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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SH3KBP1
Full Name:
SH3 domain-containing kinase-binding protein 1
Alias:
Cbl-interacting protein of 85 kDa; CD2 binding 3; CD2BP3; CIN85; HSB-1; SH3 domain-containing kinase-binding protein 1: Cbl-interacting protein of 85 kDa: Human Src family kinase-binding protein 1: CD2-binding protein 3; SH3-domain kinase binding 1; SH3-domain kinase binding protein 1; SH3K1; Src-family kinase binding 1
Type:
Adaptor/scaffold; Apoptosis
Mass (Da):
73126
Number AA:
665
UniProt ID:
Q96B97
International Prot ID:
IPI00294962
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031410
GO:0005856
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0017124
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0007267
GO:0006897
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
E
A
I
V
E
F
D
Y
Q
A
Q
H
D
D
E
Site 2
T19
A
Q
H
D
D
E
L
T
I
S
V
G
E
I
I
Site 3
S21
H
D
D
E
L
T
I
S
V
G
E
I
I
T
N
Site 4
T66
E
M
K
K
D
P
L
T
N
K
A
P
E
K
P
Site 5
S79
K
P
L
H
E
V
P
S
G
N
S
L
L
S
S
Site 6
S82
H
E
V
P
S
G
N
S
L
L
S
S
E
T
I
Site 7
S85
P
S
G
N
S
L
L
S
S
E
T
I
L
R
T
Site 8
S86
S
G
N
S
L
L
S
S
E
T
I
L
R
T
N
Site 9
S108
R
R
C
Q
V
A
F
S
Y
L
P
Q
N
D
D
Site 10
Y109
R
C
Q
V
A
F
S
Y
L
P
Q
N
D
D
E
Site 11
T144
E
G
V
L
N
G
K
T
G
M
F
P
S
N
F
Site 12
S149
G
K
T
G
M
F
P
S
N
F
I
K
E
L
S
Site 13
S156
S
N
F
I
K
E
L
S
G
E
S
D
E
L
G
Site 14
S165
E
S
D
E
L
G
I
S
Q
D
E
Q
L
S
K
Site 15
S171
I
S
Q
D
E
Q
L
S
K
S
S
L
R
E
T
Site 16
S173
Q
D
E
Q
L
S
K
S
S
L
R
E
T
T
G
Site 17
S174
D
E
Q
L
S
K
S
S
L
R
E
T
T
G
S
Site 18
T178
S
K
S
S
L
R
E
T
T
G
S
E
S
D
G
Site 19
T179
K
S
S
L
R
E
T
T
G
S
E
S
D
G
G
Site 20
S181
S
L
R
E
T
T
G
S
E
S
D
G
G
D
S
Site 21
S183
R
E
T
T
G
S
E
S
D
G
G
D
S
S
S
Site 22
S188
S
E
S
D
G
G
D
S
S
S
T
K
S
E
G
Site 23
S189
E
S
D
G
G
D
S
S
S
T
K
S
E
G
A
Site 24
S190
S
D
G
G
D
S
S
S
T
K
S
E
G
A
N
Site 25
S193
G
D
S
S
S
T
K
S
E
G
A
N
G
T
V
Site 26
S230
P
I
K
L
R
P
R
S
I
E
V
E
N
D
F
Site 27
T243
D
F
L
P
V
E
K
T
I
G
K
K
L
P
A
Site 28
T251
I
G
K
K
L
P
A
T
T
A
T
P
D
S
S
Site 29
T252
G
K
K
L
P
A
T
T
A
T
P
D
S
S
K
Site 30
T254
K
L
P
A
T
T
A
T
P
D
S
S
K
T
E
Site 31
S257
A
T
T
A
T
P
D
S
S
K
T
E
M
D
S
Site 32
T260
A
T
P
D
S
S
K
T
E
M
D
S
R
T
K
Site 33
S264
S
S
K
T
E
M
D
S
R
T
K
S
K
D
Y
Site 34
T266
K
T
E
M
D
S
R
T
K
S
K
D
Y
C
K
Site 35
S268
E
M
D
S
R
T
K
S
K
D
Y
C
K
V
I
Site 36
Y271
S
R
T
K
S
K
D
Y
C
K
V
I
F
P
Y
Site 37
T287
A
Q
N
D
D
E
L
T
I
K
E
G
D
I
V
Site 38
S344
P
K
K
P
P
P
P
S
A
P
V
I
K
Q
G
Site 39
S394
K
L
D
L
Q
K
P
S
V
P
A
I
P
P
K
Site 40
T408
K
K
P
R
P
P
K
T
N
S
L
S
R
P
G
Site 41
S410
P
R
P
P
K
T
N
S
L
S
R
P
G
A
L
Site 42
S412
P
P
K
T
N
S
L
S
R
P
G
A
L
P
P
Site 43
T430
E
R
P
V
G
P
L
T
H
T
R
G
D
S
P
Site 44
T432
P
V
G
P
L
T
H
T
R
G
D
S
P
K
I
Site 45
S436
L
T
H
T
R
G
D
S
P
K
I
D
L
A
G
Site 46
S447
D
L
A
G
S
S
L
S
G
I
L
D
K
D
L
Site 47
S455
G
I
L
D
K
D
L
S
D
R
S
N
D
I
D
Site 48
S458
D
K
D
L
S
D
R
S
N
D
I
D
L
E
G
Site 49
S468
I
D
L
E
G
F
D
S
V
V
S
S
T
E
K
Site 50
S471
E
G
F
D
S
V
V
S
S
T
E
K
L
S
H
Site 51
S472
G
F
D
S
V
V
S
S
T
E
K
L
S
H
P
Site 52
T473
F
D
S
V
V
S
S
T
E
K
L
S
H
P
T
Site 53
S477
V
S
S
T
E
K
L
S
H
P
T
T
S
R
P
Site 54
T481
E
K
L
S
H
P
T
T
S
R
P
K
A
T
G
Site 55
S482
K
L
S
H
P
T
T
S
R
P
K
A
T
G
R
Site 56
T487
T
T
S
R
P
K
A
T
G
R
R
P
P
S
Q
Site 57
S493
A
T
G
R
R
P
P
S
Q
S
L
T
S
S
S
Site 58
S495
G
R
R
P
P
S
Q
S
L
T
S
S
S
L
S
Site 59
T497
R
P
P
S
Q
S
L
T
S
S
S
L
S
S
P
Site 60
S498
P
P
S
Q
S
L
T
S
S
S
L
S
S
P
D
Site 61
S499
P
S
Q
S
L
T
S
S
S
L
S
S
P
D
I
Site 62
S500
S
Q
S
L
T
S
S
S
L
S
S
P
D
I
F
Site 63
S502
S
L
T
S
S
S
L
S
S
P
D
I
F
D
S
Site 64
S503
L
T
S
S
S
L
S
S
P
D
I
F
D
S
P
Site 65
S509
S
S
P
D
I
F
D
S
P
S
P
E
E
D
K
Site 66
S511
P
D
I
F
D
S
P
S
P
E
E
D
K
E
E
Site 67
S521
E
D
K
E
E
H
I
S
L
A
H
R
G
V
D
Site 68
S530
A
H
R
G
V
D
A
S
K
K
T
S
K
T
V
Site 69
S534
V
D
A
S
K
K
T
S
K
T
V
T
I
S
Q
Site 70
T536
A
S
K
K
T
S
K
T
V
T
I
S
Q
V
S
Site 71
T538
K
K
T
S
K
T
V
T
I
S
Q
V
S
D
N
Site 72
S540
T
S
K
T
V
T
I
S
Q
V
S
D
N
K
A
Site 73
S548
Q
V
S
D
N
K
A
S
L
P
P
K
P
G
T
Site 74
T555
S
L
P
P
K
P
G
T
M
A
A
G
G
G
G
Site 75
S568
G
G
P
A
P
L
S
S
A
A
P
S
P
L
S
Site 76
S572
P
L
S
S
A
A
P
S
P
L
S
S
S
L
G
Site 77
S575
S
A
A
P
S
P
L
S
S
S
L
G
T
A
G
Site 78
S576
A
A
P
S
P
L
S
S
S
L
G
T
A
G
H
Site 79
S577
A
P
S
P
L
S
S
S
L
G
T
A
G
H
R
Site 80
T580
P
L
S
S
S
L
G
T
A
G
H
R
A
N
S
Site 81
S587
T
A
G
H
R
A
N
S
P
S
L
F
G
T
E
Site 82
S589
G
H
R
A
N
S
P
S
L
F
G
T
E
G
K
Site 83
T593
N
S
P
S
L
F
G
T
E
G
K
P
K
M
E
Site 84
T614
A
A
V
E
E
L
R
T
Q
V
R
E
L
R
S
Site 85
S621
T
Q
V
R
E
L
R
S
I
I
E
T
M
K
D
Site 86
T625
E
L
R
S
I
I
E
T
M
K
D
Q
Q
K
R
Site 87
S639
R
E
I
K
Q
L
L
S
E
L
D
E
E
K
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation