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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCC12
Full Name:
Multidrug resistance-associated protein 9
Alias:
ATP-binding cassette transporter sub-family C 12; MRP9
Type:
Membrane, Integral membrane protein
Mass (Da):
152297
Number AA:
1359
UniProt ID:
Q96J65
International Prot ID:
IPI00063878
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042626
PhosphoSite+
KinaseNET
Biological Process:
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
V
G
E
G
P
Y
L
I
S
D
L
D
Q
Site 2
S20
D
Q
R
G
R
R
R
S
F
A
E
R
Y
D
P
Site 3
Y25
R
R
S
F
A
E
R
Y
D
P
S
L
K
T
M
Site 4
T31
R
Y
D
P
S
L
K
T
M
I
P
V
R
P
C
Site 5
T73
K
G
Y
R
Q
R
L
T
V
D
T
L
P
P
L
Site 6
T76
R
Q
R
L
T
V
D
T
L
P
P
L
S
T
Y
Site 7
S81
V
D
T
L
P
P
L
S
T
Y
D
S
S
D
T
Site 8
T82
D
T
L
P
P
L
S
T
Y
D
S
S
D
T
N
Site 9
Y83
T
L
P
P
L
S
T
Y
D
S
S
D
T
N
A
Site 10
S85
P
P
L
S
T
Y
D
S
S
D
T
N
A
K
R
Site 11
S86
P
L
S
T
Y
D
S
S
D
T
N
A
K
R
F
Site 12
T88
S
T
Y
D
S
S
D
T
N
A
K
R
F
R
V
Site 13
S110
R
V
G
P
E
K
A
S
L
S
H
V
V
W
K
Site 14
S112
G
P
E
K
A
S
L
S
H
V
V
W
K
F
Q
Site 15
T152
I
H
Q
I
L
Q
Q
T
E
R
T
S
G
K
V
Site 16
S156
L
Q
Q
T
E
R
T
S
G
K
V
W
V
G
I
Site 17
S290
L
N
S
A
F
R
R
S
A
I
L
V
T
D
K
Site 18
T301
V
T
D
K
R
V
Q
T
M
N
E
F
L
T
C
Site 19
T324
W
E
K
S
F
T
N
T
I
Q
D
I
R
R
R
Site 20
S344
E
K
A
G
F
V
Q
S
G
N
S
A
L
A
P
Site 21
S397
S
I
A
I
L
P
F
S
I
K
A
M
A
E
A
Site 22
S407
A
M
A
E
A
N
V
S
L
R
R
M
K
K
I
Site 23
S419
K
K
I
L
I
D
K
S
P
P
S
Y
I
T
Q
Site 24
S422
L
I
D
K
S
P
P
S
Y
I
T
Q
P
E
D
Site 25
Y423
I
D
K
S
P
P
S
Y
I
T
Q
P
E
D
P
Site 26
T432
T
Q
P
E
D
P
D
T
V
L
L
L
A
N
A
Site 27
S448
L
T
W
E
H
E
A
S
R
K
S
T
P
K
K
Site 28
S451
E
H
E
A
S
R
K
S
T
P
K
K
L
Q
N
Site 29
T452
H
E
A
S
R
K
S
T
P
K
K
L
Q
N
Q
Site 30
S469
H
L
C
K
K
Q
R
S
E
A
Y
S
E
R
S
Site 31
Y472
K
K
Q
R
S
E
A
Y
S
E
R
S
P
P
A
Site 32
S473
K
Q
R
S
E
A
Y
S
E
R
S
P
P
A
K
Site 33
S476
S
E
A
Y
S
E
R
S
P
P
A
K
G
A
T
Site 34
S489
A
T
G
P
E
E
Q
S
D
S
L
K
S
V
L
Site 35
S491
G
P
E
E
Q
S
D
S
L
K
S
V
L
H
S
Site 36
S494
E
Q
S
D
S
L
K
S
V
L
H
S
I
S
F
Site 37
S500
K
S
V
L
H
S
I
S
F
V
V
R
K
G
K
Site 38
S547
N
G
T
L
A
Y
V
S
Q
Q
A
W
I
F
H
Site 39
Y567
N
I
L
F
G
E
K
Y
D
H
Q
R
Y
Q
H
Site 40
S586
C
G
L
Q
K
D
L
S
N
L
P
Y
G
D
L
Site 41
Y590
K
D
L
S
N
L
P
Y
G
D
L
T
E
I
G
Site 42
T594
N
L
P
Y
G
D
L
T
E
I
G
E
R
G
L
Site 43
S604
G
E
R
G
L
N
L
S
G
G
Q
R
Q
R
I
Site 44
S612
G
G
Q
R
Q
R
I
S
L
A
R
A
V
Y
S
Site 45
Y624
V
Y
S
D
R
Q
L
Y
L
L
D
D
P
L
S
Site 46
T649
F
E
E
C
I
K
K
T
L
R
G
K
T
V
V
Site 47
T654
K
K
T
L
R
G
K
T
V
V
L
V
T
H
Q
Site 48
Y695
L
M
E
E
R
G
R
Y
A
K
L
I
H
N
L
Site 49
Y714
F
K
D
P
E
H
L
Y
N
A
A
M
V
E
A
Site 50
S725
M
V
E
A
F
K
E
S
P
A
E
R
E
E
D
Site 51
S750
E
K
D
E
G
K
E
S
E
T
G
S
E
F
V
Site 52
S754
G
K
E
S
E
T
G
S
E
F
V
D
T
K
V
Site 53
T759
T
G
S
E
F
V
D
T
K
V
P
E
H
Q
L
Site 54
T769
P
E
H
Q
L
I
Q
T
E
S
P
Q
E
G
T
Site 55
S771
H
Q
L
I
Q
T
E
S
P
Q
E
G
T
V
T
Site 56
T776
T
E
S
P
Q
E
G
T
V
T
W
K
T
Y
H
Site 57
T778
S
P
Q
E
G
T
V
T
W
K
T
Y
H
T
Y
Site 58
Y785
T
W
K
T
Y
H
T
Y
I
K
A
S
G
G
Y
Site 59
T827
L
D
K
G
S
R
M
T
C
G
P
Q
G
N
R
Site 60
T835
C
G
P
Q
G
N
R
T
M
C
E
V
G
A
V
Site 61
Y851
A
D
I
G
Q
H
V
Y
Q
W
V
Y
T
A
S
Site 62
T887
A
S
S
S
L
H
D
T
V
F
D
K
I
L
K
Site 63
S898
K
I
L
K
S
P
M
S
F
F
D
T
T
P
T
Site 64
T902
S
P
M
S
F
F
D
T
T
P
T
G
R
L
M
Site 65
T903
P
M
S
F
F
D
T
T
P
T
G
R
L
M
N
Site 66
S913
G
R
L
M
N
R
F
S
K
D
M
D
E
L
D
Site 67
S985
K
V
E
N
V
S
R
S
P
W
F
T
H
I
T
Site 68
T989
V
S
R
S
P
W
F
T
H
I
T
S
S
M
Q
Site 69
T992
S
P
W
F
T
H
I
T
S
S
M
Q
G
L
G
Site 70
T1012
G
K
K
E
S
C
I
T
Y
H
L
L
Y
F
N
Site 71
Y1013
K
K
E
S
C
I
T
Y
H
L
L
Y
F
N
C
Site 72
S1052
T
L
S
F
S
S
I
S
T
S
S
K
G
L
S
Site 73
S1054
S
F
S
S
I
S
T
S
S
K
G
L
S
L
S
Site 74
S1055
F
S
S
I
S
T
S
S
K
G
L
S
L
S
Y
Site 75
T1078
Q
V
C
V
R
T
G
T
E
T
Q
A
K
F
T
Site 76
T1080
C
V
R
T
G
T
E
T
Q
A
K
F
T
S
V
Site 77
Y1093
S
V
E
L
L
R
E
Y
I
S
T
C
V
P
E
Site 78
S1095
E
L
L
R
E
Y
I
S
T
C
V
P
E
C
T
Site 79
Y1125
G
E
I
T
F
R
D
Y
Q
M
R
Y
R
D
N
Site 80
Y1129
F
R
D
Y
Q
M
R
Y
R
D
N
T
P
L
V
Site 81
T1133
Q
M
R
Y
R
D
N
T
P
L
V
L
D
S
L
Site 82
S1146
S
L
N
L
N
I
Q
S
G
Q
T
V
G
I
V
Site 83
S1158
G
I
V
G
R
T
G
S
G
K
S
S
L
G
M
Site 84
S1161
G
R
T
G
S
G
K
S
S
L
G
M
A
L
F
Site 85
S1162
R
T
G
S
G
K
S
S
L
G
M
A
L
F
R
Site 86
T1195
L
S
L
E
D
L
R
T
K
L
T
V
I
P
Q
Site 87
T1198
E
D
L
R
T
K
L
T
V
I
P
Q
D
P
V
Site 88
T1238
E
R
T
F
M
R
D
T
I
M
K
L
P
E
K
Site 89
T1251
E
K
L
Q
A
E
V
T
E
N
G
E
N
F
S
Site 90
S1258
T
E
N
G
E
N
F
S
V
G
E
R
Q
L
L
Site 91
S1286
L
L
D
E
A
T
A
S
M
D
S
K
T
D
T
Site 92
S1289
E
A
T
A
S
M
D
S
K
T
D
T
L
V
Q
Site 93
T1291
T
A
S
M
D
S
K
T
D
T
L
V
Q
N
T
Site 94
T1293
S
M
D
S
K
T
D
T
L
V
Q
N
T
I
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation