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Updated November 2019
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Protein Info
Short Name:
ATG2B
Full Name:
Autophagy-related protein 2 homolog B
Alias:
ATG2 autophagy related 2 B; C14orf103; chromosome 14 open reading frame 103; CN103; FLJ10242; YN003
Type:
Autophagy
Mass (Da):
232732
Number AA:
2078
UniProt ID:
Q96BY7
International Prot ID:
IPI00152990
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y21
C
R
Y
L
L
Q
R
Y
L
G
H
F
L
Q
E
Site 2
S31
H
F
L
Q
E
K
L
S
L
E
Q
L
S
L
D
Site 3
Y40
E
Q
L
S
L
D
L
Y
Q
G
T
G
S
L
A
Site 4
S45
D
L
Y
Q
G
T
G
S
L
A
Q
V
P
L
D
Site 5
T110
R
P
R
P
R
P
A
T
G
S
E
P
M
Y
W
Site 6
S112
R
P
R
P
A
T
G
S
E
P
M
Y
W
S
S
Site 7
Y116
A
T
G
S
E
P
M
Y
W
S
S
F
M
T
S
Site 8
S123
Y
W
S
S
F
M
T
S
S
M
Q
L
A
K
E
Site 9
S133
Q
L
A
K
E
C
L
S
Q
K
L
T
D
E
Q
Site 10
T137
E
C
L
S
Q
K
L
T
D
E
Q
G
E
G
S
Site 11
S144
T
D
E
Q
G
E
G
S
Q
P
F
E
G
L
E
Site 12
T159
K
F
A
E
T
I
E
T
V
L
R
R
V
K
V
Site 13
S182
I
E
H
V
P
E
N
S
K
T
G
T
A
L
E
Site 14
T184
H
V
P
E
N
S
K
T
G
T
A
L
E
I
R
Site 15
T186
P
E
N
S
K
T
G
T
A
L
E
I
R
I
E
Site 16
Y197
I
R
I
E
R
T
V
Y
C
D
E
T
A
D
E
Site 17
T201
R
T
V
Y
C
D
E
T
A
D
E
S
S
G
I
Site 18
S234
S
L
F
W
D
E
F
S
A
S
A
K
S
S
P
Site 19
S236
F
W
D
E
F
S
A
S
A
K
S
S
P
V
C
Site 20
S239
E
F
S
A
S
A
K
S
S
P
V
C
S
T
A
Site 21
S240
F
S
A
S
A
K
S
S
P
V
C
S
T
A
P
Site 22
S244
A
K
S
S
P
V
C
S
T
A
P
V
E
T
E
Site 23
S255
V
E
T
E
P
K
L
S
P
S
W
N
P
K
I
Site 24
S257
T
E
P
K
L
S
P
S
W
N
P
K
I
I
Y
Site 25
Y264
S
W
N
P
K
I
I
Y
E
P
H
P
Q
L
T
Site 26
S280
N
L
P
E
I
A
P
S
D
P
V
Q
I
G
R
Site 27
S295
L
I
G
R
L
E
L
S
L
T
L
K
Q
N
E
Site 28
T297
G
R
L
E
L
S
L
T
L
K
Q
N
E
V
L
Site 29
Y364
P
M
Q
Q
E
D
E
Y
R
I
Q
M
E
L
N
Site 30
Y373
I
Q
M
E
L
N
R
Y
Y
L
R
K
D
S
L
Site 31
Y374
Q
M
E
L
N
R
Y
Y
L
R
K
D
S
L
S
Site 32
S379
R
Y
Y
L
R
K
D
S
L
S
V
G
V
S
S
Site 33
S381
Y
L
R
K
D
S
L
S
V
G
V
S
S
E
Q
Site 34
S385
D
S
L
S
V
G
V
S
S
E
Q
S
F
Y
E
Site 35
S389
V
G
V
S
S
E
Q
S
F
Y
E
T
E
T
A
Site 36
Y391
V
S
S
E
Q
S
F
Y
E
T
E
T
A
R
T
Site 37
T393
S
E
Q
S
F
Y
E
T
E
T
A
R
T
P
S
Site 38
T395
Q
S
F
Y
E
T
E
T
A
R
T
P
S
S
R
Site 39
T398
Y
E
T
E
T
A
R
T
P
S
S
R
E
E
E
Site 40
S400
T
E
T
A
R
T
P
S
S
R
E
E
E
V
F
Site 41
S401
E
T
A
R
T
P
S
S
R
E
E
E
V
F
F
Site 42
S409
R
E
E
E
V
F
F
S
M
A
D
M
D
M
S
Site 43
S416
S
M
A
D
M
D
M
S
H
S
L
S
S
L
P
Site 44
S418
A
D
M
D
M
S
H
S
L
S
S
L
P
P
L
Site 45
S420
M
D
M
S
H
S
L
S
S
L
P
P
L
G
D
Site 46
S421
D
M
S
H
S
L
S
S
L
P
P
L
G
D
P
Site 47
S436
P
N
M
D
L
E
L
S
L
T
S
T
Y
T
N
Site 48
T438
M
D
L
E
L
S
L
T
S
T
Y
T
N
T
P
Site 49
T440
L
E
L
S
L
T
S
T
Y
T
N
T
P
A
G
Site 50
T442
L
S
L
T
S
T
Y
T
N
T
P
A
G
S
P
Site 51
T444
L
T
S
T
Y
T
N
T
P
A
G
S
P
L
S
Site 52
S474
K
E
Q
P
V
R
G
S
T
F
P
S
N
L
V
Site 53
T475
E
Q
P
V
R
G
S
T
F
P
S
N
L
V
H
Site 54
S478
V
R
G
S
T
F
P
S
N
L
V
H
P
T
P
Site 55
T484
P
S
N
L
V
H
P
T
P
L
Q
K
T
S
L
Site 56
T489
H
P
T
P
L
Q
K
T
S
L
P
S
R
S
V
Site 57
S490
P
T
P
L
Q
K
T
S
L
P
S
R
S
V
S
Site 58
S493
L
Q
K
T
S
L
P
S
R
S
V
S
V
D
E
Site 59
S495
K
T
S
L
P
S
R
S
V
S
V
D
E
S
R
Site 60
S497
S
L
P
S
R
S
V
S
V
D
E
S
R
P
E
Site 61
S501
R
S
V
S
V
D
E
S
R
P
E
L
I
F
R
Site 62
S525
V
L
H
I
D
P
L
S
P
P
E
T
S
Q
N
Site 63
T529
D
P
L
S
P
P
E
T
S
Q
N
L
N
P
L
Site 64
S530
P
L
S
P
P
E
T
S
Q
N
L
N
P
L
T
Site 65
S556
K
I
D
P
A
R
F
S
T
E
D
F
K
S
F
Site 66
T557
I
D
P
A
R
F
S
T
E
D
F
K
S
F
R
Site 67
S562
F
S
T
E
D
F
K
S
F
R
A
V
F
A
E
Site 68
T581
D
H
L
R
F
I
G
T
G
I
K
V
S
Y
E
Site 69
S586
I
G
T
G
I
K
V
S
Y
E
Q
R
Q
R
S
Site 70
Y587
G
T
G
I
K
V
S
Y
E
Q
R
Q
R
S
A
Site 71
S593
S
Y
E
Q
R
Q
R
S
A
S
R
Y
F
S
T
Site 72
S595
E
Q
R
Q
R
S
A
S
R
Y
F
S
T
D
M
Site 73
Y597
R
Q
R
S
A
S
R
Y
F
S
T
D
M
S
I
Site 74
S599
R
S
A
S
R
Y
F
S
T
D
M
S
I
G
Q
Site 75
T600
S
A
S
R
Y
F
S
T
D
M
S
I
G
Q
M
Site 76
S620
L
F
P
T
D
F
H
S
V
P
P
H
Y
T
E
Site 77
Y625
F
H
S
V
P
P
H
Y
T
E
L
L
T
F
H
Site 78
T630
P
H
Y
T
E
L
L
T
F
H
S
K
E
E
T
Site 79
S633
T
E
L
L
T
F
H
S
K
E
E
T
G
S
H
Site 80
T637
T
F
H
S
K
E
E
T
G
S
H
S
P
V
C
Site 81
S639
H
S
K
E
E
T
G
S
H
S
P
V
C
L
Q
Site 82
S641
K
E
E
T
G
S
H
S
P
V
C
L
Q
L
H
Site 83
S652
L
Q
L
H
Y
K
H
S
E
N
R
G
P
Q
G
Site 84
S665
Q
G
N
Q
A
R
L
S
S
V
P
H
K
A
E
Site 85
S666
G
N
Q
A
R
L
S
S
V
P
H
K
A
E
L
Site 86
S694
S
I
V
D
R
L
N
S
L
L
Q
P
Q
K
L
Site 87
T703
L
Q
P
Q
K
L
A
T
V
E
M
M
A
S
H
Site 88
Y715
A
S
H
M
Y
T
S
Y
N
K
H
I
S
L
H
Site 89
S720
T
S
Y
N
K
H
I
S
L
H
K
A
F
T
E
Site 90
S733
T
E
V
F
L
D
D
S
H
S
P
A
N
C
R
Site 91
S735
V
F
L
D
D
S
H
S
P
A
N
C
R
I
S
Site 92
S763
F
P
I
P
D
L
R
S
D
Q
E
R
G
P
W
Site 93
S774
R
G
P
W
F
K
K
S
L
Q
K
E
I
L
Y
Site 94
T791
F
T
D
L
E
F
K
T
E
F
I
G
G
S
T
Site 95
T798
T
E
F
I
G
G
S
T
P
E
Q
I
K
L
E
Site 96
T807
E
Q
I
K
L
E
L
T
F
R
E
L
I
G
S
Site 97
S814
T
F
R
E
L
I
G
S
F
Q
E
E
K
G
D
Site 98
S823
Q
E
E
K
G
D
P
S
I
K
F
F
H
V
S
Site 99
S831
I
K
F
F
H
V
S
S
G
V
D
G
D
T
T
Site 100
T837
S
S
G
V
D
G
D
T
T
S
S
D
D
F
D
Site 101
T838
S
G
V
D
G
D
T
T
S
S
D
D
F
D
W
Site 102
S839
G
V
D
G
D
T
T
S
S
D
D
F
D
W
P
Site 103
S840
V
D
G
D
T
T
S
S
D
D
F
D
W
P
R
Site 104
Y876
E
E
E
N
D
G
H
Y
Q
E
E
E
E
G
G
Site 105
S886
E
E
E
G
G
A
H
S
L
K
D
V
C
D
L
Site 106
S899
D
L
R
R
P
A
P
S
P
F
S
S
R
R
V
Site 107
S902
R
P
A
P
S
P
F
S
S
R
R
V
M
F
E
Site 108
S903
P
A
P
S
P
F
S
S
R
R
V
M
F
E
N
Site 109
S931
E
F
Q
D
K
A
I
S
N
S
H
Y
V
L
E
Site 110
Y945
E
L
T
L
P
N
I
Y
V
T
L
P
N
K
S
Site 111
T947
T
L
P
N
I
Y
V
T
L
P
N
K
S
F
Y
Site 112
S952
Y
V
T
L
P
N
K
S
F
Y
E
K
L
Y
N
Site 113
Y958
K
S
F
Y
E
K
L
Y
N
R
I
F
N
D
L
Site 114
S974
L
W
E
P
T
A
P
S
P
V
E
T
F
E
N
Site 115
T978
T
A
P
S
P
V
E
T
F
E
N
I
S
Y
G
Site 116
T997
V
A
S
Q
L
I
N
T
F
N
K
D
S
F
S
Site 117
S1002
I
N
T
F
N
K
D
S
F
S
A
F
K
S
A
Site 118
S1004
T
F
N
K
D
S
F
S
A
F
K
S
A
V
H
Site 119
S1008
D
S
F
S
A
F
K
S
A
V
H
Y
D
E
E
Site 120
Y1012
A
F
K
S
A
V
H
Y
D
E
E
S
G
S
E
Site 121
S1016
A
V
H
Y
D
E
E
S
G
S
E
E
E
T
L
Site 122
S1018
H
Y
D
E
E
S
G
S
E
E
E
T
L
Q
Y
Site 123
T1022
E
S
G
S
E
E
E
T
L
Q
Y
F
S
T
V
Site 124
Y1025
S
E
E
E
T
L
Q
Y
F
S
T
V
D
P
N
Site 125
T1028
E
T
L
Q
Y
F
S
T
V
D
P
N
Y
R
S
Site 126
Y1033
F
S
T
V
D
P
N
Y
R
S
R
R
K
K
K
Site 127
S1035
T
V
D
P
N
Y
R
S
R
R
K
K
K
L
D
Site 128
S1043
R
R
K
K
K
L
D
S
Q
N
K
N
S
Q
S
Site 129
S1048
L
D
S
Q
N
K
N
S
Q
S
F
L
S
V
L
Site 130
S1050
S
Q
N
K
N
S
Q
S
F
L
S
V
L
L
N
Site 131
T1067
H
G
L
I
A
V
F
T
D
V
K
Q
D
N
G
Site 132
Y1099
S
L
F
C
V
T
K
Y
E
G
F
D
D
K
H
Site 133
Y1107
E
G
F
D
D
K
H
Y
I
C
L
H
S
S
S
Site 134
S1114
Y
I
C
L
H
S
S
S
F
S
L
Y
H
K
G
Site 135
Y1118
H
S
S
S
F
S
L
Y
H
K
G
I
V
N
G
Site 136
T1132
G
V
I
L
P
T
E
T
R
L
P
S
S
T
R
Site 137
S1136
P
T
E
T
R
L
P
S
S
T
R
P
H
W
L
Site 138
S1137
T
E
T
R
L
P
S
S
T
R
P
H
W
L
E
Site 139
T1138
E
T
R
L
P
S
S
T
R
P
H
W
L
E
P
Site 140
T1146
R
P
H
W
L
E
P
T
I
Y
S
S
E
E
D
Site 141
Y1148
H
W
L
E
P
T
I
Y
S
S
E
E
D
G
L
Site 142
S1150
L
E
P
T
I
Y
S
S
E
E
D
G
L
S
K
Site 143
S1156
S
S
E
E
D
G
L
S
K
T
S
S
D
G
V
Site 144
T1158
E
E
D
G
L
S
K
T
S
S
D
G
V
G
G
Site 145
S1160
D
G
L
S
K
T
S
S
D
G
V
G
G
D
S
Site 146
S1179
S
V
A
V
K
I
L
S
D
K
S
E
S
N
T
Site 147
S1182
V
K
I
L
S
D
K
S
E
S
N
T
K
E
F
Site 148
T1186
S
D
K
S
E
S
N
T
K
E
F
L
I
A
V
Site 149
S1210
R
M
L
P
S
G
L
S
W
H
E
Q
I
L
Y
Site 150
Y1217
S
W
H
E
Q
I
L
Y
F
L
N
I
A
D
E
Site 151
Y1229
A
D
E
P
V
L
G
Y
N
P
P
T
S
F
T
Site 152
S1270
E
T
F
S
V
S
S
S
V
A
L
D
K
S
S
Site 153
T1279
A
L
D
K
S
S
S
T
L
R
I
I
L
D
E
Site 154
T1297
H
L
S
D
K
C
N
T
V
T
I
N
L
S
R
Site 155
T1299
S
D
K
C
N
T
V
T
I
N
L
S
R
D
Y
Site 156
Y1306
T
I
N
L
S
R
D
Y
V
R
V
M
D
M
G
Site 157
S1324
L
T
I
T
A
V
K
S
D
S
D
G
E
Q
T
Site 158
S1326
I
T
A
V
K
S
D
S
D
G
E
Q
T
E
P
Site 159
T1331
S
D
S
D
G
E
Q
T
E
P
R
F
E
L
H
Site 160
S1340
P
R
F
E
L
H
C
S
S
D
V
V
H
I
R
Site 161
S1341
R
F
E
L
H
C
S
S
D
V
V
H
I
R
T
Site 162
T1371
A
S
Y
G
D
L
Q
T
P
N
K
A
D
M
K
Site 163
S1386
P
G
A
F
Q
R
R
S
K
V
D
S
S
G
R
Site 164
S1390
Q
R
R
S
K
V
D
S
S
G
R
S
S
S
R
Site 165
S1391
R
R
S
K
V
D
S
S
G
R
S
S
S
R
G
Site 166
S1394
K
V
D
S
S
G
R
S
S
S
R
G
P
V
L
Site 167
S1395
V
D
S
S
G
R
S
S
S
R
G
P
V
L
P
Site 168
S1396
D
S
S
G
R
S
S
S
R
G
P
V
L
P
E
Site 169
S1414
Q
M
L
R
D
L
M
S
D
A
M
E
E
I
D
Site 170
S1428
D
M
Q
Q
G
T
S
S
V
K
P
Q
A
N
G
Site 171
S1441
N
G
V
L
D
E
K
S
Q
I
Q
E
P
C
C
Site 172
S1458
L
F
L
F
P
D
E
S
G
N
V
S
Q
E
S
Site 173
S1462
P
D
E
S
G
N
V
S
Q
E
S
G
P
T
Y
Site 174
S1465
S
G
N
V
S
Q
E
S
G
P
T
Y
A
S
F
Site 175
T1468
V
S
Q
E
S
G
P
T
Y
A
S
F
S
H
H
Site 176
Y1469
S
Q
E
S
G
P
T
Y
A
S
F
S
H
H
F
Site 177
S1471
E
S
G
P
T
Y
A
S
F
S
H
H
F
I
S
Site 178
S1473
G
P
T
Y
A
S
F
S
H
H
F
I
S
D
A
Site 179
T1482
H
F
I
S
D
A
M
T
G
V
P
T
E
N
D
Site 180
S1526
V
I
R
D
N
Y
F
S
L
P
V
N
K
T
D
Site 181
T1532
F
S
L
P
V
N
K
T
D
T
S
K
A
P
L
Site 182
T1534
L
P
V
N
K
T
D
T
S
K
A
P
L
H
F
Site 183
S1535
P
V
N
K
T
D
T
S
K
A
P
L
H
F
P
Site 184
T1567
Y
G
G
K
D
F
G
T
V
P
P
T
S
P
A
Site 185
T1571
D
F
G
T
V
P
P
T
S
P
A
K
S
Y
I
Site 186
S1572
F
G
T
V
P
P
T
S
P
A
K
S
Y
I
S
Site 187
S1576
P
P
T
S
P
A
K
S
Y
I
S
P
H
S
S
Site 188
Y1577
P
T
S
P
A
K
S
Y
I
S
P
H
S
S
P
Site 189
S1579
S
P
A
K
S
Y
I
S
P
H
S
S
P
S
H
Site 190
S1582
K
S
Y
I
S
P
H
S
S
P
S
H
T
P
T
Site 191
S1583
S
Y
I
S
P
H
S
S
P
S
H
T
P
T
R
Site 192
S1585
I
S
P
H
S
S
P
S
H
T
P
T
R
H
G
Site 193
T1587
P
H
S
S
P
S
H
T
P
T
R
H
G
R
N
Site 194
T1589
S
S
P
S
H
T
P
T
R
H
G
R
N
T
V
Site 195
T1595
P
T
R
H
G
R
N
T
V
C
G
G
K
G
R
Site 196
Y1622
V
K
F
Q
H
E
V
Y
P
P
C
K
P
D
C
Site 197
S1631
P
C
K
P
D
C
D
S
S
L
S
E
H
P
V
Site 198
S1632
C
K
P
D
C
D
S
S
L
S
E
H
P
V
S
Site 199
S1634
P
D
C
D
S
S
L
S
E
H
P
V
S
R
Q
Site 200
S1639
S
L
S
E
H
P
V
S
R
Q
V
F
I
V
Q
Site 201
T1656
E
I
R
D
R
L
A
T
S
Q
M
N
K
F
L
Site 202
S1657
I
R
D
R
L
A
T
S
Q
M
N
K
F
L
Y
Site 203
Y1664
S
Q
M
N
K
F
L
Y
L
Y
C
S
K
E
M
Site 204
Y1666
M
N
K
F
L
Y
L
Y
C
S
K
E
M
P
R
Site 205
S1691
A
L
H
V
C
P
E
S
G
R
S
P
Q
E
C
Site 206
S1694
V
C
P
E
S
G
R
S
P
Q
E
C
C
L
R
Site 207
S1727
K
D
F
F
T
S
L
S
A
E
V
E
L
Q
M
Site 208
T1735
A
E
V
E
L
Q
M
T
P
D
P
E
V
K
K
Site 209
S1743
P
D
P
E
V
K
K
S
P
G
A
D
V
T
C
Site 210
T1749
K
S
P
G
A
D
V
T
C
S
L
P
R
H
L
Site 211
S1751
P
G
A
D
V
T
C
S
L
P
R
H
L
S
T
Site 212
S1757
C
S
L
P
R
H
L
S
T
S
K
E
P
N
L
Site 213
S1759
L
P
R
H
L
S
T
S
K
E
P
N
L
V
I
Site 214
S1767
K
E
P
N
L
V
I
S
F
S
G
P
K
Q
P
Site 215
S1769
P
N
L
V
I
S
F
S
G
P
K
Q
P
S
Q
Site 216
S1775
F
S
G
P
K
Q
P
S
Q
N
D
S
A
N
S
Site 217
S1779
K
Q
P
S
Q
N
D
S
A
N
S
V
E
V
V
Site 218
S1795
G
M
E
E
K
N
F
S
A
E
E
A
S
F
R
Site 219
S1800
N
F
S
A
E
E
A
S
F
R
D
Q
P
V
F
Site 220
T1814
F
F
R
E
F
R
F
T
S
E
V
P
I
R
L
Site 221
S1815
F
R
E
F
R
F
T
S
E
V
P
I
R
L
D
Site 222
Y1823
E
V
P
I
R
L
D
Y
H
G
K
H
V
S
M
Site 223
S1829
D
Y
H
G
K
H
V
S
M
D
Q
G
T
L
A
Site 224
S1856
E
L
K
L
K
R
L
S
Y
R
H
G
L
L
G
Site 225
Y1857
L
K
L
K
R
L
S
Y
R
H
G
L
L
G
V
Site 226
Y1915
V
W
L
P
I
E
Q
Y
R
K
D
G
R
I
V
Site 227
S1931
G
F
Q
R
G
A
A
S
F
G
T
S
T
A
M
Site 228
Y1959
Q
A
A
A
E
T
A
Y
D
M
V
S
P
G
T
Site 229
S1963
E
T
A
Y
D
M
V
S
P
G
T
L
S
I
E
Site 230
T1966
Y
D
M
V
S
P
G
T
L
S
I
E
P
K
K
Site 231
S1968
M
V
S
P
G
T
L
S
I
E
P
K
K
T
K
Site 232
T1974
L
S
I
E
P
K
K
T
K
R
F
P
H
H
R
Site 233
Y1997
R
E
G
V
A
K
A
Y
S
V
V
K
E
G
I
Site 234
T2025
E
H
E
S
R
G
V
T
G
A
V
G
E
V
L
Site 235
S2070
P
D
V
R
Q
D
E
S
Q
K
W
R
H
G
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation