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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FBXW7
Full Name:
F-box/WD repeat-containing protein 7
Alias:
Ago; Archipelago; Archipelago homolog; Cdc4; F-box and WD repeat domain containing 7; F-box and WD-40 domain protein 7; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box protein FBX30; F-box/WD-repeat protein 7; FBW7; FBX30; FBXW6; FLJ11071; SEL10; SEL-10
Type:
Ubiquitin conjugating system
Mass (Da):
79663
Number AA:
707
UniProt ID:
Q969H0
International Prot ID:
IPI00056349
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0016567
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
N
Q
E
L
L
S
V
G
S
K
R
R
R
Site 2
S10
Q
E
L
L
S
V
G
S
K
R
R
R
T
G
G
Site 3
T15
V
G
S
K
R
R
R
T
G
G
S
L
R
G
N
Site 4
S18
K
R
R
R
T
G
G
S
L
R
G
N
P
S
S
Site 5
S24
G
S
L
R
G
N
P
S
S
S
Q
V
D
E
E
Site 6
S25
S
L
R
G
N
P
S
S
S
Q
V
D
E
E
Q
Site 7
S26
L
R
G
N
P
S
S
S
Q
V
D
E
E
Q
M
Site 8
T53
R
Q
Q
E
E
E
H
T
A
R
N
G
E
V
V
Site 9
S72
R
P
G
G
Q
N
D
S
Q
Q
G
Q
L
E
E
Site 10
S86
E
N
N
N
R
F
I
S
V
D
E
D
S
S
G
Site 11
S91
F
I
S
V
D
E
D
S
S
G
N
Q
E
E
Q
Site 12
S92
I
S
V
D
E
D
S
S
G
N
Q
E
E
Q
E
Site 13
S122
E
E
E
M
D
Q
E
S
D
D
F
D
Q
S
D
Site 14
S128
E
S
D
D
F
D
Q
S
D
D
S
S
R
E
D
Site 15
S131
D
F
D
Q
S
D
D
S
S
R
E
D
E
H
T
Site 16
S132
F
D
Q
S
D
D
S
S
R
E
D
E
H
T
H
Site 17
T138
S
S
R
E
D
E
H
T
H
T
N
S
V
T
N
Site 18
T140
R
E
D
E
H
T
H
T
N
S
V
T
N
S
S
Site 19
S142
D
E
H
T
H
T
N
S
V
T
N
S
S
S
I
Site 20
T144
H
T
H
T
N
S
V
T
N
S
S
S
I
V
D
Site 21
S146
H
T
N
S
V
T
N
S
S
S
I
V
D
L
P
Site 22
S148
N
S
V
T
N
S
S
S
I
V
D
L
P
V
H
Site 23
S159
L
P
V
H
Q
L
S
S
P
F
Y
T
K
T
T
Site 24
Y162
H
Q
L
S
S
P
F
Y
T
K
T
T
K
M
K
Site 25
T163
Q
L
S
S
P
F
Y
T
K
T
T
K
M
K
R
Site 26
T165
S
S
P
F
Y
T
K
T
T
K
M
K
R
K
L
Site 27
S176
K
R
K
L
D
H
G
S
E
V
R
S
F
S
L
Site 28
S180
D
H
G
S
E
V
R
S
F
S
L
G
K
K
P
Site 29
S182
G
S
E
V
R
S
F
S
L
G
K
K
P
C
K
Site 30
S191
G
K
K
P
C
K
V
S
E
Y
T
S
T
T
G
Site 31
Y193
K
P
C
K
V
S
E
Y
T
S
T
T
G
L
V
Site 32
T196
K
V
S
E
Y
T
S
T
T
G
L
V
P
C
S
Site 33
T205
G
L
V
P
C
S
A
T
P
T
T
F
G
D
L
Site 34
T208
P
C
S
A
T
P
T
T
F
G
D
L
R
A
A
Site 35
T226
G
Q
Q
R
R
R
I
T
S
V
Q
P
P
T
G
Site 36
S227
Q
Q
R
R
R
I
T
S
V
Q
P
P
T
G
L
Site 37
S243
E
W
L
K
M
F
Q
S
W
S
G
P
E
K
L
Site 38
S245
L
K
M
F
Q
S
W
S
G
P
E
K
L
L
A
Site 39
S259
A
L
D
E
L
I
D
S
C
E
P
T
Q
V
K
Site 40
S282
Q
F
Q
R
D
F
I
S
L
L
P
K
E
L
A
Site 41
Y310
Q
A
A
Q
T
C
R
Y
W
R
I
L
A
E
D
Site 42
S349
I
K
P
G
F
I
H
S
P
W
K
S
A
Y
I
Site 43
Y355
H
S
P
W
K
S
A
Y
I
R
Q
H
R
I
D
Site 44
T363
I
R
Q
H
R
I
D
T
N
W
R
R
G
E
L
Site 45
S372
W
R
R
G
E
L
K
S
P
K
V
L
K
G
H
Site 46
S396
F
C
G
N
R
I
V
S
G
S
D
D
N
T
L
Site 47
S398
G
N
R
I
V
S
G
S
D
D
N
T
L
K
V
Site 48
T402
V
S
G
S
D
D
N
T
L
K
V
W
S
A
V
Site 49
S438
D
N
I
I
I
S
G
S
T
D
R
T
L
K
V
Site 50
T442
I
S
G
S
T
D
R
T
L
K
V
W
N
A
E
Site 51
T456
E
T
G
E
C
I
H
T
L
Y
G
H
T
S
T
Site 52
Y458
G
E
C
I
H
T
L
Y
G
H
T
S
T
V
R
Site 53
S476
L
H
E
K
R
V
V
S
G
S
R
D
A
T
L
Site 54
S478
E
K
R
V
V
S
G
S
R
D
A
T
L
R
V
Site 55
T482
V
S
G
S
R
D
A
T
L
R
V
W
D
I
E
Site 56
S516
Y
D
G
R
R
V
V
S
G
A
Y
D
F
M
V
Site 57
T530
V
K
V
W
D
P
E
T
E
T
C
L
H
T
L
Site 58
Y545
Q
G
H
T
N
R
V
Y
S
L
Q
F
D
G
I
Site 59
S546
G
H
T
N
R
V
Y
S
L
Q
F
D
G
I
H
Site 60
S562
V
S
G
S
L
D
T
S
I
R
V
W
D
V
E
Site 61
T576
E
T
G
N
C
I
H
T
L
T
G
H
Q
S
L
Site 62
T578
G
N
C
I
H
T
L
T
G
H
Q
S
L
T
S
Site 63
S582
H
T
L
T
G
H
Q
S
L
T
S
G
M
E
L
Site 64
S596
L
K
D
N
I
L
V
S
G
N
A
D
S
T
V
Site 65
T602
V
S
G
N
A
D
S
T
V
K
I
W
D
I
K
Site 66
S641
K
N
F
V
I
T
S
S
D
D
G
T
V
K
L
Site 67
T645
I
T
S
S
D
D
G
T
V
K
L
W
D
L
K
Site 68
T653
V
K
L
W
D
L
K
T
G
E
F
I
R
N
L
Site 69
T662
E
F
I
R
N
L
V
T
L
E
S
G
G
S
G
Site 70
S678
V
V
W
R
I
R
A
S
N
T
K
L
V
C
A
Site 71
T680
W
R
I
R
A
S
N
T
K
L
V
C
A
V
G
Site 72
S688
K
L
V
C
A
V
G
S
R
N
G
T
E
E
T
Site 73
T692
A
V
G
S
R
N
G
T
E
E
T
K
L
L
V
Site 74
T695
S
R
N
G
T
E
E
T
K
L
L
V
L
D
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation