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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HOOK2
Full Name:
Protein Hook homolog 2
Alias:
HK2; Hook 2
Type:
Cytoskeletal protein
Mass (Da):
83164
Number AA:
719
UniProt ID:
Q96ED9
International Prot ID:
IPI00002432
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0070695
GO:0005813
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0042802
GO:0008017
PhosphoSite+
KinaseNET
Biological Process:
GO:0045022
GO:0006897
GO:0007032
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
L
Q
T
F
H
V
P
S
P
C
A
S
P
Q
D
Site 2
S27
H
V
P
S
P
C
A
S
P
Q
D
L
S
S
G
Site 3
S58
E
A
W
L
Q
G
I
S
E
D
P
G
P
N
W
Site 4
S78
N
L
K
M
V
L
R
S
L
V
E
Y
S
Q
D
Site 5
S83
L
R
S
L
V
E
Y
S
Q
D
V
L
A
H
P
Site 6
S92
D
V
L
A
H
P
V
S
E
E
H
L
P
D
V
Site 7
S100
E
E
H
L
P
D
V
S
L
I
G
E
F
S
D
Site 8
S124
L
V
L
G
C
A
I
S
C
E
K
K
Q
D
H
Site 9
T137
D
H
I
Q
R
I
M
T
L
E
E
S
V
Q
H
Site 10
T158
Q
E
L
M
T
K
D
T
P
D
S
L
S
P
E
Site 11
S161
M
T
K
D
T
P
D
S
L
S
P
E
T
Y
G
Site 12
S163
K
D
T
P
D
S
L
S
P
E
T
Y
G
N
F
Site 13
T166
P
D
S
L
S
P
E
T
Y
G
N
F
D
S
Q
Site 14
Y167
D
S
L
S
P
E
T
Y
G
N
F
D
S
Q
S
Site 15
Y177
F
D
S
Q
S
R
R
Y
Y
F
L
S
E
E
A
Site 16
Y178
D
S
Q
S
R
R
Y
Y
F
L
S
E
E
A
E
Site 17
S181
S
R
R
Y
Y
F
L
S
E
E
A
E
E
G
D
Site 18
S205
E
R
Q
L
M
L
L
S
E
E
K
Q
S
L
A
Site 19
S210
L
L
S
E
E
K
Q
S
L
A
Q
E
N
A
G
Site 20
T230
G
R
P
E
G
E
G
T
P
G
L
T
A
K
K
Site 21
S243
K
K
L
L
L
L
Q
S
Q
L
E
Q
L
Q
E
Site 22
S257
E
E
N
F
R
L
E
S
G
R
E
D
E
R
L
Site 23
T284
Q
H
R
N
Q
A
L
T
S
L
A
Q
E
A
Q
Site 24
S303
E
M
D
E
L
R
Q
S
S
E
R
A
G
Q
L
Site 25
S304
M
D
E
L
R
Q
S
S
E
R
A
G
Q
L
E
Site 26
T313
R
A
G
Q
L
E
A
T
L
T
S
C
R
R
R
Site 27
T315
G
Q
L
E
A
T
L
T
S
C
R
R
R
L
G
Site 28
S316
Q
L
E
A
T
L
T
S
C
R
R
R
L
G
E
Site 29
S357
D
E
L
R
R
A
G
S
L
R
A
Q
L
E
A
Site 30
Y397
C
R
N
L
E
E
K
Y
E
S
V
T
K
E
K
Site 31
S399
N
L
E
E
K
Y
E
S
V
T
K
E
K
E
R
Site 32
S413
R
L
L
A
E
R
D
S
L
R
E
A
N
E
E
Site 33
T432
Q
L
Q
P
R
G
L
T
Q
A
D
P
S
L
D
Site 34
S437
G
L
T
Q
A
D
P
S
L
D
P
T
S
T
P
Site 35
T441
A
D
P
S
L
D
P
T
S
T
P
V
D
N
L
Site 36
S442
D
P
S
L
D
P
T
S
T
P
V
D
N
L
A
Site 37
T443
P
S
L
D
P
T
S
T
P
V
D
N
L
A
A
Site 38
T460
L
P
A
E
L
R
E
T
L
L
R
L
Q
L
E
Site 39
T501
R
A
R
H
G
L
E
T
Q
H
R
L
N
Q
Q
Site 40
T531
L
Q
E
Q
G
G
K
T
E
D
A
I
S
I
L
Site 41
S536
G
K
T
E
D
A
I
S
I
L
L
K
R
K
L
Site 42
Y563
E
L
Q
R
K
R
E
Y
I
E
E
L
E
P
P
Site 43
S573
E
L
E
P
P
T
D
S
S
T
A
R
R
I
E
Site 44
S574
L
E
P
P
T
D
S
S
T
A
R
R
I
E
E
Site 45
T575
E
P
P
T
D
S
S
T
A
R
R
I
E
E
L
Site 46
Y603
M
E
E
R
Y
R
R
Y
V
D
K
A
R
M
V
Site 47
T613
K
A
R
M
V
M
Q
T
M
E
P
K
Q
R
P
Site 48
S630
G
A
P
P
E
L
H
S
L
R
T
Q
L
R
E
Site 49
S652
L
E
M
D
F
E
K
S
R
S
Q
R
E
Q
E
Site 50
S654
M
D
F
E
K
S
R
S
Q
R
E
Q
E
E
K
Site 51
S689
R
A
P
A
H
A
Q
S
F
L
A
Q
Q
R
L
Site 52
T698
L
A
Q
Q
R
L
A
T
N
S
R
R
G
P
L
Site 53
S700
Q
Q
R
L
A
T
N
S
R
R
G
P
L
G
R
Site 54
S710
G
P
L
G
R
L
A
S
L
N
L
R
P
T
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation