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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HGD
Full Name:
Homogentisate 1,2-dioxygenase
Alias:
Homogentisate oxygenase;Homogentisic acid oxidase;Homogentisicase
Type:
Mass (Da):
49964
Number AA:
445
UniProt ID:
Q93099
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
S
G
F
G
N
E
C
S
S
E
D
P
R
C
P
Site 2
S16
G
F
G
N
E
C
S
S
E
D
P
R
C
P
G
Site 3
S24
E
D
P
R
C
P
G
S
L
P
E
G
Q
N
N
Site 4
Y40
Q
V
C
P
Y
N
L
Y
A
E
Q
L
S
G
S
Site 5
S45
N
L
Y
A
E
Q
L
S
G
S
A
F
T
C
P
Site 6
T50
Q
L
S
G
S
A
F
T
C
P
R
S
T
N
K
Site 7
S54
S
A
F
T
C
P
R
S
T
N
K
R
S
W
L
Site 8
T55
A
F
T
C
P
R
S
T
N
K
R
S
W
L
Y
Site 9
S67
W
L
Y
R
I
L
P
S
V
S
H
K
P
F
E
Site 10
S69
Y
R
I
L
P
S
V
S
H
K
P
F
E
S
I
Site 11
S75
V
S
H
K
P
F
E
S
I
D
E
G
H
V
T
Site 12
S106
P
F
E
I
P
K
A
S
Q
K
K
V
D
F
V
Site 13
S114
Q
K
K
V
D
F
V
S
G
L
H
T
L
C
G
Site 14
Y148
S
M
E
N
R
C
F
Y
N
S
D
G
D
F
L
Site 15
Y166
Q
K
G
N
L
L
I
Y
T
E
F
G
K
M
L
Site 16
S189
I
Q
R
G
M
R
F
S
I
D
V
F
E
E
T
Site 17
T244
R
Q
V
P
G
G
Y
T
V
I
N
K
Y
Q
G
Site 18
Y249
G
Y
T
V
I
N
K
Y
Q
G
K
L
F
A
A
Site 19
Y277
G
N
Y
T
P
Y
K
Y
N
L
K
N
F
M
V
Site 20
S296
A
F
D
H
A
D
P
S
I
F
T
V
L
T
A
Site 21
T302
P
S
I
F
T
V
L
T
A
K
S
V
R
P
G
Site 22
T328
R
W
G
V
A
D
K
T
F
R
P
P
Y
Y
H
Site 23
Y333
D
K
T
F
R
P
P
Y
Y
H
R
N
C
M
S
Site 24
Y334
K
T
F
R
P
P
Y
Y
H
R
N
C
M
S
E
Site 25
Y350
M
G
L
I
R
G
H
Y
E
A
K
Q
G
G
F
Site 26
S363
G
F
L
P
G
G
G
S
L
H
S
T
M
T
P
Site 27
S366
P
G
G
G
S
L
H
S
T
M
T
P
H
G
P
Site 28
T367
G
G
G
S
L
H
S
T
M
T
P
H
G
P
D
Site 29
T369
G
S
L
H
S
T
M
T
P
H
G
P
D
A
D
Site 30
T395
P
E
R
I
A
D
G
T
M
A
F
M
F
E
S
Site 31
Y423
S
R
C
L
D
E
N
Y
H
K
C
W
E
P
L
Site 32
T435
E
P
L
K
S
H
F
T
P
N
S
R
N
P
A
Site 33
S438
K
S
H
F
T
P
N
S
R
N
P
A
E
P
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation