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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DNAH8
Full Name:
Dynein heavy chain 8, axonemal
Alias:
Axonemal heavy polypeptide 8; Ciliary dynein heavy chain 8; Dyein; DYH8; Dynein, axonemal, heavy chain 8; Dynein, axonemal, heavy polypeptide 8; Hdhc9
Type:
Motor protein
Mass (Da):
514664
Number AA:
4490
UniProt ID:
Q96JB1
International Prot ID:
IPI00478021
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005858
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0016887
GO:0003777
PhosphoSite+
KinaseNET
Biological Process:
GO:0001539
GO:0007018
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S78
N
W
G
A
L
N
Q
S
K
Q
G
E
S
E
K
Site 2
T91
E
K
H
I
F
T
E
T
I
N
R
Y
L
S
F
Site 3
Y95
F
T
E
T
I
N
R
Y
L
S
F
L
D
G
A
Site 4
S97
E
T
I
N
R
Y
L
S
F
L
D
G
A
R
I
Site 5
T114
E
G
T
V
K
L
K
T
I
D
N
V
N
F
S
Site 6
S136
V
T
A
A
A
S
N
S
E
T
V
H
Q
L
E
Site 7
T138
A
A
A
S
N
S
E
T
V
H
Q
L
E
E
V
Site 8
S170
M
R
K
E
A
G
D
S
G
P
L
T
E
L
E
Site 9
T174
A
G
D
S
G
P
L
T
E
L
E
H
W
K
R
Site 10
S183
L
E
H
W
K
R
M
S
A
K
F
N
Y
I
I
Site 11
Y188
R
M
S
A
K
F
N
Y
I
I
E
Q
I
K
G
Site 12
S210
N
V
L
N
V
A
H
S
K
L
L
K
N
W
R
Site 13
T224
R
D
L
D
A
R
I
T
D
T
A
N
E
S
K
Site 14
T226
L
D
A
R
I
T
D
T
A
N
E
S
K
D
N
Site 15
Y236
E
S
K
D
N
V
R
Y
L
Y
T
L
E
K
V
Site 16
Y238
K
D
N
V
R
Y
L
Y
T
L
E
K
V
C
Q
Site 17
Y248
E
K
V
C
Q
P
L
Y
N
H
D
L
V
S
M
Site 18
Y275
M
I
H
G
V
S
R
Y
Y
N
T
S
E
R
M
Site 19
Y276
I
H
G
V
S
R
Y
Y
N
T
S
E
R
M
T
Site 20
S279
V
S
R
Y
Y
N
T
S
E
R
M
T
S
L
F
Site 21
T283
Y
N
T
S
E
R
M
T
S
L
F
I
K
V
T
Site 22
S284
N
T
S
E
R
M
T
S
L
F
I
K
V
T
N
Site 23
T314
N
H
V
W
D
Q
E
T
P
V
V
L
K
K
I
Site 24
Y331
C
I
F
L
F
K
E
Y
Q
A
S
F
H
K
T
Site 25
S334
L
F
K
E
Y
Q
A
S
F
H
K
T
R
K
L
Site 26
T338
Y
Q
A
S
F
H
K
T
R
K
L
I
S
E
S
Site 27
S343
H
K
T
R
K
L
I
S
E
S
S
G
E
K
S
Site 28
S345
T
R
K
L
I
S
E
S
S
G
E
K
S
F
E
Site 29
S346
R
K
L
I
S
E
S
S
G
E
K
S
F
E
V
Site 30
S350
S
E
S
S
G
E
K
S
F
E
V
S
E
M
Y
Site 31
S354
G
E
K
S
F
E
V
S
E
M
Y
I
F
G
K
Site 32
T381
E
M
I
T
V
V
Q
T
Y
S
T
L
S
N
S
Site 33
T384
T
V
V
Q
T
Y
S
T
L
S
N
S
T
I
E
Site 34
S386
V
Q
T
Y
S
T
L
S
N
S
T
I
E
G
I
Site 35
Y404
A
I
K
F
R
N
I
Y
Q
G
V
K
K
K
Q
Site 36
Y412
Q
G
V
K
K
K
Q
Y
D
I
L
D
P
R
R
Site 37
T420
D
I
L
D
P
R
R
T
E
F
D
T
D
F
L
Site 38
T424
P
R
R
T
E
F
D
T
D
F
L
D
F
M
T
Site 39
S453
S
S
F
G
K
I
L
S
S
Q
Q
A
L
Q
L
Site 40
T494
Y
V
A
E
L
D
A
T
K
K
L
Y
H
S
Q
Site 41
Y498
L
D
A
T
K
K
L
Y
H
S
Q
K
D
D
P
Site 42
S500
A
T
K
K
L
Y
H
S
Q
K
D
D
P
P
L
Site 43
Y525
I
L
W
V
R
Q
L
Y
R
R
I
S
E
P
I
Site 44
S529
R
Q
L
Y
R
R
I
S
E
P
I
N
Y
F
F
Site 45
Y534
R
I
S
E
P
I
N
Y
F
F
K
N
S
D
I
Site 46
S539
I
N
Y
F
F
K
N
S
D
I
L
S
S
P
D
Site 47
S543
F
K
N
S
D
I
L
S
S
P
D
G
K
A
V
Site 48
S544
K
N
S
D
I
L
S
S
P
D
G
K
A
V
I
Site 49
Y554
G
K
A
V
I
R
Q
Y
N
K
I
S
Y
V
L
Site 50
Y559
R
Q
Y
N
K
I
S
Y
V
L
V
E
F
E
V
Site 51
S577
T
A
W
I
R
E
I
S
Q
L
H
Y
A
L
Q
Site 52
Y581
R
E
I
S
Q
L
H
Y
A
L
Q
A
T
L
F
Site 53
S634
K
R
L
L
K
L
E
S
K
L
K
A
D
K
L
Site 54
Y642
K
L
K
A
D
K
L
Y
L
Q
G
L
L
Q
Y
Site 55
Y650
L
Q
G
L
L
Q
Y
Y
D
E
L
C
Q
E
V
Site 56
T666
S
V
F
V
N
L
M
T
P
K
M
K
K
V
E
Site 57
S674
P
K
M
K
K
V
E
S
V
L
R
Q
G
L
T
Site 58
S686
G
L
T
V
L
T
W
S
S
L
T
L
E
S
F
Site 59
T689
V
L
T
W
S
S
L
T
L
E
S
F
F
Q
E
Site 60
T747
T
K
V
E
D
M
L
T
L
N
E
T
Y
T
K
Site 61
S764
A
D
I
L
N
H
K
S
K
H
V
E
E
A
V
Site 62
Y782
I
S
I
F
E
Q
I
Y
E
V
K
Y
T
G
K
Site 63
Y786
E
Q
I
Y
E
V
K
Y
T
G
K
V
G
K
Q
Site 64
T787
Q
I
Y
E
V
K
Y
T
G
K
V
G
K
Q
S
Site 65
S794
T
G
K
V
G
K
Q
S
E
Q
R
K
H
V
V
Site 66
S804
R
K
H
V
V
F
G
S
E
T
G
E
G
E
N
Site 67
Y814
G
E
G
E
N
N
D
Y
E
A
N
I
V
N
E
Site 68
T824
N
I
V
N
E
F
D
T
H
D
K
E
D
E
F
Site 69
S849
F
S
H
Q
L
L
D
S
L
Q
K
A
T
R
L
Site 70
S857
L
Q
K
A
T
R
L
S
L
D
T
M
K
R
R
Site 71
T860
A
T
R
L
S
L
D
T
M
K
R
R
I
F
V
Site 72
S869
K
R
R
I
F
V
A
S
L
Y
G
R
K
Q
S
Site 73
Y871
R
I
F
V
A
S
L
Y
G
R
K
Q
S
E
D
Site 74
S876
S
L
Y
G
R
K
Q
S
E
D
I
I
S
F
I
Site 75
S881
K
Q
S
E
D
I
I
S
F
I
K
S
E
V
H
Site 76
S934
Q
Q
I
R
P
I
K
S
V
I
P
S
P
T
T
Site 77
S938
P
I
K
S
V
I
P
S
P
T
T
T
D
V
T
Site 78
T942
V
I
P
S
P
T
T
T
D
V
T
H
Q
N
T
Site 79
T945
S
P
T
T
T
D
V
T
H
Q
N
T
G
K
L
Site 80
S959
L
L
K
K
E
E
R
S
F
E
E
A
I
P
A
Site 81
Y973
A
R
K
L
K
N
F
Y
P
G
V
A
E
H
K
Site 82
S995
L
L
S
S
S
V
N
S
L
R
K
A
A
H
E
Site 83
Y1010
A
L
Q
D
F
Q
K
Y
K
T
L
W
T
E
D
Site 84
T1012
Q
D
F
Q
K
Y
K
T
L
W
T
E
D
R
D
Site 85
S1031
E
F
L
A
N
N
P
S
L
T
E
I
R
S
E
Site 86
T1033
L
A
N
N
P
S
L
T
E
I
R
S
E
I
L
Site 87
S1037
P
S
L
T
E
I
R
S
E
I
L
H
Y
A
T
Site 88
Y1042
I
R
S
E
I
L
H
Y
A
T
F
E
Q
E
I
Site 89
T1044
S
E
I
L
H
Y
A
T
F
E
Q
E
I
D
E
Site 90
S1073
E
P
M
K
L
A
L
S
I
E
A
K
A
W
K
Site 91
Y1086
W
K
M
L
L
C
R
Y
L
N
E
E
Y
K
K
Site 92
S1096
E
E
Y
K
K
K
M
S
Y
M
I
A
F
I
N
Site 93
Y1097
E
Y
K
K
K
M
S
Y
M
I
A
F
I
N
E
Site 94
Y1105
M
I
A
F
I
N
E
Y
L
K
K
L
S
R
P
Site 95
T1139
N
E
I
Q
M
D
M
T
L
G
P
I
E
E
A
Site 96
T1158
N
R
F
E
V
E
V
T
K
E
E
S
E
A
V
Site 97
T1167
E
E
S
E
A
V
D
T
L
R
Y
S
F
N
K
Site 98
S1171
A
V
D
T
L
R
Y
S
F
N
K
L
Q
S
K
Site 99
S1177
Y
S
F
N
K
L
Q
S
K
A
V
S
V
Q
E
Site 100
S1181
K
L
Q
S
K
A
V
S
V
Q
E
D
L
V
Q
Site 101
S1195
Q
V
Q
P
K
F
K
S
N
L
L
E
S
V
E
Site 102
S1200
F
K
S
N
L
L
E
S
V
E
V
F
R
E
D
Site 103
S1231
N
I
P
P
Q
E
A
S
N
R
L
Q
I
F
Q
Site 104
S1240
R
L
Q
I
F
Q
A
S
F
D
D
L
W
R
K
Site 105
Y1251
L
W
R
K
F
V
T
Y
S
S
G
E
Q
L
F
Site 106
Y1265
F
G
L
P
V
T
D
Y
E
V
L
H
K
T
R
Site 107
S1343
K
K
R
I
D
D
F
S
E
S
C
P
L
L
E
Site 108
S1345
R
I
D
D
F
S
E
S
C
P
L
L
E
M
M
Site 109
S1366
Q
R
H
W
D
R
I
S
E
L
T
G
T
P
F
Site 110
T1369
W
D
R
I
S
E
L
T
G
T
P
F
D
V
E
Site 111
T1371
R
I
S
E
L
T
G
T
P
F
D
V
E
S
D
Site 112
S1377
G
T
P
F
D
V
E
S
D
S
F
C
L
R
N
Site 113
T1415
K
D
I
E
A
K
L
T
Q
V
I
E
N
W
T
Site 114
S1460
D
S
L
M
V
L
G
S
L
L
S
N
R
Y
N
Site 115
Y1466
G
S
L
L
S
N
R
Y
N
A
P
F
K
K
N
Site 116
Y1479
K
N
I
Q
N
W
V
Y
K
L
S
T
S
S
D
Site 117
S1482
Q
N
W
V
Y
K
L
S
T
S
S
D
I
I
E
Site 118
S1568
Q
L
E
V
C
Q
K
S
L
T
G
Y
L
E
K
Site 119
Y1572
C
Q
K
S
L
T
G
Y
L
E
K
K
R
L
L
Site 120
S1601
I
L
G
Q
A
S
D
S
H
T
I
Q
P
H
L
Site 121
T1603
G
Q
A
S
D
S
H
T
I
Q
P
H
L
P
A
Site 122
S1664
D
L
L
K
M
Q
M
S
S
L
H
N
I
I
R
Site 123
Y1675
N
I
I
R
S
A
F
Y
Q
I
S
D
S
G
F
Site 124
S1678
R
S
A
F
Y
Q
I
S
D
S
G
F
Q
L
L
Site 125
T1705
L
G
I
Q
M
L
W
T
H
D
S
E
E
A
L
Site 126
S1708
Q
M
L
W
T
H
D
S
E
E
A
L
R
N
A
Site 127
S1738
D
I
L
N
T
L
I
S
Q
T
T
H
D
L
S
Site 128
S1745
S
Q
T
T
H
D
L
S
K
F
D
R
V
K
F
Site 129
T1757
V
K
F
E
T
L
I
T
I
H
V
H
Q
R
D
Site 130
S1776
L
V
K
M
H
I
K
S
P
T
D
F
E
W
L
Site 131
Y1789
W
L
K
Q
S
R
F
Y
F
K
E
D
L
D
Q
Site 132
T1797
F
K
E
D
L
D
Q
T
V
V
S
I
T
D
V
Site 133
T1822
C
T
D
R
L
V
I
T
P
L
T
D
R
C
Y
Site 134
S1893
K
G
L
A
Q
S
G
S
W
G
C
F
D
E
F
Site 135
T1920
Q
Q
I
Y
I
V
L
T
A
R
K
E
R
K
K
Site 136
S1932
R
K
K
Q
F
I
F
S
D
G
D
C
V
D
L
Site 137
Y1953
F
L
T
M
N
P
G
Y
A
G
R
Q
E
L
P
Site 138
Y2004
A
Q
K
F
Y
V
L
Y
K
L
C
E
E
Q
L
Site 139
T2012
K
L
C
E
E
Q
L
T
K
Q
V
H
Y
D
F
Site 140
T2030
N
I
L
S
V
L
R
T
L
G
S
Q
K
R
A
Site 141
S2033
S
V
L
R
T
L
G
S
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Site 293
T4188
L
H
P
N
A
D
I
T
Y
Q
S
N
T
A
S
Site 294
Y4189
H
P
N
A
D
I
T
Y
Q
S
N
T
A
S
A
Site 295
S4191
N
A
D
I
T
Y
Q
S
N
T
A
S
A
V
L
Site 296
S4195
T
Y
Q
S
N
T
A
S
A
V
L
E
T
I
T
Site 297
Y4222
E
T
R
E
A
I
V
Y
R
L
S
E
D
M
L
Site 298
S4225
E
A
I
V
Y
R
L
S
E
D
M
L
S
K
L
Site 299
S4230
R
L
S
E
D
M
L
S
K
L
P
P
D
Y
I
Site 300
Y4236
L
S
K
L
P
P
D
Y
I
P
H
E
V
K
S
Site 301
S4270
D
R
M
Q
R
V
I
S
I
L
R
S
S
L
S
Site 302
S4275
V
I
S
I
L
R
S
S
L
S
D
L
K
L
A
Site 303
Y4301
R
D
A
L
D
N
M
Y
D
A
R
I
P
Q
L
Site 304
S4313
P
Q
L
W
K
R
V
S
W
D
S
S
T
L
G
Site 305
S4317
K
R
V
S
W
D
S
S
T
L
G
F
W
F
T
Site 306
T4318
R
V
S
W
D
S
S
T
L
G
F
W
F
T
E
Site 307
S4334
L
E
R
N
A
Q
F
S
T
W
I
F
E
G
R
Site 308
T4375
H
K
G
W
A
L
D
T
V
T
I
H
N
E
V
Site 309
T4386
H
N
E
V
L
R
Q
T
K
E
E
I
T
S
P
Site 310
T4391
R
Q
T
K
E
E
I
T
S
P
P
G
E
G
V
Site 311
S4392
Q
T
K
E
E
I
T
S
P
P
G
E
G
V
Y
Site 312
Y4399
S
P
P
G
E
G
V
Y
I
Y
G
L
Y
M
D
Site 313
S4420
R
N
G
K
L
M
E
S
T
P
K
V
L
F
T
Site 314
T4421
N
G
K
L
M
E
S
T
P
K
V
L
F
T
Q
Site 315
Y4448
A
P
K
D
P
K
L
Y
V
C
P
I
Y
K
K
Site 316
Y4453
K
L
Y
V
C
P
I
Y
K
K
P
R
R
T
D
Site 317
T4459
I
Y
K
K
P
R
R
T
D
L
T
F
I
T
V
Site 318
Y4468
L
T
F
I
T
V
V
Y
L
R
T
V
L
S
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation