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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HIC2
Full Name:
Hypermethylated in cancer 2 protein
Alias:
HIC1-related gene on chromosome 22 protein;Hic-3;Zinc finger and BTB domain-containing protein 30
Type:
Mass (Da):
66156
Number AA:
615
UniProt ID:
Q96JB3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
G
P
D
M
E
L
P
S
H
S
K
Q
L
L
L
Site 2
T85
D
N
L
I
N
L
D
T
D
M
V
S
S
T
V
Site 3
S89
N
L
D
T
D
M
V
S
S
T
V
F
Q
Q
I
Site 4
T91
D
T
D
M
V
S
S
T
V
F
Q
Q
I
L
D
Site 5
S108
Y
T
G
K
L
L
P
S
D
Q
P
A
E
P
N
Site 6
S148
R
A
G
K
P
F
G
S
G
R
A
G
S
T
G
Site 7
S153
F
G
S
G
R
A
G
S
T
G
M
G
R
P
P
Site 8
S162
G
M
G
R
P
P
R
S
Q
R
L
S
T
A
S
Site 9
S166
P
P
R
S
Q
R
L
S
T
A
S
V
I
Q
A
Site 10
T167
P
R
S
Q
R
L
S
T
A
S
V
I
Q
A
R
Site 11
S169
S
Q
R
L
S
T
A
S
V
I
Q
A
R
Y
Q
Site 12
S197
E
L
P
Q
A
K
G
S
D
D
E
L
F
L
G
Site 13
S206
D
E
L
F
L
G
G
S
N
Q
D
S
V
Q
G
Site 14
S210
L
G
G
S
N
Q
D
S
V
Q
G
L
G
R
A
Site 15
S231
E
A
G
L
G
G
C
S
S
S
T
N
G
S
S
Site 16
S232
A
G
L
G
G
C
S
S
S
T
N
G
S
S
G
Site 17
S233
G
L
G
G
C
S
S
S
T
N
G
S
S
G
G
Site 18
T234
L
G
G
C
S
S
S
T
N
G
S
S
G
G
C
Site 19
S237
C
S
S
S
T
N
G
S
S
G
G
C
E
Q
E
Site 20
S250
Q
E
L
G
L
D
L
S
K
K
S
P
P
L
P
Site 21
S253
G
L
D
L
S
K
K
S
P
P
L
P
P
A
T
Site 22
T260
S
P
P
L
P
P
A
T
P
G
P
H
L
T
P
Site 23
T266
A
T
P
G
P
H
L
T
P
D
D
A
A
Q
L
Site 24
S274
P
D
D
A
A
Q
L
S
D
S
Q
H
G
S
P
Site 25
S276
D
A
A
Q
L
S
D
S
Q
H
G
S
P
P
A
Site 26
S280
L
S
D
S
Q
H
G
S
P
P
A
A
S
A
P
Site 27
S285
H
G
S
P
P
A
A
S
A
P
P
V
A
N
S
Site 28
S292
S
A
P
P
V
A
N
S
A
S
Y
S
E
L
G
Site 29
S294
P
P
V
A
N
S
A
S
Y
S
E
L
G
G
T
Site 30
S296
V
A
N
S
A
S
Y
S
E
L
G
G
T
P
D
Site 31
T301
S
Y
S
E
L
G
G
T
P
D
E
P
M
D
L
Site 32
S317
G
A
E
D
N
H
L
S
L
L
E
A
P
G
G
Site 33
S329
P
G
G
Q
P
R
K
S
L
R
H
S
T
R
K
Site 34
S333
P
R
K
S
L
R
H
S
T
R
K
K
E
W
G
Site 35
T334
R
K
S
L
R
H
S
T
R
K
K
E
W
G
K
Site 36
S348
K
K
E
P
V
A
G
S
P
F
E
R
R
E
A
Site 37
Y388
G
A
G
P
S
G
P
Y
G
E
P
P
Y
P
C
Site 38
Y393
G
P
Y
G
E
P
P
Y
P
C
K
E
E
E
E
Site 39
S406
E
E
N
G
K
D
A
S
E
D
S
A
Q
S
G
Site 40
S409
G
K
D
A
S
E
D
S
A
Q
S
G
S
E
G
Site 41
S412
A
S
E
D
S
A
Q
S
G
S
E
G
G
S
G
Site 42
S414
E
D
S
A
Q
S
G
S
E
G
G
S
G
H
A
Site 43
S418
Q
S
G
S
E
G
G
S
G
H
A
S
A
H
Y
Site 44
S422
E
G
G
S
G
H
A
S
A
H
Y
M
Y
R
Q
Site 45
Y425
S
G
H
A
S
A
H
Y
M
Y
R
Q
E
G
Y
Site 46
Y432
Y
M
Y
R
Q
E
G
Y
E
T
V
S
Y
G
D
Site 47
T434
Y
R
Q
E
G
Y
E
T
V
S
Y
G
D
N
L
Site 48
Y437
E
G
Y
E
T
V
S
Y
G
D
N
L
Y
V
C
Site 49
S453
P
C
A
K
G
F
P
S
S
E
Q
L
N
A
H
Site 50
S454
C
A
K
G
F
P
S
S
E
Q
L
N
A
H
V
Site 51
Y477
F
I
K
E
E
G
A
Y
E
T
G
S
G
G
A
Site 52
S481
E
G
A
Y
E
T
G
S
G
G
A
E
E
E
A
Site 53
S492
E
E
E
A
E
D
L
S
A
P
S
A
A
Y
T
Site 54
T499
S
A
P
S
A
A
Y
T
A
E
P
R
P
F
K
Site 55
S508
E
P
R
P
F
K
C
S
V
C
E
K
T
Y
K
Site 56
Y514
C
S
V
C
E
K
T
Y
K
D
P
A
T
L
R
Site 57
T519
K
T
Y
K
D
P
A
T
L
R
Q
H
E
K
T
Site 58
T526
T
L
R
Q
H
E
K
T
H
W
L
T
R
P
F
Site 59
S554
T
M
T
R
H
M
R
S
H
L
G
L
K
P
F
Site 60
Y574
G
M
R
F
T
R
Q
Y
R
L
T
E
H
M
R
Site 61
T577
F
T
R
Q
Y
R
L
T
E
H
M
R
V
H
S
Site 62
S584
T
E
H
M
R
V
H
S
G
E
K
P
Y
E
C
Site 63
Y589
V
H
S
G
E
K
P
Y
E
C
Q
L
C
G
G
Site 64
S606
T
Q
Q
R
N
L
I
S
H
L
R
M
H
T
S
Site 65
T612
I
S
H
L
R
M
H
T
S
P
S
_
_
_
_
Site 66
S613
S
H
L
R
M
H
T
S
P
S
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation