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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNF25
Full Name:
E3 ubiquitin-protein ligase RNF25
Alias:
AO7; FLJ13906; RING finger protein 25; ring finger protein AO7
Type:
EC 6.3.2.-; Transcription, coactivator/corepressor; Ligase; Ubiquitin conjugating system
Mass (Da):
51219
Number AA:
459
UniProt ID:
Q96BH1
International Prot ID:
IPI00059944
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
E
E
D
W
V
L
P
S
E
V
E
V
L
E
S
Site 2
S25
S
E
V
E
V
L
E
S
I
Y
L
D
E
L
Q
Site 3
S41
I
K
G
N
G
R
T
S
P
W
E
I
Y
I
T
Site 4
Y46
R
T
S
P
W
E
I
Y
I
T
L
H
P
A
T
Site 5
T48
S
P
W
E
I
Y
I
T
L
H
P
A
T
A
E
Site 6
S59
A
T
A
E
D
Q
D
S
Q
Y
V
C
F
T
L
Site 7
Y74
V
L
Q
V
P
A
E
Y
P
H
E
V
P
Q
I
Site 8
S82
P
H
E
V
P
Q
I
S
I
R
N
P
R
G
L
Site 9
S90
I
R
N
P
R
G
L
S
D
E
Q
I
H
T
I
Site 10
T126
E
K
G
K
E
I
L
T
D
N
N
I
P
H
G
Site 11
Y225
P
Q
Q
P
M
E
L
Y
Q
P
S
A
E
S
L
Site 12
S231
L
Y
Q
P
S
A
E
S
L
R
Q
Q
E
E
R
Site 13
Y242
Q
E
E
R
K
R
L
Y
Q
R
Q
Q
E
R
G
Site 14
Y261
L
E
A
E
R
N
R
Y
F
I
S
L
Q
Q
P
Site 15
S264
E
R
N
R
Y
F
I
S
L
Q
Q
P
P
A
P
Site 16
S276
P
A
P
A
E
P
E
S
A
V
D
V
S
K
G
Site 17
S281
P
E
S
A
V
D
V
S
K
G
S
Q
P
P
S
Site 18
S284
A
V
D
V
S
K
G
S
Q
P
P
S
T
L
A
Site 19
S288
S
K
G
S
Q
P
P
S
T
L
A
A
E
L
S
Site 20
T289
K
G
S
Q
P
P
S
T
L
A
A
E
L
S
T
Site 21
S302
S
T
S
P
A
V
Q
S
T
L
P
P
P
L
P
Site 22
T369
A
P
K
G
T
R
D
T
Q
E
L
P
P
P
E
Site 23
S391
D
L
K
P
E
P
H
S
Q
G
V
E
G
P
P
Site 24
S405
P
Q
E
K
G
P
G
S
W
Q
G
P
P
P
R
Site 25
T414
Q
G
P
P
P
R
R
T
R
D
C
V
R
W
E
Site 26
S423
D
C
V
R
W
E
R
S
K
G
R
T
P
G
S
Site 27
T427
W
E
R
S
K
G
R
T
P
G
S
S
Y
P
R
Site 28
S430
S
K
G
R
T
P
G
S
S
Y
P
R
L
P
R
Site 29
S431
K
G
R
T
P
G
S
S
Y
P
R
L
P
R
G
Site 30
Y432
G
R
T
P
G
S
S
Y
P
R
L
P
R
G
Q
Site 31
Y442
L
P
R
G
Q
G
A
Y
R
P
G
T
R
R
E
Site 32
T446
Q
G
A
Y
R
P
G
T
R
R
E
S
L
G
L
Site 33
S450
R
P
G
T
R
R
E
S
L
G
L
E
S
K
D
Site 34
S455
R
E
S
L
G
L
E
S
K
D
G
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation