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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRRC45
Full Name:
Leucine-rich repeat-containing protein 45
Alias:
leucine rich repeat containing 45; leucine-rich repeat-containing 45; LRC45; MGC20806
Type:
Mass (Da):
75951
Number AA:
670
UniProt ID:
Q96CN5
International Prot ID:
IPI00060474
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
E
E
F
R
R
S
Y
S
R
L
C
R
E
Site 2
Y8
M
E
E
F
R
R
S
Y
S
R
L
C
R
E
S
Site 3
S9
E
E
F
R
R
S
Y
S
R
L
C
R
E
S
G
Site 4
S15
Y
S
R
L
C
R
E
S
G
A
E
P
Q
E
A
Site 5
T39
R
G
R
L
D
L
A
T
Q
S
L
T
V
E
T
Site 6
S41
R
L
D
L
A
T
Q
S
L
T
V
E
T
C
R
Site 7
S115
K
L
L
Q
Q
N
K
S
I
Q
S
L
T
L
E
Site 8
T120
N
K
S
I
Q
S
L
T
L
E
W
N
S
L
G
Site 9
S157
D
L
R
N
N
Q
I
S
H
K
G
A
E
E
L
Site 10
T172
A
L
A
L
K
G
N
T
T
L
Q
Q
L
D
L
Site 11
T173
L
A
L
K
G
N
T
T
L
Q
Q
L
D
L
R
Site 12
T201
N
C
L
P
S
N
R
T
L
W
R
L
D
L
A
Site 13
S227
V
E
Q
A
M
G
H
S
Q
D
R
L
T
T
F
Site 14
T232
G
H
S
Q
D
R
L
T
T
F
Q
E
N
Q
A
Site 15
T233
H
S
Q
D
R
L
T
T
F
Q
E
N
Q
A
R
Site 16
S245
Q
A
R
T
H
V
L
S
K
E
V
Q
H
L
R
Site 17
S256
Q
H
L
R
E
E
K
S
K
Q
F
L
D
L
M
Site 18
S276
Q
R
E
E
M
A
K
S
S
R
A
S
A
A
R
Site 19
S280
M
A
K
S
S
R
A
S
A
A
R
V
G
Q
L
Site 20
S296
E
A
L
N
E
R
H
S
I
I
N
A
L
K
A
Site 21
T328
D
L
G
E
L
L
A
T
A
E
Q
E
Q
L
S
Site 22
S335
T
A
E
Q
E
Q
L
S
L
S
Q
R
Q
A
K
Site 23
S337
E
Q
E
Q
L
S
L
S
Q
R
Q
A
K
E
L
Site 24
S356
Q
E
A
A
E
R
E
S
K
L
L
R
D
L
S
Site 25
S363
S
K
L
L
R
D
L
S
A
A
N
E
K
N
L
Site 26
S399
Q
T
R
Q
E
M
T
S
M
S
A
E
L
K
M
Site 27
S425
E
K
R
R
C
R
Q
S
L
E
D
S
E
S
L
Site 28
S429
C
R
Q
S
L
E
D
S
E
S
L
R
I
K
E
Site 29
S431
Q
S
L
E
D
S
E
S
L
R
I
K
E
V
E
Site 30
S447
M
T
R
H
L
E
E
S
E
K
A
M
Q
E
R
Site 31
S464
R
L
E
A
A
R
L
S
L
E
E
E
L
S
R
Site 32
S478
R
V
K
A
A
A
L
S
E
R
G
Q
A
E
E
Site 33
S492
E
E
L
I
K
A
K
S
Q
A
R
L
E
E
Q
Site 34
S538
A
E
A
Q
T
R
V
S
Q
L
G
L
Q
V
E
Site 35
S559
E
E
L
Q
Q
E
L
S
L
K
D
Q
E
R
V
Site 36
S570
Q
E
R
V
A
E
V
S
R
V
R
V
E
L
Q
Site 37
S609
R
Q
L
K
V
M
A
S
D
H
R
E
A
L
L
Site 38
S620
E
A
L
L
D
R
E
S
E
N
A
S
L
R
E
Site 39
S624
D
R
E
S
E
N
A
S
L
R
E
K
L
R
L
Site 40
S648
D
E
E
A
Q
R
A
S
F
L
Q
N
A
V
L
Site 41
T665
V
Q
A
S
P
V
R
T
L
S
P
P
K
_
_
Site 42
S667
A
S
P
V
R
T
L
S
P
P
K
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation