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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRRC58
Full Name:
Leucine-rich repeat-containing protein 58
Alias:
Leucine rich repeat containing 58; LRC58
Type:
Uncharacterized protein
Mass (Da):
40586
Number AA:
371
UniProt ID:
Q96CX6
International Prot ID:
IPI00304207
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
G
E
A
E
L
N
W
S
R
L
S
V
S
T
E
Site 2
S22
E
L
N
W
S
R
L
S
V
S
T
E
T
L
E
Site 3
S24
N
W
S
R
L
S
V
S
T
E
T
L
E
S
E
Site 4
T25
W
S
R
L
S
V
S
T
E
T
L
E
S
E
L
Site 5
S30
V
S
T
E
T
L
E
S
E
L
E
A
R
G
E
Site 6
S58
L
P
H
N
R
L
V
S
L
P
R
A
L
G
S
Site 7
T95
L
A
L
R
G
L
R
T
L
L
A
K
N
N
R
Site 8
S107
N
N
R
L
G
G
P
S
A
L
P
K
G
L
A
Site 9
S116
L
P
K
G
L
A
Q
S
P
L
C
R
S
L
Q
Site 10
T147
L
E
L
R
A
L
Q
T
L
S
L
G
G
N
Q
Site 11
S149
L
R
A
L
Q
T
L
S
L
G
G
N
Q
L
Q
Site 12
Y193
G
N
L
P
S
L
N
Y
L
V
L
C
D
N
K
Site 13
S203
L
C
D
N
K
I
Q
S
I
P
P
Q
L
S
Q
Site 14
S209
Q
S
I
P
P
Q
L
S
Q
L
H
S
L
R
S
Site 15
S213
P
Q
L
S
Q
L
H
S
L
R
S
L
S
L
H
Site 16
S216
S
Q
L
H
S
L
R
S
L
S
L
H
N
N
L
Site 17
S218
L
H
S
L
R
S
L
S
L
H
N
N
L
L
T
Site 18
T225
S
L
H
N
N
L
L
T
Y
L
P
R
E
I
L
Site 19
Y226
L
H
N
N
L
L
T
Y
L
P
R
E
I
L
N
Site 20
Y257
R
F
V
R
D
L
T
Y
D
P
P
T
L
L
E
Site 21
T261
D
L
T
Y
D
P
P
T
L
L
E
L
A
A
R
Site 22
S276
T
I
K
I
R
N
I
S
Y
T
P
Y
D
L
P
Site 23
T278
K
I
R
N
I
S
Y
T
P
Y
D
L
P
G
N
Site 24
Y280
R
N
I
S
Y
T
P
Y
D
L
P
G
N
L
L
Site 25
S292
N
L
L
R
Y
L
G
S
A
S
N
C
P
N
P
Site 26
S294
L
R
Y
L
G
S
A
S
N
C
P
N
P
K
C
Site 27
Y305
N
P
K
C
G
G
V
Y
F
D
C
C
V
R
Q
Site 28
Y329
Y
R
L
P
L
M
H
Y
L
C
S
P
E
C
S
Site 29
S332
P
L
M
H
Y
L
C
S
P
E
C
S
S
P
C
Site 30
S336
Y
L
C
S
P
E
C
S
S
P
C
S
S
A
S
Site 31
S337
L
C
S
P
E
C
S
S
P
C
S
S
A
S
H
Site 32
S340
P
E
C
S
S
P
C
S
S
A
S
H
S
S
T
Site 33
S341
E
C
S
S
P
C
S
S
A
S
H
S
S
T
S
Site 34
S343
S
S
P
C
S
S
A
S
H
S
S
T
S
Q
S
Site 35
S345
P
C
S
S
A
S
H
S
S
T
S
Q
S
E
S
Site 36
S346
C
S
S
A
S
H
S
S
T
S
Q
S
E
S
D
Site 37
T347
S
S
A
S
H
S
S
T
S
Q
S
E
S
D
S
Site 38
S348
S
A
S
H
S
S
T
S
Q
S
E
S
D
S
E
Site 39
S350
S
H
S
S
T
S
Q
S
E
S
D
S
E
D
E
Site 40
S352
S
S
T
S
Q
S
E
S
D
S
E
D
E
A
S
Site 41
S354
T
S
Q
S
E
S
D
S
E
D
E
A
S
V
A
Site 42
S359
S
D
S
E
D
E
A
S
V
A
A
R
R
M
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation