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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLD4
Full Name:
Phospholipase D4
Alias:
Choline phosphatase 4;Phosphatidylcholine-hydrolyzing phospholipase D4
Type:
Enzyme, phospholipid phospholipase
Mass (Da):
55626
Number AA:
506
UniProt ID:
Q96BZ4
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0070290
GO:0004630
PhosphoSite+
KinaseNET
Biological Process:
GO:0016042
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T30
P
W
D
R
E
A
G
T
L
Q
V
L
G
A
L
Site 2
T59
W
Q
V
P
R
P
P
T
W
G
Q
V
Q
P
K
Site 3
S71
Q
P
K
D
V
P
R
S
W
E
H
G
S
S
P
Site 4
S77
R
S
W
E
H
G
S
S
P
A
W
E
P
L
E
Site 5
S93
E
A
R
Q
Q
R
D
S
C
Q
L
V
L
V
E
Site 6
S108
S
I
P
Q
D
L
P
S
A
A
G
S
P
S
A
Site 7
S112
D
L
P
S
A
A
G
S
P
S
A
Q
P
L
G
Site 8
S114
P
S
A
A
G
S
P
S
A
Q
P
L
G
Q
A
Site 9
S132
L
L
D
T
A
Q
E
S
V
H
V
A
S
Y
Y
Site 10
S137
Q
E
S
V
H
V
A
S
Y
Y
W
S
L
T
G
Site 11
Y138
E
S
V
H
V
A
S
Y
Y
W
S
L
T
G
P
Site 12
Y139
S
V
H
V
A
S
Y
Y
W
S
L
T
G
P
D
Site 13
S141
H
V
A
S
Y
Y
W
S
L
T
G
P
D
I
G
Site 14
T143
A
S
Y
Y
W
S
L
T
G
P
D
I
G
V
N
Site 15
S152
P
D
I
G
V
N
D
S
S
S
Q
L
G
E
A
Site 16
T182
A
V
A
T
S
S
P
T
L
A
R
T
S
T
D
Site 17
T209
Q
V
P
M
G
R
L
T
R
G
V
L
H
S
K
Site 18
Y226
V
V
D
G
R
H
I
Y
M
G
S
A
N
M
D
Site 19
S236
S
A
N
M
D
W
R
S
L
T
Q
V
K
E
L
Site 20
T238
N
M
D
W
R
S
L
T
Q
V
K
E
L
G
A
Site 21
T260
L
A
Q
D
L
E
K
T
F
Q
T
Y
W
V
L
Site 22
Y264
L
E
K
T
F
Q
T
Y
W
V
L
G
V
P
K
Site 23
T277
P
K
A
V
L
P
K
T
W
P
Q
N
F
S
S
Site 24
Y304
D
G
V
P
T
T
A
Y
F
S
A
S
P
P
A
Site 25
S308
T
T
A
Y
F
S
A
S
P
P
A
L
C
P
Q
Site 26
T345
S
V
M
E
Y
F
P
T
T
R
F
S
H
P
P
Site 27
T346
V
M
E
Y
F
P
T
T
R
F
S
H
P
P
R
Site 28
Y354
R
F
S
H
P
P
R
Y
W
P
V
L
D
N
A
Site 29
T386
C
G
L
N
T
D
P
T
M
F
P
Y
L
R
S
Site 30
Y390
T
D
P
T
M
F
P
Y
L
R
S
L
Q
A
L
Site 31
S393
T
M
F
P
Y
L
R
S
L
Q
A
L
S
N
P
Site 32
S398
L
R
S
L
Q
A
L
S
N
P
A
A
N
V
S
Site 33
S429
P
F
S
R
V
N
H
S
K
F
M
V
T
E
K
Site 34
Y439
M
V
T
E
K
A
A
Y
I
G
T
S
N
W
S
Site 35
S446
Y
I
G
T
S
N
W
S
E
D
Y
F
S
S
T
Site 36
Y449
T
S
N
W
S
E
D
Y
F
S
S
T
A
G
V
Site 37
S451
N
W
S
E
D
Y
F
S
S
T
A
G
V
G
L
Site 38
T472
G
A
Q
P
A
G
A
T
V
Q
E
Q
L
R
Q
Site 39
S486
Q
L
F
E
R
D
W
S
S
R
Y
A
V
G
L
Site 40
S487
L
F
E
R
D
W
S
S
R
Y
A
V
G
L
D
Site 41
Y489
E
R
D
W
S
S
R
Y
A
V
G
L
D
G
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation