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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FBXW5
Full Name:
F-box/WD repeat-containing protein 5
Alias:
F-box and WD-40 domain-containing protein 5
Type:
Mass (Da):
63922
Number AA:
566
UniProt ID:
Q969U6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
D
E
G
G
T
P
L
L
P
D
S
L
Site 2
Y54
R
E
Q
F
Y
R
Y
Y
Q
V
A
R
D
V
P
Site 3
Y70
H
P
A
A
M
S
W
Y
E
E
F
Q
R
L
Y
Site 4
Y77
Y
E
E
F
Q
R
L
Y
D
T
V
P
C
V
E
Site 5
T79
E
F
Q
R
L
Y
D
T
V
P
C
V
E
V
Q
Site 6
T87
V
P
C
V
E
V
Q
T
L
R
E
H
T
D
Q
Site 7
T92
V
Q
T
L
R
E
H
T
D
Q
V
L
H
L
S
Site 8
S99
T
D
Q
V
L
H
L
S
F
S
H
S
G
Y
Q
Site 9
S101
Q
V
L
H
L
S
F
S
H
S
G
Y
Q
F
A
Site 10
S103
L
H
L
S
F
S
H
S
G
Y
Q
F
A
S
C
Site 11
Y105
L
S
F
S
H
S
G
Y
Q
F
A
S
C
S
K
Site 12
S126
W
S
N
D
L
T
I
S
L
L
H
S
A
D
M
Site 13
S130
L
T
I
S
L
L
H
S
A
D
M
R
P
Y
N
Site 14
S151
S
Q
F
N
K
D
D
S
L
L
L
A
S
G
V
Site 15
S167
L
G
P
H
N
S
S
S
G
E
I
A
V
I
S
Site 16
S182
L
D
S
F
A
L
L
S
R
V
R
N
K
P
Y
Site 17
Y189
S
R
V
R
N
K
P
Y
D
V
F
G
C
W
L
Site 18
S262
A
D
C
S
R
F
D
S
P
D
L
L
L
E
A
Site 19
T274
L
E
A
G
D
P
A
T
S
P
C
R
I
F
D
Site 20
S275
E
A
G
D
P
A
T
S
P
C
R
I
F
D
L
Site 21
S284
C
R
I
F
D
L
G
S
D
N
E
E
V
V
A
Site 22
S319
G
R
A
Q
P
Q
L
S
E
R
M
L
E
T
K
Site 23
T344
K
P
P
E
R
S
A
T
G
A
K
S
K
Y
L
Site 24
S348
R
S
A
T
G
A
K
S
K
Y
L
I
F
T
T
Site 25
S361
T
T
G
C
L
T
Y
S
P
H
Q
I
G
I
K
Site 26
T376
Q
I
L
P
H
Q
M
T
T
A
G
P
V
L
G
Site 27
T377
I
L
P
H
Q
M
T
T
A
G
P
V
L
G
E
Site 28
S411
H
I
I
G
M
G
L
S
P
D
N
R
Y
L
Y
Site 29
Y416
G
L
S
P
D
N
R
Y
L
Y
V
N
S
R
A
Site 30
Y418
S
P
D
N
R
Y
L
Y
V
N
S
R
A
W
P
Site 31
Y466
A
L
R
A
H
R
A
Y
T
P
N
D
E
C
F
Site 32
T467
L
R
A
H
R
A
Y
T
P
N
D
E
C
F
F
Site 33
S486
V
S
R
D
F
V
A
S
G
A
E
D
R
H
G
Site 34
Y494
G
A
E
D
R
H
G
Y
I
W
D
R
H
Y
N
Site 35
Y500
G
Y
I
W
D
R
H
Y
N
I
C
L
A
R
L
Site 36
S515
R
H
E
D
V
V
N
S
V
V
F
S
P
Q
E
Site 37
T528
Q
E
Q
E
L
L
L
T
A
S
D
D
A
T
I
Site 38
S530
Q
E
L
L
L
T
A
S
D
D
A
T
I
K
A
Site 39
T534
L
T
A
S
D
D
A
T
I
K
A
W
R
S
P
Site 40
S540
A
T
I
K
A
W
R
S
P
R
T
M
R
V
L
Site 41
T543
K
A
W
R
S
P
R
T
M
R
V
L
Q
A
P
Site 42
T556
A
P
R
P
R
P
R
T
F
F
S
W
L
A
S
Site 43
S559
P
R
P
R
T
F
F
S
W
L
A
S
Q
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation