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Updated November 2019
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Protein Info
Short Name:
DOCK6
Full Name:
Dedicator of cytokinesis protein 6
Alias:
Dedicator of cytokinesis 6; KIAA1395; ZIR1
Type:
Guanine nucleotide exchange factor, misc.
Mass (Da):
229657
Number AA:
2047
UniProt ID:
Q96HP0
International Prot ID:
IPI00184772
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0051020
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
F
A
H
K
I
N
R
T
V
A
A
E
V
R
K
Site 2
S26
A
E
V
R
K
Q
V
S
R
E
R
S
G
S
P
Site 3
S30
K
Q
V
S
R
E
R
S
G
S
P
H
S
S
R
Site 4
S32
V
S
R
E
R
S
G
S
P
H
S
S
R
R
C
Site 5
S35
E
R
S
G
S
P
H
S
S
R
R
C
S
S
S
Site 6
S36
R
S
G
S
P
H
S
S
R
R
C
S
S
S
L
Site 7
S40
P
H
S
S
R
R
C
S
S
S
L
G
V
P
L
Site 8
S41
H
S
S
R
R
C
S
S
S
L
G
V
P
L
T
Site 9
S42
S
S
R
R
C
S
S
S
L
G
V
P
L
T
E
Site 10
T48
S
S
L
G
V
P
L
T
E
V
V
E
P
L
D
Site 11
S62
D
F
E
D
V
L
L
S
R
P
P
D
A
E
P
Site 12
T94
L
Q
P
R
E
C
R
T
T
E
P
G
I
P
K
Site 13
T95
Q
P
R
E
C
R
T
T
E
P
G
I
P
K
D
Site 14
Y127
W
V
I
V
H
R
R
Y
Q
Y
L
S
A
A
Y
Site 15
Y129
I
V
H
R
R
Y
Q
Y
L
S
A
A
Y
S
P
Site 16
S131
H
R
R
Y
Q
Y
L
S
A
A
Y
S
P
V
T
Site 17
S135
Q
Y
L
S
A
A
Y
S
P
V
T
T
D
T
Q
Site 18
T139
A
A
Y
S
P
V
T
T
D
T
Q
R
E
R
Q
Site 19
T141
Y
S
P
V
T
T
D
T
Q
R
E
R
Q
K
G
Site 20
S159
Q
V
F
E
Q
D
A
S
G
D
E
R
S
G
P
Site 21
S164
D
A
S
G
D
E
R
S
G
P
E
D
S
N
D
Site 22
S169
E
R
S
G
P
E
D
S
N
D
S
R
R
G
S
Site 23
S172
G
P
E
D
S
N
D
S
R
R
G
S
G
S
P
Site 24
S176
S
N
D
S
R
R
G
S
G
S
P
E
D
T
P
Site 25
S178
D
S
R
R
G
S
G
S
P
E
D
T
P
R
S
Site 26
T182
G
S
G
S
P
E
D
T
P
R
S
S
G
A
S
Site 27
S185
S
P
E
D
T
P
R
S
S
G
A
S
S
I
F
Site 28
S186
P
E
D
T
P
R
S
S
G
A
S
S
I
F
D
Site 29
S189
T
P
R
S
S
G
A
S
S
I
F
D
L
R
N
Site 30
S190
P
R
S
S
G
A
S
S
I
F
D
L
R
N
L
Site 31
T221
D
V
D
R
R
N
E
T
L
R
R
Q
H
R
P
Site 32
T233
H
R
P
P
A
L
L
T
L
Y
P
A
P
D
E
Site 33
Y235
P
P
A
L
L
T
L
Y
P
A
P
D
E
D
E
Site 34
S248
D
E
A
V
E
R
C
S
R
P
E
P
P
R
E
Site 35
Y284
I
F
G
I
L
A
L
Y
D
V
R
E
K
K
K
Site 36
Y297
K
K
I
S
E
N
F
Y
F
D
L
N
S
D
S
Site 37
S302
N
F
Y
F
D
L
N
S
D
S
M
K
G
L
L
Site 38
S304
Y
F
D
L
N
S
D
S
M
K
G
L
L
R
A
Site 39
T385
L
A
A
E
Q
F
C
T
R
L
G
R
Y
R
M
Site 40
S415
A
G
Q
L
D
R
D
S
D
S
E
G
E
R
R
Site 41
S417
Q
L
D
R
D
S
D
S
E
G
E
R
R
P
A
Site 42
T426
G
E
R
R
P
A
W
T
D
R
R
R
R
G
P
Site 43
S438
R
G
P
Q
D
R
A
S
S
G
D
D
A
C
S
Site 44
S439
G
P
Q
D
R
A
S
S
G
D
D
A
C
S
F
Site 45
S445
S
S
G
D
D
A
C
S
F
S
G
F
R
P
A
Site 46
T455
G
F
R
P
A
T
L
T
V
T
N
F
F
K
Q
Site 47
S468
K
Q
E
A
E
R
L
S
D
E
D
L
F
K
F
Site 48
S483
L
A
D
M
R
R
P
S
S
L
L
R
R
L
R
Site 49
S484
A
D
M
R
R
P
S
S
L
L
R
R
L
R
P
Site 50
T493
L
R
R
L
R
P
V
T
A
Q
L
K
I
D
I
Site 51
S501
A
Q
L
K
I
D
I
S
P
A
P
E
N
P
H
Site 52
S512
E
N
P
H
F
C
L
S
P
E
L
L
H
I
K
Site 53
Y521
E
L
L
H
I
K
P
Y
P
D
P
R
G
R
P
Site 54
T529
P
D
P
R
G
R
P
T
K
E
I
L
E
F
P
Site 55
Y541
E
F
P
A
R
E
V
Y
A
P
H
T
S
Y
R
Site 56
T545
R
E
V
Y
A
P
H
T
S
Y
R
N
L
L
Y
Site 57
Y552
T
S
Y
R
N
L
L
Y
V
Y
P
H
S
L
N
Site 58
Y554
Y
R
N
L
L
Y
V
Y
P
H
S
L
N
F
S
Site 59
S557
L
L
Y
V
Y
P
H
S
L
N
F
S
S
R
Q
Site 60
S561
Y
P
H
S
L
N
F
S
S
R
Q
G
S
V
R
Site 61
S562
P
H
S
L
N
F
S
S
R
Q
G
S
V
R
N
Site 62
S566
N
F
S
S
R
Q
G
S
V
R
N
L
A
V
R
Site 63
Y576
N
L
A
V
R
V
Q
Y
M
T
G
E
D
P
S
Site 64
T578
A
V
R
V
Q
Y
M
T
G
E
D
P
S
Q
A
Site 65
S594
P
V
I
F
G
K
S
S
C
S
E
F
T
R
E
Site 66
S596
I
F
G
K
S
S
C
S
E
F
T
R
E
A
F
Site 67
T604
E
F
T
R
E
A
F
T
P
V
V
Y
H
N
K
Site 68
Y608
E
A
F
T
P
V
V
Y
H
N
K
S
P
E
F
Site 69
S612
P
V
V
Y
H
N
K
S
P
E
F
Y
E
E
F
Site 70
Y616
H
N
K
S
P
E
F
Y
E
E
F
K
L
H
L
Site 71
Y638
H
H
L
L
F
T
F
Y
H
V
S
C
Q
P
R
Site 72
T648
S
C
Q
P
R
P
G
T
A
L
E
T
P
V
G
Site 73
T669
L
Q
H
R
R
L
R
T
G
P
F
C
L
P
V
Site 74
S677
G
P
F
C
L
P
V
S
V
D
Q
P
P
P
S
Site 75
S684
S
V
D
Q
P
P
P
S
Y
S
V
L
T
P
D
Site 76
S686
D
Q
P
P
P
S
Y
S
V
L
T
P
D
V
A
Site 77
S716
V
E
L
T
A
V
S
S
V
H
P
Q
D
P
Y
Site 78
Y723
S
V
H
P
Q
D
P
Y
L
D
K
F
F
T
L
Site 79
T746
F
P
F
R
L
K
D
T
V
L
S
E
G
N
V
Site 80
T845
Y
A
F
R
L
P
G
T
E
P
S
L
P
D
G
Site 81
S848
R
L
P
G
T
E
P
S
L
P
D
G
A
P
P
Site 82
T862
P
V
T
V
Q
A
A
T
L
A
R
G
S
G
R
Site 83
S867
A
A
T
L
A
R
G
S
G
R
P
A
S
L
Y
Site 84
S872
R
G
S
G
R
P
A
S
L
Y
L
A
R
S
K
Site 85
Y874
S
G
R
P
A
S
L
Y
L
A
R
S
K
S
I
Site 86
S878
A
S
L
Y
L
A
R
S
K
S
I
S
S
S
N
Site 87
S880
L
Y
L
A
R
S
K
S
I
S
S
S
N
P
D
Site 88
S882
L
A
R
S
K
S
I
S
S
S
N
P
D
L
A
Site 89
S883
A
R
S
K
S
I
S
S
S
N
P
D
L
A
V
Site 90
S884
R
S
K
S
I
S
S
S
N
P
D
L
A
V
A
Site 91
S894
D
L
A
V
A
P
G
S
V
D
D
E
V
S
R
Site 92
S900
G
S
V
D
D
E
V
S
R
I
L
A
S
K
L
Site 93
T954
L
L
G
Q
R
L
D
T
P
R
K
L
R
F
P
Site 94
Y1021
F
S
L
V
R
A
H
Y
K
Q
V
A
T
R
L
Site 95
S1030
Q
V
A
T
R
L
Q
S
S
P
N
P
A
A
L
Site 96
T1039
P
N
P
A
A
L
L
T
L
R
M
E
F
T
R
Site 97
S1065
N
L
P
C
C
P
L
S
P
P
A
S
P
S
P
Site 98
S1069
C
P
L
S
P
P
A
S
P
S
P
S
V
S
S
Site 99
S1071
L
S
P
P
A
S
P
S
P
S
V
S
S
T
T
Site 100
S1073
P
P
A
S
P
S
P
S
V
S
S
T
T
S
Q
Site 101
S1075
A
S
P
S
P
S
V
S
S
T
T
S
Q
S
S
Site 102
S1076
S
P
S
P
S
V
S
S
T
T
S
Q
S
S
T
Site 103
T1077
P
S
P
S
V
S
S
T
T
S
Q
S
S
T
F
Site 104
T1078
S
P
S
V
S
S
T
T
S
Q
S
S
T
F
S
Site 105
S1079
P
S
V
S
S
T
T
S
Q
S
S
T
F
S
S
Site 106
S1081
V
S
S
T
T
S
Q
S
S
T
F
S
S
Q
A
Site 107
S1082
S
S
T
T
S
Q
S
S
T
F
S
S
Q
A
P
Site 108
T1083
S
T
T
S
Q
S
S
T
F
S
S
Q
A
P
D
Site 109
S1085
T
S
Q
S
S
T
F
S
S
Q
A
P
D
P
K
Site 110
S1086
S
Q
S
S
T
F
S
S
Q
A
P
D
P
K
V
Site 111
S1095
A
P
D
P
K
V
T
S
M
F
E
L
S
G
P
Site 112
S1100
V
T
S
M
F
E
L
S
G
P
F
R
Q
Q
H
Site 113
T1148
S
L
L
C
G
H
D
T
D
P
R
Y
A
E
A
Site 114
Y1152
G
H
D
T
D
P
R
Y
A
E
A
T
V
K
A
Site 115
T1156
D
P
R
Y
A
E
A
T
V
K
A
R
V
A
E
Site 116
S1190
A
E
G
P
G
Q
R
S
R
L
A
S
M
L
D
Site 117
S1194
G
Q
R
S
R
L
A
S
M
L
D
S
D
T
E
Site 118
S1198
R
L
A
S
M
L
D
S
D
T
E
G
E
G
D
Site 119
T1200
A
S
M
L
D
S
D
T
E
G
E
G
D
I
A
Site 120
S1227
G
G
P
L
A
P
G
S
R
A
S
I
S
Q
G
Site 121
S1230
L
A
P
G
S
R
A
S
I
S
Q
G
P
P
T
Site 122
S1232
P
G
S
R
A
S
I
S
Q
G
P
P
T
A
S
Site 123
T1237
S
I
S
Q
G
P
P
T
A
S
R
A
G
C
A
Site 124
S1239
S
Q
G
P
P
T
A
S
R
A
G
C
A
L
S
Site 125
S1246
S
R
A
G
C
A
L
S
A
E
S
S
R
T
L
Site 126
T1277
Q
R
W
A
T
D
L
T
L
P
Q
L
G
R
L
Site 127
S1308
K
A
F
E
R
I
N
S
L
T
F
K
K
S
L
Site 128
T1310
F
E
R
I
N
S
L
T
F
K
K
S
L
D
M
Site 129
S1314
N
S
L
T
F
K
K
S
L
D
M
K
A
R
L
Site 130
S1339
R
Q
E
M
V
R
R
S
R
E
R
S
P
F
G
Site 131
S1343
V
R
R
S
R
E
R
S
P
F
G
N
P
E
N
Site 132
T1358
V
R
W
R
K
S
V
T
H
W
K
Q
T
S
D
Site 133
S1364
V
T
H
W
K
Q
T
S
D
R
V
D
K
T
K
Site 134
T1370
T
S
D
R
V
D
K
T
K
D
E
M
E
H
E
Site 135
S1472
R
L
L
R
H
C
G
S
R
I
S
T
I
R
T
Site 136
S1475
R
H
C
G
S
R
I
S
T
I
R
T
H
A
S
Site 137
T1476
H
C
G
S
R
I
S
T
I
R
T
H
A
S
A
Site 138
T1479
S
R
I
S
T
I
R
T
H
A
S
A
S
L
Y
Site 139
S1484
I
R
T
H
A
S
A
S
L
Y
L
L
M
R
Q
Site 140
Y1486
T
H
A
S
A
S
L
Y
L
L
M
R
Q
N
F
Site 141
S1512
Q
V
T
M
S
L
S
S
L
V
G
T
T
Q
N
Site 142
T1516
S
L
S
S
L
V
G
T
T
Q
N
F
S
E
E
Site 143
S1528
S
E
E
H
L
R
R
S
L
K
T
I
L
T
Y
Site 144
T1531
H
L
R
R
S
L
K
T
I
L
T
Y
A
E
E
Site 145
T1534
R
S
L
K
T
I
L
T
Y
A
E
E
D
M
G
Site 146
S1545
E
D
M
G
L
R
D
S
T
F
A
E
Q
V
Q
Site 147
T1546
D
M
G
L
R
D
S
T
F
A
E
Q
V
Q
D
Site 148
T1563
F
N
L
H
M
I
L
T
D
T
V
K
M
K
E
Site 149
T1565
L
H
M
I
L
T
D
T
V
K
M
K
E
H
Q
Site 150
Y1583
E
M
L
I
D
L
M
Y
R
I
A
R
G
Y
Q
Site 151
Y1589
M
Y
R
I
A
R
G
Y
Q
G
S
P
D
L
R
Site 152
S1592
I
A
R
G
Y
Q
G
S
P
D
L
R
L
T
W
Site 153
T1598
G
S
P
D
L
R
L
T
W
L
Q
N
M
A
G
Site 154
S1652
V
S
F
Q
N
I
S
S
N
V
L
E
E
S
A
Site 155
S1658
S
S
N
V
L
E
E
S
A
I
S
D
D
I
L
Site 156
S1661
V
L
E
E
S
A
I
S
D
D
I
L
S
P
D
Site 157
S1666
A
I
S
D
D
I
L
S
P
D
E
E
G
F
C
Site 158
S1674
P
D
E
E
G
F
C
S
G
K
H
F
T
E
L
Site 159
T1679
F
C
S
G
K
H
F
T
E
L
G
L
V
G
L
Site 160
Y1720
I
L
E
A
H
R
D
Y
K
K
L
A
A
V
H
Site 161
Y1751
W
E
R
V
F
G
T
Y
F
R
V
G
F
Y
G
Site 162
Y1771
L
D
E
Q
E
F
V
Y
K
E
P
S
I
T
K
Site 163
S1775
E
F
V
Y
K
E
P
S
I
T
K
L
A
E
I
Site 164
T1777
V
Y
K
E
P
S
I
T
K
L
A
E
I
S
H
Site 165
S1783
I
T
K
L
A
E
I
S
H
R
L
E
E
F
Y
Site 166
Y1790
S
H
R
L
E
E
F
Y
T
E
R
F
G
D
D
Site 167
T1791
H
R
L
E
E
F
Y
T
E
R
F
G
D
D
V
Site 168
S1811
D
S
N
P
V
D
K
S
K
L
D
S
Q
K
A
Site 169
S1815
V
D
K
S
K
L
D
S
Q
K
A
Y
I
Q
I
Site 170
Y1819
K
L
D
S
Q
K
A
Y
I
Q
I
T
Y
V
E
Site 171
Y1824
K
A
Y
I
Q
I
T
Y
V
E
P
Y
F
D
T
Site 172
Y1828
Q
I
T
Y
V
E
P
Y
F
D
T
Y
E
L
K
Site 173
Y1832
V
E
P
Y
F
D
T
Y
E
L
K
D
R
V
T
Site 174
T1839
Y
E
L
K
D
R
V
T
Y
F
D
R
N
Y
G
Site 175
Y1840
E
L
K
D
R
V
T
Y
F
D
R
N
Y
G
L
Site 176
Y1845
V
T
Y
F
D
R
N
Y
G
L
R
T
F
L
F
Site 177
T1854
L
R
T
F
L
F
C
T
P
F
T
P
D
G
R
Site 178
T1857
F
L
F
C
T
P
F
T
P
D
G
R
A
H
G
Site 179
T1874
P
E
Q
H
K
R
K
T
L
L
S
T
D
H
A
Site 180
S1877
H
K
R
K
T
L
L
S
T
D
H
A
F
P
Y
Site 181
T1878
K
R
K
T
L
L
S
T
D
H
A
F
P
Y
I
Site 182
Y1884
S
T
D
H
A
F
P
Y
I
K
T
R
I
R
V
Site 183
T1897
R
V
C
H
R
E
E
T
V
L
T
P
V
E
V
Site 184
T1900
H
R
E
E
T
V
L
T
P
V
E
V
A
I
E
Site 185
T1941
L
Q
G
S
V
G
P
T
V
N
Q
G
P
L
E
Site 186
Y1999
I
G
P
D
Q
K
E
Y
H
R
E
L
E
R
N
Site 187
Y2007
H
R
E
L
E
R
N
Y
C
R
L
R
E
A
L
Site 188
T2019
E
A
L
Q
P
L
L
T
Q
R
L
P
Q
L
M
Site 189
T2029
L
P
Q
L
M
A
P
T
P
P
G
L
R
N
S
Site 190
S2036
T
P
P
G
L
R
N
S
L
N
R
A
S
F
R
Site 191
S2041
R
N
S
L
N
R
A
S
F
R
K
A
D
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation