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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NCLN
Full Name:
Nicalin
Alias:
Nicastrin-like protein
Type:
Mass (Da):
62956
Number AA:
563
UniProt ID:
Q969V3
International Prot ID:
IPI00470649
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005730
GO:0005783
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
GO:0008152
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y49
A
A
H
E
F
T
V
Y
R
M
Q
Q
Y
D
L
Site 2
Y54
T
V
Y
R
M
Q
Q
Y
D
L
Q
G
Q
P
Y
Site 3
S93
L
M
R
L
L
D
F
S
Y
E
Q
Y
Q
K
A
Site 4
Y94
M
R
L
L
D
F
S
Y
E
Q
Y
Q
K
A
L
Site 5
S154
V
E
D
E
A
L
L
S
I
Y
K
Q
T
Q
A
Site 6
S163
Y
K
Q
T
Q
A
A
S
A
S
Q
G
S
A
S
Site 7
S165
Q
T
Q
A
A
S
A
S
Q
G
S
A
S
A
A
Site 8
T178
A
A
E
V
L
L
R
T
A
T
A
N
G
F
Q
Site 9
S189
N
G
F
Q
M
V
T
S
G
V
Q
S
K
A
V
Site 10
T209
A
S
V
E
G
R
L
T
G
L
G
G
E
D
L
Site 11
S256
L
E
L
A
R
L
F
S
R
L
Y
T
Y
K
R
Site 12
Y259
A
R
L
F
S
R
L
Y
T
Y
K
R
T
H
A
Site 13
T260
R
L
F
S
R
L
Y
T
Y
K
R
T
H
A
A
Site 14
Y261
L
F
S
R
L
Y
T
Y
K
R
T
H
A
A
Y
Site 15
Y268
Y
K
R
T
H
A
A
Y
N
L
L
F
F
A
S
Site 16
Y282
S
G
G
G
K
F
N
Y
Q
G
T
K
R
W
L
Site 17
T296
L
E
D
N
L
D
H
T
D
S
S
L
L
Q
D
Site 18
S298
D
N
L
D
H
T
D
S
S
L
L
Q
D
N
V
Site 19
S318
L
D
T
V
G
R
G
S
S
L
H
L
H
V
S
Site 20
S319
D
T
V
G
R
G
S
S
L
H
L
H
V
S
K
Site 21
S325
S
S
L
H
L
H
V
S
K
P
P
R
E
G
T
Site 22
T332
S
K
P
P
R
E
G
T
L
Q
H
A
F
L
R
Site 23
T384
I
R
R
L
P
A
F
T
L
S
H
L
E
S
H
Site 24
S386
R
L
P
A
F
T
L
S
H
L
E
S
H
R
D
Site 25
S390
F
T
L
S
H
L
E
S
H
R
D
G
Q
R
S
Site 26
S397
S
H
R
D
G
Q
R
S
S
I
M
D
V
R
S
Site 27
S398
H
R
D
G
Q
R
S
S
I
M
D
V
R
S
R
Site 28
S404
S
S
I
M
D
V
R
S
R
V
D
S
K
T
L
Site 29
S408
D
V
R
S
R
V
D
S
K
T
L
T
R
N
T
Site 30
T410
R
S
R
V
D
S
K
T
L
T
R
N
T
R
I
Site 31
T412
R
V
D
S
K
T
L
T
R
N
T
R
I
I
A
Site 32
T415
S
K
T
L
T
R
N
T
R
I
I
A
E
A
L
Site 33
T423
R
I
I
A
E
A
L
T
R
V
I
Y
N
L
T
Site 34
Y427
E
A
L
T
R
V
I
Y
N
L
T
E
K
G
T
Site 35
T430
T
R
V
I
Y
N
L
T
E
K
G
T
P
P
D
Site 36
T434
Y
N
L
T
E
K
G
T
P
P
D
M
P
V
F
Site 37
T460
D
S
V
M
D
W
L
T
N
Q
P
R
A
A
Q
Site 38
S473
A
Q
L
V
D
K
D
S
T
F
L
S
T
L
E
Site 39
T474
Q
L
V
D
K
D
S
T
F
L
S
T
L
E
H
Site 40
S477
D
K
D
S
T
F
L
S
T
L
E
H
H
L
S
Site 41
T478
K
D
S
T
F
L
S
T
L
E
H
H
L
S
R
Site 42
S484
S
T
L
E
H
H
L
S
R
Y
L
K
D
V
K
Site 43
Y486
L
E
H
H
L
S
R
Y
L
K
D
V
K
Q
H
Site 44
Y507
R
D
P
E
F
V
F
Y
D
Q
L
K
Q
V
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation