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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TATDN2
Full Name:
Putative deoxyribonuclease TATDN2
Alias:
KIAA0218; TAT2; TatD DNase domain containing 2; TatD DNase domain containing deoxyribonuclease 2; TATD2
Type:
Deoxyribonuclease; EC 3.1.21.-
Mass (Da):
85023
Number AA:
761
UniProt ID:
Q93075
International Prot ID:
IPI00004069
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0016888
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
G
K
V
K
H
N
W
S
S
T
S
E
G
C
P
Site 2
S14
K
V
K
H
N
W
S
S
T
S
E
G
C
P
R
Site 3
T15
V
K
H
N
W
S
S
T
S
E
G
C
P
R
K
Site 4
S16
K
H
N
W
S
S
T
S
E
G
C
P
R
K
R
Site 5
S24
E
G
C
P
R
K
R
S
C
L
R
E
P
C
D
Site 6
S35
E
P
C
D
V
A
P
S
S
R
P
A
Q
R
S
Site 7
S36
P
C
D
V
A
P
S
S
R
P
A
Q
R
S
A
Site 8
S42
S
S
R
P
A
Q
R
S
A
S
R
S
G
G
P
Site 9
S44
R
P
A
Q
R
S
A
S
R
S
G
G
P
S
S
Site 10
S46
A
Q
R
S
A
S
R
S
G
G
P
S
S
P
K
Site 11
S50
A
S
R
S
G
G
P
S
S
P
K
R
L
K
A
Site 12
S51
S
R
S
G
G
P
S
S
P
K
R
L
K
A
Q
Site 13
S66
K
E
D
D
V
A
C
S
R
R
L
S
W
G
S
Site 14
S70
V
A
C
S
R
R
L
S
W
G
S
S
R
R
R
Site 15
S73
S
R
R
L
S
W
G
S
S
R
R
R
N
N
S
Site 16
S74
R
R
L
S
W
G
S
S
R
R
R
N
N
S
S
Site 17
S80
S
S
R
R
R
N
N
S
S
S
S
F
S
P
H
Site 18
S81
S
R
R
R
N
N
S
S
S
S
F
S
P
H
F
Site 19
S82
R
R
R
N
N
S
S
S
S
F
S
P
H
F
L
Site 20
S83
R
R
N
N
S
S
S
S
F
S
P
H
F
L
G
Site 21
S85
N
N
S
S
S
S
F
S
P
H
F
L
G
P
G
Site 22
T106
K
G
C
L
I
R
N
T
R
G
F
L
S
S
G
Site 23
S111
R
N
T
R
G
F
L
S
S
G
G
S
P
L
R
Site 24
S112
N
T
R
G
F
L
S
S
G
G
S
P
L
R
P
Site 25
S115
G
F
L
S
S
G
G
S
P
L
R
P
A
N
A
Site 26
S123
P
L
R
P
A
N
A
S
L
E
E
M
A
S
L
Site 27
S129
A
S
L
E
E
M
A
S
L
E
E
E
A
C
S
Site 28
S136
S
L
E
E
E
A
C
S
L
K
V
D
S
K
D
Site 29
S141
A
C
S
L
K
V
D
S
K
D
S
S
H
N
S
Site 30
S144
L
K
V
D
S
K
D
S
S
H
N
S
T
N
S
Site 31
S145
K
V
D
S
K
D
S
S
H
N
S
T
N
S
E
Site 32
S148
S
K
D
S
S
H
N
S
T
N
S
E
F
A
A
Site 33
T149
K
D
S
S
H
N
S
T
N
S
E
F
A
A
E
Site 34
S151
S
S
H
N
S
T
N
S
E
F
A
A
E
A
E
Site 35
S183
D
R
L
R
D
Q
G
S
T
M
I
Y
L
K
A
Site 36
T184
R
L
R
D
Q
G
S
T
M
I
Y
L
K
A
I
Site 37
S198
I
Q
G
I
L
G
K
S
M
P
K
R
K
G
E
Site 38
S213
A
A
T
R
A
K
P
S
A
A
E
H
P
S
H
Site 39
S219
P
S
A
A
E
H
P
S
H
G
E
G
P
A
R
Site 40
S227
H
G
E
G
P
A
R
S
E
G
P
A
K
T
A
Site 41
T242
E
G
A
A
R
S
V
T
V
T
A
A
Q
K
E
Site 42
T244
A
A
R
S
V
T
V
T
A
A
Q
K
E
K
D
Site 43
T253
A
Q
K
E
K
D
A
T
P
E
V
S
M
E
E
Site 44
T263
V
S
M
E
E
D
K
T
V
P
E
R
S
S
F
Site 45
S269
K
T
V
P
E
R
S
S
F
Y
D
R
R
V
V
Site 46
Y271
V
P
E
R
S
S
F
Y
D
R
R
V
V
I
D
Site 47
T293
E
P
L
G
D
R
R
T
V
I
D
K
C
S
P
Site 48
S299
R
T
V
I
D
K
C
S
P
P
L
E
F
L
D
Site 49
S308
P
L
E
F
L
D
D
S
D
S
H
L
E
I
Q
Site 50
S310
E
F
L
D
D
S
D
S
H
L
E
I
Q
K
H
Site 51
S328
E
V
V
M
E
H
P
S
S
G
S
D
W
S
D
Site 52
S329
V
V
M
E
H
P
S
S
G
S
D
W
S
D
V
Site 53
S334
P
S
S
G
S
D
W
S
D
V
E
E
I
S
T
Site 54
S340
W
S
D
V
E
E
I
S
T
V
R
F
S
Q
E
Site 55
T341
S
D
V
E
E
I
S
T
V
R
F
S
Q
E
E
Site 56
S345
E
I
S
T
V
R
F
S
Q
E
E
P
V
S
L
Site 57
S351
F
S
Q
E
E
P
V
S
L
K
P
S
A
V
P
Site 58
S355
E
P
V
S
L
K
P
S
A
V
P
E
P
S
S
Site 59
S362
S
A
V
P
E
P
S
S
F
T
T
D
Y
V
M
Site 60
T365
P
E
P
S
S
F
T
T
D
Y
V
M
Y
P
P
Site 61
Y367
P
S
S
F
T
T
D
Y
V
M
Y
P
P
H
L
Site 62
Y370
F
T
T
D
Y
V
M
Y
P
P
H
L
Y
S
S
Site 63
Y385
P
W
C
D
Y
A
S
Y
W
T
S
S
P
K
P
Site 64
T387
C
D
Y
A
S
Y
W
T
S
S
P
K
P
S
S
Site 65
S388
D
Y
A
S
Y
W
T
S
S
P
K
P
S
S
Y
Site 66
S389
Y
A
S
Y
W
T
S
S
P
K
P
S
S
Y
P
Site 67
S393
W
T
S
S
P
K
P
S
S
Y
P
S
T
G
S
Site 68
S394
T
S
S
P
K
P
S
S
Y
P
S
T
G
S
S
Site 69
Y395
S
S
P
K
P
S
S
Y
P
S
T
G
S
S
S
Site 70
S397
P
K
P
S
S
Y
P
S
T
G
S
S
S
N
D
Site 71
T398
K
P
S
S
Y
P
S
T
G
S
S
S
N
D
A
Site 72
S400
S
S
Y
P
S
T
G
S
S
S
N
D
A
A
Q
Site 73
S401
S
Y
P
S
T
G
S
S
S
N
D
A
A
Q
V
Site 74
S411
D
A
A
Q
V
G
K
S
S
R
S
R
M
S
D
Site 75
S412
A
A
Q
V
G
K
S
S
R
S
R
M
S
D
Y
Site 76
S414
Q
V
G
K
S
S
R
S
R
M
S
D
Y
S
P
Site 77
S417
K
S
S
R
S
R
M
S
D
Y
S
P
N
S
T
Site 78
Y419
S
R
S
R
M
S
D
Y
S
P
N
S
T
G
S
Site 79
S420
R
S
R
M
S
D
Y
S
P
N
S
T
G
S
V
Site 80
S423
M
S
D
Y
S
P
N
S
T
G
S
V
Q
N
T
Site 81
T424
S
D
Y
S
P
N
S
T
G
S
V
Q
N
T
S
Site 82
S426
Y
S
P
N
S
T
G
S
V
Q
N
T
S
R
D
Site 83
T430
S
T
G
S
V
Q
N
T
S
R
D
M
E
A
S
Site 84
S437
T
S
R
D
M
E
A
S
E
E
G
W
S
Q
N
Site 85
S442
E
A
S
E
E
G
W
S
Q
N
S
R
S
F
R
Site 86
S445
E
E
G
W
S
Q
N
S
R
S
F
R
F
S
R
Site 87
S447
G
W
S
Q
N
S
R
S
F
R
F
S
R
S
S
Site 88
S451
N
S
R
S
F
R
F
S
R
S
S
E
E
R
E
Site 89
S453
R
S
F
R
F
S
R
S
S
E
E
R
E
V
K
Site 90
S454
S
F
R
F
S
R
S
S
E
E
R
E
V
K
E
Site 91
T464
R
E
V
K
E
K
R
T
F
Q
E
E
M
P
P
Site 92
S479
R
P
C
G
G
H
A
S
S
S
L
P
K
S
H
Site 93
S480
P
C
G
G
H
A
S
S
S
L
P
K
S
H
L
Site 94
S481
C
G
G
H
A
S
S
S
L
P
K
S
H
L
E
Site 95
S485
A
S
S
S
L
P
K
S
H
L
E
P
S
L
E
Site 96
S490
P
K
S
H
L
E
P
S
L
E
E
G
F
I
D
Site 97
Y506
H
C
H
L
D
M
L
Y
S
K
L
S
F
Q
G
Site 98
S510
D
M
L
Y
S
K
L
S
F
Q
G
T
F
T
K
Site 99
T514
S
K
L
S
F
Q
G
T
F
T
K
F
R
K
I
Site 100
T516
L
S
F
Q
G
T
F
T
K
F
R
K
I
Y
S
Site 101
Y522
F
T
K
F
R
K
I
Y
S
S
S
F
P
K
E
Site 102
S523
T
K
F
R
K
I
Y
S
S
S
F
P
K
E
F
Site 103
S524
K
F
R
K
I
Y
S
S
S
F
P
K
E
F
Q
Site 104
S525
F
R
K
I
Y
S
S
S
F
P
K
E
F
Q
G
Site 105
T544
F
C
D
P
R
T
L
T
D
C
L
W
E
E
L
Site 106
Y570
C
H
P
H
F
A
R
Y
Y
S
E
S
Q
E
R
Site 107
Y571
H
P
H
F
A
R
Y
Y
S
E
S
Q
E
R
N
Site 108
S572
P
H
F
A
R
Y
Y
S
E
S
Q
E
R
N
L
Site 109
S574
F
A
R
Y
Y
S
E
S
Q
E
R
N
L
L
Q
Site 110
Y598
F
G
E
M
G
L
D
Y
S
Y
K
C
T
T
P
Site 111
S599
G
E
M
G
L
D
Y
S
Y
K
C
T
T
P
V
Site 112
Y600
E
M
G
L
D
Y
S
Y
K
C
T
T
P
V
P
Site 113
T603
L
D
Y
S
Y
K
C
T
T
P
V
P
E
Q
H
Site 114
T604
D
Y
S
Y
K
C
T
T
P
V
P
E
Q
H
K
Site 115
Y650
K
K
F
V
P
P
D
Y
K
I
H
R
H
C
F
Site 116
Y710
I
V
E
T
D
A
P
Y
F
L
P
R
Q
V
P
Site 117
S719
L
P
R
Q
V
P
K
S
L
C
Q
Y
A
H
P
Site 118
S745
R
V
K
D
Q
P
L
S
L
T
L
A
A
L
R
Site 119
T747
K
D
Q
P
L
S
L
T
L
A
A
L
R
E
N
Site 120
T755
L
A
A
L
R
E
N
T
S
R
L
Y
S
L
_
Site 121
S756
A
A
L
R
E
N
T
S
R
L
Y
S
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation