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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SHD
Full Name:
SH2 domain-containing adapter protein D
Alias:
Src homology 2 domain containing transforming protein D; Srcy 2 domain containing transforming protein D
Type:
Adaptor/scaffold
Mass (Da):
38264
Number AA:
340
UniProt ID:
Q96IW2
International Prot ID:
IPI00400780
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
A
K
W
L
R
D
Y
L
S
F
G
G
R
R
Site 2
S10
K
W
L
R
D
Y
L
S
F
G
G
R
R
P
P
Site 3
T22
R
P
P
P
Q
P
P
T
P
D
Y
T
E
S
D
Site 4
Y25
P
Q
P
P
T
P
D
Y
T
E
S
D
I
L
R
Site 5
T26
Q
P
P
T
P
D
Y
T
E
S
D
I
L
R
A
Site 6
S28
P
T
P
D
Y
T
E
S
D
I
L
R
A
Y
R
Site 7
Y34
E
S
D
I
L
R
A
Y
R
A
Q
K
N
L
D
Site 8
Y46
N
L
D
F
E
D
P
Y
E
D
A
E
S
R
L
Site 9
S51
D
P
Y
E
D
A
E
S
R
L
E
P
D
P
A
Site 10
S63
D
P
A
G
P
G
D
S
K
N
P
G
D
A
K
Site 11
Y71
K
N
P
G
D
A
K
Y
G
S
P
K
H
R
L
Site 12
S73
P
G
D
A
K
Y
G
S
P
K
H
R
L
I
K
Site 13
T104
G
E
E
L
E
A
D
T
E
Y
L
D
P
F
D
Site 14
Y106
E
L
E
A
D
T
E
Y
L
D
P
F
D
A
Q
Site 15
Y123
P
A
P
P
D
D
G
Y
M
E
P
Y
D
A
Q
Site 16
Y127
D
D
G
Y
M
E
P
Y
D
A
Q
W
V
M
S
Site 17
S134
Y
D
A
Q
W
V
M
S
E
L
P
G
R
G
V
Site 18
Y144
P
G
R
G
V
Q
L
Y
D
T
P
Y
E
E
Q
Site 19
T146
R
G
V
Q
L
Y
D
T
P
Y
E
E
Q
D
P
Site 20
Y148
V
Q
L
Y
D
T
P
Y
E
E
Q
D
P
E
T
Site 21
T155
Y
E
E
Q
D
P
E
T
A
D
G
P
P
S
G
Site 22
S161
E
T
A
D
G
P
P
S
G
Q
K
P
R
Q
S
Site 23
S168
S
G
Q
K
P
R
Q
S
R
M
P
Q
E
D
E
Site 24
Y181
D
E
R
P
A
D
E
Y
D
Q
P
W
E
W
K
Site 25
S202
A
F
A
V
Q
F
D
S
P
E
W
E
R
T
P
Site 26
T208
D
S
P
E
W
E
R
T
P
G
S
A
K
E
L
Site 27
S211
E
W
E
R
T
P
G
S
A
K
E
L
R
R
P
Site 28
S222
L
R
R
P
P
P
R
S
P
Q
P
A
E
R
V
Site 29
S252
L
N
R
A
D
A
E
S
L
L
S
L
C
K
E
Site 30
S255
A
D
A
E
S
L
L
S
L
C
K
E
G
S
Y
Site 31
S261
L
S
L
C
K
E
G
S
Y
L
V
R
L
S
E
Site 32
Y262
S
L
C
K
E
G
S
Y
L
V
R
L
S
E
T
Site 33
S267
G
S
Y
L
V
R
L
S
E
T
N
P
Q
D
C
Site 34
S275
E
T
N
P
Q
D
C
S
L
S
L
R
S
S
Q
Site 35
S277
N
P
Q
D
C
S
L
S
L
R
S
S
Q
G
F
Site 36
S280
D
C
S
L
S
L
R
S
S
Q
G
F
L
H
L
Site 37
S281
C
S
L
S
L
R
S
S
Q
G
F
L
H
L
K
Site 38
S308
Q
H
S
G
P
F
P
S
V
P
E
L
V
L
H
Site 39
S317
P
E
L
V
L
H
Y
S
S
R
P
L
P
V
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation