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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMEM143
Full Name:
Transmembrane protein 143
Alias:
Type:
Mass (Da):
51715
Number AA:
459
UniProt ID:
Q96AN5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S46
G
P
P
R
A
L
S
S
L
A
A
K
M
G
E
Site 2
Y70
P
R
D
W
A
Q
Q
Y
R
E
R
F
I
P
F
Site 3
S78
R
E
R
F
I
P
F
S
K
E
Q
L
L
R
L
Site 4
S93
L
I
Q
E
F
H
S
S
P
A
E
K
A
A
L
Site 5
Y126
L
A
R
L
Q
A
L
Y
D
P
I
N
P
D
R
Site 6
T135
P
I
N
P
D
R
E
T
L
D
Q
P
S
L
T
Site 7
S140
R
E
T
L
D
Q
P
S
L
T
D
P
Q
R
L
Site 8
T142
T
L
D
Q
P
S
L
T
D
P
Q
R
L
S
N
Site 9
S148
L
T
D
P
Q
R
L
S
N
E
Q
E
V
L
R
Site 10
S170
Q
A
N
F
S
P
L
S
E
D
T
L
A
Y
A
Site 11
T190
P
Q
D
E
V
Q
V
T
V
N
L
D
Q
Y
V
Site 12
S215
V
G
Q
M
P
L
K
S
S
V
G
S
R
R
G
Site 13
S216
G
Q
M
P
L
K
S
S
V
G
S
R
R
G
F
Site 14
S219
P
L
K
S
S
V
G
S
R
R
G
F
F
T
K
Site 15
T225
G
S
R
R
G
F
F
T
K
L
P
P
A
E
R
Site 16
Y234
L
P
P
A
E
R
R
Y
F
K
R
V
V
L
A
Site 17
S253
R
G
H
L
V
L
K
S
F
K
D
T
P
L
E
Site 18
T257
V
L
K
S
F
K
D
T
P
L
E
G
L
E
Q
Site 19
T273
L
P
E
L
K
V
R
T
P
T
L
Q
R
A
L
Site 20
T275
E
L
K
V
R
T
P
T
L
Q
R
A
L
L
N
Site 21
S324
I
F
M
G
L
R
A
S
K
M
F
G
Q
R
R
Site 22
S332
K
M
F
G
Q
R
R
S
A
Q
A
L
E
L
A
Site 23
Y343
L
E
L
A
H
M
L
Y
Y
R
S
T
S
N
N
Site 24
Y344
E
L
A
H
M
L
Y
Y
R
S
T
S
N
N
S
Site 25
S346
A
H
M
L
Y
Y
R
S
T
S
N
N
S
E
L
Site 26
T347
H
M
L
Y
Y
R
S
T
S
N
N
S
E
L
L
Site 27
S348
M
L
Y
Y
R
S
T
S
N
N
S
E
L
L
S
Site 28
S351
Y
R
S
T
S
N
N
S
E
L
L
S
A
L
A
Site 29
S355
S
N
N
S
E
L
L
S
A
L
A
L
R
A
Q
Site 30
S374
K
E
A
L
L
A
H
S
F
L
A
R
R
P
G
Site 31
S386
R
P
G
G
T
Q
G
S
P
E
E
T
S
R
W
Site 32
T390
T
Q
G
S
P
E
E
T
S
R
W
L
R
S
E
Site 33
S396
E
T
S
R
W
L
R
S
E
V
E
N
W
L
L
Site 34
T411
A
K
S
G
C
E
V
T
F
N
G
T
R
A
L
Site 35
S427
H
L
Q
A
L
T
P
S
M
G
L
Y
P
P
P
Site 36
Y431
L
T
P
S
M
G
L
Y
P
P
P
G
F
P
K
Site 37
T446
L
D
P
V
A
P
I
T
S
E
P
P
Q
A
T
Site 38
S447
D
P
V
A
P
I
T
S
E
P
P
Q
A
T
P
Site 39
T453
T
S
E
P
P
Q
A
T
P
S
S
N
I
S
_
Site 40
S455
E
P
P
Q
A
T
P
S
S
N
I
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation