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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SGK3
Full Name:
Serine/threonine-protein kinase Sgk3
Alias:
CISK; EC 2.7.11.1; Serine/threonine protein kinase CISK; Serum/glucocorticoid regulated kinase family, member 3; Serum/glucocorticoid-regulated kinase 3; Serum/glucocorticoid-regulated kinase-like; SGK2; SGKL; SGK-like protein SGKL
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1;
AGC
group; SGK family
Mass (Da):
57108
Number AA:
496
UniProt ID:
Q96BR1
International Prot ID:
IPI00655852
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016023
GO:0005769
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0035091
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
GO:0006468
GO:0006950
Phosida
TranscriptoNet
STRING
Kinexus Products
GSK3b (4-10) KinSub - Glycogen synthase kinase-3-beta-derived N-terminus (R4-F10, human) peptide; Akt1 protein kinase substrate peptide - Powder PE-01ACU95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACU95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
Q
R
D
H
T
M
D
Y
K
E
S
C
P
S
V
Site 2
S12
H
T
M
D
Y
K
E
S
C
P
S
V
S
I
P
Site 3
S15
D
Y
K
E
S
C
P
S
V
S
I
P
S
S
D
Site 4
S17
K
E
S
C
P
S
V
S
I
P
S
S
D
E
H
Site 5
S21
P
S
V
S
I
P
S
S
D
E
H
R
E
K
K
Site 6
T32
R
E
K
K
K
R
F
T
V
Y
K
V
L
V
S
Site 7
Y34
K
K
K
R
F
T
V
Y
K
V
L
V
S
V
G
Site 8
Y51
E
W
F
V
F
R
R
Y
A
E
F
D
K
L
Y
Site 9
Y58
Y
A
E
F
D
K
L
Y
N
T
L
K
K
Q
F
Site 10
Y104
F
I
Q
N
L
V
R
Y
P
E
L
Y
N
H
P
Site 11
Y108
L
V
R
Y
P
E
L
Y
N
H
P
D
V
R
A
Site 12
S121
R
A
F
L
Q
M
D
S
P
K
H
Q
S
D
P
Site 13
S126
M
D
S
P
K
H
Q
S
D
P
S
E
D
E
D
Site 14
S129
P
K
H
Q
S
D
P
S
E
D
E
D
E
R
S
Site 15
S136
S
E
D
E
D
E
R
S
S
Q
K
L
H
S
T
Site 16
S137
E
D
E
D
E
R
S
S
Q
K
L
H
S
T
S
Site 17
S142
R
S
S
Q
K
L
H
S
T
S
Q
N
I
N
L
Site 18
S144
S
Q
K
L
H
S
T
S
Q
N
I
N
L
G
P
Site 19
T160
G
N
P
H
A
K
P
T
D
F
D
F
L
K
V
Site 20
Y188
R
K
L
D
G
K
F
Y
A
V
K
V
L
Q
K
Site 21
Y228
P
F
L
V
G
L
H
Y
S
F
Q
T
T
E
K
Site 22
S257
F
H
L
Q
R
E
R
S
F
P
E
H
R
A
R
Site 23
Y266
P
E
H
R
A
R
F
Y
A
A
E
I
A
S
A
Site 24
S315
C
K
E
G
I
A
I
S
D
T
T
T
T
F
C
Site 25
T318
G
I
A
I
S
D
T
T
T
T
F
C
G
T
P
Site 26
T319
I
A
I
S
D
T
T
T
T
F
C
G
T
P
E
Site 27
T320
A
I
S
D
T
T
T
T
F
C
G
T
P
E
Y
Site 28
T324
T
T
T
T
F
C
G
T
P
E
Y
L
A
P
E
Site 29
Y338
E
V
I
R
K
Q
P
Y
D
N
T
V
D
W
W
Site 30
Y370
C
R
D
V
A
E
M
Y
D
N
I
L
H
K
P
Site 31
S421
Q
N
H
P
F
F
E
S
L
S
W
A
D
L
V
Site 32
S423
H
P
F
F
E
S
L
S
W
A
D
L
V
Q
K
Site 33
Y460
F
T
E
E
T
V
P
Y
S
V
C
V
S
S
D
Site 34
S461
T
E
E
T
V
P
Y
S
V
C
V
S
S
D
Y
Site 35
S465
V
P
Y
S
V
C
V
S
S
D
Y
S
I
V
N
Site 36
S486
D
D
A
F
V
G
F
S
Y
A
P
P
S
E
D
Site 37
Y487
D
A
F
V
G
F
S
Y
A
P
P
S
E
D
L
Site 38
S491
G
F
S
Y
A
P
P
S
E
D
L
F
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation