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Updated November 2019
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Protein Info
Short Name:
TTC28
Full Name:
Tetratricopeptide repeat protein 28
Alias:
KIAA1043; LOC23331; OTTHUMP00000028696; Tetratricopeptide repeat domain 28; TPR repeat-containing KIAA1043
Type:
Unknown function
Mass (Da):
270884
Number AA:
2481
UniProt ID:
Q96AY4
International Prot ID:
IPI00879193
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
E
Q
S
P
P
P
A
P
E
P
Site 2
T12
P
P
P
A
P
E
P
T
Q
G
P
T
P
A
R
Site 3
T16
P
E
P
T
Q
G
P
T
P
A
R
S
R
R
R
Site 4
S20
Q
G
P
T
P
A
R
S
R
R
R
R
E
P
E
Site 5
S28
R
R
R
R
E
P
E
S
P
P
A
S
A
P
I
Site 6
S32
E
P
E
S
P
P
A
S
A
P
I
P
L
F
G
Site 7
T42
I
P
L
F
G
A
D
T
I
G
Q
R
S
P
D
Site 8
S47
A
D
T
I
G
Q
R
S
P
D
G
P
V
L
S
Site 9
S54
S
P
D
G
P
V
L
S
K
A
E
F
V
E
K
Site 10
Y95
D
P
Q
N
C
I
L
Y
S
N
R
S
A
A
Y
Site 11
S99
C
I
L
Y
S
N
R
S
A
A
Y
M
K
I
Q
Site 12
Y102
Y
S
N
R
S
A
A
Y
M
K
I
Q
Q
Y
D
Site 13
Y108
A
Y
M
K
I
Q
Q
Y
D
K
A
L
D
D
A
Site 14
Y129
N
P
K
W
P
K
A
Y
F
R
Q
G
V
A
L
Site 15
Y138
R
Q
G
V
A
L
Q
Y
L
G
R
H
A
D
A
Site 16
S173
M
V
E
A
A
M
K
S
P
M
R
D
S
L
E
Site 17
S178
M
K
S
P
M
R
D
S
L
E
P
T
Y
Q
Q
Site 18
T182
M
R
D
S
L
E
P
T
Y
Q
Q
L
Q
K
M
Site 19
Y183
R
D
S
L
E
P
T
Y
Q
Q
L
Q
K
M
K
Site 20
S246
A
L
S
S
A
Y
W
S
L
G
N
T
E
K
S
Site 21
T250
A
Y
W
S
L
G
N
T
E
K
S
T
G
Y
M
Site 22
S253
S
L
G
N
T
E
K
S
T
G
Y
M
Q
Q
D
Site 23
T266
Q
D
L
D
V
A
K
T
L
G
D
Q
T
G
E
Site 24
T271
A
K
T
L
G
D
Q
T
G
E
C
R
A
H
G
Site 25
S282
R
A
H
G
N
L
G
S
A
F
F
S
K
G
N
Site 26
S286
N
L
G
S
A
F
F
S
K
G
N
Y
R
E
A
Site 27
Y290
A
F
F
S
K
G
N
Y
R
E
A
L
T
N
H
Site 28
S314
L
K
D
R
E
A
A
S
S
A
L
S
S
L
G
Site 29
S315
K
D
R
E
A
A
S
S
A
L
S
S
L
G
H
Site 30
S347
C
V
L
L
A
K
Q
S
K
D
E
L
S
E
A
Site 31
S352
K
Q
S
K
D
E
L
S
E
A
R
E
L
G
N
Site 32
Y397
K
R
E
E
A
R
A
Y
S
N
L
G
S
A
Y
Site 33
S398
R
E
E
A
R
A
Y
S
N
L
G
S
A
Y
H
Site 34
S402
R
A
Y
S
N
L
G
S
A
Y
H
Y
R
R
N
Site 35
Y406
N
L
G
S
A
Y
H
Y
R
R
N
F
D
K
A
Site 36
Y416
N
F
D
K
A
M
S
Y
H
N
Y
V
L
E
L
Site 37
Y419
K
A
M
S
Y
H
N
Y
V
L
E
L
A
Q
E
Site 38
S477
R
A
A
E
G
R
A
S
S
N
L
G
I
I
H
Site 39
S478
A
A
E
G
R
A
S
S
N
L
G
I
I
H
Q
Site 40
Y490
I
H
Q
M
K
G
D
Y
D
T
A
L
K
L
H
Site 41
T492
Q
M
K
G
D
Y
D
T
A
L
K
L
H
K
T
Site 42
Y510
I
A
Q
E
L
S
D
Y
A
A
Q
G
R
A
Y
Site 43
Y517
Y
A
A
Q
G
R
A
Y
G
N
M
G
N
A
Y
Site 44
Y524
Y
G
N
M
G
N
A
Y
N
A
L
G
M
Y
D
Site 45
Y536
M
Y
D
Q
A
V
K
Y
H
R
Q
E
L
Q
I
Site 46
S544
H
R
Q
E
L
Q
I
S
M
E
V
N
D
R
A
Site 47
S552
M
E
V
N
D
R
A
S
Q
A
S
T
H
G
N
Site 48
S555
N
D
R
A
S
Q
A
S
T
H
G
N
L
A
V
Site 49
T556
D
R
A
S
Q
A
S
T
H
G
N
L
A
V
A
Site 50
Y564
H
G
N
L
A
V
A
Y
Q
A
L
G
A
H
D
Site 51
Y577
H
D
R
A
L
Q
H
Y
Q
N
H
L
N
I
A
Site 52
S592
R
E
L
R
D
I
Q
S
E
A
R
A
L
S
N
Site 53
S598
Q
S
E
A
R
A
L
S
N
L
G
N
F
H
C
Site 54
Y610
F
H
C
S
R
G
E
Y
V
Q
A
A
P
Y
Y
Site 55
Y616
E
Y
V
Q
A
A
P
Y
Y
E
Q
Y
L
R
L
Site 56
Y617
Y
V
Q
A
A
P
Y
Y
E
Q
Y
L
R
L
A
Site 57
Y620
A
A
P
Y
Y
E
Q
Y
L
R
L
A
P
D
L
Site 58
Y650
A
H
Y
C
L
G
N
Y
Q
E
A
V
K
Y
Y
Site 59
Y656
N
Y
Q
E
A
V
K
Y
Y
E
Q
D
L
A
L
Site 60
S672
K
D
L
H
D
K
L
S
Q
A
K
A
Y
C
N
Site 61
Y699
K
A
E
E
C
Q
K
Y
L
L
S
L
A
Q
S
Site 62
S702
E
C
Q
K
Y
L
L
S
L
A
Q
S
L
N
N
Site 63
S706
Y
L
L
S
L
A
Q
S
L
N
N
S
Q
A
K
Site 64
S710
L
A
Q
S
L
N
N
S
Q
A
K
F
R
A
L
Site 65
S755
K
D
R
R
L
E
A
S
A
Y
A
A
L
G
T
Site 66
Y757
R
R
L
E
A
S
A
Y
A
A
L
G
T
A
Y
Site 67
Y770
A
Y
R
M
I
Q
K
Y
D
K
A
L
G
Y
H
Site 68
Y776
K
Y
D
K
A
L
G
Y
H
T
Q
E
L
E
V
Site 69
Y784
H
T
Q
E
L
E
V
Y
Q
E
L
S
D
L
P
Site 70
S788
L
E
V
Y
Q
E
L
S
D
L
P
G
E
C
R
Site 71
S831
G
Q
K
L
K
D
P
S
L
E
A
Q
V
Y
G
Site 72
Y837
P
S
L
E
A
Q
V
Y
G
N
M
G
I
T
K
Site 73
S872
Q
Q
L
S
G
N
E
S
V
L
D
R
G
R
A
Site 74
Y880
V
L
D
R
G
R
A
Y
G
N
L
G
D
C
Y
Site 75
Y887
Y
G
N
L
G
D
C
Y
E
A
L
G
D
Y
E
Site 76
Y893
C
Y
E
A
L
G
D
Y
E
E
A
I
K
Y
Y
Site 77
Y899
D
Y
E
E
A
I
K
Y
Y
E
Q
Y
L
S
V
Site 78
Y903
A
I
K
Y
Y
E
Q
Y
L
S
V
A
Q
S
L
Site 79
S905
K
Y
Y
E
Q
Y
L
S
V
A
Q
S
L
N
R
Site 80
S909
Q
Y
L
S
V
A
Q
S
L
N
R
M
Q
D
Q
Site 81
S932
N
G
H
R
A
M
G
S
L
Q
Q
A
L
V
C
Site 82
Y960
A
F
N
K
A
Q
A
Y
G
E
L
G
S
L
H
Site 83
S965
Q
A
Y
G
E
L
G
S
L
H
S
Q
L
G
N
Site 84
S968
G
E
L
G
S
L
H
S
Q
L
G
N
Y
E
Q
Site 85
Y973
L
H
S
Q
L
G
N
Y
E
Q
A
I
S
C
L
Site 86
S978
G
N
Y
E
Q
A
I
S
C
L
E
R
Q
L
N
Site 87
S997
M
K
D
R
A
L
E
S
D
A
A
C
G
L
G
Site 88
Y1007
A
C
G
L
G
G
V
Y
Q
Q
M
G
E
Y
D
Site 89
Y1040
P
T
C
Q
G
R
A
Y
G
N
L
G
L
T
Y
Site 90
Y1047
Y
G
N
L
G
L
T
Y
E
S
L
G
T
F
E
Site 91
Y1059
T
F
E
R
A
V
V
Y
Q
E
Q
H
L
S
I
Site 92
T1077
M
N
D
L
A
A
K
T
V
S
Y
S
S
L
G
Site 93
S1079
D
L
A
A
K
T
V
S
Y
S
S
L
G
R
T
Site 94
S1081
A
A
K
T
V
S
Y
S
S
L
G
R
T
H
H
Site 95
S1082
A
K
T
V
S
Y
S
S
L
G
R
T
H
H
A
Site 96
T1086
S
Y
S
S
L
G
R
T
H
H
A
L
Q
N
Y
Site 97
Y1099
N
Y
S
Q
A
V
M
Y
L
Q
E
G
L
R
L
Site 98
S1130
L
G
L
S
L
W
A
S
G
N
L
E
E
A
Q
Site 99
Y1141
E
E
A
Q
H
Q
L
Y
R
A
S
A
L
F
E
Site 100
S1144
Q
H
Q
L
Y
R
A
S
A
L
F
E
T
I
R
Site 101
S1157
I
R
H
E
A
Q
L
S
T
D
Y
K
L
S
L
Site 102
Y1160
E
A
Q
L
S
T
D
Y
K
L
S
L
F
D
L
Site 103
S1163
L
S
T
D
Y
K
L
S
L
F
D
L
Q
T
S
Site 104
T1169
L
S
L
F
D
L
Q
T
S
S
Y
Q
A
L
Q
Site 105
S1171
L
F
D
L
Q
T
S
S
Y
Q
A
L
Q
R
V
Site 106
T1197
A
V
A
E
R
G
R
T
R
A
F
A
D
L
L
Site 107
T1209
D
L
L
V
E
R
Q
T
G
Q
Q
D
S
D
P
Site 108
S1214
R
Q
T
G
Q
Q
D
S
D
P
Y
S
P
V
T
Site 109
Y1217
G
Q
Q
D
S
D
P
Y
S
P
V
T
I
D
Q
Site 110
S1218
Q
Q
D
S
D
P
Y
S
P
V
T
I
D
Q
I
Site 111
T1221
S
D
P
Y
S
P
V
T
I
D
Q
I
L
E
M
Site 112
T1269
E
H
Y
L
G
E
N
T
V
E
N
S
S
D
F
Site 113
S1274
E
N
T
V
E
N
S
S
D
F
Q
A
S
S
S
Site 114
S1279
N
S
S
D
F
Q
A
S
S
S
V
T
L
P
T
Site 115
S1280
S
S
D
F
Q
A
S
S
S
V
T
L
P
T
A
Site 116
S1281
S
D
F
Q
A
S
S
S
V
T
L
P
T
A
T
Site 117
T1283
F
Q
A
S
S
S
V
T
L
P
T
A
T
G
S
Site 118
Y1309
A
L
G
V
E
S
H
Y
S
R
A
C
A
S
S
Site 119
S1310
L
G
V
E
S
H
Y
S
R
A
C
A
S
S
E
Site 120
S1315
H
Y
S
R
A
C
A
S
S
E
T
E
S
E
A
Site 121
S1316
Y
S
R
A
C
A
S
S
E
T
E
S
E
A
G
Site 122
S1320
C
A
S
S
E
T
E
S
E
A
G
D
I
M
D
Site 123
S1359
R
N
N
L
F
N
R
S
C
Q
S
M
T
S
L
Site 124
S1362
L
F
N
R
S
C
Q
S
M
T
S
L
F
S
N
Site 125
S1365
R
S
C
Q
S
M
T
S
L
F
S
N
T
V
S
Site 126
S1368
Q
S
M
T
S
L
F
S
N
T
V
S
P
T
Q
Site 127
T1370
M
T
S
L
F
S
N
T
V
S
P
T
Q
D
G
Site 128
S1372
S
L
F
S
N
T
V
S
P
T
Q
D
G
T
S
Site 129
T1374
F
S
N
T
V
S
P
T
Q
D
G
T
S
S
L
Site 130
S1379
S
P
T
Q
D
G
T
S
S
L
P
R
R
Q
S
Site 131
S1380
P
T
Q
D
G
T
S
S
L
P
R
R
Q
S
S
Site 132
S1386
S
S
L
P
R
R
Q
S
S
F
A
K
P
P
L
Site 133
S1387
S
L
P
R
R
Q
S
S
F
A
K
P
P
L
R
Site 134
S1411
M
E
G
G
L
M
H
S
S
G
P
V
G
R
H
Site 135
S1412
E
G
G
L
M
H
S
S
G
P
V
G
R
H
R
Site 136
S1440
P
F
A
L
L
K
G
S
S
S
N
E
Y
L
Y
Site 137
S1441
F
A
L
L
K
G
S
S
S
N
E
Y
L
Y
E
Site 138
S1442
A
L
L
K
G
S
S
S
N
E
Y
L
Y
E
R
Site 139
Y1445
K
G
S
S
S
N
E
Y
L
Y
E
R
F
G
L
Site 140
Y1447
S
S
S
N
E
Y
L
Y
E
R
F
G
L
L
A
Site 141
S1462
V
P
S
I
R
S
L
S
V
Q
S
K
S
H
L
Site 142
S1467
S
L
S
V
Q
S
K
S
H
L
R
K
N
P
P
Site 143
T1475
H
L
R
K
N
P
P
T
Y
S
S
S
T
S
M
Site 144
Y1476
L
R
K
N
P
P
T
Y
S
S
S
T
S
M
A
Site 145
S1477
R
K
N
P
P
T
Y
S
S
S
T
S
M
A
A
Site 146
S1479
N
P
P
T
Y
S
S
S
T
S
M
A
A
V
I
Site 147
S1481
P
T
Y
S
S
S
T
S
M
A
A
V
I
G
N
Site 148
Y1512
P
S
A
E
E
E
A
Y
M
V
S
E
L
L
G
Site 149
S1535
A
T
K
E
R
V
M
S
A
L
T
Q
A
E
C
Site 150
S1568
S
M
D
G
N
P
A
S
S
K
S
S
F
G
H
Site 151
S1569
M
D
G
N
P
A
S
S
K
S
S
F
G
H
P
Site 152
S1571
G
N
P
A
S
S
K
S
S
F
G
H
P
Y
T
Site 153
S1572
N
P
A
S
S
K
S
S
F
G
H
P
Y
T
I
Site 154
Y1577
K
S
S
F
G
H
P
Y
T
I
P
E
S
L
R
Site 155
T1578
S
S
F
G
H
P
Y
T
I
P
E
S
L
R
V
Site 156
S1582
H
P
Y
T
I
P
E
S
L
R
V
Q
D
D
A
Site 157
S1590
L
R
V
Q
D
D
A
S
D
G
E
S
I
S
D
Site 158
S1594
D
D
A
S
D
G
E
S
I
S
D
C
P
P
L
Site 159
S1596
A
S
D
G
E
S
I
S
D
C
P
P
L
Q
E
Site 160
S1625
V
K
L
V
V
L
G
S
S
Q
E
S
N
S
K
Site 161
S1626
K
L
V
V
L
G
S
S
Q
E
S
N
S
K
V
Site 162
S1629
V
L
G
S
S
Q
E
S
N
S
K
V
T
A
D
Site 163
S1631
G
S
S
Q
E
S
N
S
K
V
T
A
D
G
V
Site 164
S1695
E
A
M
K
V
V
Q
S
S
K
A
F
S
H
P
Site 165
S1696
A
M
K
V
V
Q
S
S
K
A
F
S
H
P
S
Site 166
S1700
V
Q
S
S
K
A
F
S
H
P
S
N
W
A
G
Site 167
S1713
A
G
F
M
L
I
G
S
D
V
K
L
N
S
P
Site 168
S1719
G
S
D
V
K
L
N
S
P
S
S
L
I
G
Q
Site 169
S1752
L
L
H
L
V
E
K
S
L
Q
R
I
Q
N
G
Site 170
Y1765
N
G
Q
R
N
A
M
Y
T
S
Q
Q
S
V
E
Site 171
T1766
G
Q
R
N
A
M
Y
T
S
Q
Q
S
V
E
N
Site 172
S1767
Q
R
N
A
M
Y
T
S
Q
Q
S
V
E
N
K
Site 173
S1770
A
M
Y
T
S
Q
Q
S
V
E
N
K
V
G
G
Site 174
S1808
A
A
V
F
F
P
T
S
D
P
G
D
R
L
Q
Site 175
S1818
G
D
R
L
Q
Q
C
S
S
T
L
Q
S
L
L
Site 176
S1819
D
R
L
Q
Q
C
S
S
T
L
Q
S
L
L
G
Site 177
S1823
Q
C
S
S
T
L
Q
S
L
L
G
L
P
N
P
Site 178
S1850
E
T
G
E
Q
L
I
S
R
A
V
K
N
M
V
Site 179
S1878
E
K
E
Q
D
L
A
S
A
P
I
Q
V
S
I
Site 180
T1926
G
K
Q
A
N
R
R
T
V
H
F
A
L
Q
S
Site 181
S1940
S
L
L
S
L
F
D
S
T
E
L
P
K
R
L
Site 182
T1941
L
L
S
L
F
D
S
T
E
L
P
K
R
L
S
Site 183
S1948
T
E
L
P
K
R
L
S
L
D
S
S
S
S
L
Site 184
S1951
P
K
R
L
S
L
D
S
S
S
S
L
E
S
L
Site 185
S1952
K
R
L
S
L
D
S
S
S
S
L
E
S
L
A
Site 186
S1953
R
L
S
L
D
S
S
S
S
L
E
S
L
A
S
Site 187
S1957
D
S
S
S
S
L
E
S
L
A
S
A
Q
S
V
Site 188
S1960
S
S
L
E
S
L
A
S
A
Q
S
V
S
N
A
Site 189
Y1972
S
N
A
L
P
L
G
Y
Q
Q
P
P
F
S
P
Site 190
S1978
G
Y
Q
Q
P
P
F
S
P
T
G
A
D
S
I
Site 191
T1980
Q
Q
P
P
F
S
P
T
G
A
D
S
I
A
S
Site 192
S2003
S
S
I
A
S
S
M
S
F
V
S
K
P
E
G
Site 193
S2006
A
S
S
M
S
F
V
S
K
P
E
G
G
S
E
Site 194
S2012
V
S
K
P
E
G
G
S
E
G
G
G
P
G
G
Site 195
S2026
G
R
Q
D
H
D
R
S
K
N
A
Y
L
Q
R
Site 196
Y2030
H
D
R
S
K
N
A
Y
L
Q
R
S
T
L
P
Site 197
S2034
K
N
A
Y
L
Q
R
S
T
L
P
R
S
Q
L
Site 198
T2035
N
A
Y
L
Q
R
S
T
L
P
R
S
Q
L
P
Site 199
S2039
Q
R
S
T
L
P
R
S
Q
L
P
P
Q
T
R
Site 200
Y2056
G
N
K
D
E
E
E
Y
E
G
F
S
I
I
S
Site 201
T2069
I
S
N
E
P
L
A
T
Y
Q
E
N
R
N
T
Site 202
Y2070
S
N
E
P
L
A
T
Y
Q
E
N
R
N
T
C
Site 203
S2079
E
N
R
N
T
C
F
S
P
D
H
K
Q
P
Q
Site 204
S2096
T
A
G
G
M
R
V
S
V
S
S
K
G
S
I
Site 205
S2098
G
G
M
R
V
S
V
S
S
K
G
S
I
S
T
Site 206
S2099
G
M
R
V
S
V
S
S
K
G
S
I
S
T
P
Site 207
S2102
V
S
V
S
S
K
G
S
I
S
T
P
N
S
P
Site 208
S2104
V
S
S
K
G
S
I
S
T
P
N
S
P
V
K
Site 209
T2105
S
S
K
G
S
I
S
T
P
N
S
P
V
K
M
Site 210
S2108
G
S
I
S
T
P
N
S
P
V
K
M
T
L
I
Site 211
T2113
P
N
S
P
V
K
M
T
L
I
P
S
P
N
S
Site 212
S2117
V
K
M
T
L
I
P
S
P
N
S
P
F
Q
K
Site 213
S2120
T
L
I
P
S
P
N
S
P
F
Q
K
V
G
K
Site 214
S2131
K
V
G
K
L
A
S
S
D
T
G
E
S
D
Q
Site 215
T2133
G
K
L
A
S
S
D
T
G
E
S
D
Q
S
S
Site 216
S2136
A
S
S
D
T
G
E
S
D
Q
S
S
T
E
T
Site 217
S2139
D
T
G
E
S
D
Q
S
S
T
E
T
D
S
T
Site 218
S2140
T
G
E
S
D
Q
S
S
T
E
T
D
S
T
V
Site 219
T2141
G
E
S
D
Q
S
S
T
E
T
D
S
T
V
K
Site 220
T2143
S
D
Q
S
S
T
E
T
D
S
T
V
K
S
Q
Site 221
S2145
Q
S
S
T
E
T
D
S
T
V
K
S
Q
E
E
Site 222
T2146
S
S
T
E
T
D
S
T
V
K
S
Q
E
E
S
Site 223
S2149
E
T
D
S
T
V
K
S
Q
E
E
S
N
P
K
Site 224
S2153
T
V
K
S
Q
E
E
S
N
P
K
L
D
P
Q
Site 225
S2172
K
I
L
E
E
T
Q
S
H
L
I
A
V
E
R
Site 226
S2188
Q
R
S
G
G
Q
V
S
K
S
N
N
P
E
D
Site 227
S2190
S
G
G
Q
V
S
K
S
N
N
P
E
D
G
V
Site 228
S2202
D
G
V
Q
A
P
S
S
T
A
V
F
R
A
S
Site 229
S2209
S
T
A
V
F
R
A
S
E
T
S
A
F
S
R
Site 230
S2215
A
S
E
T
S
A
F
S
R
P
V
L
S
H
Q
Site 231
S2220
A
F
S
R
P
V
L
S
H
Q
K
S
Q
P
S
Site 232
S2224
P
V
L
S
H
Q
K
S
Q
P
S
P
V
T
V
Site 233
S2227
S
H
Q
K
S
Q
P
S
P
V
T
V
K
P
K
Site 234
T2230
K
S
Q
P
S
P
V
T
V
K
P
K
P
P
A
Site 235
S2239
K
P
K
P
P
A
R
S
S
S
L
P
K
V
S
Site 236
S2240
P
K
P
P
A
R
S
S
S
L
P
K
V
S
S
Site 237
S2241
K
P
P
A
R
S
S
S
L
P
K
V
S
S
G
Site 238
S2246
S
S
S
L
P
K
V
S
S
G
Y
S
S
P
T
Site 239
S2247
S
S
L
P
K
V
S
S
G
Y
S
S
P
T
T
Site 240
Y2249
L
P
K
V
S
S
G
Y
S
S
P
T
T
S
E
Site 241
S2250
P
K
V
S
S
G
Y
S
S
P
T
T
S
E
M
Site 242
S2251
K
V
S
S
G
Y
S
S
P
T
T
S
E
M
S
Site 243
T2253
S
S
G
Y
S
S
P
T
T
S
E
M
S
I
K
Site 244
T2254
S
G
Y
S
S
P
T
T
S
E
M
S
I
K
D
Site 245
S2255
G
Y
S
S
P
T
T
S
E
M
S
I
K
D
S
Site 246
S2258
S
P
T
T
S
E
M
S
I
K
D
S
P
S
Q
Site 247
S2262
S
E
M
S
I
K
D
S
P
S
Q
H
S
G
R
Site 248
S2264
M
S
I
K
D
S
P
S
Q
H
S
G
R
P
S
Site 249
S2267
K
D
S
P
S
Q
H
S
G
R
P
S
P
G
C
Site 250
S2271
S
Q
H
S
G
R
P
S
P
G
C
D
S
Q
T
Site 251
S2276
R
P
S
P
G
C
D
S
Q
T
S
Q
L
D
Q
Site 252
S2279
P
G
C
D
S
Q
T
S
Q
L
D
Q
P
L
F
Site 253
Y2290
Q
P
L
F
K
L
K
Y
P
S
S
P
Y
S
A
Site 254
S2292
L
F
K
L
K
Y
P
S
S
P
Y
S
A
H
I
Site 255
S2293
F
K
L
K
Y
P
S
S
P
Y
S
A
H
I
S
Site 256
Y2295
L
K
Y
P
S
S
P
Y
S
A
H
I
S
K
S
Site 257
S2296
K
Y
P
S
S
P
Y
S
A
H
I
S
K
S
P
Site 258
S2300
S
P
Y
S
A
H
I
S
K
S
P
R
N
M
S
Site 259
S2302
Y
S
A
H
I
S
K
S
P
R
N
M
S
P
S
Site 260
S2307
S
K
S
P
R
N
M
S
P
S
S
G
H
Q
S
Site 261
S2309
S
P
R
N
M
S
P
S
S
G
H
Q
S
P
A
Site 262
S2310
P
R
N
M
S
P
S
S
G
H
Q
S
P
A
G
Site 263
S2314
S
P
S
S
G
H
Q
S
P
A
G
S
A
P
S
Site 264
S2318
G
H
Q
S
P
A
G
S
A
P
S
P
A
L
S
Site 265
S2321
S
P
A
G
S
A
P
S
P
A
L
S
Y
S
S
Site 266
S2325
S
A
P
S
P
A
L
S
Y
S
S
A
G
S
A
Site 267
S2327
P
S
P
A
L
S
Y
S
S
A
G
S
A
R
S
Site 268
S2328
S
P
A
L
S
Y
S
S
A
G
S
A
R
S
S
Site 269
S2331
L
S
Y
S
S
A
G
S
A
R
S
S
P
A
D
Site 270
S2335
S
A
G
S
A
R
S
S
P
A
D
A
P
D
I
Site 271
T2367
L
K
M
F
W
Q
S
T
P
Q
H
S
T
G
P
Site 272
S2371
W
Q
S
T
P
Q
H
S
T
G
P
M
K
I
F
Site 273
T2384
I
F
R
G
A
P
G
T
M
T
S
K
R
D
V
Site 274
T2386
R
G
A
P
G
T
M
T
S
K
R
D
V
L
S
Site 275
S2387
G
A
P
G
T
M
T
S
K
R
D
V
L
S
L
Site 276
S2393
T
S
K
R
D
V
L
S
L
L
N
L
S
P
R
Site 277
S2398
V
L
S
L
L
N
L
S
P
R
H
N
K
K
E
Site 278
T2436
P
P
N
G
H
W
R
T
E
T
T
S
L
G
S
Site 279
T2438
N
G
H
W
R
T
E
T
T
S
L
G
S
L
P
Site 280
T2439
G
H
W
R
T
E
T
T
S
L
G
S
L
P
L
Site 281
S2440
H
W
R
T
E
T
T
S
L
G
S
L
P
L
P
Site 282
T2453
L
P
A
G
P
P
A
T
A
P
A
R
P
L
R
Site 283
S2463
A
R
P
L
R
L
P
S
G
N
G
Y
K
F
L
Site 284
Y2467
R
L
P
S
G
N
G
Y
K
F
L
S
P
G
R
Site 285
S2471
G
N
G
Y
K
F
L
S
P
G
R
F
F
P
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation