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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WDR22
Full Name:
DDB1- and CUL4-associated factor 5
Alias:
BCRG2; BCRP2; Breakpoint cluster region 2; Breakpoint cluster region protein 2; D14S1461E; DDB1 and CUL4 associated factor 5; KIAA1824; WD repeat protein 22
Type:
Unknown function
Mass (Da):
103945
Number AA:
942
UniProt ID:
Q96JK2
International Prot ID:
IPI00382979
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
R
R
A
G
L
G
G
S
M
R
S
V
V
G
F
Site 2
S19
R
S
V
V
G
F
L
S
Q
R
G
L
H
G
D
Site 3
Y45
L
R
G
C
R
N
L
Y
K
K
D
L
L
G
H
Site 4
S71
N
G
G
Q
W
L
V
S
G
G
D
D
R
R
V
Site 5
S118
S
G
N
T
K
V
F
S
G
G
N
D
E
Q
V
Site 6
T135
H
D
V
E
S
S
E
T
L
D
V
F
A
H
E
Site 7
S149
E
D
A
V
Y
G
L
S
V
S
P
V
N
D
N
Site 8
S160
V
N
D
N
I
F
A
S
S
S
D
D
G
R
V
Site 9
S162
D
N
I
F
A
S
S
S
D
D
G
R
V
L
I
Site 10
S208
R
L
L
A
T
A
N
S
K
E
G
V
G
L
W
Site 11
S222
W
D
I
R
K
P
Q
S
S
L
L
R
Y
G
G
Site 12
S223
D
I
R
K
P
Q
S
S
L
L
R
Y
G
G
N
Site 13
Y227
P
Q
S
S
L
L
R
Y
G
G
N
L
S
L
Q
Site 14
S235
G
G
N
L
S
L
Q
S
A
M
S
V
R
F
N
Site 15
S238
L
S
L
Q
S
A
M
S
V
R
F
N
S
N
G
Site 16
Y260
R
R
L
P
P
V
L
Y
D
I
H
S
R
L
P
Site 17
Y276
F
Q
F
D
N
Q
G
Y
F
N
S
C
T
M
K
Site 18
Y294
F
A
G
D
R
D
Q
Y
I
L
S
G
S
D
D
Site 19
S297
D
R
D
Q
Y
I
L
S
G
S
D
D
F
N
L
Site 20
S299
D
Q
Y
I
L
S
G
S
D
D
F
N
L
Y
M
Site 21
Y305
G
S
D
D
F
N
L
Y
M
W
R
I
P
A
D
Site 22
S334
M
V
L
K
G
H
R
S
I
V
N
Q
V
R
F
Site 23
T345
Q
V
R
F
N
P
H
T
Y
M
I
C
S
S
G
Site 24
Y363
I
I
K
I
W
S
P
Y
K
Q
P
G
C
T
G
Site 25
S380
D
G
R
I
E
D
D
S
R
C
L
Y
T
H
E
Site 26
Y384
E
D
D
S
R
C
L
Y
T
H
E
E
Y
I
S
Site 27
S391
Y
T
H
E
E
Y
I
S
L
V
L
N
S
G
S
Site 28
S401
L
N
S
G
S
G
L
S
H
D
Y
A
N
Q
S
Site 29
Y404
G
S
G
L
S
H
D
Y
A
N
Q
S
V
Q
E
Site 30
S408
S
H
D
Y
A
N
Q
S
V
Q
E
D
P
R
M
Site 31
S421
R
M
M
A
F
F
D
S
L
V
R
R
E
I
E
Site 32
S431
R
R
E
I
E
G
W
S
S
D
S
D
S
D
L
Site 33
S432
R
E
I
E
G
W
S
S
D
S
D
S
D
L
S
Site 34
S434
I
E
G
W
S
S
D
S
D
S
D
L
S
E
S
Site 35
S436
G
W
S
S
D
S
D
S
D
L
S
E
S
T
I
Site 36
S439
S
D
S
D
S
D
L
S
E
S
T
I
L
Q
L
Site 37
S451
L
Q
L
H
A
G
V
S
E
R
S
G
Y
T
D
Site 38
Y456
G
V
S
E
R
S
G
Y
T
D
S
E
S
S
A
Site 39
T457
V
S
E
R
S
G
Y
T
D
S
E
S
S
A
S
Site 40
S459
E
R
S
G
Y
T
D
S
E
S
S
A
S
L
P
Site 41
S461
S
G
Y
T
D
S
E
S
S
A
S
L
P
R
S
Site 42
S464
T
D
S
E
S
S
A
S
L
P
R
S
P
P
P
Site 43
S468
S
S
A
S
L
P
R
S
P
P
P
T
V
D
E
Site 44
T472
L
P
R
S
P
P
P
T
V
D
E
S
A
D
N
Site 45
S476
P
P
P
T
V
D
E
S
A
D
N
A
F
H
L
Site 46
T489
H
L
G
P
L
R
V
T
T
T
N
T
V
A
S
Site 47
T491
G
P
L
R
V
T
T
T
N
T
V
A
S
T
P
Site 48
T493
L
R
V
T
T
T
N
T
V
A
S
T
P
P
T
Site 49
S496
T
T
T
N
T
V
A
S
T
P
P
T
P
T
C
Site 50
T497
T
T
N
T
V
A
S
T
P
P
T
P
T
C
E
Site 51
T500
T
V
A
S
T
P
P
T
P
T
C
E
D
A
A
Site 52
S508
P
T
C
E
D
A
A
S
R
Q
Q
R
L
S
A
Site 53
S514
A
S
R
Q
Q
R
L
S
A
L
R
R
Y
Q
D
Site 54
Y519
R
L
S
A
L
R
R
Y
Q
D
K
R
L
L
A
Site 55
S528
D
K
R
L
L
A
L
S
N
E
S
D
S
E
E
Site 56
S531
L
L
A
L
S
N
E
S
D
S
E
E
N
V
C
Site 57
S533
A
L
S
N
E
S
D
S
E
E
N
V
C
E
V
Site 58
S552
D
L
F
P
R
P
R
S
P
S
P
E
D
E
S
Site 59
S554
F
P
R
P
R
S
P
S
P
E
D
E
S
S
S
Site 60
S559
S
P
S
P
E
D
E
S
S
S
S
S
S
S
S
Site 61
S560
P
S
P
E
D
E
S
S
S
S
S
S
S
S
S
Site 62
S561
S
P
E
D
E
S
S
S
S
S
S
S
S
S
S
Site 63
S562
P
E
D
E
S
S
S
S
S
S
S
S
S
S
E
Site 64
S563
E
D
E
S
S
S
S
S
S
S
S
S
S
E
D
Site 65
S564
D
E
S
S
S
S
S
S
S
S
S
S
E
D
E
Site 66
S565
E
S
S
S
S
S
S
S
S
S
S
E
D
E
E
Site 67
S566
S
S
S
S
S
S
S
S
S
S
E
D
E
E
E
Site 68
S567
S
S
S
S
S
S
S
S
S
E
D
E
E
E
L
Site 69
S568
S
S
S
S
S
S
S
S
E
D
E
E
E
L
N
Site 70
S580
E
L
N
E
R
R
A
S
T
W
Q
R
N
A
M
Site 71
T581
L
N
E
R
R
A
S
T
W
Q
R
N
A
M
R
Site 72
T593
A
M
R
R
R
Q
K
T
T
R
E
D
K
P
S
Site 73
T594
M
R
R
R
Q
K
T
T
R
E
D
K
P
S
A
Site 74
S600
T
T
R
E
D
K
P
S
A
P
I
K
P
T
N
Site 75
Y615
T
Y
I
G
E
D
N
Y
D
Y
P
Q
I
K
V
Site 76
Y617
I
G
E
D
N
Y
D
Y
P
Q
I
K
V
D
D
Site 77
S626
Q
I
K
V
D
D
L
S
S
S
P
T
S
S
P
Site 78
S627
I
K
V
D
D
L
S
S
S
P
T
S
S
P
E
Site 79
S628
K
V
D
D
L
S
S
S
P
T
S
S
P
E
R
Site 80
T630
D
D
L
S
S
S
P
T
S
S
P
E
R
S
T
Site 81
S631
D
L
S
S
S
P
T
S
S
P
E
R
S
T
S
Site 82
S632
L
S
S
S
P
T
S
S
P
E
R
S
T
S
T
Site 83
S636
P
T
S
S
P
E
R
S
T
S
T
L
E
I
Q
Site 84
T637
T
S
S
P
E
R
S
T
S
T
L
E
I
Q
P
Site 85
S638
S
S
P
E
R
S
T
S
T
L
E
I
Q
P
S
Site 86
T639
S
P
E
R
S
T
S
T
L
E
I
Q
P
S
R
Site 87
S645
S
T
L
E
I
Q
P
S
R
A
S
P
T
S
D
Site 88
S648
E
I
Q
P
S
R
A
S
P
T
S
D
I
E
S
Site 89
S651
P
S
R
A
S
P
T
S
D
I
E
S
V
E
R
Site 90
S655
S
P
T
S
D
I
E
S
V
E
R
K
I
Y
K
Site 91
Y661
E
S
V
E
R
K
I
Y
K
A
Y
K
W
L
R
Site 92
Y669
K
A
Y
K
W
L
R
Y
S
Y
I
S
Y
S
N
Site 93
Y671
Y
K
W
L
R
Y
S
Y
I
S
Y
S
N
N
K
Site 94
Y674
L
R
Y
S
Y
I
S
Y
S
N
N
K
D
G
E
Site 95
S675
R
Y
S
Y
I
S
Y
S
N
N
K
D
G
E
T
Site 96
T682
S
N
N
K
D
G
E
T
S
L
V
T
G
E
A
Site 97
T696
A
D
E
G
R
A
G
T
S
H
K
D
N
P
A
Site 98
S705
H
K
D
N
P
A
P
S
S
S
K
E
A
C
L
Site 99
S706
K
D
N
P
A
P
S
S
S
K
E
A
C
L
N
Site 100
S707
D
N
P
A
P
S
S
S
K
E
A
C
L
N
I
Site 101
T732
P
E
G
C
S
K
D
T
F
K
E
E
T
P
R
Site 102
T737
K
D
T
F
K
E
E
T
P
R
T
P
S
N
G
Site 103
T740
F
K
E
E
T
P
R
T
P
S
N
G
P
G
H
Site 104
S742
E
E
T
P
R
T
P
S
N
G
P
G
H
E
H
Site 105
S750
N
G
P
G
H
E
H
S
S
H
A
W
A
E
V
Site 106
T765
P
E
G
T
S
Q
D
T
G
N
S
G
S
V
E
Site 107
S770
Q
D
T
G
N
S
G
S
V
E
H
P
F
E
T
Site 108
S786
K
L
N
G
K
A
L
S
S
R
A
E
E
P
P
Site 109
S794
S
R
A
E
E
P
P
S
P
P
V
P
K
A
S
Site 110
S801
S
P
P
V
P
K
A
S
G
S
T
L
N
S
G
Site 111
S803
P
V
P
K
A
S
G
S
T
L
N
S
G
S
G
Site 112
S807
A
S
G
S
T
L
N
S
G
S
G
N
C
P
R
Site 113
T815
G
S
G
N
C
P
R
T
Q
S
D
D
S
E
E
Site 114
S817
G
N
C
P
R
T
Q
S
D
D
S
E
E
R
S
Site 115
S820
P
R
T
Q
S
D
D
S
E
E
R
S
L
E
T
Site 116
S824
S
D
D
S
E
E
R
S
L
E
T
I
C
A
N
Site 117
Y859
G
E
L
E
V
V
A
Y
S
S
P
G
H
S
D
Site 118
S860
E
L
E
V
V
A
Y
S
S
P
G
H
S
D
T
Site 119
S861
L
E
V
V
A
Y
S
S
P
G
H
S
D
T
D
Site 120
S865
A
Y
S
S
P
G
H
S
D
T
D
R
D
N
S
Site 121
T867
S
S
P
G
H
S
D
T
D
R
D
N
S
S
L
Site 122
S872
S
D
T
D
R
D
N
S
S
L
T
G
T
L
L
Site 123
S873
D
T
D
R
D
N
S
S
L
T
G
T
L
L
H
Site 124
T877
D
N
S
S
L
T
G
T
L
L
H
K
D
C
C
Site 125
T892
G
S
E
M
A
C
E
T
P
N
A
G
T
R
E
Site 126
T902
A
G
T
R
E
D
P
T
D
T
P
A
T
D
S
Site 127
T904
T
R
E
D
P
T
D
T
P
A
T
D
S
S
R
Site 128
S909
T
D
T
P
A
T
D
S
S
R
A
V
H
G
H
Site 129
S910
D
T
P
A
T
D
S
S
R
A
V
H
G
H
S
Site 130
T929
Q
R
I
E
L
E
D
T
D
S
E
N
S
S
S
Site 131
S931
I
E
L
E
D
T
D
S
E
N
S
S
S
E
K
Site 132
S935
D
T
D
S
E
N
S
S
S
E
K
K
L
K
T
Site 133
S936
T
D
S
E
N
S
S
S
E
K
K
L
K
T
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation