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Updated November 2019
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Protein Info
Short Name:
CCDC136
Full Name:
Coiled-coil domain-containing protein 136
Alias:
CC136; Coiled-coil domain containing 136; DKFZP434G156; KIAA1793; NAG6; Nasopharyngeal carcinoma-associated gene 6 protein
Type:
Mitochondrial; Membrane protein, integral
Mass (Da):
134046
Number AA:
1154
UniProt ID:
Q96JN2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
E
V
L
L
P
A
L
Y
E
E
E
E
E
E
E
Site 2
S39
E
Q
V
Q
K
G
G
S
V
G
S
L
S
V
N
Site 3
S42
Q
K
G
G
S
V
G
S
L
S
V
N
K
H
R
Site 4
S44
G
G
S
V
G
S
L
S
V
N
K
H
R
G
L
Site 5
S52
V
N
K
H
R
G
L
S
L
T
E
T
E
L
E
Site 6
T54
K
H
R
G
L
S
L
T
E
T
E
L
E
E
L
Site 7
T56
R
G
L
S
L
T
E
T
E
L
E
E
L
R
A
Site 8
T75
L
V
A
E
L
E
E
T
R
E
L
A
G
Q
H
Site 9
S86
A
G
Q
H
E
D
D
S
L
E
L
Q
G
L
L
Site 10
S100
L
E
D
E
R
L
A
S
A
Q
Q
A
E
V
F
Site 11
T108
A
Q
Q
A
E
V
F
T
K
Q
I
Q
Q
L
Q
Site 12
S120
Q
L
Q
G
E
L
R
S
L
R
E
E
I
S
L
Site 13
S126
R
S
L
R
E
E
I
S
L
L
E
H
E
K
E
Site 14
S152
L
A
Q
A
E
I
Q
S
L
R
Q
A
A
E
D
Site 15
S160
L
R
Q
A
A
E
D
S
A
T
E
H
E
S
D
Site 16
T162
Q
A
A
E
D
S
A
T
E
H
E
S
D
I
A
Site 17
S166
D
S
A
T
E
H
E
S
D
I
A
S
L
Q
E
Site 18
S170
E
H
E
S
D
I
A
S
L
Q
E
D
L
C
R
Site 19
Y192
M
E
R
I
R
G
D
Y
E
M
E
I
A
S
L
Site 20
S198
D
Y
E
M
E
I
A
S
L
R
A
E
M
E
M
Site 21
S207
R
A
E
M
E
M
K
S
S
E
P
S
G
S
L
Site 22
S208
A
E
M
E
M
K
S
S
E
P
S
G
S
L
G
Site 23
S211
E
M
K
S
S
E
P
S
G
S
L
G
L
S
D
Site 24
S213
K
S
S
E
P
S
G
S
L
G
L
S
D
Y
S
Site 25
S217
P
S
G
S
L
G
L
S
D
Y
S
G
L
Q
E
Site 26
Y219
G
S
L
G
L
S
D
Y
S
G
L
Q
E
E
L
Site 27
Y233
L
Q
E
L
R
E
R
Y
H
F
L
N
E
E
Y
Site 28
S246
E
Y
R
A
L
Q
E
S
N
S
S
L
T
G
Q
Site 29
S248
R
A
L
Q
E
S
N
S
S
L
T
G
Q
L
A
Site 30
S249
A
L
Q
E
S
N
S
S
L
T
G
Q
L
A
D
Site 31
S259
G
Q
L
A
D
L
E
S
E
R
T
Q
R
A
T
Site 32
T262
A
D
L
E
S
E
R
T
Q
R
A
T
E
R
W
Site 33
T266
S
E
R
T
Q
R
A
T
E
R
W
L
Q
S
Q
Site 34
S272
A
T
E
R
W
L
Q
S
Q
T
L
S
M
T
S
Site 35
T274
E
R
W
L
Q
S
Q
T
L
S
M
T
S
A
E
Site 36
S276
W
L
Q
S
Q
T
L
S
M
T
S
A
E
S
Q
Site 37
T278
Q
S
Q
T
L
S
M
T
S
A
E
S
Q
T
S
Site 38
S279
S
Q
T
L
S
M
T
S
A
E
S
Q
T
S
E
Site 39
S282
L
S
M
T
S
A
E
S
Q
T
S
E
M
D
F
Site 40
S285
T
S
A
E
S
Q
T
S
E
M
D
F
L
E
P
Site 41
S334
L
Q
H
H
R
Q
V
S
E
E
E
Q
R
R
L
Site 42
T357
N
E
V
L
R
F
Q
T
S
H
S
V
T
Q
N
Site 43
S358
E
V
L
R
F
Q
T
S
H
S
V
T
Q
N
E
Site 44
S360
L
R
F
Q
T
S
H
S
V
T
Q
N
E
E
L
Site 45
T362
F
Q
T
S
H
S
V
T
Q
N
E
E
L
K
S
Site 46
S369
T
Q
N
E
E
L
K
S
R
L
C
T
L
Q
K
Site 47
T373
E
L
K
S
R
L
C
T
L
Q
K
K
Y
D
T
Site 48
T380
T
L
Q
K
K
Y
D
T
S
Q
D
E
Q
N
E
Site 49
S381
L
Q
K
K
Y
D
T
S
Q
D
E
Q
N
E
L
Site 50
S407
R
Q
L
K
V
M
K
S
T
L
V
E
N
Q
S
Site 51
S414
S
T
L
V
E
N
Q
S
E
K
E
L
L
C
R
Site 52
T463
E
L
Q
H
L
R
D
T
V
A
S
F
K
E
S
Site 53
S466
H
L
R
D
T
V
A
S
F
K
E
S
N
E
K
Site 54
S470
T
V
A
S
F
K
E
S
N
E
K
D
T
E
T
Site 55
T477
S
N
E
K
D
T
E
T
H
A
Q
L
Q
E
M
Site 56
Y488
L
Q
E
M
K
Q
L
Y
Q
A
S
K
D
E
L
Site 57
Y502
L
E
R
Q
K
H
M
Y
D
Q
L
E
Q
D
L
Site 58
S522
E
L
K
E
L
K
A
S
H
P
I
P
E
D
K
Site 59
T538
K
C
A
N
K
C
D
T
L
L
S
R
L
T
E
Site 60
S541
N
K
C
D
T
L
L
S
R
L
T
E
L
Q
E
Site 61
T544
D
T
L
L
S
R
L
T
E
L
Q
E
K
Y
K
Site 62
S553
L
Q
E
K
Y
K
A
S
Q
K
E
M
G
Q
L
Site 63
T589
Q
E
E
L
H
R
L
T
L
P
L
P
K
S
G
Site 64
S595
L
T
L
P
L
P
K
S
G
L
L
L
K
S
Q
Site 65
S601
K
S
G
L
L
L
K
S
Q
E
L
L
T
K
L
Site 66
Y618
L
C
E
L
Q
L
L
Y
Q
G
M
Q
E
E
Q
Site 67
S652
E
L
R
R
F
K
E
S
H
F
Q
E
V
L
E
Site 68
S664
V
L
E
N
P
D
D
S
K
L
A
K
S
S
K
Site 69
S669
D
D
S
K
L
A
K
S
S
K
C
N
R
N
K
Site 70
S736
L
L
Q
V
Q
S
P
S
I
K
M
S
L
E
S
Site 71
S740
Q
S
P
S
I
K
M
S
L
E
S
Y
G
K
S
Site 72
S743
S
I
K
M
S
L
E
S
Y
G
K
S
Y
G
S
Site 73
Y744
I
K
M
S
L
E
S
Y
G
K
S
Y
G
S
M
Site 74
S747
S
L
E
S
Y
G
K
S
Y
G
S
M
V
P
S
Site 75
Y748
L
E
S
Y
G
K
S
Y
G
S
M
V
P
S
N
Site 76
S750
S
Y
G
K
S
Y
G
S
M
V
P
S
N
E
N
Site 77
S754
S
Y
G
S
M
V
P
S
N
E
N
C
R
K
T
Site 78
T761
S
N
E
N
C
R
K
T
Y
D
T
T
V
D
D
Site 79
Y762
N
E
N
C
R
K
T
Y
D
T
T
V
D
D
N
Site 80
T764
N
C
R
K
T
Y
D
T
T
V
D
D
N
E
S
Site 81
T765
C
R
K
T
Y
D
T
T
V
D
D
N
E
S
Y
Site 82
S771
T
T
V
D
D
N
E
S
Y
Y
K
S
Y
T
S
Site 83
Y772
T
V
D
D
N
E
S
Y
Y
K
S
Y
T
S
T
Site 84
Y773
V
D
D
N
E
S
Y
Y
K
S
Y
T
S
T
Q
Site 85
S775
D
N
E
S
Y
Y
K
S
Y
T
S
T
Q
T
S
Site 86
T777
E
S
Y
Y
K
S
Y
T
S
T
Q
T
S
S
K
Site 87
S778
S
Y
Y
K
S
Y
T
S
T
Q
T
S
S
K
S
Site 88
T779
Y
Y
K
S
Y
T
S
T
Q
T
S
S
K
S
F
Site 89
T781
K
S
Y
T
S
T
Q
T
S
S
K
S
F
L
K
Site 90
S782
S
Y
T
S
T
Q
T
S
S
K
S
F
L
K
S
Site 91
S783
Y
T
S
T
Q
T
S
S
K
S
F
L
K
S
Y
Site 92
S785
S
T
Q
T
S
S
K
S
F
L
K
S
Y
D
S
Site 93
S789
S
S
K
S
F
L
K
S
Y
D
S
S
T
S
A
Site 94
Y790
S
K
S
F
L
K
S
Y
D
S
S
T
S
A
S
Site 95
S792
S
F
L
K
S
Y
D
S
S
T
S
A
S
E
A
Site 96
S793
F
L
K
S
Y
D
S
S
T
S
A
S
E
A
Y
Site 97
T794
L
K
S
Y
D
S
S
T
S
A
S
E
A
Y
G
Site 98
S795
K
S
Y
D
S
S
T
S
A
S
E
A
Y
G
K
Site 99
S797
Y
D
S
S
T
S
A
S
E
A
Y
G
K
S
Y
Site 100
S803
A
S
E
A
Y
G
K
S
Y
C
T
T
S
N
S
Site 101
Y804
S
E
A
Y
G
K
S
Y
C
T
T
S
N
S
S
Site 102
T806
A
Y
G
K
S
Y
C
T
T
S
N
S
S
I
T
Site 103
T807
Y
G
K
S
Y
C
T
T
S
N
S
S
I
T
Y
Site 104
S808
G
K
S
Y
C
T
T
S
N
S
S
I
T
Y
K
Site 105
S810
S
Y
C
T
T
S
N
S
S
I
T
Y
K
K
S
Site 106
T813
T
T
S
N
S
S
I
T
Y
K
K
S
Y
G
S
Site 107
Y814
T
S
N
S
S
I
T
Y
K
K
S
Y
G
S
T
Site 108
S817
S
S
I
T
Y
K
K
S
Y
G
S
T
S
S
S
Site 109
Y818
S
I
T
Y
K
K
S
Y
G
S
T
S
S
S
D
Site 110
S820
T
Y
K
K
S
Y
G
S
T
S
S
S
D
T
C
Site 111
T821
Y
K
K
S
Y
G
S
T
S
S
S
D
T
C
Q
Site 112
S822
K
K
S
Y
G
S
T
S
S
S
D
T
C
Q
K
Site 113
S824
S
Y
G
S
T
S
S
S
D
T
C
Q
K
S
F
Site 114
T826
G
S
T
S
S
S
D
T
C
Q
K
S
F
V
S
Site 115
S830
S
S
D
T
C
Q
K
S
F
V
S
S
C
T
D
Site 116
S834
C
Q
K
S
F
V
S
S
C
T
D
E
E
P
A
Site 117
S870
V
Q
A
M
Y
Q
I
S
Q
E
E
H
S
Q
L
Site 118
T927
N
E
I
K
E
L
Q
T
K
L
R
E
L
Q
L
Site 119
S939
L
Q
L
Q
Y
Q
A
S
M
D
E
Q
G
R
L
Site 120
S973
Q
L
R
E
K
R
P
S
V
V
K
E
A
R
G
Site 121
S1004
K
K
V
T
K
P
C
S
D
T
S
E
S
D
L
Site 122
T1006
V
T
K
P
C
S
D
T
S
E
S
D
L
E
T
Site 123
S1007
T
K
P
C
S
D
T
S
E
S
D
L
E
T
R
Site 124
S1009
P
C
S
D
T
S
E
S
D
L
E
T
R
K
S
Site 125
T1013
T
S
E
S
D
L
E
T
R
K
S
L
E
V
V
Site 126
S1016
S
D
L
E
T
R
K
S
L
E
V
V
L
Y
Y
Site 127
Y1022
K
S
L
E
V
V
L
Y
Y
K
A
S
Q
R
K
Site 128
S1026
V
V
L
Y
Y
K
A
S
Q
R
K
L
D
G
L
Site 129
S1074
A
D
P
E
E
A
K
S
T
E
D
Q
E
E
N
Site 130
T1075
D
P
E
E
A
K
S
T
E
D
Q
E
E
N
E
Site 131
S1094
E
E
E
K
E
E
D
S
E
E
E
E
D
D
A
Site 132
S1103
E
E
E
D
D
A
D
S
S
L
E
S
P
E
E
Site 133
S1104
E
E
D
D
A
D
S
S
L
E
S
P
E
E
N
Site 134
S1107
D
A
D
S
S
L
E
S
P
E
E
N
N
P
L
Site 135
S1117
E
N
N
P
L
R
L
S
E
S
K
K
S
S
P
Site 136
S1119
N
P
L
R
L
S
E
S
K
K
S
S
P
T
P
Site 137
S1123
L
S
E
S
K
K
S
S
P
T
P
N
P
P
I
Site 138
T1125
E
S
K
K
S
S
P
T
P
N
P
P
I
F
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation