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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BHMT
Full Name:
Betaine--homocysteine S-methyltransferase 1
Alias:
Betaine homocysteine methyltransferase; Betaine-homocysteine methyltransferase; Betaine-homocysteine S-methyltransferase; BHMT1; EC 2.1.1.5
Type:
Amino Acid Metabolism - glycine, serine and threonine; EC 2.1.1.5; Amino Acid Metabolism - cysteine and methionine; Methyltransferase
Mass (Da):
44998
Number AA:
406
UniProt ID:
Q93088
International Prot ID:
IPI00004101
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0047150
GO:0008898
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0009086
GO:0006479
GO:0050666
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y38
F
A
L
E
K
R
G
Y
V
K
A
G
P
W
T
Site 2
T45
Y
V
K
A
G
P
W
T
P
E
A
A
V
E
H
Site 3
S68
R
E
F
L
R
A
G
S
N
V
M
Q
T
F
T
Site 4
T73
A
G
S
N
V
M
Q
T
F
T
F
Y
A
S
E
Site 5
T75
S
N
V
M
Q
T
F
T
F
Y
A
S
E
D
K
Site 6
S79
Q
T
F
T
F
Y
A
S
E
D
K
L
E
N
R
Site 7
Y89
K
L
E
N
R
G
N
Y
V
L
E
K
I
S
G
Site 8
T125
V
A
G
G
V
S
Q
T
P
S
Y
L
S
C
K
Site 9
S127
G
G
V
S
Q
T
P
S
Y
L
S
C
K
S
E
Site 10
Y128
G
V
S
Q
T
P
S
Y
L
S
C
K
S
E
T
Site 11
S130
S
Q
T
P
S
Y
L
S
C
K
S
E
T
E
V
Site 12
S133
P
S
Y
L
S
C
K
S
E
T
E
V
K
K
V
Site 13
T222
V
N
C
H
F
D
P
T
I
S
L
K
T
V
K
Site 14
S246
R
L
K
A
H
L
M
S
Q
P
L
A
Y
H
T
Site 15
Y251
L
M
S
Q
P
L
A
Y
H
T
P
D
C
N
K
Site 16
T253
S
Q
P
L
A
Y
H
T
P
D
C
N
K
Q
G
Site 17
T277
G
L
E
P
R
V
A
T
R
W
D
I
Q
K
Y
Site 18
Y284
T
R
W
D
I
Q
K
Y
A
R
E
A
Y
N
L
Site 19
Y289
Q
K
Y
A
R
E
A
Y
N
L
G
V
R
Y
I
Site 20
Y305
G
C
C
G
F
E
P
Y
H
I
R
A
I
A
E
Site 21
S325
R
G
F
L
P
P
A
S
E
K
H
G
S
W
G
Site 22
S330
P
A
S
E
K
H
G
S
W
G
S
G
L
D
M
Site 23
T339
G
S
G
L
D
M
H
T
K
P
W
V
R
A
R
Site 24
Y351
R
A
R
A
R
K
E
Y
W
E
N
L
R
I
A
Site 25
S359
W
E
N
L
R
I
A
S
G
R
P
Y
N
P
S
Site 26
Y363
R
I
A
S
G
R
P
Y
N
P
S
M
S
K
P
Site 27
S366
S
G
R
P
Y
N
P
S
M
S
K
P
D
G
W
Site 28
S368
R
P
Y
N
P
S
M
S
K
P
D
G
W
G
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation