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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SENP5
Full Name:
Sentrin-specific protease 5
Alias:
Sentrin/SUMO-specific protease SENP5
Type:
Mass (Da):
86715
Number AA:
755
UniProt ID:
Q96HI0
International Prot ID:
IPI00063106
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0008233
GO:0008234
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
GO:0006511
GO:0007049
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
A
F
S
E
K
W
N
T
G
F
G
G
F
K
K
Site 2
T49
A
K
L
G
R
P
V
T
W
N
R
Q
L
R
H
Site 3
T69
K
A
L
Q
I
Q
K
T
W
I
K
D
E
H
L
Site 4
T86
K
T
K
F
N
V
A
T
Q
N
V
S
T
L
S
Site 5
S94
Q
N
V
S
T
L
S
S
K
V
K
R
K
D
A
Site 6
S106
K
D
A
K
H
F
I
S
S
S
K
T
L
L
R
Site 7
S107
D
A
K
H
F
I
S
S
S
K
T
L
L
R
L
Site 8
S108
A
K
H
F
I
S
S
S
K
T
L
L
R
L
Q
Site 9
T110
H
F
I
S
S
S
K
T
L
L
R
L
Q
A
E
Site 10
S121
L
Q
A
E
K
L
L
S
S
A
K
N
S
D
H
Site 11
S122
Q
A
E
K
L
L
S
S
A
K
N
S
D
H
E
Site 12
S126
L
L
S
S
A
K
N
S
D
H
E
Y
C
R
E
Site 13
Y130
A
K
N
S
D
H
E
Y
C
R
E
K
N
L
L
Site 14
T141
K
N
L
L
K
A
V
T
D
F
P
S
N
S
A
Site 15
S145
K
A
V
T
D
F
P
S
N
S
A
L
G
Q
A
Site 16
T159
A
N
G
H
R
P
R
T
D
P
Q
P
S
D
F
Site 17
S164
P
R
T
D
P
Q
P
S
D
F
P
M
K
F
N
Site 18
S174
P
M
K
F
N
G
E
S
Q
S
P
G
E
S
G
Site 19
S176
K
F
N
G
E
S
Q
S
P
G
E
S
G
T
I
Site 20
S180
E
S
Q
S
P
G
E
S
G
T
I
V
V
T
L
Site 21
T182
Q
S
P
G
E
S
G
T
I
V
V
T
L
N
N
Site 22
Y197
H
K
R
K
G
F
C
Y
G
C
C
Q
G
P
E
Site 23
S228
Q
H
R
R
I
K
L
S
P
L
M
M
Y
E
K
Site 24
Y233
K
L
S
P
L
M
M
Y
E
K
L
S
M
I
R
Site 25
Y243
L
S
M
I
R
F
R
Y
R
I
L
R
S
Q
H
Site 26
S248
F
R
Y
R
I
L
R
S
Q
H
F
R
T
K
S
Site 27
S255
S
Q
H
F
R
T
K
S
K
V
C
K
L
R
K
Site 28
S266
K
L
R
K
A
Q
R
S
W
V
Q
K
V
T
G
Site 29
S287
R
E
N
G
E
G
G
S
C
S
P
F
P
S
P
Site 30
S289
N
G
E
G
G
S
C
S
P
F
P
S
P
E
P
Site 31
S293
G
S
C
S
P
F
P
S
P
E
P
K
D
P
S
Site 32
S300
S
P
E
P
K
D
P
S
C
R
H
Q
P
Y
F
Site 33
Y306
P
S
C
R
H
Q
P
Y
F
P
D
M
D
S
S
Site 34
S312
P
Y
F
P
D
M
D
S
S
A
V
V
K
G
T
Site 35
S313
Y
F
P
D
M
D
S
S
A
V
V
K
G
T
N
Site 36
T319
S
S
A
V
V
K
G
T
N
S
H
V
P
D
C
Site 37
S321
A
V
V
K
G
T
N
S
H
V
P
D
C
H
T
Site 38
T328
S
H
V
P
D
C
H
T
K
G
S
S
F
L
G
Site 39
S332
D
C
H
T
K
G
S
S
F
L
G
K
E
L
S
Site 40
S339
S
F
L
G
K
E
L
S
L
D
E
A
F
P
D
Site 41
S359
A
T
N
A
W
D
Q
S
S
C
S
S
P
K
W
Site 42
S360
T
N
A
W
D
Q
S
S
C
S
S
P
K
W
E
Site 43
S363
W
D
Q
S
S
C
S
S
P
K
W
E
C
T
E
Site 44
S382
I
P
L
P
E
H
R
S
N
T
M
F
I
S
E
Site 45
T384
L
P
E
H
R
S
N
T
M
F
I
S
E
T
E
Site 46
S388
R
S
N
T
M
F
I
S
E
T
E
R
E
I
M
Site 47
T390
N
T
M
F
I
S
E
T
E
R
E
I
M
T
L
Site 48
S404
L
G
Q
E
N
Q
T
S
S
V
S
D
D
R
V
Site 49
S405
G
Q
E
N
Q
T
S
S
V
S
D
D
R
V
K
Site 50
S407
E
N
Q
T
S
S
V
S
D
D
R
V
K
L
S
Site 51
S414
S
D
D
R
V
K
L
S
V
S
G
A
D
T
S
Site 52
S416
D
R
V
K
L
S
V
S
G
A
D
T
S
V
S
Site 53
S421
S
V
S
G
A
D
T
S
V
S
S
V
D
G
P
Site 54
S423
S
G
A
D
T
S
V
S
S
V
D
G
P
V
S
Site 55
S424
G
A
D
T
S
V
S
S
V
D
G
P
V
S
Q
Site 56
S430
S
S
V
D
G
P
V
S
Q
K
A
V
Q
N
E
Site 57
S439
K
A
V
Q
N
E
N
S
Y
Q
M
E
E
D
G
Site 58
S447
Y
Q
M
E
E
D
G
S
L
K
Q
S
I
L
S
Site 59
S451
E
D
G
S
L
K
Q
S
I
L
S
S
E
L
L
Site 60
S455
L
K
Q
S
I
L
S
S
E
L
L
D
H
P
Y
Site 61
Y462
S
E
L
L
D
H
P
Y
C
K
S
P
L
E
A
Site 62
S465
L
D
H
P
Y
C
K
S
P
L
E
A
P
L
V
Site 63
S488
Q
V
G
G
G
K
N
S
Q
K
A
S
P
V
D
Site 64
S492
G
K
N
S
Q
K
A
S
P
V
D
D
E
Q
L
Site 65
Y514
L
D
E
V
M
K
K
Y
G
S
L
V
P
L
S
Site 66
S516
E
V
M
K
K
Y
G
S
L
V
P
L
S
E
K
Site 67
S521
Y
G
S
L
V
P
L
S
E
K
E
V
L
G
R
Site 68
Y551
I
N
R
E
I
T
N
Y
R
A
R
H
Q
K
C
Site 69
T576
L
D
M
D
D
L
A
T
L
D
G
Q
N
W
L
Site 70
Y619
R
Q
L
V
T
K
G
Y
N
G
V
K
R
W
T
Site 71
S660
T
L
S
N
R
I
I
S
F
Y
D
S
Q
G
I
Site 72
Y662
S
N
R
I
I
S
F
Y
D
S
Q
G
I
H
F
Site 73
Y679
C
V
E
N
I
R
K
Y
L
L
T
E
A
R
E
Site 74
T682
N
I
R
K
Y
L
L
T
E
A
R
E
K
N
R
Site 75
S711
I
P
Q
Q
K
N
D
S
D
C
G
V
F
V
L
Site 76
S733
L
E
Q
P
F
Q
F
S
Q
E
D
M
P
R
V
Site 77
Y745
P
R
V
R
K
R
I
Y
K
E
L
C
E
C
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation