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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ITPKC
Full Name:
Inositol-trisphosphate 3-kinase C
Alias:
EC 2.7.1.127; IP3KC
Type:
Cytoplasm, Nucleus protein
Mass (Da):
75207
Number AA:
683
UniProt ID:
Q96DU7
International Prot ID:
IPI00061203
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005516
GO:0008440
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
R
R
C
P
C
R
G
S
L
N
E
A
E
A
G
Site 2
T62
G
G
G
P
W
A
R
T
E
G
S
S
L
H
S
Site 3
S65
P
W
A
R
T
E
G
S
S
L
H
S
E
P
E
Site 4
S66
W
A
R
T
E
G
S
S
L
H
S
E
P
E
R
Site 5
S69
T
E
G
S
S
L
H
S
E
P
E
R
A
G
L
Site 6
T82
G
L
G
P
A
P
G
T
E
S
P
Q
A
E
F
Site 7
S84
G
P
A
P
G
T
E
S
P
Q
A
E
F
W
T
Site 8
T106
A
A
G
L
G
V
E
T
E
R
P
K
Q
K
T
Site 9
T113
T
E
R
P
K
Q
K
T
E
P
D
R
S
S
L
Site 10
S118
Q
K
T
E
P
D
R
S
S
L
R
T
H
L
E
Site 11
S119
K
T
E
P
D
R
S
S
L
R
T
H
L
E
W
Site 12
T122
P
D
R
S
S
L
R
T
H
L
E
W
S
W
S
Site 13
S127
L
R
T
H
L
E
W
S
W
S
E
L
E
T
T
Site 14
T134
S
W
S
E
L
E
T
T
C
L
W
T
E
T
G
Site 15
T147
T
G
T
D
G
L
W
T
D
P
H
R
S
D
L
Site 16
S152
L
W
T
D
P
H
R
S
D
L
Q
F
Q
P
E
Site 17
S162
Q
F
Q
P
E
E
A
S
P
W
T
Q
P
G
V
Site 18
T165
P
E
E
A
S
P
W
T
Q
P
G
V
H
G
P
Site 19
T174
P
G
V
H
G
P
W
T
E
L
E
T
H
G
S
Site 20
S181
T
E
L
E
T
H
G
S
Q
T
Q
P
E
R
V
Site 21
S190
T
Q
P
E
R
V
K
S
W
A
D
N
L
W
T
Site 22
T197
S
W
A
D
N
L
W
T
H
Q
N
S
S
S
L
Site 23
S201
N
L
W
T
H
Q
N
S
S
S
L
Q
T
H
P
Site 24
S203
W
T
H
Q
N
S
S
S
L
Q
T
H
P
E
G
Site 25
T206
Q
N
S
S
S
L
Q
T
H
P
E
G
A
C
P
Site 26
S214
H
P
E
G
A
C
P
S
K
E
P
S
A
D
G
Site 27
S218
A
C
P
S
K
E
P
S
A
D
G
S
W
K
E
Site 28
S222
K
E
P
S
A
D
G
S
W
K
E
L
Y
T
D
Site 29
Y227
D
G
S
W
K
E
L
Y
T
D
G
S
R
T
Q
Site 30
S231
K
E
L
Y
T
D
G
S
R
T
Q
Q
D
I
E
Site 31
T242
Q
D
I
E
G
P
W
T
E
P
Y
T
D
G
S
Site 32
Y245
E
G
P
W
T
E
P
Y
T
D
G
S
Q
K
K
Site 33
S249
T
E
P
Y
T
D
G
S
Q
K
K
Q
D
T
E
Site 34
T264
A
A
R
K
Q
P
G
T
G
G
F
Q
I
Q
Q
Site 35
T273
G
F
Q
I
Q
Q
D
T
D
G
S
W
T
Q
P
Site 36
S281
D
G
S
W
T
Q
P
S
T
D
G
S
Q
T
A
Site 37
T282
G
S
W
T
Q
P
S
T
D
G
S
Q
T
A
P
Site 38
S285
T
Q
P
S
T
D
G
S
Q
T
A
P
G
T
D
Site 39
T291
G
S
Q
T
A
P
G
T
D
C
L
L
G
E
P
Site 40
T313
P
E
P
G
E
L
L
T
H
L
Y
S
H
L
K
Site 41
Y316
G
E
L
L
T
H
L
Y
S
H
L
K
C
S
P
Site 42
S322
L
Y
S
H
L
K
C
S
P
L
C
P
V
P
R
Site 43
T333
P
V
P
R
L
I
I
T
P
E
T
P
E
P
E
Site 44
T336
R
L
I
I
T
P
E
T
P
E
P
E
A
Q
P
Site 45
S348
A
Q
P
V
G
P
P
S
R
V
E
G
G
S
G
Site 46
S354
P
S
R
V
E
G
G
S
G
G
F
S
S
A
S
Site 47
S358
E
G
G
S
G
G
F
S
S
A
S
S
F
D
E
Site 48
S359
G
G
S
G
G
F
S
S
A
S
S
F
D
E
S
Site 49
S361
S
G
G
F
S
S
A
S
S
F
D
E
S
E
D
Site 50
S362
G
G
F
S
S
A
S
S
F
D
E
S
E
D
D
Site 51
S366
S
A
S
S
F
D
E
S
E
D
D
V
V
A
G
Site 52
S378
V
A
G
G
G
G
A
S
D
P
E
D
R
S
G
Site 53
S384
A
S
D
P
E
D
R
S
G
S
K
P
W
K
K
Site 54
S386
D
P
E
D
R
S
G
S
K
P
W
K
K
L
K
Site 55
T394
K
P
W
K
K
L
K
T
V
L
K
Y
S
P
F
Site 56
Y398
K
L
K
T
V
L
K
Y
S
P
F
V
V
S
F
Site 57
Y409
V
V
S
F
R
K
H
Y
P
W
V
Q
L
S
G
Site 58
Y456
L
R
P
F
V
P
A
Y
Y
G
M
V
L
Q
D
Site 59
Y457
R
P
F
V
P
A
Y
Y
G
M
V
L
Q
D
G
Site 60
T466
M
V
L
Q
D
G
Q
T
F
N
Q
M
E
D
L
Site 61
Y492
C
K
M
G
S
R
T
Y
L
E
E
E
L
V
K
Site 62
Y511
P
R
P
R
K
D
M
Y
E
K
M
V
A
V
D
Site 63
T523
A
V
D
P
G
A
P
T
P
E
E
H
A
Q
G
Site 64
T533
E
H
A
Q
G
A
V
T
K
P
R
Y
M
Q
W
Site 65
Y537
G
A
V
T
K
P
R
Y
M
Q
W
R
E
T
M
Site 66
T543
R
Y
M
Q
W
R
E
T
M
S
S
T
S
T
L
Site 67
S545
M
Q
W
R
E
T
M
S
S
T
S
T
L
G
F
Site 68
S546
Q
W
R
E
T
M
S
S
T
S
T
L
G
F
R
Site 69
T549
E
T
M
S
S
T
S
T
L
G
F
R
I
E
G
Site 70
T563
G
I
K
K
A
D
G
T
C
N
T
N
F
K
K
Site 71
S609
L
R
E
A
L
E
I
S
P
F
F
K
T
H
E
Site 72
T614
E
I
S
P
F
F
K
T
H
E
V
V
G
S
S
Site 73
T650
V
A
L
P
D
H
Q
T
L
S
H
R
L
P
W
Site 74
S652
L
P
D
H
Q
T
L
S
H
R
L
P
W
A
E
Site 75
Y666
E
G
N
R
E
D
G
Y
L
W
G
L
D
N
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation