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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
REXON
Full Name:
Putative RNA exonuclease NEF-sp
Alias:
Exonuclease NEF-sp; LOC81691; RNA exonuclease NEF-sp
Type:
Hydrolase; EC 3.1.-.-
Mass (Da):
86890
Number AA:
UniProt ID:
Q96IC2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0004527
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
E
P
E
R
E
G
T
E
R
H
P
R
K
V
Site 2
S18
H
P
R
K
V
R
E
S
R
Q
A
P
N
K
L
Site 3
S41
A
G
W
D
L
E
E
S
Q
P
E
A
K
K
A
Site 4
S51
E
A
K
K
A
R
L
S
T
I
L
F
T
D
N
Site 5
T52
A
K
K
A
R
L
S
T
I
L
F
T
D
N
C
Site 6
S78
K
Y
A
V
L
G
K
S
N
V
P
K
P
S
W
Site 7
Y111
G
M
S
Q
L
H
F
Y
R
F
Y
L
E
F
G
Site 8
Y114
Q
L
H
F
Y
R
F
Y
L
E
F
G
C
L
R
Site 9
S134
K
F
R
L
P
P
P
S
S
D
F
L
A
D
V
Site 10
T156
R
A
G
D
L
P
K
T
M
E
G
P
L
P
S
Site 11
Y180
D
D
P
I
I
Q
K
Y
G
S
K
K
V
G
L
Site 12
S182
P
I
I
Q
K
Y
G
S
K
K
V
G
L
T
R
Site 13
T199
L
T
K
E
E
M
R
T
F
H
F
P
L
Q
G
Site 14
S221
L
L
T
K
C
N
G
S
I
A
D
N
S
P
L
Site 15
S226
N
G
S
I
A
D
N
S
P
L
F
G
L
D
C
Site 16
T238
L
D
C
E
M
C
L
T
S
K
G
R
E
L
T
Site 17
S239
D
C
E
M
C
L
T
S
K
G
R
E
L
T
R
Site 18
T245
T
S
K
G
R
E
L
T
R
I
S
L
V
A
E
Site 19
Y271
P
E
N
K
I
L
D
Y
L
T
S
F
S
G
I
Site 20
T273
N
K
I
L
D
Y
L
T
S
F
S
G
I
T
K
Site 21
S274
K
I
L
D
Y
L
T
S
F
S
G
I
T
K
K
Site 22
S330
H
P
Y
V
I
D
T
S
L
L
Y
V
R
E
Q
Site 23
Y333
V
I
D
T
S
L
L
Y
V
R
E
Q
G
R
R
Site 24
T366
D
R
L
G
H
D
A
T
E
D
A
R
T
I
L
Site 25
T371
D
A
T
E
D
A
R
T
I
L
E
L
A
R
Y
Site 26
Y378
T
I
L
E
L
A
R
Y
F
L
K
H
G
P
K
Site 27
T411
A
G
Q
E
P
K
N
T
A
E
V
L
Q
H
P
Site 28
T440
L
L
F
L
T
R
E
T
D
A
G
E
L
P
S
Site 29
S447
T
D
A
G
E
L
P
S
S
R
N
C
Q
T
I
Site 30
S448
D
A
G
E
L
P
S
S
R
N
C
Q
T
I
K
Site 31
T453
P
S
S
R
N
C
Q
T
I
K
C
L
S
N
K
Site 32
S486
Q
F
S
F
K
A
F
S
P
V
L
T
E
E
M
Site 33
T490
K
A
F
S
P
V
L
T
E
E
M
N
K
R
M
Site 34
Y508
W
T
E
I
S
T
V
Y
A
G
P
F
S
K
N
Site 35
S513
T
V
Y
A
G
P
F
S
K
N
C
N
L
R
A
Site 36
S527
A
L
K
R
L
F
K
S
F
G
P
V
Q
S
M
Site 37
T535
F
G
P
V
Q
S
M
T
F
V
L
E
T
R
Q
Site 38
T579
I
K
V
Q
R
P
V
T
E
L
T
L
D
C
D
Site 39
T582
Q
R
P
V
T
E
L
T
L
D
C
D
T
L
V
Site 40
T587
E
L
T
L
D
C
D
T
L
V
N
E
L
E
G
Site 41
S596
V
N
E
L
E
G
D
S
E
N
Q
G
S
I
Y
Site 42
S601
G
D
S
E
N
Q
G
S
I
Y
L
S
G
V
S
Site 43
Y603
S
E
N
Q
G
S
I
Y
L
S
G
V
S
E
T
Site 44
S605
N
Q
G
S
I
Y
L
S
G
V
S
E
T
F
K
Site 45
T610
Y
L
S
G
V
S
E
T
F
K
E
Q
L
L
Q
Site 46
S636
I
L
P
K
D
L
K
S
G
K
Q
K
K
Y
C
Site 47
Y642
K
S
G
K
Q
K
K
Y
C
F
L
K
F
K
S
Site 48
S649
Y
C
F
L
K
F
K
S
F
G
S
A
Q
Q
A
Site 49
S652
L
K
F
K
S
F
G
S
A
Q
Q
A
L
N
I
Site 50
T661
Q
Q
A
L
N
I
L
T
G
K
D
W
K
L
K
Site 51
T674
L
K
G
R
H
A
L
T
P
R
H
L
H
A
W
Site 52
S689
L
R
G
L
P
P
E
S
T
R
L
P
G
L
R
Site 53
T690
R
G
L
P
P
E
S
T
R
L
P
G
L
R
V
Site 54
T709
F
E
Q
E
A
L
Q
T
L
K
L
D
H
P
K
Site 55
Y730
S
R
K
I
G
K
L
Y
N
S
L
C
P
G
T
Site 56
S748
I
L
L
P
G
T
K
S
T
H
G
S
L
S
G
Site 57
S752
G
T
K
S
T
H
G
S
L
S
G
L
G
L
M
Site 58
S767
G
I
K
E
E
E
E
S
A
G
P
G
L
C
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation