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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SIPA1
Full Name:
Signal-induced proliferation-associated protein 1
Alias:
GTPase-activating protein Spa-1; Signal-induced proliferation-associated protein 1: GTPase-activating protein Spa-1: p130 SPA-1
Type:
Mass (Da):
112149
Number AA:
1042
UniProt ID:
Q96FS4
International Prot ID:
IPI00305305
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005634
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0046582
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0007010
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
M
W
A
G
G
V
G
S
P
R
R
G
M
A
P
Site 2
S19
R
R
G
M
A
P
A
S
T
D
D
L
F
A
R
Site 3
T20
R
G
M
A
P
A
S
T
D
D
L
F
A
R
K
Site 4
T37
Q
P
A
R
P
P
L
T
P
H
T
F
E
P
R
Site 5
T40
R
P
P
L
T
P
H
T
F
E
P
R
P
V
R
Site 6
S53
V
R
G
P
L
L
R
S
G
S
D
A
G
E
A
Site 7
S55
G
P
L
L
R
S
G
S
D
A
G
E
A
R
P
Site 8
T64
A
G
E
A
R
P
P
T
P
A
S
P
R
A
R
Site 9
S67
A
R
P
P
T
P
A
S
P
R
A
R
A
H
S
Site 10
S74
S
P
R
A
R
A
H
S
H
E
E
A
S
R
P
Site 11
S85
A
S
R
P
A
A
T
S
T
R
L
F
T
D
P
Site 12
Y119
E
P
R
W
F
A
H
Y
D
V
Q
S
L
L
F
Site 13
S132
L
F
D
W
A
P
R
S
Q
G
M
G
S
H
S
Site 14
S137
P
R
S
Q
G
M
G
S
H
S
E
A
S
S
G
Site 15
S139
S
Q
G
M
G
S
H
S
E
A
S
S
G
T
L
Site 16
S143
G
S
H
S
E
A
S
S
G
T
L
A
S
A
E
Site 17
S148
A
S
S
G
T
L
A
S
A
E
D
Q
A
A
S
Site 18
S156
A
E
D
Q
A
A
S
S
D
L
L
H
G
A
P
Site 19
S195
A
L
P
N
A
A
V
S
I
L
E
E
P
Q
N
Site 20
S205
E
E
P
Q
N
R
T
S
A
Y
S
L
E
H
A
Site 21
S208
Q
N
R
T
S
A
Y
S
L
E
H
A
D
L
G
Site 22
Y218
H
A
D
L
G
A
G
Y
Y
R
K
Y
F
Y
G
Site 23
Y219
A
D
L
G
A
G
Y
Y
R
K
Y
F
Y
G
K
Site 24
Y222
G
A
G
Y
Y
R
K
Y
F
Y
G
K
E
H
Q
Site 25
S244
S
L
G
P
V
A
V
S
L
R
R
E
E
K
E
Site 26
S253
R
R
E
E
K
E
G
S
G
G
G
T
L
H
S
Site 27
T257
K
E
G
S
G
G
G
T
L
H
S
Y
R
V
I
Site 28
S260
S
G
G
G
T
L
H
S
Y
R
V
I
V
R
T
Site 29
Y261
G
G
G
T
L
H
S
Y
R
V
I
V
R
T
T
Site 30
T267
S
Y
R
V
I
V
R
T
T
Q
L
R
T
L
R
Site 31
T268
Y
R
V
I
V
R
T
T
Q
L
R
T
L
R
G
Site 32
T272
V
R
T
T
Q
L
R
T
L
R
G
T
I
S
E
Site 33
T276
Q
L
R
T
L
R
G
T
I
S
E
D
A
L
P
Site 34
S278
R
T
L
R
G
T
I
S
E
D
A
L
P
P
G
Site 35
S291
P
G
P
P
R
G
L
S
P
R
K
L
L
E
H
Site 36
S304
E
H
V
A
P
Q
L
S
P
S
C
L
R
L
G
Site 37
S312
P
S
C
L
R
L
G
S
A
S
P
K
V
P
R
Site 38
S314
C
L
R
L
G
S
A
S
P
K
V
P
R
T
L
Site 39
T320
A
S
P
K
V
P
R
T
L
L
T
L
D
E
Q
Site 40
T323
K
V
P
R
T
L
L
T
L
D
E
Q
V
L
S
Site 41
S330
T
L
D
E
Q
V
L
S
F
Q
R
K
V
G
I
Site 42
Y339
Q
R
K
V
G
I
L
Y
C
R
A
G
Q
G
S
Site 43
Y351
Q
G
S
E
E
E
M
Y
N
N
Q
E
A
G
P
Site 44
S378
V
R
L
K
G
F
E
S
Y
R
A
Q
L
D
T
Site 45
T385
S
Y
R
A
Q
L
D
T
K
T
D
S
T
G
T
Site 46
T387
R
A
Q
L
D
T
K
T
D
S
T
G
T
H
S
Site 47
S389
Q
L
D
T
K
T
D
S
T
G
T
H
S
L
Y
Site 48
T390
L
D
T
K
T
D
S
T
G
T
H
S
L
Y
T
Site 49
S394
T
D
S
T
G
T
H
S
L
Y
T
T
Y
Q
D
Site 50
Y396
S
T
G
T
H
S
L
Y
T
T
Y
Q
D
H
E
Site 51
T398
G
T
H
S
L
Y
T
T
Y
Q
D
H
E
I
M
Site 52
Y399
T
H
S
L
Y
T
T
Y
Q
D
H
E
I
M
F
Site 53
T415
V
S
T
M
L
P
Y
T
P
N
N
Q
Q
Q
L
Site 54
S442
I
V
F
Q
E
P
G
S
K
P
F
C
P
T
T
Site 55
T448
G
S
K
P
F
C
P
T
T
I
R
S
H
F
Q
Site 56
T468
V
R
A
H
T
P
C
T
P
H
T
T
Y
R
V
Site 57
T471
H
T
P
C
T
P
H
T
T
Y
R
V
A
V
S
Site 58
T472
T
P
C
T
P
H
T
T
Y
R
V
A
V
S
R
Site 59
T483
A
V
S
R
T
Q
D
T
P
A
F
G
P
A
L
Site 60
Y535
A
T
R
T
R
Q
Q
Y
L
Q
D
L
A
T
N
Site 61
T541
Q
Y
L
Q
D
L
A
T
N
E
V
T
T
T
S
Site 62
T547
A
T
N
E
V
T
T
T
S
L
D
S
A
S
R
Site 63
S548
T
N
E
V
T
T
T
S
L
D
S
A
S
R
F
Site 64
S551
V
T
T
T
S
L
D
S
A
S
R
F
G
L
P
Site 65
S553
T
T
S
L
D
S
A
S
R
F
G
L
P
S
L
Site 66
S559
A
S
R
F
G
L
P
S
L
G
G
R
R
R
A
Site 67
T641
C
R
D
V
L
A
W
T
F
S
E
Q
Q
L
D
Site 68
S643
D
V
L
A
W
T
F
S
E
Q
Q
L
D
L
Y
Site 69
Y650
S
E
Q
Q
L
D
L
Y
H
G
R
G
E
A
I
Site 70
T658
H
G
R
G
E
A
I
T
L
R
F
D
G
S
P
Site 71
S664
I
T
L
R
F
D
G
S
P
G
Q
A
V
G
E
Site 72
S680
V
A
R
L
Q
L
V
S
R
G
C
E
T
R
E
Site 73
T685
L
V
S
R
G
C
E
T
R
E
L
A
L
P
R
Site 74
T735
L
L
R
V
C
G
Q
T
L
P
S
L
R
P
E
Site 75
S764
T
V
L
P
P
D
E
S
G
R
P
R
R
S
F
Site 76
S770
E
S
G
R
P
R
R
S
F
S
E
L
Y
T
L
Site 77
S772
G
R
P
R
R
S
F
S
E
L
Y
T
L
S
L
Site 78
Y775
R
R
S
F
S
E
L
Y
T
L
S
L
Q
E
P
Site 79
T776
R
S
F
S
E
L
Y
T
L
S
L
Q
E
P
S
Site 80
S778
F
S
E
L
Y
T
L
S
L
Q
E
P
S
R
R
Site 81
S783
T
L
S
L
Q
E
P
S
R
R
G
A
P
D
P
Site 82
S817
L
C
L
Q
D
G
G
S
P
P
G
P
G
D
L
Site 83
S834
E
R
T
E
F
L
H
S
Q
N
S
L
S
P
R
Site 84
S837
E
F
L
H
S
Q
N
S
L
S
P
R
S
S
L
Site 85
S839
L
H
S
Q
N
S
L
S
P
R
S
S
L
S
D
Site 86
S843
N
S
L
S
P
R
S
S
L
S
D
E
A
P
V
Site 87
S845
L
S
P
R
S
S
L
S
D
E
A
P
V
L
P
Site 88
S867
L
A
T
T
A
K
P
S
V
P
S
A
D
S
E
Site 89
S873
P
S
V
P
S
A
D
S
E
T
P
L
T
Q
D
Site 90
T875
V
P
S
A
D
S
E
T
P
L
T
Q
D
R
P
Site 91
T878
A
D
S
E
T
P
L
T
Q
D
R
P
G
S
P
Site 92
S884
L
T
Q
D
R
P
G
S
P
S
G
S
E
D
K
Site 93
S886
Q
D
R
P
G
S
P
S
G
S
E
D
K
G
N
Site 94
S888
R
P
G
S
P
S
G
S
E
D
K
G
N
P
A
Site 95
S901
P
A
P
E
L
R
A
S
F
L
P
R
T
L
S
Site 96
T906
R
A
S
F
L
P
R
T
L
S
L
R
N
S
I
Site 97
S908
S
F
L
P
R
T
L
S
L
R
N
S
I
S
R
Site 98
S912
R
T
L
S
L
R
N
S
I
S
R
I
M
S
E
Site 99
S914
L
S
L
R
N
S
I
S
R
I
M
S
E
A
G
Site 100
S918
N
S
I
S
R
I
M
S
E
A
G
S
G
T
L
Site 101
S922
R
I
M
S
E
A
G
S
G
T
L
E
D
E
W
Site 102
T941
E
I
A
S
T
C
N
T
I
L
E
S
L
S
R
Site 103
S945
T
C
N
T
I
L
E
S
L
S
R
E
G
Q
P
Site 104
S947
N
T
I
L
E
S
L
S
R
E
G
Q
P
I
P
Site 105
S956
E
G
Q
P
I
P
E
S
G
D
P
K
G
T
P
Site 106
T962
E
S
G
D
P
K
G
T
P
K
S
D
A
E
P
Site 107
S965
D
P
K
G
T
P
K
S
D
A
E
P
E
P
G
Site 108
S975
E
P
E
P
G
N
L
S
E
K
V
S
H
L
E
Site 109
S979
G
N
L
S
E
K
V
S
H
L
E
S
M
L
R
Site 110
S983
E
K
V
S
H
L
E
S
M
L
R
K
L
Q
E
Site 111
S1008
A
L
E
E
E
V
R
S
L
R
H
N
N
R
R
Site 112
S1020
N
R
R
L
Q
A
E
S
E
S
A
A
T
R
L
Site 113
S1031
A
T
R
L
L
L
A
S
K
Q
L
G
S
P
T
Site 114
S1036
L
A
S
K
Q
L
G
S
P
T
A
D
L
A
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation