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Updated November 2019
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Protein Info
Short Name:
SPG11
Full Name:
Spatacsin
Alias:
FLJ21439; KIAA1840; LOC80208; Spastic paraplegia 11 (autosomal recessive); SPTCS
Type:
Unknown function
Mass (Da):
278808
Number AA:
2443
UniProt ID:
Q96JI7
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0016021
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0008219
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
E
G
V
A
S
A
A
S
A
G
G
S
W
G
T
Site 2
T49
G
S
R
A
Q
L
R
T
Q
P
E
A
L
G
S
Site 3
T69
S
L
Q
V
L
S
L
T
P
G
S
R
G
G
G
Site 4
S95
L
W
E
D
S
R
N
S
S
T
P
T
E
K
P
Site 5
S96
W
E
D
S
R
N
S
S
T
P
T
E
K
P
K
Site 6
T97
E
D
S
R
N
S
S
T
P
T
E
K
P
K
L
Site 7
T99
S
R
N
S
S
T
P
T
E
K
P
K
L
L
A
Site 8
Y116
E
N
Y
E
L
L
I
Y
E
F
N
L
K
D
G
Site 9
T128
K
D
G
R
C
D
A
T
I
L
Y
S
C
S
R
Site 10
Y131
R
C
D
A
T
I
L
Y
S
C
S
R
E
A
L
Site 11
S132
C
D
A
T
I
L
Y
S
C
S
R
E
A
L
Q
Site 12
S148
L
I
D
D
Q
D
I
S
I
S
L
L
S
L
R
Site 13
S257
Q
Q
E
P
A
K
I
S
S
F
T
S
L
K
V
Site 14
S258
Q
E
P
A
K
I
S
S
F
T
S
L
K
V
S
Site 15
S261
A
K
I
S
S
F
T
S
L
K
V
S
Q
D
L
Site 16
Y288
V
A
L
N
L
N
L
Y
F
R
Q
H
P
G
H
Site 17
S337
F
S
F
Q
I
D
R
S
W
K
A
Q
L
S
S
Site 18
S343
R
S
W
K
A
Q
L
S
S
L
N
E
T
I
K
Site 19
S344
S
W
K
A
Q
L
S
S
L
N
E
T
I
K
N
Site 20
T348
Q
L
S
S
L
N
E
T
I
K
N
S
K
L
E
Site 21
S371
Q
D
I
L
H
L
E
S
P
E
S
G
N
H
S
Site 22
S374
L
H
L
E
S
P
E
S
G
N
H
S
T
S
V
Site 23
S378
S
P
E
S
G
N
H
S
T
S
V
Q
S
W
A
Site 24
T379
P
E
S
G
N
H
S
T
S
V
Q
S
W
A
F
Site 25
S380
E
S
G
N
H
S
T
S
V
Q
S
W
A
F
I
Site 26
T406
L
Q
K
D
H
A
K
T
S
D
P
G
R
S
W
Site 27
S407
Q
K
D
H
A
K
T
S
D
P
G
R
S
W
K
Site 28
S419
S
W
K
I
M
H
I
S
E
Q
E
E
P
I
E
Site 29
Y448
W
E
V
E
R
M
G
Y
T
I
T
L
W
D
L
Site 30
T451
E
R
M
G
Y
T
I
T
L
W
D
L
E
T
Q
Site 31
S463
E
T
Q
G
M
Q
C
S
S
L
G
T
K
C
I
Site 32
S464
T
Q
G
M
Q
C
S
S
L
G
T
K
C
I
P
Site 33
S474
T
K
C
I
P
V
D
S
S
G
D
Q
Q
L
C
Site 34
S475
K
C
I
P
V
D
S
S
G
D
Q
Q
L
C
F
Site 35
S510
N
R
L
M
I
H
G
S
A
S
T
V
D
T
L
Site 36
T516
G
S
A
S
T
V
D
T
L
C
H
L
N
G
W
Site 37
T544
I
E
N
R
Q
L
D
T
V
N
F
F
L
K
S
Site 38
S551
T
V
N
F
F
L
K
S
K
E
N
L
F
N
P
Site 39
S559
K
E
N
L
F
N
P
S
S
K
S
S
V
S
D
Site 40
S560
E
N
L
F
N
P
S
S
K
S
S
V
S
D
Q
Site 41
S562
L
F
N
P
S
S
K
S
S
V
S
D
Q
F
D
Site 42
S563
F
N
P
S
S
K
S
S
V
S
D
Q
F
D
H
Site 43
S565
P
S
S
K
S
S
V
S
D
Q
F
D
H
L
S
Site 44
S572
S
D
Q
F
D
H
L
S
S
H
L
Y
L
R
N
Site 45
Y576
D
H
L
S
S
H
L
Y
L
R
N
V
E
E
L
Site 46
S597
L
C
S
A
I
R
E
S
Y
S
E
P
Q
S
K
Site 47
Y598
C
S
A
I
R
E
S
Y
S
E
P
Q
S
K
H
Site 48
S599
S
A
I
R
E
S
Y
S
E
P
Q
S
K
H
F
Site 49
S603
E
S
Y
S
E
P
Q
S
K
H
F
S
E
Q
L
Site 50
S607
E
P
Q
S
K
H
F
S
E
Q
L
L
N
L
T
Site 51
T614
S
E
Q
L
L
N
L
T
L
S
F
L
N
N
Q
Site 52
T644
Q
K
G
V
N
I
L
T
S
Y
I
N
E
L
R
Site 53
S645
K
G
V
N
I
L
T
S
Y
I
N
E
L
R
T
Site 54
Y668
L
T
D
A
I
D
E
Y
D
V
H
E
N
V
P
Site 55
S687
S
N
I
W
K
K
L
S
F
E
E
V
I
A
S
Site 56
T706
N
K
I
P
E
A
Q
T
F
F
R
I
D
S
H
Site 57
S712
Q
T
F
F
R
I
D
S
H
S
A
Q
K
L
E
Site 58
S714
F
F
R
I
D
S
H
S
A
Q
K
L
E
E
L
Site 59
Y762
Q
L
L
K
I
C
F
Y
T
T
N
K
N
I
R
Site 60
Y781
E
I
L
K
E
K
N
Y
F
S
E
K
E
K
R
Site 61
S783
L
K
E
K
N
Y
F
S
E
K
E
K
R
T
I
Site 62
Y800
V
H
Q
V
E
K
L
Y
L
G
H
F
Q
E
N
Site 63
Y816
Q
I
Q
S
F
P
R
Y
W
I
K
E
Q
D
F
Site 64
S828
Q
D
F
F
K
H
K
S
V
L
D
S
F
L
K
Site 65
S832
K
H
K
S
V
L
D
S
F
L
K
Y
D
C
K
Site 66
Y836
V
L
D
S
F
L
K
Y
D
C
K
D
E
F
N
Site 67
S871
S
I
L
L
P
R
I
S
P
E
E
Y
K
S
Y
Site 68
Y875
P
R
I
S
P
E
E
Y
K
S
Y
S
P
E
A
Site 69
S877
I
S
P
E
E
Y
K
S
Y
S
P
E
A
L
W
Site 70
Y878
S
P
E
E
Y
K
S
Y
S
P
E
A
L
W
R
Site 71
S879
P
E
E
Y
K
S
Y
S
P
E
A
L
W
R
Y
Site 72
Y886
S
P
E
A
L
W
R
Y
L
T
A
R
H
D
W
Site 73
S908
G
E
F
Q
T
Q
H
S
Y
A
S
L
Q
Q
N
Site 74
T921
Q
N
K
W
P
L
L
T
V
D
V
I
N
Q
N
Site 75
Y934
Q
N
T
S
C
N
N
Y
M
R
N
E
I
L
D
Site 76
T974
I
G
G
V
I
Q
D
T
L
P
V
Q
N
Y
K
Site 77
Y980
D
T
L
P
V
Q
N
Y
K
T
K
E
G
W
D
Site 78
Y1006
H
S
L
Q
H
L
L
Y
V
Y
L
D
C
Y
K
Site 79
Y1012
L
Y
V
Y
L
D
C
Y
K
L
S
P
E
N
C
Site 80
S1073
P
T
N
Q
A
S
V
S
S
M
L
L
E
G
H
Site 81
T1121
Q
L
L
K
M
A
L
T
P
Y
P
K
L
K
T
Site 82
S1138
F
P
Q
C
T
P
P
S
V
L
P
S
D
I
T
Site 83
S1152
T
I
Y
H
L
I
Q
S
L
S
P
F
D
P
S
Site 84
S1154
Y
H
L
I
Q
S
L
S
P
F
D
P
S
R
L
Site 85
S1159
S
L
S
P
F
D
P
S
R
L
F
G
W
Q
S
Site 86
S1183
W
S
H
L
P
H
F
S
S
P
D
L
V
N
K
Site 87
S1184
S
H
L
P
H
F
S
S
P
D
L
V
N
K
Y
Site 88
Y1191
S
P
D
L
V
N
K
Y
A
I
V
E
R
L
N
Site 89
Y1201
V
E
R
L
N
F
A
Y
Y
L
H
N
G
R
P
Site 90
Y1202
E
R
L
N
F
A
Y
Y
L
H
N
G
R
P
S
Site 91
S1223
L
V
Q
E
L
I
K
S
K
T
P
K
Q
L
I
Site 92
T1225
Q
E
L
I
K
S
K
T
P
K
Q
L
I
Q
Q
Site 93
Y1290
C
R
N
E
D
A
Q
Y
S
F
I
R
E
S
V
Site 94
S1291
R
N
E
D
A
Q
Y
S
F
I
R
E
S
V
A
Site 95
S1296
Q
Y
S
F
I
R
E
S
V
A
E
K
L
S
K
Site 96
S1336
Q
Q
E
I
K
R
L
S
S
E
S
S
S
Q
W
Site 97
S1337
Q
E
I
K
R
L
S
S
E
S
S
S
Q
W
A
Site 98
S1339
I
K
R
L
S
S
E
S
S
S
Q
W
A
L
V
Site 99
S1340
K
R
L
S
S
E
S
S
S
Q
W
A
L
V
V
Site 100
S1341
R
L
S
S
E
S
S
S
Q
W
A
L
V
V
Q
Site 101
S1358
R
L
H
N
M
K
L
S
I
S
Y
L
R
E
C
Site 102
S1360
H
N
M
K
L
S
I
S
Y
L
R
E
C
A
K
Site 103
S1390
Y
H
P
A
E
V
K
S
L
I
Q
Y
F
S
P
Site 104
Y1394
E
V
K
S
L
I
Q
Y
F
S
P
V
I
Q
D
Site 105
S1396
K
S
L
I
Q
Y
F
S
P
V
I
Q
D
H
L
Site 106
S1412
L
A
F
E
N
L
P
S
V
P
T
S
K
M
D
Site 107
S1416
N
L
P
S
V
P
T
S
K
M
D
S
D
Q
V
Site 108
S1449
F
E
I
L
L
Q
C
S
E
E
P
D
S
W
H
Site 109
T1529
V
I
W
R
T
L
L
T
R
Q
K
S
K
T
L
Site 110
S1533
T
L
L
T
R
Q
K
S
K
T
L
I
R
G
F
Site 111
T1535
L
T
R
Q
K
S
K
T
L
I
R
G
F
Q
L
Site 112
Y1565
L
C
M
F
F
R
N
Y
K
E
A
E
A
K
L
Site 113
S1578
K
L
L
E
F
Q
K
S
L
E
T
L
N
T
A
Site 114
T1584
K
S
L
E
T
L
N
T
A
A
T
K
V
H
P
Site 115
T1615
L
M
L
Q
Q
C
K
T
Q
Y
E
L
G
K
L
Site 116
Y1617
L
Q
Q
C
K
T
Q
Y
E
L
G
K
L
L
Q
Site 117
S1634
V
E
R
E
H
L
F
S
D
G
P
D
V
K
K
Site 118
T1709
N
L
V
I
K
E
I
T
Q
E
M
Q
T
L
K
Site 119
T1714
E
I
T
Q
E
M
Q
T
L
K
H
I
E
Q
W
Site 120
S1722
L
K
H
I
E
Q
W
S
L
K
Q
A
R
I
D
Site 121
S1742
H
E
N
F
K
K
N
S
I
S
S
K
A
A
S
Site 122
S1744
N
F
K
K
N
S
I
S
S
K
A
A
S
S
F
Site 123
S1745
F
K
K
N
S
I
S
S
K
A
A
S
S
F
F
Site 124
S1749
S
I
S
S
K
A
A
S
S
F
F
S
T
Q
A
Site 125
S1750
I
S
S
K
A
A
S
S
F
F
S
T
Q
A
H
Site 126
S1768
E
H
P
T
G
W
S
S
M
E
E
R
H
L
L
Site 127
T1810
L
C
R
I
T
Q
H
T
L
G
R
N
Q
E
E
Site 128
T1818
L
G
R
N
Q
E
E
T
E
P
R
F
S
R
Q
Site 129
S1823
E
E
T
E
P
R
F
S
R
Q
I
S
T
S
G
Site 130
S1827
P
R
F
S
R
Q
I
S
T
S
G
E
L
S
F
Site 131
S1829
F
S
R
Q
I
S
T
S
G
E
L
S
F
D
S
Site 132
S1833
I
S
T
S
G
E
L
S
F
D
S
L
A
S
E
Site 133
S1836
S
G
E
L
S
F
D
S
L
A
S
E
F
S
F
Site 134
Y1854
A
A
L
N
T
S
K
Y
L
E
L
N
S
L
P
Site 135
S1859
S
K
Y
L
E
L
N
S
L
P
S
K
E
T
C
Site 136
Y1900
E
A
S
R
V
C
R
Y
F
H
F
Y
N
P
D
Site 137
S1919
L
H
C
R
A
L
A
S
G
E
A
S
M
E
D
Site 138
S1923
A
L
A
S
G
E
A
S
M
E
D
L
H
P
E
Site 139
S1955
I
P
L
R
R
V
H
S
T
S
S
L
D
S
Q
Site 140
T1956
P
L
R
R
V
H
S
T
S
S
L
D
S
Q
K
Site 141
S1957
L
R
R
V
H
S
T
S
S
L
D
S
Q
K
F
Site 142
S1958
R
R
V
H
S
T
S
S
L
D
S
Q
K
F
V
Site 143
S1961
H
S
T
S
S
L
D
S
Q
K
F
V
T
V
P
Site 144
T1966
L
D
S
Q
K
F
V
T
V
P
S
S
N
E
V
Site 145
S1982
T
N
L
E
V
L
T
S
K
C
L
H
G
K
N
Site 146
Y1990
K
C
L
H
G
K
N
Y
C
R
Q
V
L
C
L
Site 147
S2026
M
L
R
K
I
L
A
S
Q
Q
P
D
R
C
K
Site 148
T2048
T
Q
G
L
K
P
D
T
V
A
E
L
V
A
E
Site 149
S2064
V
T
R
E
L
L
T
S
S
Q
G
T
G
H
K
Site 150
S2065
T
R
E
L
L
T
S
S
Q
G
T
G
H
K
Q
Site 151
T2082
N
P
T
E
E
S
Q
T
F
L
Q
L
T
T
L
Site 152
S2105
M
K
L
L
D
K
I
S
S
V
P
H
G
E
L
Site 153
S2106
K
L
L
D
K
I
S
S
V
P
H
G
E
L
S
Site 154
Y2169
L
L
T
G
I
G
R
Y
N
E
M
T
Y
I
F
Site 155
Y2174
G
R
Y
N
E
M
T
Y
I
F
D
L
L
H
K
Site 156
Y2184
D
L
L
H
K
K
H
Y
F
E
V
L
M
R
K
Site 157
T2198
K
K
L
D
P
S
G
T
L
K
T
A
L
L
D
Site 158
Y2206
L
K
T
A
L
L
D
Y
I
K
R
C
R
P
G
Site 159
S2226
N
M
I
A
L
C
F
S
M
C
R
E
I
G
E
Site 160
S2248
I
Q
L
K
L
I
E
S
Q
P
W
E
D
S
L
Site 161
S2254
E
S
Q
P
W
E
D
S
L
K
D
G
H
Q
L
Site 162
S2335
L
P
R
F
Y
Q
A
S
I
V
A
E
A
Y
D
Site 163
Y2352
P
D
W
A
E
I
L
Y
Q
Q
V
I
L
K
G
Site 164
Y2363
I
L
K
G
D
F
N
Y
L
E
E
F
K
Q
Q
Site 165
S2375
K
Q
Q
R
L
L
K
S
S
I
F
E
E
I
S
Site 166
S2376
Q
Q
R
L
L
K
S
S
I
F
E
E
I
S
K
Site 167
S2382
S
S
I
F
E
E
I
S
K
K
Y
K
Q
H
Q
Site 168
T2403
E
N
L
K
K
L
L
T
Y
C
E
D
V
Y
L
Site 169
Y2404
N
L
K
K
L
L
T
Y
C
E
D
V
Y
L
Y
Site 170
Y2411
Y
C
E
D
V
Y
L
Y
Y
K
L
A
Y
E
H
Site 171
Y2412
C
E
D
V
Y
L
Y
Y
K
L
A
Y
E
H
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation