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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DISP1
Full Name:
Protein dispatched homolog 1
Alias:
Type:
Mass (Da):
170916
Number AA:
1524
UniProt ID:
Q96F81
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0008158
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
N
N
D
F
V
V
L
S
N
S
S
I
A
T
S
Site 2
T20
L
S
N
S
S
I
A
T
S
A
A
N
P
S
P
Site 3
S21
S
N
S
S
I
A
T
S
A
A
N
P
S
P
L
Site 4
S26
A
T
S
A
A
N
P
S
P
L
T
P
C
D
G
Site 5
T29
A
A
N
P
S
P
L
T
P
C
D
G
D
H
A
Site 6
T41
D
H
A
A
Q
Q
L
T
P
K
E
A
T
R
T
Site 7
T48
T
P
K
E
A
T
R
T
K
V
S
P
N
G
C
Site 8
S51
E
A
T
R
T
K
V
S
P
N
G
C
L
Q
L
Site 9
S64
Q
L
N
G
T
V
K
S
S
F
L
P
L
D
N
Site 10
S65
L
N
G
T
V
K
S
S
F
L
P
L
D
N
Q
Site 11
T92
C
P
Y
H
H
P
L
T
S
H
S
S
H
Q
E
Site 12
S95
H
H
P
L
T
S
H
S
S
H
Q
E
C
H
P
Site 13
S124
M
Q
P
H
S
E
Y
S
A
S
L
C
P
N
H
Site 14
S126
P
H
S
E
Y
S
A
S
L
C
P
N
H
S
P
Site 15
S132
A
S
L
C
P
N
H
S
P
V
Y
Q
T
T
C
Site 16
T138
H
S
P
V
Y
Q
T
T
C
C
L
Q
P
S
P
Site 17
S172
H
I
A
N
I
R
P
S
R
P
F
K
L
P
K
Site 18
S180
R
P
F
K
L
P
K
S
Y
A
A
L
I
A
D
Site 19
S217
V
P
E
L
P
D
F
S
D
P
L
L
G
F
E
Site 20
T236
A
I
G
Q
R
L
V
T
W
N
N
M
V
K
N
Site 21
Y253
Y
K
A
T
L
A
N
Y
P
F
K
Y
A
D
E
Site 22
S264
Y
A
D
E
Q
A
K
S
H
R
D
D
R
W
S
Site 23
S271
S
H
R
D
D
R
W
S
D
D
H
Y
E
R
E
Site 24
Y275
D
R
W
S
D
D
H
Y
E
R
E
K
R
E
V
Site 25
S290
D
W
N
F
H
K
D
S
F
F
C
D
V
P
S
Site 26
S297
S
F
F
C
D
V
P
S
D
R
Y
S
R
V
V
Site 27
Y300
C
D
V
P
S
D
R
Y
S
R
V
V
F
T
S
Site 28
S301
D
V
P
S
D
R
Y
S
R
V
V
F
T
S
S
Site 29
S307
Y
S
R
V
V
F
T
S
S
G
G
E
T
L
W
Site 30
S308
S
R
V
V
F
T
S
S
G
G
E
T
L
W
N
Site 31
S328
S
M
C
N
V
D
N
S
R
I
R
S
H
P
Q
Site 32
S332
V
D
N
S
R
I
R
S
H
P
Q
F
G
D
L
Site 33
T344
G
D
L
C
Q
R
T
T
A
A
S
C
C
P
S
Site 34
Y357
P
S
W
T
L
G
N
Y
I
A
I
L
N
N
R
Site 35
S366
A
I
L
N
N
R
S
S
C
Q
K
I
V
E
R
Site 36
S376
K
I
V
E
R
D
V
S
H
T
L
K
L
L
R
Site 37
T378
V
E
R
D
V
S
H
T
L
K
L
L
R
T
C
Site 38
T384
H
T
L
K
L
L
R
T
C
A
K
H
Y
Q
N
Site 39
Y389
L
R
T
C
A
K
H
Y
Q
N
G
T
L
G
P
Site 40
T412
R
K
D
Q
L
K
C
T
N
V
P
R
K
C
T
Site 41
Y421
V
P
R
K
C
T
K
Y
N
A
V
Y
Q
I
L
Site 42
T438
L
V
D
K
D
F
M
T
P
K
T
A
D
Y
A
Site 43
T441
K
D
F
M
T
P
K
T
A
D
Y
A
T
P
A
Site 44
Y444
M
T
P
K
T
A
D
Y
A
T
P
A
L
K
Y
Site 45
T446
P
K
T
A
D
Y
A
T
P
A
L
K
Y
S
M
Site 46
S452
A
T
P
A
L
K
Y
S
M
L
F
S
P
T
E
Site 47
S456
L
K
Y
S
M
L
F
S
P
T
E
K
G
E
S
Site 48
S463
S
P
T
E
K
G
E
S
M
M
N
I
Y
L
D
Site 49
Y468
G
E
S
M
M
N
I
Y
L
D
N
F
E
N
W
Site 50
T482
W
N
S
S
D
G
V
T
T
I
T
G
I
E
F
Site 51
Y499
K
H
S
L
F
Q
D
Y
L
L
M
D
T
V
Y
Site 52
S594
D
K
P
H
A
E
T
S
E
T
V
S
I
T
L
Site 53
T596
P
H
A
E
T
S
E
T
V
S
I
T
L
Q
H
Site 54
S598
A
E
T
S
E
T
V
S
I
T
L
Q
H
A
A
Site 55
T668
R
Y
L
L
N
I
F
T
C
F
K
K
P
Q
Q
Site 56
Y678
K
K
P
Q
Q
Q
I
Y
D
N
K
S
C
W
T
Site 57
S746
N
P
K
M
K
L
P
S
L
E
L
S
E
F
Q
Site 58
S750
K
L
P
S
L
E
L
S
E
F
Q
V
F
R
S
Site 59
S757
S
E
F
Q
V
F
R
S
S
H
P
F
E
R
Y
Site 60
S758
E
F
Q
V
F
R
S
S
H
P
F
E
R
Y
D
Site 61
Y764
S
S
H
P
F
E
R
Y
D
A
E
Y
K
K
L
Site 62
Y768
F
E
R
Y
D
A
E
Y
K
K
L
F
M
F
E
Site 63
S794
I
T
V
I
W
G
V
S
P
E
D
N
G
N
P
Site 64
S806
G
N
P
L
N
P
K
S
K
G
K
L
T
L
D
Site 65
T811
P
K
S
K
G
K
L
T
L
D
S
S
F
N
I
Site 66
S814
K
G
K
L
T
L
D
S
S
F
N
I
A
S
P
Site 67
S815
G
K
L
T
L
D
S
S
F
N
I
A
S
P
A
Site 68
S820
D
S
S
F
N
I
A
S
P
A
S
Q
A
W
I
Site 69
Y841
L
R
N
Q
T
F
F
Y
Q
T
D
E
Q
D
F
Site 70
S900
A
I
M
E
L
E
R
S
T
G
Y
H
L
D
S
Site 71
T901
I
M
E
L
E
R
S
T
G
Y
H
L
D
S
K
Site 72
S907
S
T
G
Y
H
L
D
S
K
T
P
G
P
R
F
Site 73
T909
G
Y
H
L
D
S
K
T
P
G
P
R
F
D
I
Site 74
T919
P
R
F
D
I
N
D
T
I
R
A
V
V
L
E
Site 75
Y937
T
Y
L
F
T
L
A
Y
E
K
M
H
Q
F
Y
Site 76
Y944
Y
E
K
M
H
Q
F
Y
K
E
V
D
S
W
I
Site 77
S949
Q
F
Y
K
E
V
D
S
W
I
S
S
E
L
S
Site 78
S952
K
E
V
D
S
W
I
S
S
E
L
S
S
A
P
Site 79
S953
E
V
D
S
W
I
S
S
E
L
S
S
A
P
E
Site 80
S956
S
W
I
S
S
E
L
S
S
A
P
E
G
L
S
Site 81
S957
W
I
S
S
E
L
S
S
A
P
E
G
L
S
N
Site 82
S963
S
S
A
P
E
G
L
S
N
G
W
F
V
S
N
Site 83
S979
E
F
Y
D
L
Q
D
S
L
S
D
G
T
L
I
Site 84
S981
Y
D
L
Q
D
S
L
S
D
G
T
L
I
A
M
Site 85
S1075
R
E
G
K
V
I
F
S
L
S
R
V
G
S
A
Site 86
S1077
G
K
V
I
F
S
L
S
R
V
G
S
A
M
A
Site 87
T1139
R
C
L
G
P
Q
G
T
C
G
Q
I
P
L
P
Site 88
S1152
L
P
K
K
L
Q
C
S
A
F
S
H
A
L
S
Site 89
S1155
K
L
Q
C
S
A
F
S
H
A
L
S
T
S
P
Site 90
S1159
S
A
F
S
H
A
L
S
T
S
P
S
D
K
G
Site 91
S1161
F
S
H
A
L
S
T
S
P
S
D
K
G
Q
S
Site 92
S1163
H
A
L
S
T
S
P
S
D
K
G
Q
S
K
T
Site 93
S1168
S
P
S
D
K
G
Q
S
K
T
H
T
I
N
A
Site 94
T1170
S
D
K
G
Q
S
K
T
H
T
I
N
A
Y
H
Site 95
T1172
K
G
Q
S
K
T
H
T
I
N
A
Y
H
L
D
Site 96
S1185
L
D
P
R
G
P
K
S
E
L
E
H
E
F
Y
Site 97
Y1192
S
E
L
E
H
E
F
Y
E
L
E
P
L
A
S
Site 98
S1199
Y
E
L
E
P
L
A
S
H
S
C
T
A
P
E
Site 99
T1203
P
L
A
S
H
S
C
T
A
P
E
K
T
T
Y
Site 100
T1208
S
C
T
A
P
E
K
T
T
Y
E
E
T
H
I
Site 101
Y1210
T
A
P
E
K
T
T
Y
E
E
T
H
I
C
S
Site 102
Y1235
G
M
P
V
H
A
A
Y
N
S
E
L
S
K
S
Site 103
S1240
A
A
Y
N
S
E
L
S
K
S
T
E
S
D
A
Site 104
S1242
Y
N
S
E
L
S
K
S
T
E
S
D
A
G
S
Site 105
S1245
E
L
S
K
S
T
E
S
D
A
G
S
A
L
L
Site 106
S1249
S
T
E
S
D
A
G
S
A
L
L
Q
P
P
L
Site 107
T1260
Q
P
P
L
E
Q
H
T
V
C
H
F
F
S
L
Site 108
Y1277
R
C
S
C
P
D
A
Y
K
H
L
N
Y
G
P
Site 109
Y1282
D
A
Y
K
H
L
N
Y
G
P
H
S
C
Q
Q
Site 110
S1299
D
C
L
C
H
Q
C
S
P
T
T
S
S
F
V
Site 111
S1304
Q
C
S
P
T
T
S
S
F
V
Q
I
Q
N
G
Site 112
S1350
K
P
A
G
M
Q
N
S
L
P
R
N
F
F
L
Site 113
T1372
A
Q
E
K
I
G
K
T
N
V
H
S
L
Q
R
Site 114
S1376
I
G
K
T
N
V
H
S
L
Q
R
S
I
E
E
Site 115
S1380
N
V
H
S
L
Q
R
S
I
E
E
H
L
P
K
Site 116
S1393
P
K
M
A
E
P
S
S
F
V
C
R
S
T
G
Site 117
S1398
P
S
S
F
V
C
R
S
T
G
S
L
L
K
T
Site 118
T1405
S
T
G
S
L
L
K
T
C
C
D
P
E
N
K
Site 119
S1423
L
C
K
N
R
D
V
S
N
L
E
S
S
G
G
Site 120
S1427
R
D
V
S
N
L
E
S
S
G
G
T
E
N
K
Site 121
S1442
A
G
G
K
V
E
L
S
L
S
Q
T
D
A
S
Site 122
S1444
G
K
V
E
L
S
L
S
Q
T
D
A
S
V
N
Site 123
T1446
V
E
L
S
L
S
Q
T
D
A
S
V
N
S
E
Site 124
S1449
S
L
S
Q
T
D
A
S
V
N
S
E
H
F
N
Site 125
S1482
S
C
P
N
N
S
Q
S
C
G
R
I
V
R
V
Site 126
T1510
A
N
V
P
A
V
L
T
H
S
E
L
S
G
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation