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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMEM66
Full Name:
Transmembrane protein 66
Alias:
HBV X-transactivated gene 3 protein;HBV XAg-transactivated protein 3;Protein FOAP-7
Type:
Mass (Da):
36975
Number AA:
339
UniProt ID:
Q96BY9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T46
L
R
D
V
K
A
L
T
L
H
Y
D
R
Y
T
Site 2
Y49
V
K
A
L
T
L
H
Y
D
R
Y
T
T
S
R
Site 3
Y52
L
T
L
H
Y
D
R
Y
T
T
S
R
R
L
D
Site 4
T53
T
L
H
Y
D
R
Y
T
T
S
R
R
L
D
P
Site 5
T54
L
H
Y
D
R
Y
T
T
S
R
R
L
D
P
I
Site 6
S55
H
Y
D
R
Y
T
T
S
R
R
L
D
P
I
P
Site 7
S75
G
G
T
A
G
C
D
S
Y
T
P
K
V
I
Q
Site 8
Y76
G
T
A
G
C
D
S
Y
T
P
K
V
I
Q
C
Site 9
T77
T
A
G
C
D
S
Y
T
P
K
V
I
Q
C
Q
Site 10
Y105
K
T
D
L
D
I
A
Y
K
F
G
K
T
V
V
Site 11
S113
K
F
G
K
T
V
V
S
C
E
G
Y
E
S
S
Site 12
Y117
T
V
V
S
C
E
G
Y
E
S
S
E
D
Q
Y
Site 13
S119
V
S
C
E
G
Y
E
S
S
E
D
Q
Y
V
L
Site 14
S120
S
C
E
G
Y
E
S
S
E
D
Q
Y
V
L
R
Site 15
Y124
Y
E
S
S
E
D
Q
Y
V
L
R
G
S
C
G
Site 16
S129
D
Q
Y
V
L
R
G
S
C
G
L
E
Y
N
L
Site 17
Y134
R
G
S
C
G
L
E
Y
N
L
D
Y
T
E
L
Site 18
Y138
G
L
E
Y
N
L
D
Y
T
E
L
G
L
Q
K
Site 19
T139
L
E
Y
N
L
D
Y
T
E
L
G
L
Q
K
L
Site 20
Y161
G
F
A
S
F
S
D
Y
Y
Y
K
W
S
S
A
Site 21
Y162
F
A
S
F
S
D
Y
Y
Y
K
W
S
S
A
D
Site 22
Y163
A
S
F
S
D
Y
Y
Y
K
W
S
S
A
D
S
Site 23
S195
V
V
Y
K
L
F
L
S
D
G
Q
Y
S
P
P
Site 24
Y199
L
F
L
S
D
G
Q
Y
S
P
P
P
Y
S
E
Site 25
S200
F
L
S
D
G
Q
Y
S
P
P
P
Y
S
E
Y
Site 26
Y204
G
Q
Y
S
P
P
P
Y
S
E
Y
P
P
F
S
Site 27
S205
Q
Y
S
P
P
P
Y
S
E
Y
P
P
F
S
H
Site 28
Y207
S
P
P
P
Y
S
E
Y
P
P
F
S
H
R
Y
Site 29
Y214
Y
P
P
F
S
H
R
Y
Q
R
F
T
N
S
A
Site 30
T218
S
H
R
Y
Q
R
F
T
N
S
A
G
P
P
P
Site 31
S220
R
Y
Q
R
F
T
N
S
A
G
P
P
P
P
G
Site 32
S230
P
P
P
P
G
F
K
S
E
F
T
G
P
Q
N
Site 33
S244
N
T
G
H
G
A
T
S
G
F
G
S
A
F
T
Site 34
S248
G
A
T
S
G
F
G
S
A
F
T
G
Q
Q
G
Site 35
Y256
A
F
T
G
Q
Q
G
Y
E
N
S
G
P
G
F
Site 36
S259
G
Q
Q
G
Y
E
N
S
G
P
G
F
W
T
G
Site 37
T265
N
S
G
P
G
F
W
T
G
L
G
T
G
G
I
Site 38
T284
F
G
S
N
R
A
A
T
P
F
S
D
S
W
Y
Site 39
S287
N
R
A
A
T
P
F
S
D
S
W
Y
Y
P
S
Site 40
S289
A
A
T
P
F
S
D
S
W
Y
Y
P
S
Y
P
Site 41
Y291
T
P
F
S
D
S
W
Y
Y
P
S
Y
P
P
S
Site 42
Y292
P
F
S
D
S
W
Y
Y
P
S
Y
P
P
S
Y
Site 43
S294
S
D
S
W
Y
Y
P
S
Y
P
P
S
Y
P
G
Site 44
Y295
D
S
W
Y
Y
P
S
Y
P
P
S
Y
P
G
T
Site 45
Y299
Y
P
S
Y
P
P
S
Y
P
G
T
W
N
R
A
Site 46
T302
Y
P
P
S
Y
P
G
T
W
N
R
A
Y
S
P
Site 47
Y307
P
G
T
W
N
R
A
Y
S
P
L
H
G
G
S
Site 48
S308
G
T
W
N
R
A
Y
S
P
L
H
G
G
S
G
Site 49
S314
Y
S
P
L
H
G
G
S
G
S
Y
S
V
C
S
Site 50
S316
P
L
H
G
G
S
G
S
Y
S
V
C
S
N
S
Site 51
S318
H
G
G
S
G
S
Y
S
V
C
S
N
S
D
T
Site 52
S321
S
G
S
Y
S
V
C
S
N
S
D
T
K
T
R
Site 53
S323
S
Y
S
V
C
S
N
S
D
T
K
T
R
T
A
Site 54
T325
S
V
C
S
N
S
D
T
K
T
R
T
A
S
G
Site 55
T327
C
S
N
S
D
T
K
T
R
T
A
S
G
Y
G
Site 56
S331
D
T
K
T
R
T
A
S
G
Y
G
G
T
R
R
Site 57
Y333
K
T
R
T
A
S
G
Y
G
G
T
R
R
R
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation