H
Y
S
L
T
D
S
R
I
K
T
G
S
P
Site 41
T390
L
T
D
S
R
I
K
T
G
S
P
L
D
H
L
Site 42
S392
D
S
R
I
K
T
G
S
P
L
D
H
L
P
I
Site 43
S402
D
H
L
P
I
A
P
S
N
L
P
M
P
E
G
Site 44
S440
Q
A
V
E
V
R
W
S
F
D
K
C
Q
E
A
Site 45
S465
H
T
L
E
V
L
D
S
H
S
F
E
R
S
D
Site 46
S467
L
E
V
L
D
S
H
S
F
E
R
S
D
F
S
Site 47
S471
D
S
H
S
F
E
R
S
D
F
S
N
S
L
D
Site 48
S474
S
F
E
R
S
D
F
S
N
S
L
D
S
L
C
Site 49
S476
E
R
S
D
F
S
N
S
L
D
S
L
C
N
R
Site 50
S479
D
F
S
N
S
L
D
S
L
C
N
R
I
F
G
Site 51
S490
R
I
F
G
L
G
P
S
K
D
G
H
E
I
S
Site 52
S497
S
K
D
G
H
E
I
S
S
D
D
D
A
V
V
Site 53
S498
K
D
G
H
E
I
S
S
D
D
D
A
V
V
S
Site 54
S552
E
A
A
D
E
K
G
S
I
A
S
G
S
L
S
Site 55
S555
D
E
K
G
S
I
A
S
G
S
L
S
A
P
S
Site 56
S557
K
G
S
I
A
S
G
S
L
S
A
P
S
A
P
Site 57
T582
D
T
Q
A
P
M
L
T
D
P
R
S
E
S
E
Site 58
S586
P
M
L
T
D
P
R
S
E
S
E
R
V
E
F
Site 59
S588
L
T
D
P
R
S
E
S
E
R
V
E
F
F
N
Site 60
Y614
D
V
F
S
H
N
M
Y
T
C
T
L
I
S
R
Site 61
T617
S
H
N
M
Y
T
C
T
L
I
S
R
G
D
L
Site 62
S635
A
P
G
P
R
P
P
S
P
F
D
D
P
A
D
Site 63
S652
E
H
K
E
A
E
G
S
S
S
S
K
L
E
D
Site 64
S654
K
E
A
E
G
S
S
S
S
K
L
E
D
P
G
Site 65
S663
K
L
E
D
P
G
L
S
E
S
M
D
I
D
P
Site 66
S665
E
D
P
G
L
S
E
S
M
D
I
D
P
S
S
Site 67
S671
E
S
M
D
I
D
P
S
S
S
V
L
F
E
D
Site 68
S672
S
M
D
I
D
P
S
S
S
V
L
F
E
D
M
Site 69
S673
M
D
I
D
P
S
S
S
V
L
F
E
D
M
E
Site 70
S685
D
M
E
K
P
D
F
S
L
F
S
P
T
M
P
Site 71
S688
K
P
D
F
S
L
F
S
P
T
M
P
C
E
G
Site 72
S698
M
P
C
E
G
K
G
S
P
S
P
E
K
P
D
Site 73
S700
C
E
G
K
G
S
P
S
P
E
K
P
D
V
E
Site 74
Y726
E
G
T
L
G
V
L
Y
D
Q
P
R
H
V
Q
Site 75
Y734
D
Q
P
R
H
V
Q
Y
A
T
H
F
P
I
P
Site 76
T736
P
R
H
V
Q
Y
A
T
H
F
P
I
P
Q
E
Site 77
S747
I
P
Q
E
E
S
C
S
H
E
C
N
Q
R
L
Site 78
T787
K
V
L
N
R
K
G
T
A
E
T
D
Q
L
A
Site 79
T805
P
L
N
P
G
D
L
T
F
L
G
G
E
D
G
Site 80
T825
N
R
P
E
A
F
P
T
A
E
D
I
F
A
K
Site 81
Y839
K
F
Q
H
L
S
H
Y
D
Q
H
Q
V
T
A
Site 82
T845
H
Y
D
Q
H
Q
V
T
A
Q
V
S
R
N
V
Site 83
S911
E
A
E
L
L
L
K
S
S
D
L
V
G
S
Y
Site 84
S962
V
K
H
G
M
N
R
S
D
G
S
S
A
E
R
Site 85
S966
M
N
R
S
D
G
S
S
A
E
R
C
I
L
A
Site 86
T980
A
Y
L
Y
D
L
Y
T
S
C
S
H
L
K
N
Site 87
S994
N
K
F
G
E
L
F
S
D
F
C
S
K
V
K
Site 88
Y1005
S
K
V
K
N
T
I
Y
C
N
V
E
P
S
E
Site 89
T1025
A
P
E
F
M
I
D
T
L
E
N
P
A
A
H
Site 90
T1033
L
E
N
P
A
A
H
T
F
T
Y
T
G
L
G
Site 91
Y1036
P
A
A
H
T
F
T
Y
T
G
L
G
K
S
L
Site 92
S1042
T
Y
T
G
L
G
K
S
L
S
E
N
P
A
N
Site 93
S1044
T
G
L
G
K
S
L
S
E
N
P
A
N
R
Y
Site 94
S1087
E
L
T
G
Y
C
K
S
L
S
A
E
W
L
G
Site 95
S1123
N
V
D
V
S
D
L
S
F
H
D
S
L
A
T
Site 96
S1161
S
L
L
N
A
A
C
S
E
Q
D
S
E
P
G
Site 97
S1165
A
A
C
S
E
Q
D
S
E
P
G
A
R
L
T
Site 98
S1190
P
Q
L
N
P
C
Q
S
D
G
N
K
P
T
V
Site 99
T1196
Q
S
D
G
N
K
P
T
V
G
I
R
S
S
C
Site 100
S1201
K
P
T
V
G
I
R
S
S
C
D
R
H
L
L
Site 101
S1202
P
T
V
G
I
R
S
S
C
D
R
H
L
L
A
Site 102
S1211
D
R
H
L
L
A
A
S
Q
N
R
I
V
D
G
Site 103
S1238
G
D
A
E
L
K
G
S
G
F
T
V
T
G
G
Site 104
S1258
E
E
E
G
G
G
G
S
G
G
R
R
Q
G
G
Site 105
S1269
R
Q
G
G
R
N
I
S
V
E
T
A
S
L
D
Site 106
S1274
N
I
S
V
E
T
A
S
L
D
V
Y
A
K
Y
Site 107
Y1278
E
T
A
S
L
D
V
Y
A
K
Y
V
L
R
S
Site 108
S1299
V
G
E
R
C
L
K
S
L
C
E
D
S
N
D
Site 109
S1304
R
Q
G
G
R
N
I
S
V
E
T
A
S
L
D
Site 110
Y1326
R
L
M
Q
L
I
C
Y
P
H
R
L
L
D
N
Site 111
T1355
L
Q
N
L
D
Q
W
T
M
R
Q
S
S
L
E
Site 112
S1359
D
Q
W
T
M
R
Q
S
S
L
E
L
Q
L
M
Site 113
S1360
Q
W
T
M
R
Q
S
S
L
E
L
Q
L
M
I
Site 114
T1370
L
Q
L
M
I
K
Q
T
P
N
N
E
M
N
S
Site 115
S1393
T
I
E
V
F
Q
Q
S
A
E
T
G
S
S
S
Site 116
T1396
V
F
Q
Q
S
A
E
T
G
S
S
S
G
S
T
Site 117
S1398
Q
Q
S
A
E
T
G
S
S
S
G
S
T
A
S
Site 118
S1399
Q
S
A
E
T
G
S
S
S
G
S
T
A
S
N
Site 119
S1400
S
A
E
T
G
S
S
S
G
S
T
A
S
N
M
Site 120
S1402
E
T
G
S
S
S
G
S
T
A
S
N
M
P
S
Site 121
T1403
T
G
S
S
S
G
S
T
A
S
N
M
P
S
S
Site 122
S1405
S
S
S
G
S
T
A
S
N
M
P
S
S
S
K
Site 123
S1409
S
T
A
S
N
M
P
S
S
S
K
T
K
P
V
Site 124
S1410
T
A
S
N
M
P
S
S
S
K
T
K
P
V
L
Site 125
S1411
A
S
N
M
P
S
S
S
K
T
K
P
V
L
S
Site 126
T1413
N
M
P
S
S
S
K
T
K
P
V
L
S
S
L
Site 127
S1418
S
K
T
K
P
V
L
S
S
L
E
R
S
G
V
Site 128
S1419
K
T
K
P
V
L
S
S
L
E
R
S
G
V
W
Site 129
S1459
E
K
G
Q
H
L
G
S
S
S
R
K
E
R
D
Site 130
S1460
K
G
Q
H
L
G
S
S
S
R
K
E
R
D
R
Site 131
S1472
R
D
R
Q
K
Q
K
S
M
S
L
L
S
Q
Q
Site 132
S1474
R
Q
K
Q
K
S
M
S
L
L
S
Q
Q
P
F
Site 133
S1477
Q
K
S
M
S
L
L
S
Q
Q
P
F
L
S
L
Site 134
T1501
E
Q
R
E
G
L
L
T
S
L
Y
S
Q
V
H
Site 135
S1502
Q
R
E
G
L
L
T
S
L
Y
S
Q
V
H
Q
Site 136
Y1519
N
N
W
R
D
D
Q
Y
L
D
D
C
K
P
K
Site 137
T1546
L
V
G
G
M
F
D
T
V
Q
R
S
T
Q
Q
Site 138
T1551
F
D
T
V
Q
R
S
T
Q
Q
T
T
E
W
A
Site 139
T1554
V
Q
R
S
T
Q
Q
T
T
E
W
A
M
L
L
Site 140
S1574
S
G
T
V
D
M
Q
S
N
N
E
L
F
T
T
Site 141
S1600
T
L
A
A
D
M
S
S
I
S
Q
G
S
M
E
Site 142
S1602
A
A
D
M
S
S
I
S
Q
G
S
M
E
E
N
Site 143
Y1613
M
E
E
N
K
R
A
Y
M
N
L
A
K
K
L
Site 144
S1629
K
E
L
G
E
R
Q
S
D
S
L
E
K
V
R
Site 145
S1631
L
G
E
R
Q
S
D
S
L
E
K
V
R
Q
L
Site 146
T1650
K
Q
T
R
D
V
I
T
C
E
P
Q
G
S
L
Site 147
S1656
I
T
C
E
P
Q
G
S
L
I
D
T
K
G
N
Site 148
T1660
P
Q
G
S
L
I
D
T
K
G
N
K
I
A
G
Site 149
S1670
N
K
I
A
G
F
D
S
I
F
K
K
E
G
L
Site 150
S1680
K
K
E
G
L
Q
V
S
T
K
Q
K
I
S
P
Site 151
S1686
V
S
T
K
Q
K
I
S
P
W
D
L
F
E
G
Site 152
S1697
L
F
E
G
L
K
P
S
A
P
L
S
W
G
W
Site 153
Y1726
E
Q
Q
R
L
L
L
Y
H
T
H
L
R
P
R
Site 154
T1728
Q
R
L
L
L
Y
H
T
H
L
R
P
R
P
R
Site 155
Y1737
L
R
P
R
P
R
A
Y
Y
L
E
P
L
P
L
Site 156
Y1738
R
P
R
P
R
A
Y
Y
L
E
P
L
P
L
P
Site 157
T1769
K
A
P
E
P
P
K
T
D
K
P
G
A
A
P
Site 158
S1778
K
P
G
A
A
P
P
S
T
E
E
R
K
K
K
Site 159
T1779
P
G
A
A
P
P
S
T
E
E
R
K
K
K
S
Site 160
S1786
T
E
E
R
K
K
K
S
T
K
G
K
K
R
S
Site 161
T1787
E
E
R
K
K
K
S
T
K
G
K
K
R
S
Q
Site 162
S1793
S
T
K
G
K
K
R
S
Q
P
A
T
K
T
E
Site 163
T1797
K
K
R
S
Q
P
A
T
K
T
E
D
Y
G
M
Site 164
T1799
R
S
Q
P
A
T
K
T
E
D
Y
G
M
G
P
Site 165
Y1802
P
A
T
K
T
E
D
Y
G
M
G
P
G
R
S
Site 166
S1809
Y
G
M
G
P
G
R
S
G
P
Y
G
V
T
V
Site 167
T1815
R
S
G
P
Y
G
V
T
V
P
P
D
L
L
H
Site 168
Y1834
G
S
I
T
H
L
N
Y
R
Q
G
S
I
G
L
Site 169
S1838
H
L
N
Y
R
Q
G
S
I
G
L
Y
T
Q
N
Site 170
Y1842
R
Q
G
S
I
G
L
Y
T
Q
N
Q
P
L
P
Site 171
T1843
Q
G
S
I
G
L
Y
T
Q
N
Q
P
L
P
A
Site 172
Y1858
G
G
P
R
V
D
P
Y
R
P
V
R
L
P
M
Site 173
T1873
Q
K
L
P
T
R
P
T
Y
P
G
V
L
P
T
Site 174
Y1874
K
L
P
T
R
P
T
Y
P
G
V
L
P
T
T
Site 175
S1891
G
V
M
G
L
E
P
S
S
Y
K
T
S
V
Y
Site 176
S1892
V
M
G
L
E
P
S
S
Y
K
T
S
V
Y
R
Site 177
Y1893
M
G
L
E
P
S
S
Y
K
T
S
V
Y
R
Q
Site 178
T1895
L
E
P
S
S
Y
K
T
S
V
Y
R
Q
Q
Q
Site 179
S1896
E
P
S
S
Y
K
T
S
V
Y
R
Q
Q
Q
P
Site 180
Y1898
S
S
Y
K
T
S
V
Y
R
Q
Q
Q
P
A
V
Site 181
S1918
L
R
Q
Q
L
Q
Q
S
Q
G
M
L
G
Q
S
Site 182
S1925
S
Q
G
M
L
G
Q
S
S
V
H
Q
M
T
P
Site 183
S1926
Q
G
M
L
G
Q
S
S
V
H
Q
M
T
P
S
Site 184
T1931
Q
S
S
V
H
Q
M
T
P
S
S
S
Y
G
L
Site 185
S1933
S
V
H
Q
M
T
P
S
S
S
Y
G
L
Q
T
Site 186
S1934
V
H
Q
M
T
P
S
S
S
Y
G
L
Q
T
S
Site 187
S1935
H
Q
M
T
P
S
S
S
Y
G
L
Q
T
S
Q
Site 188
S1941
S
S
Y
G
L
Q
T
S
Q
G
Y
T
P
Y
V
Site 189
T1945
L
Q
T
S
Q
G
Y
T
P
Y
V
S
H
V
G
Site 190
Y1947
T
S
Q
G
Y
T
P
Y
V
S
H
V
G
L
Q
Site 191
T1962
Q
H
T
G
P
A
G
T
M
V
P
P
S
Y
S
Site 192
S1967
A
G
T
M
V
P
P
S
Y
S
S
Q
P
Y
Q
Site 193
Y1968
G
T
M
V
P
P
S
Y
S
S
Q
P
Y
Q
S
Site 194
S1969
T
M
V
P
P
S
Y
S
S
Q
P
Y
Q
S
T
Site 195
S1970
M
V
P
P
S
Y
S
S
Q
P
Y
Q
S
T
H
Site 196
Y1973
P
S
Y
S
S
Q
P
Y
Q
S
T
H
P
S
T
Site 197
S1975
Y
S
S
Q
P
Y
Q
S
T
H
P
S
T
N
P
Site 198
T1976
S
S
Q
P
Y
Q
S
T
H
P
S
T
N
P
T
Site 199
S1979
P
Y
Q
S
T
H
P
S
T
N
P
T
L
V
D
Site 200
T1983
T
H
P
S
T
N
P
T
L
V
D
P
T
R
H
Site 201
S1996
R
H
L
Q
Q
R
P
S
G
Y
V
H
Q
Q
A
Site 202
Y1998
L
Q
Q
R
P
S
G
Y
V
H
Q
Q
A
P
T
Site 203
Y2006
V
H
Q
Q
A
P
T
Y
G
H
G
L
T
S
T
Site 204
S2012
T
Y
G
H
G
L
T
S
T
Q
R
F
S
H
Q
Site 205
T2013
Y
G
H
G
L
T
S
T
Q
R
F
S
H
Q
T
Site 206
S2017
L
T
S
T
Q
R
F
S
H
Q
T
L
Q
Q
T
Site 207
T2020
T
Q
R
F
S
H
Q
T
L
Q
Q
T
P
M
I
Site 208
T2024
S
H
Q
T
L
Q
Q
T
P
M
I
S
T
M
T
Site 209
S2028
L
Q
Q
T
P
M
I
S
T
M
T
P
M
S
A
Site 210
T2029
Q
Q
T
P
M
I
S
T
M
T
P
M
S
A
Q
Site 211
T2045
V
Q
A
G
V
R
S
T
A
I
L
P
E
Q
Q
Site 212
S2133
P
P
Q
P
Q
P
Q
S
Q
P
Q
F
Q
R
Q
Site 213
S2163
R
Q
L
Q
Q
Q
L
S
N
T
Q
P
Q
P
S
Site 214
S2170
S
N
T
Q
P
Q
P
S
T
N
I
F
G
R
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation