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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CPB2
Full Name:
Carboxypeptidase B2
Alias:
Carboxypeptidase B2; Carboxypeptidase B2 (plasma); Carboxypeptidase U; CBPB2; CPU; EC 3.4.17.20; PCPB; Plasma carboxypeptidase B; TAFI; Thrombin-activable fibrinolysis inhibitor; Thrombin-activatable fibrinolysis inhibitor
Type:
EC 3.4.17.20; Protease
Mass (Da):
48412
Number AA:
423
UniProt ID:
Q96IY4
International Prot ID:
Isoform1 - IPI00329775
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0004181
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S36
L
A
A
L
P
R
T
S
R
Q
V
Q
V
L
Q
Site 2
S107
D
L
I
Q
Q
Q
I
S
N
D
T
V
S
P
R
Site 3
T110
Q
Q
Q
I
S
N
D
T
V
S
P
R
A
S
A
Site 4
S112
Q
I
S
N
D
T
V
S
P
R
A
S
A
S
Y
Site 5
S116
D
T
V
S
P
R
A
S
A
S
Y
Y
E
Q
Y
Site 6
S118
V
S
P
R
A
S
A
S
Y
Y
E
Q
Y
H
S
Site 7
Y119
S
P
R
A
S
A
S
Y
Y
E
Q
Y
H
S
L
Site 8
Y120
P
R
A
S
A
S
Y
Y
E
Q
Y
H
S
L
N
Site 9
Y123
S
A
S
Y
Y
E
Q
Y
H
S
L
N
E
I
Y
Site 10
T145
E
R
H
P
D
M
L
T
K
I
H
I
G
S
S
Site 11
S152
T
K
I
H
I
G
S
S
F
E
K
Y
P
L
Y
Site 12
Y156
I
G
S
S
F
E
K
Y
P
L
Y
V
L
K
V
Site 13
Y159
S
F
E
K
Y
P
L
Y
V
L
K
V
S
G
K
Site 14
Y228
P
V
V
N
V
D
G
Y
D
Y
S
W
K
K
N
Site 15
Y230
V
N
V
D
G
Y
D
Y
S
W
K
K
N
R
M
Site 16
S270
H
W
C
E
E
G
A
S
S
S
S
C
S
E
T
Site 17
S271
W
C
E
E
G
A
S
S
S
S
C
S
E
T
Y
Site 18
S272
C
E
E
G
A
S
S
S
S
C
S
E
T
Y
C
Site 19
S273
E
E
G
A
S
S
S
S
C
S
E
T
Y
C
G
Site 20
S275
G
A
S
S
S
S
C
S
E
T
Y
C
G
L
Y
Site 21
T277
S
S
S
S
C
S
E
T
Y
C
G
L
Y
P
E
Site 22
Y282
S
E
T
Y
C
G
L
Y
P
E
S
E
P
E
V
Site 23
S285
Y
C
G
L
Y
P
E
S
E
P
E
V
K
A
V
Site 24
S294
P
E
V
K
A
V
A
S
F
L
R
R
N
I
N
Site 25
Y306
N
I
N
Q
I
K
A
Y
I
S
M
H
S
Y
S
Site 26
Y320
S
Q
H
I
V
F
P
Y
S
Y
T
R
S
K
S
Site 27
S321
Q
H
I
V
F
P
Y
S
Y
T
R
S
K
S
K
Site 28
Y322
H
I
V
F
P
Y
S
Y
T
R
S
K
S
K
D
Site 29
T323
I
V
F
P
Y
S
Y
T
R
S
K
S
K
D
H
Site 30
S325
F
P
Y
S
Y
T
R
S
K
S
K
D
H
E
E
Site 31
S327
Y
S
Y
T
R
S
K
S
K
D
H
E
E
L
S
Site 32
S334
S
K
D
H
E
E
L
S
L
V
A
S
E
A
V
Site 33
T347
A
V
R
A
I
E
K
T
S
K
N
T
R
Y
T
Site 34
Y353
K
T
S
K
N
T
R
Y
T
H
G
H
G
S
E
Site 35
T354
T
S
K
N
T
R
Y
T
H
G
H
G
S
E
T
Site 36
S359
R
Y
T
H
G
H
G
S
E
T
L
Y
L
A
P
Site 37
T361
T
H
G
H
G
S
E
T
L
Y
L
A
P
G
G
Site 38
Y363
G
H
G
S
E
T
L
Y
L
A
P
G
G
G
D
Site 39
Y374
G
G
G
D
D
W
I
Y
D
L
G
I
K
Y
S
Site 40
Y380
I
Y
D
L
G
I
K
Y
S
F
T
I
E
L
R
Site 41
S381
Y
D
L
G
I
K
Y
S
F
T
I
E
L
R
D
Site 42
T383
L
G
I
K
Y
S
F
T
I
E
L
R
D
T
G
Site 43
T391
I
E
L
R
D
T
G
T
Y
G
F
L
L
P
E
Site 44
Y392
E
L
R
D
T
G
T
Y
G
F
L
L
P
E
R
Site 45
Y400
G
F
L
L
P
E
R
Y
I
K
P
T
C
R
E
Site 46
T404
P
E
R
Y
I
K
P
T
C
R
E
A
F
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation