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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEIL1
Full Name:
Endonuclease 8-like 1
Alias:
DNA glycosylase/ap lyase neil1; DNA-(apurinic or apyrimidinic site) lyase neil1; EC 3.2.2.-; EC 4.2.99.18; Endonuclease viii; Endonuclease viii-like 1; Fpg1; Hfpg1; Neh1; Nei endonuclease viii-like 1; Nei1; Neil1; Nei-like 1
Type:
Mass (Da):
43684
Number AA:
390
UniProt ID:
Q96FI4
International Prot ID:
IPI00305213
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003906
GO:0003684
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0006284
GO:0032074
GO:0006289
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
G
P
E
L
H
L
A
S
Q
F
V
N
E
A
C
Site 2
S30
F
G
G
C
V
E
K
S
S
V
S
R
N
P
E
Site 3
S31
G
G
C
V
E
K
S
S
V
S
R
N
P
E
V
Site 4
S43
P
E
V
P
F
E
S
S
A
Y
R
I
S
A
S
Site 5
Y45
V
P
F
E
S
S
A
Y
R
I
S
A
S
A
R
Site 6
S48
E
S
S
A
Y
R
I
S
A
S
A
R
G
K
E
Site 7
S50
S
A
Y
R
I
S
A
S
A
R
G
K
E
L
R
Site 8
S61
K
E
L
R
L
I
L
S
P
L
P
G
A
Q
P
Site 9
S84
F
R
F
G
M
S
G
S
F
Q
L
V
P
R
E
Site 10
Y102
R
H
A
H
L
R
F
Y
T
A
P
P
G
P
R
Site 11
T103
H
A
H
L
R
F
Y
T
A
P
P
G
P
R
L
Site 12
Y141
G
P
C
V
L
Q
E
Y
Q
Q
F
R
E
N
V
Site 13
S196
P
P
F
E
K
A
R
S
V
L
E
A
L
Q
Q
Site 14
S207
A
L
Q
Q
H
R
P
S
P
E
L
T
L
S
Q
Site 15
T211
H
R
P
S
P
E
L
T
L
S
Q
K
I
R
T
Site 16
S213
P
S
P
E
L
T
L
S
Q
K
I
R
T
K
L
Site 17
Y244
V
Q
L
G
G
K
G
Y
G
S
E
S
G
E
E
Site 18
S246
L
G
G
K
G
Y
G
S
E
S
G
E
E
D
F
Site 19
Y263
F
R
A
W
L
R
C
Y
G
M
P
G
M
S
S
Site 20
S269
C
Y
G
M
P
G
M
S
S
L
Q
D
R
H
G
Site 21
S270
Y
G
M
P
G
M
S
S
L
Q
D
R
H
G
R
Site 22
S295
L
A
P
K
G
R
K
S
R
K
K
K
S
K
A
Site 23
S300
R
K
S
R
K
K
K
S
K
A
T
Q
L
S
P
Site 24
S306
K
S
K
A
T
Q
L
S
P
E
D
R
V
E
D
Site 25
S318
V
E
D
A
L
P
P
S
K
A
P
S
R
T
R
Site 26
S322
L
P
P
S
K
A
P
S
R
T
R
R
A
K
R
Site 27
T337
D
L
P
K
R
T
A
T
Q
R
P
E
G
T
S
Site 28
S344
T
Q
R
P
E
G
T
S
L
Q
Q
D
P
E
A
Site 29
T353
Q
Q
D
P
E
A
P
T
V
P
K
K
G
R
R
Site 30
S367
R
K
G
R
Q
A
A
S
G
H
C
R
P
R
K
Site 31
S381
K
V
K
A
D
I
P
S
L
E
P
E
G
T
S
Site 32
T387
P
S
L
E
P
E
G
T
S
A
S
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation