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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EDC3
Full Name:
Enhancer of mRNA-decapping protein 3
Alias:
Enhancer of mRNA decapping 3; FLJ21128; LOC80153; LSM16; YJDC; YjeF domain-containing protein 1; YJEFN2
Type:
RNA processing
Mass (Da):
56078
Number AA:
508
UniProt ID:
Q96F86
International Prot ID:
IPI00018009
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000932
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
V
S
I
N
C
G
D
S
L
G
V
Y
Q
G
R
Site 2
S26
G
V
Y
Q
G
R
V
S
A
V
D
Q
V
S
Q
Site 3
S36
D
Q
V
S
Q
T
I
S
L
T
R
P
F
H
N
Site 4
S87
H
Q
T
E
L
G
P
S
G
A
G
C
Q
V
G
Site 5
T100
V
G
I
N
Q
N
G
T
G
K
F
V
K
K
P
Site 6
S109
K
F
V
K
K
P
A
S
S
S
S
A
P
Q
N
Site 7
S111
V
K
K
P
A
S
S
S
S
A
P
Q
N
I
P
Site 8
S112
K
K
P
A
S
S
S
S
A
P
Q
N
I
P
K
Site 9
S125
P
K
R
T
D
V
K
S
Q
D
V
A
V
S
P
Site 10
S131
K
S
Q
D
V
A
V
S
P
Q
Q
Q
Q
C
S
Site 11
S138
S
P
Q
Q
Q
Q
C
S
K
S
Y
V
D
R
H
Site 12
S140
Q
Q
Q
Q
C
S
K
S
Y
V
D
R
H
M
E
Site 13
Y141
Q
Q
Q
C
S
K
S
Y
V
D
R
H
M
E
S
Site 14
S148
Y
V
D
R
H
M
E
S
L
S
Q
S
K
S
F
Site 15
S150
D
R
H
M
E
S
L
S
Q
S
K
S
F
R
R
Site 16
S152
H
M
E
S
L
S
Q
S
K
S
F
R
R
R
H
Site 17
S154
E
S
L
S
Q
S
K
S
F
R
R
R
H
N
S
Site 18
S161
S
F
R
R
R
H
N
S
W
S
S
S
S
R
H
Site 19
S163
R
R
R
H
N
S
W
S
S
S
S
R
H
P
N
Site 20
S164
R
R
H
N
S
W
S
S
S
S
R
H
P
N
Q
Site 21
S165
R
H
N
S
W
S
S
S
S
R
H
P
N
Q
A
Site 22
S166
H
N
S
W
S
S
S
S
R
H
P
N
Q
A
T
Site 23
T173
S
R
H
P
N
Q
A
T
P
K
K
S
G
L
K
Site 24
T202
D
I
E
E
I
P
D
T
D
F
D
F
E
G
N
Site 25
T224
A
V
F
E
E
I
D
T
Y
E
R
R
S
G
T
Site 26
Y225
V
F
E
E
I
D
T
Y
E
R
R
S
G
T
R
Site 27
S229
I
D
T
Y
E
R
R
S
G
T
R
S
R
G
I
Site 28
T231
T
Y
E
R
R
S
G
T
R
S
R
G
I
P
N
Site 29
S233
E
R
R
S
G
T
R
S
R
G
I
P
N
E
R
Site 30
T242
G
I
P
N
E
R
P
T
R
Y
R
H
D
E
N
Site 31
Y258
L
E
S
E
P
I
V
Y
R
R
I
I
V
P
H
Site 32
S281
D
S
G
L
V
V
P
S
I
S
Y
E
L
H
K
Site 33
S292
E
L
H
K
K
L
L
S
V
A
E
K
H
G
L
Site 34
T300
V
A
E
K
H
G
L
T
L
E
R
R
L
E
M
Site 35
T308
L
E
R
R
L
E
M
T
G
V
C
A
S
Q
M
Site 36
T318
C
A
S
Q
M
A
L
T
L
L
G
G
P
N
R
Site 37
T336
K
N
V
H
Q
R
P
T
V
A
L
L
C
G
P
Site 38
S352
V
K
G
A
Q
G
I
S
C
G
R
H
L
A
N
Site 39
S383
E
S
I
T
N
E
L
S
L
F
S
K
T
Q
G
Site 40
S386
T
N
E
L
S
L
F
S
K
T
Q
G
Q
Q
V
Site 41
T388
E
L
S
L
F
S
K
T
Q
G
Q
Q
V
S
S
Site 42
S395
T
Q
G
Q
Q
V
S
S
L
K
D
L
P
T
S
Site 43
Y425
F
L
R
D
Q
P
W
Y
K
A
A
V
A
W
A
Site 44
S441
Q
N
R
A
P
V
L
S
I
D
P
P
V
H
E
Site 45
Y493
F
Q
E
V
G
I
N
Y
H
S
P
F
G
C
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation