KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
THOC1
Full Name:
THO complex subunit 1
Alias:
HPR1; Nuclear matrix p84; Nuclear matrix protein p84; P84; THO complex 1; Thoc 1
Type:
Mass (Da):
75666
Number AA:
657
UniProt ID:
Q96FV9
International Prot ID:
IPI00305374
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000445
GO:0005737
GO:0016363
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003723
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006915
GO:0046784
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
P
T
P
P
L
F
S
Site 2
T4
_
_
_
_
M
S
P
T
P
P
L
F
S
L
P
Site 3
S9
S
P
T
P
P
L
F
S
L
P
E
A
R
T
R
Site 4
T18
P
E
A
R
T
R
F
T
K
S
T
R
E
A
L
Site 5
S20
A
R
T
R
F
T
K
S
T
R
E
A
L
N
N
Site 6
T21
R
T
R
F
T
K
S
T
R
E
A
L
N
N
K
Site 7
S35
K
N
I
K
P
L
L
S
T
F
S
Q
V
P
G
Site 8
T36
N
I
K
P
L
L
S
T
F
S
Q
V
P
G
S
Site 9
S38
K
P
L
L
S
T
F
S
Q
V
P
G
S
E
N
Site 10
S43
T
F
S
Q
V
P
G
S
E
N
E
K
K
C
T
Site 11
T50
S
E
N
E
K
K
C
T
L
D
Q
A
F
R
G
Site 12
T127
V
A
T
W
K
S
N
T
F
Y
S
A
G
K
N
Site 13
Y129
T
W
K
S
N
T
F
Y
S
A
G
K
N
Y
L
Site 14
Y135
F
Y
S
A
G
K
N
Y
L
L
R
M
C
N
D
Site 15
S148
N
D
L
L
R
R
L
S
K
S
Q
N
T
V
F
Site 16
S150
L
L
R
R
L
S
K
S
Q
N
T
V
F
C
G
Site 17
T153
R
L
S
K
S
Q
N
T
V
F
C
G
R
I
Q
Site 18
S173
L
F
P
L
S
E
K
S
G
L
N
L
Q
S
Q
Site 19
S179
K
S
G
L
N
L
Q
S
Q
F
N
L
E
N
V
Site 20
T197
N
T
N
E
Q
E
S
T
L
G
Q
K
H
T
E
Site 21
T203
S
T
L
G
Q
K
H
T
E
D
R
E
E
G
M
Site 22
T224
M
G
D
E
E
A
P
T
T
C
S
I
P
I
D
Site 23
T225
G
D
E
E
A
P
T
T
C
S
I
P
I
D
Y
Site 24
Y232
T
C
S
I
P
I
D
Y
N
L
Y
R
K
F
W
Site 25
Y235
I
P
I
D
Y
N
L
Y
R
K
F
W
S
L
Q
Site 26
Y244
K
F
W
S
L
Q
D
Y
F
R
N
P
V
Q
C
Site 27
Y252
F
R
N
P
V
Q
C
Y
E
K
I
S
W
K
T
Site 28
T259
Y
E
K
I
S
W
K
T
F
L
K
Y
S
E
E
Site 29
Y263
S
W
K
T
F
L
K
Y
S
E
E
V
L
A
V
Site 30
S273
E
V
L
A
V
F
K
S
Y
K
L
D
D
T
Q
Site 31
Y274
V
L
A
V
F
K
S
Y
K
L
D
D
T
Q
A
Site 32
T279
K
S
Y
K
L
D
D
T
Q
A
S
R
K
K
M
Site 33
T291
K
K
M
E
E
L
K
T
G
G
E
H
V
Y
F
Site 34
Y297
K
T
G
G
E
H
V
Y
F
A
K
F
L
T
S
Site 35
S313
K
L
M
D
L
Q
L
S
D
S
N
F
R
R
H
Site 36
S315
M
D
L
Q
L
S
D
S
N
F
R
R
H
I
L
Site 37
S340
K
G
Q
V
K
F
K
S
S
N
Y
V
L
T
D
Site 38
Y343
V
K
F
K
S
S
N
Y
V
L
T
D
E
Q
S
Site 39
T346
K
S
S
N
Y
V
L
T
D
E
Q
S
L
W
I
Site 40
S350
Y
V
L
T
D
E
Q
S
L
W
I
E
D
T
T
Site 41
T356
Q
S
L
W
I
E
D
T
T
K
S
V
Y
Q
L
Site 42
T357
S
L
W
I
E
D
T
T
K
S
V
Y
Q
L
L
Site 43
S359
W
I
E
D
T
T
K
S
V
Y
Q
L
L
S
E
Site 44
Y361
E
D
T
T
K
S
V
Y
Q
L
L
S
E
N
P
Site 45
S365
K
S
V
Y
Q
L
L
S
E
N
P
P
D
G
E
Site 46
S375
P
P
D
G
E
R
F
S
K
M
V
E
H
I
L
Site 47
S398
W
K
N
E
G
C
P
S
F
V
K
E
R
T
S
Site 48
S405
S
F
V
K
E
R
T
S
D
T
K
P
T
R
I
Site 49
T417
T
R
I
I
R
K
R
T
A
P
E
D
F
L
G
Site 50
T428
D
F
L
G
K
G
P
T
K
K
I
L
M
G
N
Site 51
T439
L
M
G
N
E
E
L
T
R
L
W
N
L
C
P
Site 52
T462
E
T
R
E
H
M
P
T
L
E
E
F
F
E
E
Site 53
Y484
E
N
M
V
E
N
E
Y
K
A
V
N
N
S
N
Site 54
Y492
K
A
V
N
N
S
N
Y
G
W
R
A
L
R
L
Site 55
S504
L
R
L
L
A
R
R
S
P
H
F
F
Q
P
T
Site 56
S517
P
T
N
Q
Q
F
K
S
L
P
E
Y
L
E
N
Site 57
Y521
Q
F
K
S
L
P
E
Y
L
E
N
M
V
I
K
Site 58
S537
A
K
E
L
P
P
P
S
E
E
I
K
T
G
E
Site 59
T542
P
P
S
E
E
I
K
T
G
E
D
E
D
E
E
Site 60
S560
A
L
L
K
E
N
E
S
P
D
V
R
R
D
K
Site 61
T570
V
R
R
D
K
P
V
T
G
E
Q
I
E
V
F
Site 62
Y591
Q
W
K
I
L
A
P
Y
L
E
M
K
D
S
E
Site 63
S597
P
Y
L
E
M
K
D
S
E
I
R
Q
I
E
C
Site 64
T629
D
Q
E
G
V
H
A
T
P
E
N
L
I
N
A
Site 65
S643
A
L
N
K
S
G
L
S
D
L
A
E
S
L
T
Site 66
S648
G
L
S
D
L
A
E
S
L
T
N
D
N
E
T
Site 67
T650
S
D
L
A
E
S
L
T
N
D
N
E
T
N
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation