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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRRIQ1
Full Name:
Leucine-rich repeat and IQ domain-containing protein 1
Alias:
Type:
Mass (Da):
154705
Number AA:
1336
UniProt ID:
Q96JM4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
E
A
E
L
D
K
L
S
I
S
S
L
E
K
E
Site 2
S31
L
E
K
E
D
I
E
S
D
A
K
S
E
T
Q
Site 3
S35
D
I
E
S
D
A
K
S
E
T
Q
S
D
D
S
Site 4
S39
D
A
K
S
E
T
Q
S
D
D
S
D
T
D
S
Site 5
S42
S
E
T
Q
S
D
D
S
D
T
D
S
V
E
L
Site 6
T44
T
Q
S
D
D
S
D
T
D
S
V
E
L
P
E
Site 7
S46
S
D
D
S
D
T
D
S
V
E
L
P
E
S
V
Site 8
T78
I
L
Q
D
L
E
D
T
D
I
L
S
C
S
Y
Site 9
Y85
T
D
I
L
S
C
S
Y
G
A
V
S
N
N
H
Site 10
S100
M
H
L
R
T
G
L
S
T
E
Y
E
E
S
S
Site 11
T101
H
L
R
T
G
L
S
T
E
Y
E
E
S
S
E
Site 12
Y103
R
T
G
L
S
T
E
Y
E
E
S
S
E
Q
L
Site 13
S106
L
S
T
E
Y
E
E
S
S
E
Q
L
I
K
I
Site 14
S107
S
T
E
Y
E
E
S
S
E
Q
L
I
K
I
L
Site 15
S115
E
Q
L
I
K
I
L
S
E
I
E
K
E
E
F
Site 16
T127
E
E
F
M
R
S
K
T
D
C
A
T
P
D
F
Site 17
T131
R
S
K
T
D
C
A
T
P
D
F
V
P
E
P
Site 18
S139
P
D
F
V
P
E
P
S
P
H
D
L
P
M
D
Site 19
Y160
D
A
D
I
N
F
G
Y
C
E
V
E
E
K
C
Site 20
S170
V
E
E
K
C
R
Q
S
F
E
A
W
Q
E
K
Site 21
Y237
D
K
M
N
D
E
L
Y
K
E
E
K
I
W
K
Site 22
Y253
K
F
K
Q
H
E
E
Y
I
R
N
L
H
L
Q
Site 23
Y300
K
Y
K
A
F
V
A
Y
Q
K
Y
G
P
I
I
Site 24
Y303
A
F
V
A
Y
Q
K
Y
G
P
I
I
K
E
Q
Site 25
S313
I
I
K
E
Q
I
E
S
K
K
R
K
A
Q
E
Site 26
Y364
R
K
R
R
E
K
E
Y
E
E
K
K
N
I
V
Site 27
S380
Q
E
R
E
Q
L
I
S
K
E
K
I
I
L
R
Site 28
S397
A
S
Q
Q
L
I
I
S
S
A
L
K
K
S
G
Site 29
S398
S
Q
Q
L
I
I
S
S
A
L
K
K
S
G
Y
Site 30
S403
I
S
S
A
L
K
K
S
G
Y
N
N
K
H
L
Site 31
Y405
S
A
L
K
K
S
G
Y
N
N
K
H
L
S
L
Site 32
S411
G
Y
N
N
K
H
L
S
L
E
D
I
S
N
D
Site 33
S431
K
N
L
V
D
E
N
S
K
K
Q
E
D
V
L
Site 34
T455
K
E
N
V
D
R
Q
T
I
L
K
E
S
I
Q
Site 35
S470
V
K
L
K
E
S
I
S
S
Q
T
I
L
A
D
Site 36
S471
K
L
K
E
S
I
S
S
Q
T
I
L
A
D
F
Site 37
S493
N
L
A
K
K
R
C
S
E
E
L
V
K
Q
E
Site 38
Y503
L
V
K
Q
E
R
K
Y
E
N
T
D
N
K
T
Site 39
T506
Q
E
R
K
Y
E
N
T
D
N
K
T
E
L
G
Site 40
T510
Y
E
N
T
D
N
K
T
E
L
G
N
S
D
L
Site 41
S515
N
K
T
E
L
G
N
S
D
L
K
G
N
L
K
Site 42
S532
F
P
L
Q
E
L
K
S
D
A
Q
K
E
E
K
Site 43
T553
N
E
N
T
G
Q
K
T
Q
I
I
L
G
H
N
Site 44
S564
L
G
H
N
Q
E
I
S
E
V
K
T
N
E
E
Site 45
T568
Q
E
I
S
E
V
K
T
N
E
E
Q
K
I
I
Site 46
T604
L
L
Y
K
D
K
D
T
L
V
I
S
V
K
Q
Site 47
S608
D
K
D
T
L
V
I
S
V
K
Q
R
S
L
S
Site 48
S613
V
I
S
V
K
Q
R
S
L
S
L
T
S
E
N
Site 49
S615
S
V
K
Q
R
S
L
S
L
T
S
E
N
S
K
Site 50
T617
K
Q
R
S
L
S
L
T
S
E
N
S
K
D
V
Site 51
S621
L
S
L
T
S
E
N
S
K
D
V
R
E
N
V
Site 52
Y636
I
L
Q
E
K
E
I
Y
S
K
S
K
E
I
E
Site 53
S639
E
K
E
I
Y
S
K
S
K
E
I
E
E
N
P
Site 54
Y676
G
K
R
N
D
Q
D
Y
V
L
G
R
H
A
P
Site 55
S688
H
A
P
C
E
G
L
S
N
Y
N
A
E
S
S
Site 56
Y690
P
C
E
G
L
S
N
Y
N
A
E
S
S
M
V
Site 57
S694
L
S
N
Y
N
A
E
S
S
M
V
S
K
E
V
Site 58
S695
S
N
Y
N
A
E
S
S
M
V
S
K
E
V
N
Site 59
S698
N
A
E
S
S
M
V
S
K
E
V
N
S
L
K
Site 60
S703
M
V
S
K
E
V
N
S
L
K
S
E
I
R
N
Site 61
S706
K
E
V
N
S
L
K
S
E
I
R
N
I
S
E
Site 62
S712
K
S
E
I
R
N
I
S
E
K
C
H
E
N
A
Site 63
S724
E
N
A
P
E
P
D
S
M
T
C
C
V
S
E
Site 64
T726
A
P
E
P
D
S
M
T
C
C
V
S
E
S
T
Site 65
Y736
V
S
E
S
T
L
L
Y
S
I
E
E
R
R
L
Site 66
S737
S
E
S
T
L
L
Y
S
I
E
E
R
R
L
A
Site 67
T778
V
K
C
P
A
N
M
T
P
A
L
D
K
L
E
Site 68
T794
L
R
C
G
P
W
D
T
L
Q
Q
V
T
T
V
Site 69
T800
D
T
L
Q
Q
V
T
T
V
T
F
Q
D
L
P
Site 70
T831
S
L
R
R
C
G
L
T
S
L
H
S
L
S
N
Site 71
S832
L
R
R
C
G
L
T
S
L
H
S
L
S
N
C
Site 72
S835
C
G
L
T
S
L
H
S
L
S
N
C
K
K
L
Site 73
S837
L
T
S
L
H
S
L
S
N
C
K
K
L
K
Y
Site 74
Y844
S
N
C
K
K
L
K
Y
I
D
A
Q
E
N
H
Site 75
Y900
N
K
I
T
R
I
G
Y
S
F
F
L
E
E
K
Site 76
S901
K
I
T
R
I
G
Y
S
F
F
L
E
E
K
L
Site 77
T922
C
H
H
L
G
T
S
T
S
Y
L
S
L
A
Q
Site 78
S923
H
H
L
G
T
S
T
S
Y
L
S
L
A
Q
V
Site 79
T990
N
T
K
G
L
C
D
T
P
T
I
V
Y
L
D
Site 80
S1026
K
L
Q
G
N
Y
L
S
E
L
P
S
L
E
N
Site 81
S1046
E
L
H
L
D
D
N
S
I
S
T
V
E
A
F
Site 82
T1049
L
D
D
N
S
I
S
T
V
E
A
F
S
S
Y
Site 83
S1089
S
L
E
K
L
D
V
S
H
N
C
L
S
D
L
Site 84
S1094
D
V
S
H
N
C
L
S
D
L
K
S
A
I
K
Site 85
T1115
S
L
H
E
L
S
L
T
G
N
P
L
L
Q
E
Site 86
T1123
G
N
P
L
L
Q
E
T
N
W
R
D
S
L
L
Site 87
S1128
Q
E
T
N
W
R
D
S
L
L
K
V
L
P
A
Site 88
S1146
L
N
G
N
I
L
N
S
N
S
E
S
R
T
E
Site 89
S1148
G
N
I
L
N
S
N
S
E
S
R
T
E
E
H
Site 90
S1150
I
L
N
S
N
S
E
S
R
T
E
E
H
N
Q
Site 91
T1152
N
S
N
S
E
S
R
T
E
E
H
N
Q
L
G
Site 92
T1190
T
G
K
G
D
V
F
T
L
D
T
A
E
N
L
Site 93
T1193
G
D
V
F
T
L
D
T
A
E
N
L
C
H
Y
Site 94
T1209
K
K
L
M
I
L
S
T
E
Y
R
H
A
H
E
Site 95
T1221
A
H
E
R
G
D
V
T
I
T
K
K
D
E
S
Site 96
S1228
T
I
T
K
K
D
E
S
E
A
Q
K
N
H
L
Site 97
T1238
Q
K
N
H
L
A
P
T
N
S
D
S
T
L
Q
Site 98
S1240
N
H
L
A
P
T
N
S
D
S
T
L
Q
N
G
Site 99
S1242
L
A
P
T
N
S
D
S
T
L
Q
N
G
V
F
Site 100
T1243
A
P
T
N
S
D
S
T
L
Q
N
G
V
F
Y
Site 101
S1251
L
Q
N
G
V
F
Y
S
C
A
R
E
G
E
P
Site 102
S1260
A
R
E
G
E
P
D
S
P
D
I
P
E
K
W
Site 103
S1270
I
P
E
K
W
M
D
S
V
S
S
H
S
P
L
Site 104
S1272
E
K
W
M
D
S
V
S
S
H
S
P
L
S
K
Site 105
S1273
K
W
M
D
S
V
S
S
H
S
P
L
S
K
S
Site 106
S1275
M
D
S
V
S
S
H
S
P
L
S
K
S
A
T
Site 107
S1278
V
S
S
H
S
P
L
S
K
S
A
T
C
E
N
Site 108
S1280
S
H
S
P
L
S
K
S
A
T
C
E
N
M
E
Site 109
T1282
S
P
L
S
K
S
A
T
C
E
N
M
E
G
R
Site 110
S1302
V
C
Q
K
R
E
D
S
K
A
S
S
I
P
T
Site 111
S1306
R
E
D
S
K
A
S
S
I
P
T
I
R
I
P
Site 112
T1309
S
K
A
S
S
I
P
T
I
R
I
P
F
K
E
Site 113
T1320
P
F
K
E
V
V
M
T
N
S
L
L
R
N
H
Site 114
S1322
K
E
V
V
M
T
N
S
L
L
R
N
H
Q
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation