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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MTBP
Full Name:
Mdm2-binding protein
Alias:
MDM2 (mouse double minute 2)-binding protein, 104kD; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa; Mdm2-binding protein; MDM2BP
Type:
Ubiquitin conjugating system
Mass (Da):
102193
Number AA:
904
UniProt ID:
Q96DY7
International Prot ID:
IPI00061277
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007050
GO:0019941
GO:0007049
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
E
H
G
P
E
V
S
S
G
E
G
T
E
N
Q
Site 2
T35
E
V
S
S
G
E
G
T
E
N
Q
P
D
F
T
Site 3
T42
T
E
N
Q
P
D
F
T
A
A
N
V
Y
H
L
Site 4
S53
V
Y
H
L
L
K
R
S
I
S
A
S
I
N
P
Site 5
S55
H
L
L
K
R
S
I
S
A
S
I
N
P
E
D
Site 6
S57
L
K
R
S
I
S
A
S
I
N
P
E
D
S
T
Site 7
S63
A
S
I
N
P
E
D
S
T
F
P
A
C
S
V
Site 8
T64
S
I
N
P
E
D
S
T
F
P
A
C
S
V
G
Site 9
S132
E
C
F
E
E
E
D
S
N
S
R
E
S
L
S
Site 10
S134
F
E
E
E
D
S
N
S
R
E
S
L
S
L
A
Site 11
S137
E
D
S
N
S
R
E
S
L
S
L
A
D
L
Y
Site 12
S139
S
N
S
R
E
S
L
S
L
A
D
L
Y
E
E
Site 13
Y144
S
L
S
L
A
D
L
Y
E
E
A
A
E
N
L
Site 14
Y183
D
P
P
K
L
K
D
Y
L
P
T
V
G
A
L
Site 15
T186
K
L
K
D
Y
L
P
T
V
G
A
L
K
H
L
Site 16
Y197
L
K
H
L
R
E
W
Y
S
A
K
I
T
I
A
Site 17
Y218
N
C
Q
K
I
A
E
Y
L
S
A
N
V
V
S
Site 18
S235
D
L
R
N
V
I
D
S
K
E
L
W
R
G
K
Site 19
S255
R
K
F
G
F
E
I
S
F
P
E
F
C
L
K
Site 20
T265
E
F
C
L
K
G
V
T
L
K
N
F
S
T
S
Site 21
S270
G
V
T
L
K
N
F
S
T
S
N
L
N
T
D
Site 22
S316
I
K
L
S
D
L
P
S
C
Y
M
S
D
I
E
Site 23
Y318
L
S
D
L
P
S
C
Y
M
S
D
I
E
F
E
Site 24
S320
D
L
P
S
C
Y
M
S
D
I
E
F
E
L
G
Site 25
T329
I
E
F
E
L
G
L
T
N
S
T
K
Q
N
S
Site 26
S331
F
E
L
G
L
T
N
S
T
K
Q
N
S
V
L
Site 27
S372
I
P
P
P
N
Q
L
S
S
R
K
W
K
E
Y
Site 28
S373
P
P
P
N
Q
L
S
S
R
K
W
K
E
Y
I
Site 29
Y379
S
S
R
K
W
K
E
Y
I
A
K
K
P
K
T
Site 30
T386
Y
I
A
K
K
P
K
T
I
S
V
P
D
V
E
Site 31
S400
E
V
K
G
E
C
S
S
Y
Y
L
L
L
Q
G
Site 32
Y401
V
K
G
E
C
S
S
Y
Y
L
L
L
Q
G
N
Site 33
Y402
K
G
E
C
S
S
Y
Y
L
L
L
Q
G
N
G
Site 34
T416
G
N
R
R
C
K
A
T
L
I
H
S
A
N
Q
Site 35
T441
H
G
K
M
K
T
K
T
E
E
A
K
L
S
F
Site 36
S447
K
T
E
E
A
K
L
S
F
P
F
D
L
L
S
Site 37
S454
S
F
P
F
D
L
L
S
L
P
H
F
S
G
E
Site 38
T493
K
L
A
K
Q
P
E
T
V
S
V
A
E
L
K
Site 39
S495
A
K
Q
P
E
T
V
S
V
A
E
L
K
S
L
Site 40
Y513
T
R
K
H
F
L
D
Y
F
D
A
V
I
P
K
Site 41
T531
R
K
M
D
K
I
K
T
F
N
I
L
N
D
F
Site 42
S539
F
N
I
L
N
D
F
S
P
V
E
P
N
S
S
Site 43
S545
F
S
P
V
E
P
N
S
S
S
L
M
E
T
N
Site 44
S546
S
P
V
E
P
N
S
S
S
L
M
E
T
N
P
Site 45
S547
P
V
E
P
N
S
S
S
L
M
E
T
N
P
L
Site 46
T551
N
S
S
S
L
M
E
T
N
P
L
E
W
P
E
Site 47
T567
H
V
L
Q
N
L
E
T
F
E
K
T
K
Q
K
Site 48
T577
K
T
K
Q
K
M
R
T
G
S
L
P
H
S
S
Site 49
S579
K
Q
K
M
R
T
G
S
L
P
H
S
S
E
Q
Site 50
S583
R
T
G
S
L
P
H
S
S
E
Q
L
L
G
H
Site 51
S584
T
G
S
L
P
H
S
S
E
Q
L
L
G
H
K
Site 52
S597
H
K
E
G
P
R
D
S
I
T
L
L
D
A
K
Site 53
T599
E
G
P
R
D
S
I
T
L
L
D
A
K
E
L
Site 54
Y609
D
A
K
E
L
L
K
Y
F
T
S
D
G
L
P
Site 55
T611
K
E
L
L
K
Y
F
T
S
D
G
L
P
I
G
Site 56
S612
E
L
L
K
Y
F
T
S
D
G
L
P
I
G
D
Site 57
T631
P
I
Q
K
G
E
K
T
F
V
L
T
P
E
L
Site 58
T635
G
E
K
T
F
V
L
T
P
E
L
S
P
G
K
Site 59
S639
F
V
L
T
P
E
L
S
P
G
K
L
Q
V
L
Site 60
Y656
E
K
A
S
V
C
H
Y
H
G
I
E
Y
C
L
Site 61
Y661
C
H
Y
H
G
I
E
Y
C
L
D
D
R
K
A
Site 62
S676
L
E
R
D
G
G
F
S
E
L
Q
S
R
L
I
Site 63
S680
G
G
F
S
E
L
Q
S
R
L
I
R
Y
E
T
Site 64
T687
S
R
L
I
R
Y
E
T
Q
T
T
C
T
R
E
Site 65
T689
L
I
R
Y
E
T
Q
T
T
C
T
R
E
S
F
Site 66
T690
I
R
Y
E
T
Q
T
T
C
T
R
E
S
F
P
Site 67
S695
Q
T
T
C
T
R
E
S
F
P
V
P
T
V
L
Site 68
T700
R
E
S
F
P
V
P
T
V
L
S
P
L
P
S
Site 69
S703
F
P
V
P
T
V
L
S
P
L
P
S
P
V
V
Site 70
S707
T
V
L
S
P
L
P
S
P
V
V
S
S
D
P
Site 71
S711
P
L
P
S
P
V
V
S
S
D
P
G
S
V
P
Site 72
S712
L
P
S
P
V
V
S
S
D
P
G
S
V
P
D
Site 73
S738
V
S
R
L
K
R
R
S
K
D
L
N
C
L
Y
Site 74
Y745
S
K
D
L
N
C
L
Y
P
R
K
R
L
V
K
Site 75
S753
P
R
K
R
L
V
K
S
E
S
S
E
S
L
L
Site 76
S755
K
R
L
V
K
S
E
S
S
E
S
L
L
S
Q
Site 77
S756
R
L
V
K
S
E
S
S
E
S
L
L
S
Q
T
Site 78
S758
V
K
S
E
S
S
E
S
L
L
S
Q
T
T
G
Site 79
S761
E
S
S
E
S
L
L
S
Q
T
T
G
N
S
N
Site 80
T763
S
E
S
L
L
S
Q
T
T
G
N
S
N
H
Y
Site 81
Y770
T
T
G
N
S
N
H
Y
H
H
H
V
T
S
R
Site 82
T781
V
T
S
R
K
P
Q
T
E
R
S
L
P
V
T
Site 83
S784
R
K
P
Q
T
E
R
S
L
P
V
T
C
P
L
Site 84
T799
V
P
I
P
S
C
E
T
P
K
L
A
T
K
T
Site 85
T804
C
E
T
P
K
L
A
T
K
T
S
S
G
Q
K
Site 86
T806
T
P
K
L
A
T
K
T
S
S
G
Q
K
S
M
Site 87
S807
P
K
L
A
T
K
T
S
S
G
Q
K
S
M
H
Site 88
S808
K
L
A
T
K
T
S
S
G
Q
K
S
M
H
E
Site 89
S812
K
T
S
S
G
Q
K
S
M
H
E
S
K
T
S
Site 90
S816
G
Q
K
S
M
H
E
S
K
T
S
R
Q
I
K
Site 91
T818
K
S
M
H
E
S
K
T
S
R
Q
I
K
E
S
Site 92
S819
S
M
H
E
S
K
T
S
R
Q
I
K
E
S
R
Site 93
S825
T
S
R
Q
I
K
E
S
R
S
Q
K
H
T
R
Site 94
S827
R
Q
I
K
E
S
R
S
Q
K
H
T
R
I
L
Site 95
T831
E
S
R
S
Q
K
H
T
R
I
L
K
E
V
V
Site 96
T839
R
I
L
K
E
V
V
T
E
T
L
K
K
H
S
Site 97
T850
K
K
H
S
I
T
E
T
H
E
C
F
T
A
C
Site 98
S865
S
Q
R
L
F
E
I
S
K
F
Y
L
K
D
L
Site 99
T874
F
Y
L
K
D
L
K
T
S
R
G
L
F
E
E
Site 100
T885
L
F
E
E
M
K
K
T
A
N
N
N
A
V
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation