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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CHFR
Full Name:
E3 ubiquitin-protein ligase CHFR
Alias:
Checkpoint with forkhead and ring finger domains; Checkpoint with forkhead and RING finger domains protein; FLJ10796; FLJ33629; RING finger protein 196; RNF116; RNF196
Type:
Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 6.3.2.-
Mass (Da):
73368
Number AA:
664
UniProt ID:
Q96EP1
International Prot ID:
IPI00023513
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016605
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0005515
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
GO:0007093
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
R
P
E
E
G
K
Q
S
P
P
P
Q
P
W
G
Site 2
T39
L
L
R
K
R
E
W
T
I
G
R
R
R
G
C
Site 3
S49
R
R
R
G
C
D
L
S
F
P
S
N
K
L
V
Site 4
S69
R
I
V
V
D
E
K
S
G
Q
V
T
L
E
D
Site 5
T73
D
E
K
S
G
Q
V
T
L
E
D
T
S
T
S
Site 6
T79
V
T
L
E
D
T
S
T
S
G
T
V
I
N
K
Site 7
T82
E
D
T
S
T
S
G
T
V
I
N
K
L
K
V
Site 8
Y104
L
Q
T
G
D
V
I
Y
L
V
Y
R
K
N
E
Site 9
Y107
G
D
V
I
Y
L
V
Y
R
K
N
E
P
E
H
Site 10
Y118
E
P
E
H
N
V
A
Y
L
Y
E
S
L
S
E
Site 11
Y120
E
H
N
V
A
Y
L
Y
E
S
L
S
E
K
Q
Site 12
S124
A
Y
L
Y
E
S
L
S
E
K
Q
G
M
T
Q
Site 13
T130
L
S
E
K
Q
G
M
T
Q
E
S
F
E
A
N
Site 14
S133
K
Q
G
M
T
Q
E
S
F
E
A
N
K
E
N
Site 15
S149
F
H
G
T
K
D
T
S
G
A
G
A
G
R
G
Site 16
S164
A
D
P
R
V
P
P
S
S
P
A
T
Q
V
C
Site 17
S165
D
P
R
V
P
P
S
S
P
A
T
Q
V
C
F
Site 18
T168
V
P
P
S
S
P
A
T
Q
V
C
F
E
E
P
Site 19
S178
C
F
E
E
P
Q
P
S
T
S
T
S
D
L
F
Site 20
S180
E
E
P
Q
P
S
T
S
T
S
D
L
F
P
T
Site 21
S182
P
Q
P
S
T
S
T
S
D
L
F
P
T
A
S
Site 22
T187
S
T
S
D
L
F
P
T
A
S
A
S
S
T
E
Site 23
S189
S
D
L
F
P
T
A
S
A
S
S
T
E
P
S
Site 24
S191
L
F
P
T
A
S
A
S
S
T
E
P
S
P
A
Site 25
S192
F
P
T
A
S
A
S
S
T
E
P
S
P
A
G
Site 26
T193
P
T
A
S
A
S
S
T
E
P
S
P
A
G
R
Site 27
S196
S
A
S
S
T
E
P
S
P
A
G
R
E
R
S
Site 28
S203
S
P
A
G
R
E
R
S
S
S
C
G
S
G
G
Site 29
S204
P
A
G
R
E
R
S
S
S
C
G
S
G
G
G
Site 30
S205
A
G
R
E
R
S
S
S
C
G
S
G
G
G
G
Site 31
S208
E
R
S
S
S
C
G
S
G
G
G
G
I
S
P
Site 32
S214
G
S
G
G
G
G
I
S
P
K
G
S
G
P
S
Site 33
S218
G
G
I
S
P
K
G
S
G
P
S
V
A
S
D
Site 34
S221
S
P
K
G
S
G
P
S
V
A
S
D
E
V
S
Site 35
S224
G
S
G
P
S
V
A
S
D
E
V
S
S
F
A
Site 36
S232
D
E
V
S
S
F
A
S
A
L
P
D
R
K
T
Site 37
T239
S
A
L
P
D
R
K
T
A
S
F
S
S
L
E
Site 38
S241
L
P
D
R
K
T
A
S
F
S
S
L
E
P
Q
Site 39
S244
R
K
T
A
S
F
S
S
L
E
P
Q
D
Q
E
Site 40
T283
Q
P
R
R
N
A
Q
T
V
H
E
D
V
R
A
Site 41
T341
E
R
S
S
L
C
P
T
C
R
C
P
V
E
R
Site 42
S370
L
I
Q
H
P
D
K
S
R
S
E
E
D
V
Q
Site 43
S372
Q
H
P
D
K
S
R
S
E
E
D
V
Q
S
M
Site 44
S378
R
S
E
E
D
V
Q
S
M
D
A
R
N
K
I
Site 45
S397
L
Q
P
K
V
R
R
S
F
S
D
E
E
G
S
Site 46
S399
P
K
V
R
R
S
F
S
D
E
E
G
S
S
E
Site 47
S404
S
F
S
D
E
E
G
S
S
E
D
L
L
E
L
Site 48
S405
F
S
D
E
E
G
S
S
E
D
L
L
E
L
S
Site 49
S412
S
E
D
L
L
E
L
S
D
V
D
S
E
S
S
Site 50
S416
L
E
L
S
D
V
D
S
E
S
S
D
I
S
Q
Site 51
S418
L
S
D
V
D
S
E
S
S
D
I
S
Q
P
Y
Site 52
S419
S
D
V
D
S
E
S
S
D
I
S
Q
P
Y
V
Site 53
S422
D
S
E
S
S
D
I
S
Q
P
Y
V
V
C
R
Site 54
Y425
S
S
D
I
S
Q
P
Y
V
V
C
R
Q
C
P
Site 55
Y434
V
C
R
Q
C
P
E
Y
R
R
Q
A
A
Q
P
Site 56
S462
Q
A
L
G
D
A
P
S
T
S
V
S
L
T
T
Site 57
S466
D
A
P
S
T
S
V
S
L
T
T
A
V
Q
D
Site 58
Y555
G
V
L
N
N
N
S
Y
E
S
D
I
L
K
N
Site 59
Y563
E
S
D
I
L
K
N
Y
L
A
T
R
G
L
T
Site 60
T570
Y
L
A
T
R
G
L
T
W
K
N
M
L
T
E
Site 61
S578
W
K
N
M
L
T
E
S
L
V
A
L
Q
R
G
Site 62
S590
Q
R
G
V
F
L
L
S
D
Y
R
V
T
G
D
Site 63
T613
L
R
S
F
R
E
L
T
Y
Q
Y
R
Q
N
I
Site 64
Y614
R
S
F
R
E
L
T
Y
Q
Y
R
Q
N
I
P
Site 65
S623
Y
R
Q
N
I
P
A
S
E
L
P
V
A
V
T
Site 66
T630
S
E
L
P
V
A
V
T
S
R
P
D
C
Y
W
Site 67
Y636
V
T
S
R
P
D
C
Y
W
G
R
N
C
R
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation