KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TXNDC10
Full Name:
Protein disulfide-isomerase TMX3
Alias:
EC 5.3.4.1; KIAA1830; Protein disulfide-isomerase TXNDC10 precursor; Thioredoxin domain-containing protein 10; Thioredoxin-related transmembrane protein 3; TMX3
Type:
Mass (Da):
51872
Number AA:
454
UniProt ID:
Q96JJ7
International Prot ID:
IPI00064193
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0003756
PhosphoSite+
KinaseNET
Biological Process:
GO:0045454
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
F
V
E
D
L
D
E
S
F
K
E
N
R
N
D
Site 2
S75
L
E
M
K
S
I
G
S
P
V
K
V
G
K
M
Site 3
T85
K
V
G
K
M
D
A
T
S
Y
S
S
I
A
S
Site 4
S86
V
G
K
M
D
A
T
S
Y
S
S
I
A
S
E
Site 5
Y87
G
K
M
D
A
T
S
Y
S
S
I
A
S
E
F
Site 6
S88
K
M
D
A
T
S
Y
S
S
I
A
S
E
F
G
Site 7
S92
T
S
Y
S
S
I
A
S
E
F
G
V
R
G
Y
Site 8
Y99
S
E
F
G
V
R
G
Y
P
T
I
K
L
L
K
Site 9
Y111
L
L
K
G
D
L
A
Y
N
Y
R
G
P
R
T
Site 10
Y113
K
G
D
L
A
Y
N
Y
R
G
P
R
T
K
D
Site 11
S139
A
L
I
R
P
L
P
S
Q
Q
M
F
E
H
M
Site 12
S161
F
V
Y
V
G
G
E
S
P
L
K
E
K
Y
I
Site 13
Y167
E
S
P
L
K
E
K
Y
I
D
A
A
S
E
L
Site 14
S172
E
K
Y
I
D
A
A
S
E
L
I
V
Y
T
Y
Site 15
S184
Y
T
Y
F
F
S
A
S
E
E
V
V
P
E
Y
Site 16
Y191
S
E
E
V
V
P
E
Y
V
T
L
K
E
M
P
Site 17
Y208
L
V
F
K
D
E
T
Y
F
V
Y
D
E
Y
E
Site 18
Y211
K
D
E
T
Y
F
V
Y
D
E
Y
E
D
G
D
Site 19
Y214
T
Y
F
V
Y
D
E
Y
E
D
G
D
L
S
S
Site 20
S220
E
Y
E
D
G
D
L
S
S
W
I
N
R
E
R
Site 21
S221
Y
E
D
G
D
L
S
S
W
I
N
R
E
R
F
Site 22
Y231
N
R
E
R
F
Q
N
Y
L
A
M
D
G
F
L
Site 23
Y240
A
M
D
G
F
L
L
Y
E
L
G
D
T
G
K
Site 24
S260
V
I
D
E
K
N
T
S
V
E
H
T
R
L
K
Site 25
T264
K
N
T
S
V
E
H
T
R
L
K
S
I
I
Q
Site 26
S268
V
E
H
T
R
L
K
S
I
I
Q
E
V
A
R
Site 27
Y277
I
Q
E
V
A
R
D
Y
R
D
L
F
H
R
D
Site 28
Y295
G
H
M
D
G
N
D
Y
I
N
T
L
L
M
D
Site 29
Y319
L
N
T
S
N
Q
Q
Y
F
L
L
D
R
Q
I
Site 30
T343
I
N
N
I
L
D
G
T
V
E
A
Q
G
G
D
Site 31
T401
Y
G
I
Y
T
A
D
T
D
G
G
Y
I
E
E
Site 32
Y405
T
A
D
T
D
G
G
Y
I
E
E
R
Y
E
V
Site 33
Y410
G
G
Y
I
E
E
R
Y
E
V
S
K
S
E
N
Site 34
S415
E
R
Y
E
V
S
K
S
E
N
E
N
Q
E
Q
Site 35
S433
S
K
E
Q
Q
E
P
S
S
G
G
S
V
V
P
Site 36
S434
K
E
Q
Q
E
P
S
S
G
G
S
V
V
P
T
Site 37
S437
Q
E
P
S
S
G
G
S
V
V
P
T
V
Q
E
Site 38
T441
S
G
G
S
V
V
P
T
V
Q
E
P
K
D
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation