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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MPP4
Full Name:
MAGUK p55 subfamily member 4
Alias:
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein;Discs large homolog 6
Type:
Mass (Da):
72779
Number AA:
637
UniProt ID:
Q96JB8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S44
Q
E
L
S
L
F
Y
S
R
D
V
N
G
V
C
Site 2
T84
E
K
K
L
V
P
A
T
P
H
A
Q
V
L
S
Site 3
T101
V
V
E
L
L
R
E
T
P
T
S
P
E
I
Q
Site 4
S104
L
L
R
E
T
P
T
S
P
E
I
Q
E
L
R
Site 5
S124
P
H
F
K
A
L
L
S
A
H
D
T
I
A
Q
Site 6
T128
A
L
L
S
A
H
D
T
I
A
Q
K
D
F
E
Site 7
S148
L
P
D
N
I
P
E
S
E
E
A
M
R
I
V
Site 8
Y195
A
E
R
S
G
L
L
Y
A
G
D
K
L
V
E
Site 9
S235
M
F
K
V
V
P
V
S
D
P
P
V
N
S
Q
Site 10
S241
V
S
D
P
P
V
N
S
Q
Q
M
V
Y
V
R
Site 11
Y246
V
N
S
Q
Q
M
V
Y
V
R
A
M
T
E
Y
Site 12
Y253
Y
V
R
A
M
T
E
Y
W
P
Q
E
D
P
D
Site 13
T297
R
K
I
S
D
P
A
T
C
A
G
L
V
P
S
Site 14
S304
T
C
A
G
L
V
P
S
N
H
L
L
K
R
K
Site 15
T325
S
Q
P
Y
Q
P
H
T
C
L
K
S
T
L
S
Site 16
S329
Q
P
H
T
C
L
K
S
T
L
S
I
S
M
E
Site 17
T330
P
H
T
C
L
K
S
T
L
S
I
S
M
E
E
Site 18
S332
T
C
L
K
S
T
L
S
I
S
M
E
E
E
D
Site 19
S334
L
K
S
T
L
S
I
S
M
E
E
E
D
D
M
Site 20
T354
C
V
E
A
D
E
E
T
F
E
S
E
E
L
S
Site 21
S357
A
D
E
E
T
F
E
S
E
E
L
S
E
D
K
Site 22
S361
T
F
E
S
E
E
L
S
E
D
K
E
E
F
V
Site 23
Y370
D
K
E
E
F
V
G
Y
G
Q
K
F
F
I
A
Site 24
S382
F
I
A
G
F
R
R
S
M
R
L
C
R
R
K
Site 25
S390
M
R
L
C
R
R
K
S
H
L
S
P
L
H
A
Site 26
S393
C
R
R
K
S
H
L
S
P
L
H
A
S
V
C
Site 27
Y413
Y
S
A
V
G
A
P
Y
E
E
V
V
R
Y
Q
Site 28
Y419
P
Y
E
E
V
V
R
Y
Q
R
R
P
S
D
K
Site 29
S424
V
R
Y
Q
R
R
P
S
D
K
Y
R
L
I
V
Site 30
Y427
Q
R
R
P
S
D
K
Y
R
L
I
V
L
M
G
Site 31
S453
Q
L
I
E
F
N
P
S
H
F
Q
S
A
V
P
Site 32
S457
F
N
P
S
H
F
Q
S
A
V
P
H
T
T
R
Site 33
T462
F
Q
S
A
V
P
H
T
T
R
T
K
K
S
Y
Site 34
Y469
T
T
R
T
K
K
S
Y
E
M
N
G
R
E
Y
Site 35
Y476
Y
E
M
N
G
R
E
Y
H
Y
V
S
K
E
T
Site 36
Y478
M
N
G
R
E
Y
H
Y
V
S
K
E
T
F
E
Site 37
S480
G
R
E
Y
H
Y
V
S
K
E
T
F
E
N
L
Site 38
Y489
E
T
F
E
N
L
I
Y
S
H
R
M
L
E
Y
Site 39
Y496
Y
S
H
R
M
L
E
Y
G
E
Y
K
G
H
L
Site 40
Y499
R
M
L
E
Y
G
E
Y
K
G
H
L
Y
G
T
Site 41
Y504
G
E
Y
K
G
H
L
Y
G
T
S
V
D
A
V
Site 42
S507
K
G
H
L
Y
G
T
S
V
D
A
V
Q
T
V
Site 43
Y541
R
T
H
E
L
K
P
Y
V
I
F
I
K
P
S
Site 44
Y566
N
A
K
V
I
T
D
Y
Y
V
D
M
K
F
K
Site 45
Y567
A
K
V
I
T
D
Y
Y
V
D
M
K
F
K
D
Site 46
T589
N
L
A
Q
R
M
E
T
Q
F
G
Q
F
F
D
Site 47
S613
D
A
C
A
Q
L
L
S
A
I
Q
K
A
Q
E
Site 48
T628
E
P
Q
W
V
P
A
T
W
I
S
S
D
T
E
Site 49
S632
V
P
A
T
W
I
S
S
D
T
E
S
Q
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation