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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FAM125A
Full Name:
Multivesicular body subunit 12A
Alias:
CFBP; CIN85/CD2AP family-binding protein; F125A; Family with sequence similarity 125, member A; FLJ32495
Type:
Adaptor/scaffold
Mass (Da):
28783
Number AA:
273
UniProt ID:
Q96EY5
International Prot ID:
IPI00744702
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005768
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0017124
GO:0005515
GO:0017124
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
D
P
V
P
G
T
D
S
A
P
L
A
G
Site 2
S19
L
A
G
L
A
W
S
S
A
S
A
P
P
P
R
Site 3
S21
G
L
A
W
S
S
A
S
A
P
P
P
R
G
F
Site 4
S29
A
P
P
P
R
G
F
S
A
I
S
C
T
V
E
Site 5
S41
T
V
E
G
A
P
A
S
F
G
K
S
F
A
Q
Site 6
S45
A
P
A
S
F
G
K
S
F
A
Q
K
S
G
Y
Site 7
S50
G
K
S
F
A
Q
K
S
G
Y
F
L
C
L
S
Site 8
S61
L
C
L
S
S
L
G
S
L
E
N
P
Q
E
N
Site 9
S95
P
V
C
D
P
M
D
S
K
A
S
V
S
K
K
Site 10
S98
D
P
M
D
S
K
A
S
V
S
K
K
K
R
M
Site 11
S125
A
V
F
D
V
R
L
S
G
K
T
K
T
V
P
Site 12
T128
D
V
R
L
S
G
K
T
K
T
V
P
G
Y
L
Site 13
T130
R
L
S
G
K
T
K
T
V
P
G
Y
L
R
I
Site 14
Y134
K
T
K
T
V
P
G
Y
L
R
I
G
D
M
G
Site 15
S163
V
P
K
P
R
G
L
S
R
D
M
Q
G
L
S
Site 16
S170
S
R
D
M
Q
G
L
S
L
D
A
A
S
Q
P
Site 17
S175
G
L
S
L
D
A
A
S
Q
P
S
K
G
G
L
Site 18
S178
L
D
A
A
S
Q
P
S
K
G
G
L
L
E
R
Site 19
T186
K
G
G
L
L
E
R
T
A
S
R
L
G
S
R
Site 20
S188
G
L
L
E
R
T
A
S
R
L
G
S
R
A
S
Site 21
S192
R
T
A
S
R
L
G
S
R
A
S
T
L
R
R
Site 22
S195
S
R
L
G
S
R
A
S
T
L
R
R
N
D
S
Site 23
T196
R
L
G
S
R
A
S
T
L
R
R
N
D
S
I
Site 24
S202
S
T
L
R
R
N
D
S
I
Y
E
A
S
S
L
Site 25
Y204
L
R
R
N
D
S
I
Y
E
A
S
S
L
Y
G
Site 26
S207
N
D
S
I
Y
E
A
S
S
L
Y
G
I
S
A
Site 27
S208
D
S
I
Y
E
A
S
S
L
Y
G
I
S
A
M
Site 28
Y210
I
Y
E
A
S
S
L
Y
G
I
S
A
M
D
G
Site 29
T221
A
M
D
G
V
P
F
T
L
H
P
R
F
E
G
Site 30
S230
H
P
R
F
E
G
K
S
C
S
P
L
A
F
S
Site 31
S232
R
F
E
G
K
S
C
S
P
L
A
F
S
A
F
Site 32
S246
F
G
D
L
T
I
K
S
L
A
D
I
E
E
E
Site 33
Y254
L
A
D
I
E
E
E
Y
N
Y
G
F
V
V
E
Site 34
Y256
D
I
E
E
E
Y
N
Y
G
F
V
V
E
K
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation