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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NKD2
Full Name:
Protein naked cuticle homolog 2
Alias:
Dvl-binding protein NKD2; Naked cuticle 2; Naked cuticle-2
Type:
Mass (Da):
50055
Number AA:
451
UniProt ID:
Q969F2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016023
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0006887
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
A
A
R
K
R
R
E
S
P
E
G
D
S
F
V
Site 2
S23
R
E
S
P
E
G
D
S
F
V
A
S
A
Y
A
Site 3
S27
E
G
D
S
F
V
A
S
A
Y
A
S
G
R
K
Site 4
S31
F
V
A
S
A
Y
A
S
G
R
K
G
A
E
E
Site 5
S86
E
H
P
G
Q
L
L
S
A
D
D
G
E
R
A
Site 6
S117
D
A
L
Q
C
D
V
S
V
E
E
D
D
R
Q
Site 7
Y131
Q
E
W
T
F
T
L
Y
D
F
D
N
C
G
K
Site 8
S145
K
V
T
R
E
D
M
S
S
L
M
H
T
I
Y
Site 9
S146
V
T
R
E
D
M
S
S
L
M
H
T
I
Y
E
Site 10
S158
I
Y
E
V
V
D
A
S
V
N
H
S
S
G
S
Site 11
S162
V
D
A
S
V
N
H
S
S
G
S
S
K
T
L
Site 12
S163
D
A
S
V
N
H
S
S
G
S
S
K
T
L
R
Site 13
S166
V
N
H
S
S
G
S
S
K
T
L
R
V
K
L
Site 14
T168
H
S
S
G
S
S
K
T
L
R
V
K
L
T
V
Site 15
T174
K
T
L
R
V
K
L
T
V
S
P
E
P
S
S
Site 16
S176
L
R
V
K
L
T
V
S
P
E
P
S
S
K
R
Site 17
S180
L
T
V
S
P
E
P
S
S
K
R
K
E
G
P
Site 18
S181
T
V
S
P
E
P
S
S
K
R
K
E
G
P
P
Site 19
T196
A
G
Q
D
R
E
P
T
R
C
R
M
E
G
E
Site 20
S216
R
V
A
D
R
R
L
S
A
H
V
R
R
P
S
Site 21
S223
S
A
H
V
R
R
P
S
T
D
P
Q
P
C
S
Site 22
T224
A
H
V
R
R
P
S
T
D
P
Q
P
C
S
E
Site 23
S230
S
T
D
P
Q
P
C
S
E
R
G
P
Y
C
V
Site 24
Y235
P
C
S
E
R
G
P
Y
C
V
D
E
N
T
E
Site 25
Y247
N
T
E
R
R
N
H
Y
L
D
L
A
G
I
E
Site 26
Y256
D
L
A
G
I
E
N
Y
T
S
R
F
G
P
G
Site 27
T257
L
A
G
I
E
N
Y
T
S
R
F
G
P
G
S
Site 28
S258
A
G
I
E
N
Y
T
S
R
F
G
P
G
S
P
Site 29
S264
T
S
R
F
G
P
G
S
P
P
V
Q
A
K
Q
Site 30
S278
Q
E
P
Q
G
R
A
S
H
L
Q
A
R
S
R
Site 31
S286
H
L
Q
A
R
S
R
S
Q
E
P
D
T
H
A
Site 32
T291
S
R
S
Q
E
P
D
T
H
A
V
H
H
R
R
Site 33
S299
H
A
V
H
H
R
R
S
Q
V
L
V
E
H
V
Site 34
T319
P
A
A
R
A
L
D
T
Q
P
R
P
K
G
P
Site 35
S333
P
E
K
Q
F
L
K
S
P
K
G
S
G
K
P
Site 36
S337
F
L
K
S
P
K
G
S
G
K
P
P
G
V
P
Site 37
S346
K
P
P
G
V
P
A
S
S
K
S
G
K
A
F
Site 38
S347
P
P
G
V
P
A
S
S
K
S
G
K
A
F
S
Site 39
S349
G
V
P
A
S
S
K
S
G
K
A
F
S
Y
Y
Site 40
Y380
P
Q
P
P
P
P
P
Y
G
H
K
R
Y
R
Q
Site 41
S394
Q
K
G
R
E
G
H
S
P
L
K
A
P
H
A
Site 42
T405
A
P
H
A
Q
P
A
T
V
E
H
E
V
V
R
Site 43
T417
V
V
R
D
L
P
P
T
P
A
G
E
G
Y
A
Site 44
Y423
P
T
P
A
G
E
G
Y
A
V
P
V
I
Q
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation