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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
L3MBTL2
Full Name:
Lethal(3)malignant brain tumor-like protein 2
Alias:
dJ756G23.3; DKFZP761I141; H-l(3)mbt-l; l (3)mbt-like 2; l(3)mbt-l; l(3)mbt-like; l(3)mbt-like 2; L3MBT; lethal(3)malignant brain tumor-like 2; LMBL2
Type:
Mass (Da):
79110
Number AA:
705
UniProt ID:
Q969R5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0042393
GO:0003714
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
K
P
R
S
I
E
E
T
P
S
S
Site 2
T10
K
P
R
S
I
E
E
T
P
S
S
E
P
M
E
Site 3
S12
R
S
I
E
E
T
P
S
S
E
P
M
E
E
E
Site 4
S13
S
I
E
E
T
P
S
S
E
P
M
E
E
E
E
Site 5
Y30
D
L
E
L
F
G
G
Y
D
S
F
R
S
Y
N
Site 6
S32
E
L
F
G
G
Y
D
S
F
R
S
Y
N
S
S
Site 7
S35
G
G
Y
D
S
F
R
S
Y
N
S
S
V
G
S
Site 8
Y36
G
Y
D
S
F
R
S
Y
N
S
S
V
G
S
E
Site 9
S38
D
S
F
R
S
Y
N
S
S
V
G
S
E
S
S
Site 10
S39
S
F
R
S
Y
N
S
S
V
G
S
E
S
S
S
Site 11
S42
S
Y
N
S
S
V
G
S
E
S
S
S
Y
L
E
Site 12
S44
N
S
S
V
G
S
E
S
S
S
Y
L
E
E
S
Site 13
S45
S
S
V
G
S
E
S
S
S
Y
L
E
E
S
S
Site 14
S46
S
V
G
S
E
S
S
S
Y
L
E
E
S
S
E
Site 15
Y47
V
G
S
E
S
S
S
Y
L
E
E
S
S
E
A
Site 16
S51
S
S
S
Y
L
E
E
S
S
E
A
E
N
E
D
Site 17
S52
S
S
Y
L
E
E
S
S
E
A
E
N
E
D
R
Site 18
T66
R
E
A
G
E
L
P
T
S
P
L
H
L
L
S
Site 19
S67
E
A
G
E
L
P
T
S
P
L
H
L
L
S
P
Site 20
S73
T
S
P
L
H
L
L
S
P
G
T
P
R
S
L
Site 21
T76
L
H
L
L
S
P
G
T
P
R
S
L
D
G
S
Site 22
S79
L
S
P
G
T
P
R
S
L
D
G
S
G
S
E
Site 23
S83
T
P
R
S
L
D
G
S
G
S
E
P
A
V
C
Site 24
S85
R
S
L
D
G
S
G
S
E
P
A
V
C
E
M
Site 25
S104
G
T
R
E
A
F
F
S
K
T
K
R
F
C
S
Site 26
T106
R
E
A
F
F
S
K
T
K
R
F
C
S
V
S
Site 27
S111
S
K
T
K
R
F
C
S
V
S
C
S
R
S
Y
Site 28
S113
T
K
R
F
C
S
V
S
C
S
R
S
Y
S
S
Site 29
S115
R
F
C
S
V
S
C
S
R
S
Y
S
S
N
S
Site 30
S117
C
S
V
S
C
S
R
S
Y
S
S
N
S
K
K
Site 31
Y118
S
V
S
C
S
R
S
Y
S
S
N
S
K
K
A
Site 32
S119
V
S
C
S
R
S
Y
S
S
N
S
K
K
A
S
Site 33
S120
S
C
S
R
S
Y
S
S
N
S
K
K
A
S
I
Site 34
S122
S
R
S
Y
S
S
N
S
K
K
A
S
I
L
A
Site 35
S126
S
S
N
S
K
K
A
S
I
L
A
R
L
Q
G
Site 36
T168
T
G
Q
L
A
D
G
T
P
T
G
Q
D
A
L
Site 37
S189
G
K
F
L
K
D
H
S
Y
K
A
A
P
V
S
Site 38
Y190
K
F
L
K
D
H
S
Y
K
A
A
P
V
S
C
Site 39
S221
M
K
V
E
V
L
N
S
D
A
V
L
P
S
R
Site 40
S227
N
S
D
A
V
L
P
S
R
V
Y
W
I
A
S
Site 41
Y247
G
Y
R
V
L
L
R
Y
E
G
F
E
N
D
A
Site 42
T285
K
I
L
V
P
P
R
T
I
H
A
K
F
T
D
Site 43
Y296
K
F
T
D
W
K
G
Y
L
M
K
R
L
V
G
Site 44
S304
L
M
K
R
L
V
G
S
R
T
L
P
V
D
F
Site 45
T306
K
R
L
V
G
S
R
T
L
P
V
D
F
H
I
Site 46
Y321
K
M
V
E
S
M
K
Y
P
F
R
Q
G
M
R
Site 47
S335
R
L
E
V
V
D
K
S
Q
V
S
R
T
R
M
Site 48
S338
V
V
D
K
S
Q
V
S
R
T
R
M
A
V
V
Site 49
Y357
G
G
R
L
R
L
L
Y
E
D
G
D
S
D
D
Site 50
S391
V
G
H
G
I
K
M
S
E
R
R
S
D
M
A
Site 51
S395
I
K
M
S
E
R
R
S
D
M
A
H
H
P
T
Site 52
Y407
H
P
T
F
R
K
I
Y
C
D
A
V
P
Y
L
Site 53
Y413
I
Y
C
D
A
V
P
Y
L
F
K
K
V
R
A
Site 54
Y422
F
K
K
V
R
A
V
Y
T
E
G
G
W
F
E
Site 55
T498
Q
K
N
D
I
E
L
T
P
P
K
G
Y
E
A
Site 56
Y513
Q
T
F
N
W
E
N
Y
L
E
K
T
K
S
K
Site 57
S519
N
Y
L
E
K
T
K
S
K
A
A
P
S
R
L
Site 58
Y589
D
C
E
S
P
D
I
Y
P
V
G
W
C
E
L
Site 59
Y599
G
W
C
E
L
T
G
Y
Q
L
Q
P
P
V
A
Site 60
T611
P
V
A
A
E
P
A
T
P
L
K
A
K
E
A
Site 61
T636
K
R
K
R
I
P
P
T
K
T
R
P
L
R
Q
Site 62
S645
T
R
P
L
R
Q
G
S
K
K
P
L
L
E
D
Site 63
S661
P
Q
G
A
R
K
I
S
S
E
P
V
P
G
E
Site 64
S662
Q
G
A
R
K
I
S
S
E
P
V
P
G
E
I
Site 65
S683
E
E
H
L
D
V
A
S
P
D
K
A
S
S
P
Site 66
S688
V
A
S
P
D
K
A
S
S
P
E
L
P
V
S
Site 67
S689
A
S
P
D
K
A
S
S
P
E
L
P
V
S
V
Site 68
S695
S
S
P
E
L
P
V
S
V
E
N
I
K
Q
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation