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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LGP2
Full Name:
Probable ATP-dependent RNA helicase DHX58
Alias:
ATP-dependent helicase LGP2; D11LGP2; DEXH (Asp-Glu-X-His) box polypeptide 58; DHX58; RNA helicase LGP2
Type:
Inhibitor protein; Helicase; EC 3.6.1.-
Mass (Da):
76610
Number AA:
UniProt ID:
Q96C10
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0045087
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y36
G
K
T
R
A
A
A
Y
V
A
K
R
H
L
E
Site 2
T61
V
N
R
V
H
L
V
T
Q
H
G
E
E
F
R
Site 3
T76
R
M
L
D
G
R
W
T
V
T
T
L
S
G
D
Site 4
T79
D
G
R
W
T
V
T
T
L
S
G
D
M
G
P
Site 5
S81
R
W
T
V
T
T
L
S
G
D
M
G
P
R
A
Site 6
S113
L
L
Q
M
A
L
T
S
P
E
E
E
E
H
V
Site 7
Y142
H
T
H
K
D
T
V
Y
N
V
I
M
S
Q
Y
Site 8
Y149
Y
N
V
I
M
S
Q
Y
L
E
L
K
L
Q
R
Site 9
S225
Y
N
L
C
H
R
R
S
Q
D
P
F
G
D
L
Site 10
S250
H
L
E
M
P
E
L
S
R
K
F
G
T
Q
M
Site 11
Y258
R
K
F
G
T
Q
M
Y
E
Q
Q
V
V
K
L
Site 12
Y280
G
L
Q
E
Q
R
V
Y
A
L
H
L
R
R
Y
Site 13
Y287
Y
A
L
H
L
R
R
Y
N
D
A
L
L
I
H
Site 14
Y310
L
A
A
L
Q
D
F
Y
H
R
E
H
V
T
K
Site 15
T343
N
E
L
A
H
L
A
T
H
G
P
E
N
P
K
Site 16
S363
K
I
L
Q
R
Q
F
S
S
S
N
S
P
R
G
Site 17
S365
L
Q
R
Q
F
S
S
S
N
S
P
R
G
I
I
Site 18
S367
R
Q
F
S
S
S
N
S
P
R
G
I
I
F
T
Site 19
T374
S
P
R
G
I
I
F
T
R
T
R
Q
S
A
H
Site 20
S379
I
F
T
R
T
R
Q
S
A
H
S
L
L
L
W
Site 21
S382
R
T
R
Q
S
A
H
S
L
L
L
W
L
Q
Q
Site 22
S410
L
I
G
A
G
N
S
S
Q
S
T
H
M
T
Q
Site 23
T413
A
G
N
S
S
Q
S
T
H
M
T
Q
R
D
Q
Site 24
T416
S
S
Q
S
T
H
M
T
Q
R
D
Q
Q
E
V
Site 25
S464
G
L
L
T
N
E
I
S
M
V
Q
A
R
G
R
Site 26
S477
G
R
A
R
A
D
Q
S
V
Y
A
F
V
A
T
Site 27
Y518
Q
K
M
D
Q
A
E
Y
Q
A
K
I
R
D
L
Site 28
S567
M
V
A
V
G
H
G
S
D
L
R
K
V
E
G
Site 29
T575
D
L
R
K
V
E
G
T
H
H
V
N
V
N
P
Site 30
Y587
V
N
P
N
F
S
N
Y
Y
N
V
S
R
D
P
Site 31
T642
V
R
S
M
L
L
E
T
P
Q
G
R
I
Q
A
Site 32
S653
R
I
Q
A
K
K
W
S
R
V
P
F
S
V
P
Site 33
S658
K
W
S
R
V
P
F
S
V
P
D
F
D
F
L
Site 34
S673
Q
H
C
A
E
N
L
S
D
L
S
L
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation