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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MIB2
Full Name:
E3 ubiquitin-protein ligase MIB2
Alias:
Mind bomb homologue 2
Type:
EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; Ligase
Mass (Da):
109939
Number AA:
1013
UniProt ID:
Q96AX9
International Prot ID:
IPI00477349
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0004871
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007219
GO:0019941
GO:0043123
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
P
S
E
A
R
G
Q
S
Q
S
F
Q
A
S
G
Site 2
S14
E
A
R
G
Q
S
Q
S
F
Q
A
S
G
L
Q
Site 3
S18
Q
S
Q
S
F
Q
A
S
G
L
Q
P
R
S
L
Site 4
S24
A
S
G
L
Q
P
R
S
L
K
A
A
R
R
A
Site 5
T32
L
K
A
A
R
R
A
T
G
R
P
D
R
S
R
Site 6
S38
A
T
G
R
P
D
R
S
R
A
A
R
P
T
M
Site 7
T44
R
S
R
A
A
R
P
T
M
D
P
S
A
H
R
Site 8
S48
A
R
P
T
M
D
P
S
A
H
R
S
R
A
A
Site 9
S52
M
D
P
S
A
H
R
S
R
A
A
P
P
N
M
Site 10
T93
G
G
E
G
G
V
G
T
V
V
E
L
G
R
H
Site 11
S102
V
E
L
G
R
H
G
S
P
S
T
P
D
R
T
Site 12
S104
L
G
R
H
G
S
P
S
T
P
D
R
T
V
V
Site 13
T105
G
R
H
G
S
P
S
T
P
D
R
T
V
V
V
Site 14
T109
S
P
S
T
P
D
R
T
V
V
V
Q
W
D
Q
Site 15
Y122
D
Q
G
T
R
T
N
Y
R
A
G
Y
Q
G
A
Site 16
Y126
R
T
N
Y
R
A
G
Y
Q
G
A
H
D
L
L
Site 17
Y170
K
C
R
V
C
L
D
Y
D
L
C
T
Q
C
Y
Site 18
Y191
L
A
H
A
F
D
R
Y
E
T
A
H
S
R
P
Site 19
T193
H
A
F
D
R
Y
E
T
A
H
S
R
P
V
T
Site 20
S196
D
R
Y
E
T
A
H
S
R
P
V
T
L
S
P
Site 21
T200
T
A
H
S
R
P
V
T
L
S
P
R
Q
G
L
Site 22
S202
H
S
R
P
V
T
L
S
P
R
Q
G
L
P
R
Site 23
S231
G
P
D
W
E
W
G
S
Q
D
G
G
E
G
K
Site 24
T252
I
R
G
W
D
V
E
T
G
R
S
V
A
S
V
Site 25
S255
W
D
V
E
T
G
R
S
V
A
S
V
T
W
A
Site 26
T265
S
V
T
W
A
D
G
T
T
N
V
Y
R
V
G
Site 27
Y269
A
D
G
T
T
N
V
Y
R
V
G
H
K
G
K
Site 28
Y291
E
A
A
G
G
F
Y
Y
K
D
H
L
P
R
L
Site 29
S309
A
E
L
Q
R
R
V
S
A
D
S
Q
P
F
Q
Site 30
S312
Q
R
R
V
S
A
D
S
Q
P
F
Q
H
G
D
Site 31
T327
K
V
K
C
L
L
D
T
D
V
L
R
E
M
Q
Site 32
T353
E
F
I
G
Q
T
G
T
V
H
R
I
T
D
R
Site 33
T358
T
G
T
V
H
R
I
T
D
R
G
D
V
R
V
Site 34
T400
R
V
I
G
D
L
D
T
V
K
R
L
Q
A
G
Site 35
S472
E
R
A
R
E
N
K
S
S
L
S
V
A
L
D
Site 36
S473
R
A
R
E
N
K
S
S
L
S
V
A
L
D
K
Site 37
S475
R
E
N
K
S
S
L
S
V
A
L
D
K
L
R
Site 38
S486
D
K
L
R
A
Q
K
S
D
P
E
H
P
G
R
Site 39
T519
R
R
P
E
Q
V
D
T
K
N
Q
G
R
T
A
Site 40
Y562
E
G
N
T
A
L
H
Y
A
A
L
G
N
Q
P
Site 41
T588
R
A
D
A
I
N
S
T
Q
S
T
A
L
H
V
Site 42
S622
V
N
L
P
D
A
H
S
D
T
P
L
H
S
A
Site 43
T624
L
P
D
A
H
S
D
T
P
L
H
S
A
I
S
Site 44
S628
H
S
D
T
P
L
H
S
A
I
S
A
G
T
G
Site 45
T652
E
V
P
N
I
D
V
T
A
T
N
S
Q
G
F
Site 46
T660
A
T
N
S
Q
G
F
T
L
L
H
H
A
S
L
Site 47
S728
V
R
N
R
K
L
Q
S
P
L
H
L
A
V
Q
Site 48
T761
A
E
D
E
E
G
D
T
A
L
H
V
A
L
Q
Site 49
S796
L
L
S
R
L
Q
A
S
G
L
P
G
S
A
E
Site 50
S822
A
L
E
G
A
D
V
S
Y
T
N
H
R
G
R
Site 51
Y823
L
E
G
A
D
V
S
Y
T
N
H
R
G
R
S
Site 52
T824
E
G
A
D
V
S
Y
T
N
H
R
G
R
S
P
Site 53
S830
Y
T
N
H
R
G
R
S
P
L
D
L
A
A
E
Site 54
T867
A
A
P
G
P
R
Q
T
L
G
T
P
N
T
V
Site 55
T870
G
P
R
Q
T
L
G
T
P
N
T
V
T
N
L
Site 56
T873
Q
T
L
G
T
P
N
T
V
T
N
L
H
V
G
Site 57
S929
I
R
C
Q
V
V
V
S
K
K
L
R
P
D
G
Site 58
S937
K
K
L
R
P
D
G
S
E
V
A
S
A
A
P
Site 59
S941
P
D
G
S
E
V
A
S
A
A
P
A
P
G
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation