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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EXOC4
Full Name:
Exocyst complex component 4
Alias:
Exocyst complex component Sec8; KIAA1699; MGC27170; REC8; SEC8; SEC8L1; Sec8p
Type:
Vesicle protein
Mass (Da):
110498
Number AA:
974
UniProt ID:
Q96A65
International Prot ID:
IPI00059279
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000145
Uniprot
OncoNet
Molecular Function:
GO:0047485
PhosphoSite+
KinaseNET
Biological Process:
GO:0006904
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
A
A
G
G
K
Y
R
S
T
V
S
K
S
K
D
Site 2
T13
A
G
G
K
Y
R
S
T
V
S
K
S
K
D
P
Site 3
S15
G
K
Y
R
S
T
V
S
K
S
K
D
P
S
G
Site 4
S17
Y
R
S
T
V
S
K
S
K
D
P
S
G
L
L
Site 5
T30
L
L
I
S
V
I
R
T
L
S
T
S
D
D
V
Site 6
S32
I
S
V
I
R
T
L
S
T
S
D
D
V
E
D
Site 7
T33
S
V
I
R
T
L
S
T
S
D
D
V
E
D
R
Site 8
S34
V
I
R
T
L
S
T
S
D
D
V
E
D
R
E
Site 9
Y51
K
G
R
L
E
E
A
Y
E
K
C
D
R
D
L
Site 10
Y76
L
T
T
A
I
R
T
Y
Q
S
I
T
E
R
I
Site 11
T80
I
R
T
Y
Q
S
I
T
E
R
I
T
N
S
R
Site 12
T84
Q
S
I
T
E
R
I
T
N
S
R
N
K
I
K
Site 13
S183
D
L
R
L
E
L
H
S
K
K
M
N
L
H
L
Site 14
Y201
D
E
L
H
R
H
L
Y
I
K
S
T
S
R
V
Site 15
S204
H
R
H
L
Y
I
K
S
T
S
R
V
V
Q
R
Site 16
T205
R
H
L
Y
I
K
S
T
S
R
V
V
Q
R
N
Site 17
S220
K
E
K
G
K
I
S
S
L
V
K
D
A
S
V
Site 18
S226
S
S
L
V
K
D
A
S
V
P
L
I
D
V
T
Site 19
T233
S
V
P
L
I
D
V
T
N
L
P
T
P
R
K
Site 20
T237
I
D
V
T
N
L
P
T
P
R
K
F
L
D
T
Site 21
T244
T
P
R
K
F
L
D
T
S
H
Y
S
T
A
G
Site 22
S245
P
R
K
F
L
D
T
S
H
Y
S
T
A
G
S
Site 23
Y247
K
F
L
D
T
S
H
Y
S
T
A
G
S
S
S
Site 24
S248
F
L
D
T
S
H
Y
S
T
A
G
S
S
S
V
Site 25
T249
L
D
T
S
H
Y
S
T
A
G
S
S
S
V
R
Site 26
S252
S
H
Y
S
T
A
G
S
S
S
V
R
E
I
N
Site 27
S253
H
Y
S
T
A
G
S
S
S
V
R
E
I
N
L
Site 28
S254
Y
S
T
A
G
S
S
S
V
R
E
I
N
L
Q
Site 29
T295
K
L
K
K
I
P
E
T
V
K
A
I
I
E
R
Site 30
T315
K
Q
I
V
K
R
S
T
T
Q
V
A
D
S
G
Site 31
T316
Q
I
V
K
R
S
T
T
Q
V
A
D
S
G
Y
Site 32
S321
S
T
T
Q
V
A
D
S
G
Y
Q
R
G
E
N
Site 33
Y323
T
Q
V
A
D
S
G
Y
Q
R
G
E
N
V
T
Site 34
T330
Y
Q
R
G
E
N
V
T
V
E
N
Q
P
R
L
Site 35
T369
Y
L
Q
D
T
V
V
T
P
L
T
Q
Q
E
D
Site 36
Y380
Q
Q
E
D
I
K
L
Y
D
M
A
D
V
W
V
Site 37
T398
D
V
L
Q
M
L
L
T
E
Y
L
D
M
K
N
Site 38
Y400
L
Q
M
L
L
T
E
Y
L
D
M
K
N
T
R
Site 39
T406
E
Y
L
D
M
K
N
T
R
T
A
S
E
P
S
Site 40
S410
M
K
N
T
R
T
A
S
E
P
S
A
Q
L
S
Site 41
S413
T
R
T
A
S
E
P
S
A
Q
L
S
Y
A
S
Site 42
S417
S
E
P
S
A
Q
L
S
Y
A
S
T
G
R
E
Site 43
S420
S
A
Q
L
S
Y
A
S
T
G
R
E
F
A
A
Site 44
T421
A
Q
L
S
Y
A
S
T
G
R
E
F
A
A
F
Site 45
S440
K
P
Q
R
P
K
N
S
L
F
K
F
E
S
S
Site 46
S446
N
S
L
F
K
F
E
S
S
S
H
A
I
S
M
Site 47
S447
S
L
F
K
F
E
S
S
S
H
A
I
S
M
S
Site 48
S452
E
S
S
S
H
A
I
S
M
S
A
Y
L
R
E
Site 49
Y456
H
A
I
S
M
S
A
Y
L
R
E
Q
R
R
E
Site 50
Y465
R
E
Q
R
R
E
L
Y
S
R
S
G
E
L
Q
Site 51
S466
E
Q
R
R
E
L
Y
S
R
S
G
E
L
Q
G
Site 52
S468
R
R
E
L
Y
S
R
S
G
E
L
Q
G
G
P
Site 53
T485
N
L
I
E
G
G
G
T
K
F
V
C
K
P
G
Site 54
T554
E
I
E
G
V
T
K
T
S
D
P
L
K
I
L
Site 55
S555
I
E
G
V
T
K
T
S
D
P
L
K
I
L
A
Site 56
S598
L
N
L
M
H
D
L
S
A
Y
S
D
Q
F
L
Site 57
Y600
L
M
H
D
L
S
A
Y
S
D
Q
F
L
N
M
Site 58
T618
K
L
Q
E
Y
K
D
T
C
T
A
A
Y
R
G
Site 59
T620
Q
E
Y
K
D
T
C
T
A
A
Y
R
G
I
V
Site 60
Y623
K
D
T
C
T
A
A
Y
R
G
I
V
Q
S
E
Site 61
S629
A
Y
R
G
I
V
Q
S
E
E
K
L
V
I
S
Site 62
S638
E
K
L
V
I
S
A
S
W
A
K
D
D
D
I
Site 63
S646
W
A
K
D
D
D
I
S
R
L
L
K
S
L
P
Site 64
S705
Q
D
I
L
R
D
V
S
D
L
K
A
L
A
N
Site 65
S716
A
L
A
N
M
H
E
S
L
E
W
L
A
S
R
Site 66
S722
E
S
L
E
W
L
A
S
R
T
K
S
A
F
S
Site 67
T724
L
E
W
L
A
S
R
T
K
S
A
F
S
N
L
Site 68
S726
W
L
A
S
R
T
K
S
A
F
S
N
L
S
T
Site 69
S729
S
R
T
K
S
A
F
S
N
L
S
T
S
Q
M
Site 70
S732
K
S
A
F
S
N
L
S
T
S
Q
M
L
S
P
Site 71
T733
S
A
F
S
N
L
S
T
S
Q
M
L
S
P
A
Site 72
S734
A
F
S
N
L
S
T
S
Q
M
L
S
P
A
Q
Site 73
S738
L
S
T
S
Q
M
L
S
P
A
Q
D
S
H
T
Site 74
S743
M
L
S
P
A
Q
D
S
H
T
N
T
D
L
P
Site 75
T745
S
P
A
Q
D
S
H
T
N
T
D
L
P
P
V
Site 76
T747
A
Q
D
S
H
T
N
T
D
L
P
P
V
S
E
Site 77
S753
N
T
D
L
P
P
V
S
E
Q
I
M
Q
T
L
Site 78
S761
E
Q
I
M
Q
T
L
S
E
L
A
K
S
F
Q
Site 79
S766
T
L
S
E
L
A
K
S
F
Q
D
M
A
D
R
Site 80
S822
V
K
L
N
K
D
I
S
A
I
E
E
A
M
S
Site 81
S829
S
A
I
E
E
A
M
S
A
S
L
Q
Q
H
K
Site 82
Y839
L
Q
Q
H
K
F
Q
Y
I
F
E
G
L
G
H
Site 83
Y858
I
L
I
N
G
A
Q
Y
F
R
R
I
S
E
S
Site 84
S863
A
Q
Y
F
R
R
I
S
E
S
G
I
K
K
M
Site 85
S865
Y
F
R
R
I
S
E
S
G
I
K
K
M
C
R
Site 86
T882
F
V
L
Q
Q
N
L
T
N
I
T
M
S
R
E
Site 87
S887
N
L
T
N
I
T
M
S
R
E
A
D
L
D
F
Site 88
Y898
D
L
D
F
A
R
Q
Y
Y
E
M
L
Y
N
T
Site 89
Y899
L
D
F
A
R
Q
Y
Y
E
M
L
Y
N
T
A
Site 90
Y903
R
Q
Y
Y
E
M
L
Y
N
T
A
D
E
L
L
Site 91
Y920
V
V
D
Q
G
V
K
Y
T
E
L
E
Y
I
H
Site 92
T930
L
E
Y
I
H
A
L
T
L
L
H
R
S
Q
T
Site 93
T937
T
L
L
H
R
S
Q
T
G
V
G
E
L
T
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation