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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OSBP2
Full Name:
Oxysterol-binding protein 2
Alias:
ORP4; ORP-4; OSBPL1; OSBPL4; OSBP-related 4; Oxysterol binding 2; Oxysterol-binding 2; Oxysterol-binding protein-related 4; Oxysterol-binding protein-related protein 4
Type:
Membrane protein
Mass (Da):
101266
Number AA:
916
UniProt ID:
Q969R2
International Prot ID:
IPI00746936
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006869
GO:0008202
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
G
K
A
A
A
P
S
R
G
G
G
C
G
G
Site 2
S17
G
G
G
C
G
G
R
S
R
G
L
S
S
L
F
Site 3
S40
H
T
A
A
P
G
M
S
A
S
T
S
G
S
G
Site 4
S42
A
A
P
G
M
S
A
S
T
S
G
S
G
P
E
Site 5
S44
P
G
M
S
A
S
T
S
G
S
G
P
E
P
K
Site 6
S46
M
S
A
S
T
S
G
S
G
P
E
P
K
P
Q
Site 7
S66
E
P
E
R
G
P
L
S
E
Q
V
S
E
A
V
Site 8
S70
G
P
L
S
E
Q
V
S
E
A
V
S
E
A
V
Site 9
S74
E
Q
V
S
E
A
V
S
E
A
V
P
R
S
E
Site 10
S80
V
S
E
A
V
P
R
S
E
P
V
S
E
T
T
Site 11
S84
V
P
R
S
E
P
V
S
E
T
T
S
E
P
E
Site 12
T87
S
E
P
V
S
E
T
T
S
E
P
E
P
G
A
Site 13
S88
E
P
V
S
E
T
T
S
E
P
E
P
G
A
G
Site 14
S104
P
S
E
L
L
Q
G
S
R
P
G
S
E
S
S
Site 15
S108
L
Q
G
S
R
P
G
S
E
S
S
S
G
V
G
Site 16
S110
G
S
R
P
G
S
E
S
S
S
G
V
G
A
G
Site 17
S111
S
R
P
G
S
E
S
S
S
G
V
G
A
G
P
Site 18
S112
R
P
G
S
E
S
S
S
G
V
G
A
G
P
F
Site 19
T120
G
V
G
A
G
P
F
T
K
A
A
S
E
P
L
Site 20
S124
G
P
F
T
K
A
A
S
E
P
L
S
R
A
V
Site 21
S128
K
A
A
S
E
P
L
S
R
A
V
G
S
A
T
Site 22
T135
S
R
A
V
G
S
A
T
F
L
R
P
E
S
G
Site 23
S141
A
T
F
L
R
P
E
S
G
S
L
P
A
L
K
Site 24
S143
F
L
R
P
E
S
G
S
L
P
A
L
K
P
L
Site 25
T160
L
R
P
G
Q
A
K
T
P
L
G
V
P
M
S
Site 26
S167
T
P
L
G
V
P
M
S
G
T
G
T
T
S
S
Site 27
T169
L
G
V
P
M
S
G
T
G
T
T
S
S
A
P
Site 28
Y195
W
L
L
K
W
T
N
Y
L
K
G
Y
Q
R
R
Site 29
Y199
W
T
N
Y
L
K
G
Y
Q
R
R
W
F
V
L
Site 30
S212
V
L
G
N
G
L
L
S
Y
Y
R
N
Q
G
E
Site 31
Y213
L
G
N
G
L
L
S
Y
Y
R
N
Q
G
E
M
Site 32
Y214
G
N
G
L
L
S
Y
Y
R
N
Q
G
E
M
A
Site 33
T223
N
Q
G
E
M
A
H
T
C
R
G
T
I
N
L
Site 34
T227
M
A
H
T
C
R
G
T
I
N
L
S
T
A
H
Site 35
S231
C
R
G
T
I
N
L
S
T
A
H
I
D
T
E
Site 36
T246
D
S
C
G
I
L
L
T
S
G
A
R
S
Y
H
Site 37
S251
L
L
T
S
G
A
R
S
Y
H
L
K
A
S
S
Site 38
Y252
L
T
S
G
A
R
S
Y
H
L
K
A
S
S
E
Site 39
S284
V
R
V
M
N
T
H
S
D
D
S
G
D
D
D
Site 40
S287
M
N
T
H
S
D
D
S
G
D
D
D
E
A
T
Site 41
T294
S
G
D
D
D
E
A
T
T
P
A
D
K
S
E
Site 42
T295
G
D
D
D
E
A
T
T
P
A
D
K
S
E
L
Site 43
S300
A
T
T
P
A
D
K
S
E
L
H
H
T
L
K
Site 44
T305
D
K
S
E
L
H
H
T
L
K
N
L
S
L
K
Site 45
T318
L
K
L
D
D
L
S
T
C
N
D
L
I
A
K
Site 46
S333
H
G
A
A
L
Q
R
S
L
T
E
L
D
G
L
Site 47
T358
K
V
V
N
E
R
A
T
L
F
R
I
T
S
N
Site 48
S412
Q
L
A
K
Q
H
N
S
L
E
R
A
F
H
S
Site 49
S419
S
L
E
R
A
F
H
S
A
P
G
R
P
A
N
Site 50
S428
P
G
R
P
A
N
P
S
K
S
F
I
E
G
S
Site 51
S430
R
P
A
N
P
S
K
S
F
I
E
G
S
L
L
Site 52
T438
F
I
E
G
S
L
L
T
P
K
G
E
D
S
E
Site 53
S444
L
T
P
K
G
E
D
S
E
E
D
E
D
T
E
Site 54
T450
D
S
E
E
D
E
D
T
E
Y
F
D
A
M
E
Site 55
Y452
E
E
D
E
D
T
E
Y
F
D
A
M
E
D
S
Site 56
S461
D
A
M
E
D
S
T
S
F
I
T
V
I
T
E
Site 57
S473
I
T
E
A
K
E
D
S
R
K
A
E
G
S
T
Site 58
S479
D
S
R
K
A
E
G
S
T
G
T
S
S
V
D
Site 59
S483
A
E
G
S
T
G
T
S
S
V
D
W
S
S
A
Site 60
S484
E
G
S
T
G
T
S
S
V
D
W
S
S
A
D
Site 61
S488
G
T
S
S
V
D
W
S
S
A
D
N
V
L
D
Site 62
S489
T
S
S
V
D
W
S
S
A
D
N
V
L
D
G
Site 63
S498
D
N
V
L
D
G
A
S
L
V
P
K
G
S
S
Site 64
S504
A
S
L
V
P
K
G
S
S
K
V
K
R
R
V
Site 65
Y519
R
I
P
N
K
P
N
Y
S
L
N
L
W
S
I
Site 66
S536
N
C
I
G
R
E
L
S
R
I
P
M
P
V
N
Site 67
S549
V
N
F
N
E
P
L
S
M
L
Q
R
L
T
E
Site 68
T555
L
S
M
L
Q
R
L
T
E
D
L
E
Y
H
H
Site 69
Y560
R
L
T
E
D
L
E
Y
H
H
L
L
D
K
A
Site 70
T590
F
S
V
S
S
Y
S
T
T
V
H
R
I
A
K
Site 71
T591
S
V
S
S
Y
S
T
T
V
H
R
I
A
K
P
Site 72
S619
L
D
D
M
G
L
R
S
L
C
E
Q
V
S
H
Site 73
S625
R
S
L
C
E
Q
V
S
H
H
P
P
S
A
A
Site 74
S630
Q
V
S
H
H
P
P
S
A
A
H
Y
V
F
S
Site 75
Y634
H
P
P
S
A
A
H
Y
V
F
S
K
H
G
W
Site 76
T648
W
S
L
W
Q
E
I
T
I
S
S
K
F
R
G
Site 77
Y657
S
S
K
F
R
G
K
Y
I
S
I
M
P
L
G
Site 78
Y677
F
Q
A
S
G
N
H
Y
V
W
R
K
S
T
S
Site 79
S699
G
K
L
W
I
D
Q
S
G
D
I
E
I
V
N
Site 80
S721
Q
L
K
F
L
P
Y
S
Y
F
S
K
E
A
A
Site 81
Y722
L
K
F
L
P
Y
S
Y
F
S
K
E
A
A
R
Site 82
T732
K
E
A
A
R
K
V
T
G
V
V
S
D
S
Q
Site 83
S736
R
K
V
T
G
V
V
S
D
S
Q
G
K
A
H
Site 84
S738
V
T
G
V
V
S
D
S
Q
G
K
A
H
Y
V
Site 85
Y744
D
S
Q
G
K
A
H
Y
V
L
S
G
S
W
D
Site 86
S747
G
K
A
H
Y
V
L
S
G
S
W
D
E
Q
M
Site 87
S762
E
C
S
K
V
M
H
S
S
P
S
S
P
S
S
Site 88
S763
C
S
K
V
M
H
S
S
P
S
S
P
S
S
D
Site 89
S765
K
V
M
H
S
S
P
S
S
P
S
S
D
G
K
Site 90
S766
V
M
H
S
S
P
S
S
P
S
S
D
G
K
Q
Site 91
S768
H
S
S
P
S
S
P
S
S
D
G
K
Q
K
T
Site 92
S769
S
S
P
S
S
P
S
S
D
G
K
Q
K
T
V
Site 93
T775
S
S
D
G
K
Q
K
T
V
Y
Q
T
L
S
A
Site 94
Y777
D
G
K
Q
K
T
V
Y
Q
T
L
S
A
K
L
Site 95
T779
K
Q
K
T
V
Y
Q
T
L
S
A
K
L
L
W
Site 96
Y789
A
K
L
L
W
K
K
Y
P
L
P
E
N
A
E
Site 97
Y799
P
E
N
A
E
N
M
Y
Y
F
S
E
L
A
L
Site 98
Y800
E
N
A
E
N
M
Y
Y
F
S
E
L
A
L
T
Site 99
T807
Y
F
S
E
L
A
L
T
L
N
E
H
E
E
G
Site 100
S820
E
G
V
A
P
T
D
S
R
L
R
P
D
Q
R
Site 101
S851
L
E
E
K
Q
R
L
S
R
R
R
R
L
E
A
Site 102
S863
L
E
A
C
G
P
G
S
S
C
S
S
E
E
E
Site 103
S864
E
A
C
G
P
G
S
S
C
S
S
E
E
E
K
Site 104
S867
G
P
G
S
S
C
S
S
E
E
E
K
E
A
D
Site 105
Y876
E
E
K
E
A
D
A
Y
T
P
L
W
F
E
K
Site 106
T877
E
K
E
A
D
A
Y
T
P
L
W
F
E
K
R
Site 107
T889
E
K
R
L
D
P
L
T
G
E
M
A
C
V
Y
Site 108
Y896
T
G
E
M
A
C
V
Y
K
G
G
Y
W
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation