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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRAMD1A
Full Name:
GRAM domain-containing protein 1A
Alias:
FLJ22411; FLJ90346; GRAM domain containing 1A; GRAM domain-containing protein 1A: GRAM domain-containing protein 1A: GRAM domain-containing protein 1A; GRM1A; KIAA1533
Type:
Membrane protein
Mass (Da):
80680
Number AA:
724
UniProt ID:
Q96CP6
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
F
D
T
T
P
H
S
G
R
S
T
P
S
S
Site 2
S11
T
T
P
H
S
G
R
S
T
P
S
S
S
P
S
Site 3
T12
T
P
H
S
G
R
S
T
P
S
S
S
P
S
L
Site 4
S14
H
S
G
R
S
T
P
S
S
S
P
S
L
R
K
Site 5
S15
S
G
R
S
T
P
S
S
S
P
S
L
R
K
R
Site 6
S16
G
R
S
T
P
S
S
S
P
S
L
R
K
R
L
Site 7
S18
S
T
P
S
S
S
P
S
L
R
K
R
L
Q
L
Site 8
S29
R
L
Q
L
L
P
P
S
R
P
P
P
E
P
E
Site 9
T39
P
P
E
P
E
P
G
T
M
V
E
K
G
S
D
Site 10
S45
G
T
M
V
E
K
G
S
D
S
S
S
E
K
G
Site 11
S47
M
V
E
K
G
S
D
S
S
S
E
K
G
G
V
Site 12
S48
V
E
K
G
S
D
S
S
S
E
K
G
G
V
P
Site 13
S49
E
K
G
S
D
S
S
S
E
K
G
G
V
P
G
Site 14
T57
E
K
G
G
V
P
G
T
P
S
T
Q
S
L
G
Site 15
S59
G
G
V
P
G
T
P
S
T
Q
S
L
G
S
R
Site 16
T60
G
V
P
G
T
P
S
T
Q
S
L
G
S
R
N
Site 17
S62
P
G
T
P
S
T
Q
S
L
G
S
R
N
F
I
Site 18
S65
P
S
T
Q
S
L
G
S
R
N
F
I
R
N
S
Site 19
S77
R
N
S
K
K
M
Q
S
W
Y
S
M
L
S
P
Site 20
Y79
S
K
K
M
Q
S
W
Y
S
M
L
S
P
T
Y
Site 21
S83
Q
S
W
Y
S
M
L
S
P
T
Y
K
Q
R
N
Site 22
Y110
A
E
R
L
I
V
D
Y
S
C
A
L
Q
R
E
Site 23
S111
E
R
L
I
V
D
Y
S
C
A
L
Q
R
E
I
Site 24
T142
S
N
I
F
R
W
E
T
T
I
S
I
Q
L
K
Site 25
T159
T
C
L
K
K
E
K
T
A
K
L
I
P
N
A
Site 26
S180
S
E
K
H
F
F
T
S
F
G
A
R
D
R
C
Site 27
T203
Q
N
A
L
L
E
K
T
L
S
P
R
E
L
W
Site 28
S205
A
L
L
E
K
T
L
S
P
R
E
L
W
H
L
Site 29
Y217
W
H
L
V
H
Q
C
Y
G
S
E
L
G
L
T
Site 30
S219
L
V
H
Q
C
Y
G
S
E
L
G
L
T
S
E
Site 31
T224
Y
G
S
E
L
G
L
T
S
E
D
E
D
Y
V
Site 32
S225
G
S
E
L
G
L
T
S
E
D
E
D
Y
V
S
Site 33
Y230
L
T
S
E
D
E
D
Y
V
S
P
L
Q
L
N
Site 34
S232
S
E
D
E
D
Y
V
S
P
L
Q
L
N
G
L
Site 35
T241
L
Q
L
N
G
L
G
T
P
K
E
V
G
D
V
Site 36
S256
I
A
L
S
D
I
T
S
S
G
A
A
D
R
S
Site 37
S257
A
L
S
D
I
T
S
S
G
A
A
D
R
S
Q
Site 38
S263
S
S
G
A
A
D
R
S
Q
E
P
S
P
V
G
Site 39
S267
A
D
R
S
Q
E
P
S
P
V
G
S
R
R
G
Site 40
S271
Q
E
P
S
P
V
G
S
R
R
G
H
V
T
P
Site 41
T277
G
S
R
R
G
H
V
T
P
N
L
S
R
A
S
Site 42
S281
G
H
V
T
P
N
L
S
R
A
S
S
D
A
D
Site 43
S284
T
P
N
L
S
R
A
S
S
D
A
D
H
G
A
Site 44
S285
P
N
L
S
R
A
S
S
D
A
D
H
G
A
E
Site 45
S301
D
K
E
E
Q
V
D
S
Q
P
D
A
S
S
S
Site 46
S307
D
S
Q
P
D
A
S
S
S
Q
T
V
T
P
V
Site 47
S308
S
Q
P
D
A
S
S
S
Q
T
V
T
P
V
A
Site 48
T310
P
D
A
S
S
S
Q
T
V
T
P
V
A
E
P
Site 49
T312
A
S
S
S
Q
T
V
T
P
V
A
E
P
P
S
Site 50
S319
T
P
V
A
E
P
P
S
T
E
P
T
Q
P
D
Site 51
T320
P
V
A
E
P
P
S
T
E
P
T
Q
P
D
G
Site 52
T323
E
P
P
S
T
E
P
T
Q
P
D
G
P
T
T
Site 53
T330
T
Q
P
D
G
P
T
T
L
G
P
L
D
L
L
Site 54
S339
G
P
L
D
L
L
P
S
E
E
L
L
T
D
T
Site 55
T344
L
P
S
E
E
L
L
T
D
T
S
N
S
S
S
Site 56
T346
S
E
E
L
L
T
D
T
S
N
S
S
S
S
T
Site 57
S347
E
E
L
L
T
D
T
S
N
S
S
S
S
T
G
Site 58
S349
L
L
T
D
T
S
N
S
S
S
S
T
G
E
E
Site 59
S351
T
D
T
S
N
S
S
S
S
T
G
E
E
A
D
Site 60
S389
R
L
Q
Q
M
L
F
S
D
S
P
F
L
Q
G
Site 61
T407
Q
C
K
F
T
D
V
T
L
S
P
W
S
G
D
Site 62
S409
K
F
T
D
V
T
L
S
P
W
S
G
D
S
K
Site 63
S412
D
V
T
L
S
P
W
S
G
D
S
K
C
H
Q
Site 64
S415
L
S
P
W
S
G
D
S
K
C
H
Q
R
R
V
Site 65
T424
C
H
Q
R
R
V
L
T
Y
T
I
P
I
S
N
Site 66
Y425
H
Q
R
R
V
L
T
Y
T
I
P
I
S
N
P
Site 67
T426
Q
R
R
V
L
T
Y
T
I
P
I
S
N
P
L
Site 68
S430
L
T
Y
T
I
P
I
S
N
P
L
G
P
K
S
Site 69
S437
S
N
P
L
G
P
K
S
A
S
V
V
E
T
Q
Site 70
S439
P
L
G
P
K
S
A
S
V
V
E
T
Q
T
L
Site 71
T443
K
S
A
S
V
V
E
T
Q
T
L
F
R
R
G
Site 72
T445
A
S
V
V
E
T
Q
T
L
F
R
R
G
P
Q
Site 73
T464
V
V
D
S
E
V
L
T
Q
G
I
P
Y
Q
D
Site 74
Y472
Q
G
I
P
Y
Q
D
Y
F
Y
T
A
H
R
Y
Site 75
S494
N
K
A
R
L
R
V
S
S
E
I
R
Y
R
K
Site 76
S495
K
A
R
L
R
V
S
S
E
I
R
Y
R
K
Q
Site 77
Y499
R
V
S
S
E
I
R
Y
R
K
Q
P
W
S
L
Site 78
S505
R
Y
R
K
Q
P
W
S
L
V
K
S
L
I
E
Site 79
S509
Q
P
W
S
L
V
K
S
L
I
E
K
N
S
W
Site 80
S515
K
S
L
I
E
K
N
S
W
S
G
I
E
D
Y
Site 81
Y522
S
W
S
G
I
E
D
Y
F
H
H
L
E
R
E
Site 82
S537
L
A
K
A
E
K
L
S
L
E
E
G
G
K
D
Site 83
S550
K
D
A
R
G
L
L
S
G
L
R
R
R
K
R
Site 84
S560
R
R
R
K
R
P
L
S
W
R
A
H
G
D
G
Site 85
T583
C
A
R
A
G
I
H
T
S
G
S
L
S
S
R
Site 86
S584
A
R
A
G
I
H
T
S
G
S
L
S
S
R
F
Site 87
S586
A
G
I
H
T
S
G
S
L
S
S
R
F
S
E
Site 88
S588
I
H
T
S
G
S
L
S
S
R
F
S
E
P
S
Site 89
S589
H
T
S
G
S
L
S
S
R
F
S
E
P
S
V
Site 90
S592
G
S
L
S
S
R
F
S
E
P
S
V
D
Q
G
Site 91
S595
S
S
R
F
S
E
P
S
V
D
Q
G
P
G
A
Site 92
S635
L
L
F
Y
R
L
W
S
L
E
R
T
A
H
T
Site 93
T639
R
L
W
S
L
E
R
T
A
H
T
F
E
S
W
Site 94
T642
S
L
E
R
T
A
H
T
F
E
S
W
H
S
L
Site 95
S648
H
T
F
E
S
W
H
S
L
A
L
A
K
G
K
Site 96
S688
W
R
Q
I
L
R
A
S
V
E
L
L
D
E
M
Site 97
S698
L
L
D
E
M
K
F
S
L
E
K
L
H
Q
G
Site 98
T707
E
K
L
H
Q
G
I
T
V
S
D
P
P
F
D
Site 99
S709
L
H
Q
G
I
T
V
S
D
P
P
F
D
T
Q
Site 100
T715
V
S
D
P
P
F
D
T
Q
P
R
P
D
D
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation