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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OPTN
Full Name:
Optineurin
Alias:
FIP2; GLC1E; HIP7; HYPL; NRP; Optic neuropathy-inducing protein; TFIIIA-INTP
Type:
Inhibitor protein
Mass (Da):
65922
Number AA:
577
UniProt ID:
Q96CV9
International Prot ID:
IPI00304189
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0007030
GO:0043001
GO:0008219
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
H
Q
P
L
S
C
L
T
E
K
E
D
Site 2
S15
C
L
T
E
K
E
D
S
P
S
E
S
T
G
N
Site 3
S17
T
E
K
E
D
S
P
S
E
S
T
G
N
G
P
Site 4
S19
K
E
D
S
P
S
E
S
T
G
N
G
P
P
H
Site 5
T34
L
A
H
P
N
L
D
T
F
T
P
E
E
L
L
Site 6
T36
H
P
N
L
D
T
F
T
P
E
E
L
L
Q
Q
Site 7
S73
K
G
R
F
E
E
L
S
A
W
T
E
K
Q
K
Site 8
S101
K
E
R
L
M
A
L
S
H
E
N
E
K
L
K
Site 9
S118
L
G
K
L
K
G
K
S
E
R
S
S
E
D
P
Site 10
S122
K
G
K
S
E
R
S
S
E
D
P
T
D
D
S
Site 11
T126
E
R
S
S
E
D
P
T
D
D
S
R
L
P
R
Site 12
S129
S
E
D
P
T
D
D
S
R
L
P
R
A
E
A
Site 13
S162
A
D
L
L
G
I
V
S
E
L
Q
L
K
L
N
Site 14
S170
E
L
Q
L
K
L
N
S
S
G
S
S
E
D
S
Site 15
S171
L
Q
L
K
L
N
S
S
G
S
S
E
D
S
F
Site 16
S173
L
K
L
N
S
S
G
S
S
E
D
S
F
V
E
Site 17
S174
K
L
N
S
S
G
S
S
E
D
S
F
V
E
I
Site 18
S177
S
S
G
S
S
E
D
S
F
V
E
I
R
M
A
Site 19
S191
A
E
G
E
A
E
G
S
V
K
E
I
K
H
S
Site 20
S198
S
V
K
E
I
K
H
S
P
G
P
T
R
T
V
Site 21
T202
I
K
H
S
P
G
P
T
R
T
V
S
T
G
T
Site 22
T204
H
S
P
G
P
T
R
T
V
S
T
G
T
A
L
Site 23
S206
P
G
P
T
R
T
V
S
T
G
T
A
L
S
K
Site 24
T209
T
R
T
V
S
T
G
T
A
L
S
K
Y
R
S
Site 25
S212
V
S
T
G
T
A
L
S
K
Y
R
S
R
S
A
Site 26
Y214
T
G
T
A
L
S
K
Y
R
S
R
S
A
D
G
Site 27
S216
T
A
L
S
K
Y
R
S
R
S
A
D
G
A
K
Site 28
S218
L
S
K
Y
R
S
R
S
A
D
G
A
K
N
Y
Site 29
Y225
S
A
D
G
A
K
N
Y
F
E
H
E
E
L
T
Site 30
S262
K
E
A
K
E
R
V
S
D
F
E
K
K
T
S
Site 31
T268
V
S
D
F
E
K
K
T
S
N
R
S
E
I
E
Site 32
S269
S
D
F
E
K
K
T
S
N
R
S
E
I
E
T
Site 33
T276
S
N
R
S
E
I
E
T
Q
T
E
G
S
T
E
Site 34
T294
D
E
E
K
G
P
E
T
V
G
S
E
V
E
A
Site 35
S297
K
G
P
E
T
V
G
S
E
V
E
A
L
N
L
Site 36
S342
Q
A
L
E
R
K
N
S
A
I
P
S
E
L
N
Site 37
S346
R
K
N
S
A
I
P
S
E
L
N
E
K
Q
E
Site 38
Y356
N
E
K
Q
E
L
V
Y
T
N
K
K
L
E
L
Site 39
T357
E
K
Q
E
L
V
Y
T
N
K
K
L
E
L
Q
Site 40
S370
L
Q
V
E
S
M
L
S
E
I
K
M
E
Q
A
Site 41
T379
I
K
M
E
Q
A
K
T
E
D
E
K
S
K
L
Site 42
S384
A
K
T
E
D
E
K
S
K
L
T
V
L
Q
M
Site 43
T387
E
D
E
K
S
K
L
T
V
L
Q
M
T
H
N
Site 44
T406
E
H
N
N
A
L
K
T
I
E
E
L
T
R
K
Site 45
S415
E
E
L
T
R
K
E
S
E
K
V
D
R
A
V
Site 46
S427
R
A
V
L
K
E
L
S
E
K
L
E
L
A
E
Site 47
T450
Q
M
D
E
M
K
Q
T
I
A
K
Q
E
E
D
Site 48
T460
K
Q
E
E
D
L
E
T
M
T
I
L
R
A
Q
Site 49
Y471
L
R
A
Q
M
E
V
Y
C
S
D
F
H
A
E
Site 50
S473
A
Q
M
E
V
Y
C
S
D
F
H
A
E
R
A
Site 51
S513
F
E
D
G
G
R
Q
S
L
M
E
M
Q
S
R
Site 52
S519
Q
S
L
M
E
M
Q
S
R
H
G
A
R
T
S
Site 53
T525
Q
S
R
H
G
A
R
T
S
D
S
D
Q
Q
A
Site 54
S526
S
R
H
G
A
R
T
S
D
S
D
Q
Q
A
Y
Site 55
S528
H
G
A
R
T
S
D
S
D
Q
Q
A
Y
L
V
Site 56
Y533
S
D
S
D
Q
Q
A
Y
L
V
Q
R
G
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation