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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX11
Full Name:
Probable ATP-dependent RNA helicase DDX11
Alias:
CHL1; CHL1-related helicase gene-1; CHL1-related protein 1; CHLR1; DEAD,H box protein 11; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11; Keratinocyte growth factor-regulated gene 2; KRG2; KRG-2
Type:
EC 3.6.1.-; Helicase
Mass (Da):
108313
Number AA:
970
UniProt ID:
Q96FC9
International Prot ID:
IPI00061926
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004003
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0000086
GO:0000084
GO:0000070
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
I
H
F
P
F
P
F
T
P
Y
S
I
Q
E
D
Site 2
Y31
E
D
F
M
A
E
L
Y
R
V
L
E
A
G
K
Site 3
S44
G
K
I
G
I
F
E
S
P
T
G
T
G
K
S
Site 4
S91
L
H
D
E
K
D
E
S
L
C
L
S
S
S
C
Site 5
S95
K
D
E
S
L
C
L
S
S
S
C
E
G
A
A
Site 6
T104
S
C
E
G
A
A
G
T
P
R
P
A
G
E
P
Site 7
Y155
Q
H
R
V
Q
L
K
Y
A
A
K
R
L
R
Q
Site 8
S174
R
E
N
L
L
R
L
S
R
E
M
L
E
T
G
Site 9
T180
L
S
R
E
M
L
E
T
G
P
E
A
E
R
L
Site 10
S192
E
R
L
E
Q
L
E
S
G
E
E
E
L
V
L
Site 11
Y202
E
E
L
V
L
A
E
Y
E
S
D
E
E
K
K
Site 12
S204
L
V
L
A
E
Y
E
S
D
E
E
K
K
V
A
Site 13
Y230
E
E
H
I
T
K
I
Y
Y
C
S
R
T
H
S
Site 14
Y231
E
H
I
T
K
I
Y
Y
C
S
R
T
H
S
Q
Site 15
S249
F
V
H
E
V
K
K
S
P
F
G
K
D
V
R
Site 16
S259
G
K
D
V
R
L
V
S
L
G
S
R
Q
N
L
Site 17
S274
C
V
N
E
D
V
K
S
L
G
S
V
Q
L
I
Site 18
Y318
K
Q
A
A
C
P
F
Y
N
H
E
Q
M
G
L
Site 19
Y353
E
A
R
A
C
P
Y
Y
G
S
R
L
A
I
P
Site 20
T401
E
A
H
N
L
I
D
T
I
T
G
M
H
S
V
Site 21
S407
D
T
I
T
G
M
H
S
V
E
V
S
G
S
Q
Site 22
S411
G
M
H
S
V
E
V
S
G
S
Q
L
C
Q
A
Site 23
S413
H
S
V
E
V
S
G
S
Q
L
C
Q
A
H
S
Site 24
S420
S
Q
L
C
Q
A
H
S
Q
L
L
Q
Y
V
E
Site 25
Y425
A
H
S
Q
L
L
Q
Y
V
E
R
Y
G
K
R
Site 26
T465
N
I
K
Q
N
P
N
T
Q
S
L
S
Q
T
G
Site 27
S467
K
Q
N
P
N
T
Q
S
L
S
Q
T
G
T
E
Site 28
S469
N
P
N
T
Q
S
L
S
Q
T
G
T
E
L
K
Site 29
T471
N
T
Q
S
L
S
Q
T
G
T
E
L
K
T
I
Site 30
T473
Q
S
L
S
Q
T
G
T
E
L
K
T
I
N
D
Site 31
T477
Q
T
G
T
E
L
K
T
I
N
D
F
L
F
Q
Site 32
Y498
N
L
F
K
V
Q
R
Y
C
E
K
S
M
I
S
Site 33
Y515
L
F
G
F
T
E
R
Y
G
A
V
F
S
S
R
Site 34
S520
E
R
Y
G
A
V
F
S
S
R
E
Q
P
K
L
Site 35
S536
G
F
Q
Q
F
L
Q
S
L
Q
P
R
T
T
E
Site 36
T542
Q
S
L
Q
P
R
T
T
E
A
L
A
A
P
A
Site 37
S552
L
A
A
P
A
D
E
S
Q
A
S
T
L
R
P
Site 38
S555
P
A
D
E
S
Q
A
S
T
L
R
P
A
S
P
Site 39
T556
A
D
E
S
Q
A
S
T
L
R
P
A
S
P
L
Site 40
S561
A
S
T
L
R
P
A
S
P
L
M
H
I
Q
G
Site 41
T574
Q
G
F
L
A
A
L
T
T
A
N
Q
D
G
R
Site 42
S585
Q
D
G
R
V
I
L
S
R
Q
G
S
L
S
Q
Site 43
S589
V
I
L
S
R
Q
G
S
L
S
Q
S
T
L
K
Site 44
S591
L
S
R
Q
G
S
L
S
Q
S
T
L
K
F
L
Site 45
S593
R
Q
G
S
L
S
Q
S
T
L
K
F
L
L
L
Site 46
S627
G
G
T
M
Q
P
V
S
D
F
R
Q
Q
L
L
Site 47
T675
S
N
Q
P
L
E
F
T
F
Q
K
R
E
L
P
Site 48
Y712
C
F
F
P
S
Y
E
Y
L
R
Q
V
H
A
H
Site 49
S741
K
I
F
Q
E
P
K
S
A
H
Q
V
E
Q
V
Site 50
Y752
V
E
Q
V
L
L
A
Y
S
R
C
I
Q
A
C
Site 51
S753
E
Q
V
L
L
A
Y
S
R
C
I
Q
A
C
G
Site 52
S780
S
V
V
G
G
K
M
S
E
G
I
N
F
S
D
Site 53
S786
M
S
E
G
I
N
F
S
D
N
L
G
R
C
V
Site 54
Y814
E
L
Q
E
K
M
A
Y
L
D
Q
T
L
S
P
Site 55
T818
K
M
A
Y
L
D
Q
T
L
S
P
R
P
G
T
Site 56
S820
A
Y
L
D
Q
T
L
S
P
R
P
G
T
P
R
Site 57
T825
T
L
S
P
R
P
G
T
P
R
E
G
S
G
G
Site 58
S830
P
G
T
P
R
E
G
S
G
G
E
P
V
H
E
Site 59
S878
Q
A
A
G
L
D
P
S
P
C
G
G
Q
S
Y
Site 60
T938
V
V
C
G
D
P
V
T
K
V
K
P
R
R
R
Site 61
S948
K
P
R
R
R
V
W
S
P
E
C
C
Q
D
P
Site 62
T957
E
C
C
Q
D
P
G
T
G
V
S
S
R
R
R
Site 63
S960
Q
D
P
G
T
G
V
S
S
R
R
R
K
W
G
Site 64
S961
D
P
G
T
G
V
S
S
R
R
R
K
W
G
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation